RESUMO
UNLABELLED: Our study is the type case-control realized at the Hospital of Constantine, discusses the relationship between polymorphism of apolipoprotein E and stroke. METHODS: The determination of the polymorphism of apolipoprotein E was carried out by PCR- digestion (polymerase chain reaction) using the enzyme of restriction HhaI. The study population consisted of 218 Algerian patients with stroke (divided into 63% ischemic and 37% hemorrhagic), and 509 control subjects. RESULTS: Three isoforms of apolipoprotéin E have been identified. The allelic distribution of apo E in the general population showed a predominance of the allele É3 (84.3%) followed distantly by allele É4 (10.7%) and É2 (5%) respectively. É3/É4 genotype was significantly more represented among subjects with ischemic stroke (29.5%) compared with control subjects (18.8%). The odds ratio is 1.72 compared to carriers of the genotype É3/É3 (CI is 95% and p <0.05). CONCLUSIONS: The distribution of allelic frequencies of apolipoprotein E in the population of Constantine is similar to that of Southern Europe. Our results imply a role of the genotype of apolipoprotein E (É4 allele) in the pathogenesis of stroke and are limited to the accidents of the ischemic type. The É2 allele does not appear to be implied in occurred of this affection; however, large additional studies are necessary to confirm this result.