1.
Bioorg Med Chem Lett
; 24(4): 1148-53, 2014 Feb 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24461295
RESUMO
A collection of αIIbß3 integrin receptor antagonists possessing a unique MIDAS metal ion displacement mechanism of action is presented. Insight into these agents' structure-activity relationships, binding modality, and pharmacokinetic and pharmacodynamic profiles highlight the potential of these small molecule ion displacement ligands as attractive candidates for clinical development.