Segmental arterial mediolysis after fenestrated endovascular abdominal aortic aneurysm repair-A rare complication.

Segmental arterial mediolysis (SAM) is a rare, noninflammatory, nonatherosclerotic condition that occurs commonly in mesenteric vessels. There are no known predisposing risk factors to the development of SAM. We present a case of a 67-year-old woman who presented with abdominal pain 2 days following discharge after an elective endovascular abdominal aortic intervention. Repeat imaging 2 days after readmission showed the presence of multiple new aneurysms involving the mesenteric vasculature. She underwent attempted endovascular embolization of the largest aneurysm. The postmortem and histopathologic examinations confirmed the diagnosis of SAM.

Percutaneous Treatments of Benign Bone Tumors.

Benign bone tumors consist of a wide variety of neoplasms that do not metastasize but can still cause local complications. Historical management of these tumors has included surgical treatment for lesion resection and possible mechanical stabilization. Initial percutaneous ablation techniques were described for osteoid osteoma management. The successful experience from these resulted in further percutaneous image-guided techniques being attempted, and in other benign bone tumor types. In this article, we present the most common benign bone tumors and describe the available results for the percutaneous treatment of these lesions.

Multivariate modeling of diffuse reflectance infrared fourier transform (DRIFT) spectra of mixtures with low-content polymorphic impurities with analysis of outliers.

Diffuse Reflectance Fourier Transform Infrared Spectroscopy (DRIFTS)-based multivariate models were developed to quantify the content of two polymorphic impurities in mixtures with the desired active pharmaceutical ingredient (API) form, with the impurities not exceeding 2% wt/wt. In addition, close attention was paid to the outlier detection criteria: Q residuals; Hotelling T2; and score bi-plot. While reasonably accurate results were obtained for the relatively simple calibration models for both forms of the impurity, the predictions for "blank" samples (separately verified to be impurity-free) were apparently biased. Thus, the model training sets were augmented with spectra from calibration mixtures incorporating some of the API from batches used in the prediction. The performance of the updated models as assessed by cross-validation was somewhat degraded as a result, while predictions against independent batches of API showed a decrease in bias indicating robustness had improved. Nevertheless, the Q residuals criterion disqualified a large number of prediction samples as outliers in contrast to the other two criteria that reported no issues at all. The results here demonstrated the effectiveness of DRIFTS for quantifying low concentration polymorphic impurities, while simultaneously highlighting the variability issues that can be encountered in practice and which need to be understood and managed appropriately to ensure the success of any automated or Good Manufacturing Practice (GMP) compliant application of multivariate modeling.

DRIFTS-based multivariate calibration and prediction of low-concentration polymorphic impurities in multiple lots of an active pharmaceutical ingredient, and outlier criteria.

Mixtures of two polymorphic impurities with one lot of the desired form of an Active Pharmaceutical Ingredient (API), mostly binary mixtures, with up to 2% wt/wt of an impurity, were used for multivariate modeling via Diffuse Reflectance Infrared Fourier Transform (DRIFT) spectra. The two obtained cross-validated models, significantly differing in accuracy, were used to predict the concentrations of these impurities in independent API lots. The predictions were found to be biased and with outliers, as revealed by the Q residuals criterion but not the other two outlier criteria. Updating the models with the spectra from the mixtures using multiple API lots produced very different calibration results: the model of the impurity with the strong IR response became noticeably worse, while the model of the impurity with less responsive IR signal changed only marginally. The updated models performed much better in the prediction as the bias for both polymorphs was reduced and the outlier-related issues mostly disappeared.

The np Rydberg series of boron monohydride: l-uncoupling and Rydberg electron interactions with the rovibrational motion of the ion core.

A simple two-channel quantum defect theory approach accounts for resonance positions in the np Rydberg series of (11)BH. The transition from Hund's case (b) to (d) in the interacting levels of this np series represents a fundamental example of electron orbital ⇔ cation core rotational coupling, and frame transformation theory offers a means to connect close-coupled electronically excited-state potentials and l-uncoupled Rydberg positions. This evolving interaction of the np Rydberg electron with the rotational and the vibrational motion of the (11)BH(+) core is formulated in terms of quantum defects, µ(λ)(v(+)).

Dynamics of dissociative recombination versus electron ejection in single rovibronic resonances of BH.

Optical-optical-optical triple resonance spectroscopy isolates transitions to vibrationless Rydberg states of BH with principal quantum numbers from n=7 to 50. Corresponding resonances appear in the excitation spectrum of excited boron atoms produced by the dissociative relaxation of these states. The decay to neutral products occurs on a nanosecond time scale. Yet, corresponding resonances show Fano coupling widths that approach 1 cm-1. Above threshold, spontaneous ionization dominates, but line shapes match for resonances with the same electron orbital quantum numbers built on v+=0 and v+=1 cores. This striking feature-for-feature similarity in predissociation and autoionization line shapes affirms that inelastic electron-cation scattering pathways leading to electron ejection and dissociative recombination proceed through a common continuum.

Rovibrational characterization of X 2Sigma+ 11BH+ by the extrapolation of photoselected high Rydberg series in 11BH.

Optical-optical-optical triple-resonance spectroscopy of (11)BH isolates high Rydberg states that form series converging to rotational state specific ionization potentials in the vibrational levels of (11)BH(+) from nu(+)=0 through 4. Limits defined by a comprehensive fit of these series to state-detailed thresholds yield rovibrational constants describing the X (2)Sigma(+) state of (11)BH(+). The data provide a first determination of the vibrational-rotational interaction parameter alpha(e)=0.4821 cm(-1) and a more accurate estimate of omega(e)=2526.58 cm(-1) together with the higher-order anharmonic terms omega(e)x(e)=61.98 cm(-1) and omega(e)y(e)=-1.989 cm(-1). The deperturbation and global fit of series to state-detailed limits also yield a precise value of the adiabatic ionization potential of (11)BH of 79 120.3+/-0.1 cm(-1), or 9.810 33+/-1x10(-5) eV. High precision is afforded here by the use of graphical analysis techniques, narrow-bandwidth laser systems, and an analysis of newly observed, high principal quantum number Rydberg states that conform well with Hund's case (d) electron-core coupling limit.