[Use of fibrin glue in gynecologic operations]. / Primenenie fibrinovogo kleia pri ginekologicheskikh operatsiiakh.

Anastomosing of the uterine horns in 98 experimental rats has employed a fibrin glue FK-1 (USSR) and Beriplast (FRG) or microsurgical techniques in a control group. Intactness and sealing of the anastomoses and the incidence of pelvic adhesions were assessed at 5 minutes, 1 hour and 1, 2, 3, 4, 5, and 6 days following the operation. The fibrin glue Beriplast was used clinically in 6 patients during reconstructive-plastic operations. The results with seamless anastomosing of uterine horns in rats using the fibrin glue and preliminary clinical evidence suggests a high effectiveness of the glue in gynecologic reconstructive plastic surgery.

[Use of fibrin glue in pulmonary surgery]. / Primenenie fibrinovogo kleia v legochnoi khirurgii.

The article deals with the experimental data on the use of the "Beriplast" (GFR) and phi K-1 (USSR) fibrin glue (FG) for providing hemostasis and hermetization of the resected surface of the lung. The results were evaluated during the operation by the method of pneumopressure and by means of morphological studies. The "Beriplast" FG was applied in the clinic for aerostasis in incomplete +hermetization of the sutured pulmonary wound in 11 patients. Complete +hermetization was produced in all cases. Complications linked with the use of FG were not encountered.

[Use of fibrin glue in surgery of parenchymatous organs]. / Primenenie fibrinovogo kleia pri operatsiiakh na parenkhimatoznykh organakh.

The article discusses the results of one of the first studies conducted in the Soviet Union on the use of various types of fibrinous glue in operations on the parenchymatous organs. The data of 67 experiments on rabbits and 20 clinical cases are reported. The experiments were carried out to test the efficacy of fibrinous glue application for arresting parenchymatous bleeding and appraise the air-tightness of wounds of the liver, spleen, and kidney by the method of hydropressure with morphological control. The effect of fibrinous glue made of Soviet-produced components was also tested in experiment. In the clinic, fibrinous glue was used for arresting bleeding from wounds of the liver and spleen and for ensuring air-tightness of anastomoses and filling residual cavities after removal of hepatic cysts. The hemostatic effect of various types of fibrinous glue was found to be high both in experiments and in the clinic. Essential advantage over synthetic cyanoacrylate glues was proved. It was noted that the use of fibrinous glue in operations on the parenchymatous organs is promising.

[Endoprosthesis of the larynx using polymer materials]. / Endoprotezirovanie gortani polimernymi materialami.

An endoprosthesis for the formation of the larynx lumen in the postoperative period has been developed. The possibility of using the endoprosthesis was proved experimentally. An experience with 112 operations on the larynx with this prosthesis for the prevention of postoperative complications and earlier social rehabilitation of such patients allowed it to be recommended for clinical practice.

Three clinical methods of circulatory assistance.

Three clinical methods of circulatory assistance are described: intraaortic balloon counterpulsation, left ventricular bypass using a roller pump, and the artificial ventricle. All three methods have hemodynamic effectiveness. The first method is indicated in cases of widespread cardiosclerosis and pronounced coronary insufficiency and may be contraindicated in pathology of the valvular apparatus. The second method demonstrated a temporary positive effect in patients in whom it was not possible to discontinue artificial circulation. The artificial ventricle is useful in treating patients with cardiogenic shock following cardiac surgery.

Modeling and prospects for study of cardiovascular pathology with the artificial heart.

A series of models of the artificial heart has been developed for simulating different heart defects including stenosis of the atrioventricular ostium and mitral and tricuspid incompetence. Simulation of ventricular fibrillation is also possible. Repeated perturbation and restoration of artificial heart function are possible in the same animal. These processes are controlled externally. The surgical technique of implanting the artificial heart does not differ from the usual technique. Models of the artificial heart permit the study of fundamental problems in the physiology and pathology of the cardiovascular system.

[Ampicillin concentration in the blood when administered by jet injection and needle-syringe methods]. / Kontsentratsiia amptisillina v krovi pri bezygol'nom struinom i igol'no-shpritsevom sposobakh vvedeniia.

The studies were carried out on 50 persons. Ampicillin was administered with the help of a jet injector B1-2 and needle syringe in doses of 250 or 500 and 500 mg respectively. When the drug was administered by infusion, its maximum blood levels were achieved earlier than after needle-syringe administration of the drug and were higher (22.83+/-4.10 and 6.3+/-0.09 gamma/ml respectively). Even when ampicillin was administered with the help of the injector in a dose of 250 mg its blood levels were much higher than those after needle-syringe administration in a dose of 500 mg. After jet infusion the prolongation of the drug retention time in the blood at therapeutical levels was observed as compared to the needle-syringe administration.