RESUMO
Tenosynovial giant cell tumor (TSGCT) of localized type is a common disease occurring mostly in the hands. Diagnosis of this tumor is relatively easy to render with hematoxylin-eosin-stained sections as compared with that of TSGCT of diffuse type. However, very rare cases with chondroid metaplasia that have recently been reported mainly in diffuse type can make pathological differentiation from soft tissue cartilaginous tumors extremely difficult. In this article, the authors present the second reported case of TSGCT of localized type showing extensive chondroid metaplasia. Pathological interpretation was difficult without utilizing immunohistochemistry and fluorescence in situ hybridization. One must be careful not to misdiagnose this lesion as cartilaginous tumors of soft tissue, and we suspect at least some chondroblastoma-like chondroma could be reclassified as TSGCT of localized type with extensive chondroid metaplasia. Morphological, immunohistochemical, and molecular genetic characteristics are presented and discussed.
Assuntos
Biomarcadores Tumorais/análise , Tumor de Células Gigantes de Bainha Tendinosa/diagnóstico , Cartilagem Hialina/patologia , Membrana Sinovial/patologia , Tendões/patologia , Idoso , Biomarcadores Tumorais/genética , Biomarcadores Tumorais/metabolismo , Colágeno Tipo VI/genética , Tumor de Células Gigantes de Bainha Tendinosa/genética , Tumor de Células Gigantes de Bainha Tendinosa/patologia , Mãos , Humanos , Cartilagem Hialina/diagnóstico por imagem , Cartilagem Hialina/cirurgia , Imuno-Histoquímica , Hibridização in Situ Fluorescente , Fator Estimulador de Colônias de Macrófagos/genética , Masculino , Metaplasia/diagnóstico , Metaplasia/genética , Metaplasia/patologia , Metaplasia/cirurgia , Membrana Sinovial/diagnóstico por imagem , Tendões/diagnóstico por imagem , Tendões/cirurgia , Tomografia Computadorizada por Raios XRESUMO
A polyoxotetradecamolybdate cluster [Mo(14)O(38)(OAc)(6)](2-), which has a lacunary core of the Wells-Dawson structure, is isolated by the reduction of [Mo(6)O(19)](2-). The Mo(14) core is comprised of a mixed valence of [Mo(V)(4)Mo(VI)(10)], exhibiting multi-step reversible redox processes that experience both oxidation and reduction.