SPLIT: Statistical Positronium Lifetime Image Reconstruction via Time-Thresholding.

Positron emission tomography (PET) is a widely utilized medical imaging modality that uses positron-emitting radiotracers to visualize biochemical processes in a living body. The spatiotemporal distribution of a radiotracer is estimated by detecting the coincidence photon pairs generated through positron annihilations. In human tissue, about 40% of the positrons form positroniums prior to the annihilation. The lifetime of these positroniums is influenced by the microenvironment in the tissue and could provide valuable information for better understanding of disease progression and treatment response. Currently, there are few methods available for reconstructing high-resolution lifetime images in practical applications. This paper presents an efficient statistical image reconstruction method for positronium lifetime imaging (PLI). We also analyze the random triple-coincidence events in PLI and propose a correction method for random events, which is essential for real applications. Both simulation and experimental studies demonstrate that the proposed method can produce lifetime images with high numerical accuracy, low variance, and resolution comparable to that of the activity images generated by a PET scanner with currently available time-of-flight resolution.

Positronium Lifetime Image Reconstruction for TOF PET.

Positron emission tomography is widely used in clinical and preclinical applications. Positronium lifetime carries information about the tissue microenvironment where positrons are emitted, but such information has not been captured because of two technical challenges. One challenge is the low sensitivity in detecting triple coincidence events. This problem has been mitigated by the recent developments of PET scanners with long (1-2 m) axial field of view. The other challenge is the low spatial resolution of the positronium lifetime images formed by existing methods that is determined by the time-of-flight (TOF) resolution (200-500 ps) of existing PET scanners. This paper solves the second challenge by developing a new image reconstruction method to generate high-resolution positronium lifetime images using existing TOF PET. Simulation studies demonstrate that the proposed method can reconstruct positronium lifetime images at much better spatial resolution than the limit set by the TOF resolution of the PET scanner. The proposed method opens up the possibility of performing positronium lifetime imaging using existing TOF PET scanners. The lifetime information can be used to understand the tissue microenvironment in vivo which could facilitate the study of disease mechanism and selection of proper treatments.

MRI super-resolution via realistic downsampling with adversarial learning.

Many deep learning (DL) frameworks have demonstrated state-of-the-art performance in the super-resolution (SR) task of magnetic resonance imaging, but most performances have been achieved with simulated low-resolution (LR) images rather than LR images from real acquisition. Due to the limited generalizability of the SR network, enhancement is not guaranteed for real LR images because of the unreality of the training LR images. In this study, we proposed a DL-based SR framework with an emphasis on data construction to achieve better performance on real LR MR images. The framework comprised two steps: (a) downsampling training using a generative adversarial network (GAN) to construct more realistic and perfectly matched LR/high-resolution (HR) pairs. The downsampling GAN input was real LR and HR images. The generator translated the HR images to LR images and the discriminator distinguished the patch-level difference between the synthetic and real LR images. (b) SR training was performed using an enhance4d deep super-resolution network (EDSR). In the controlled experiments, three EDSRs were trained using our proposed method, Gaussian blur, and k-space zero-filling. As for the data, liver MR images were obtained from 24 patients using breath-hold serial LR and HR scans (only HR images were used in the conventional methods). The k-space zero-filling group delivered almost zero enhancement on the real LR images and the Gaussian group produced a considerable number of artifacts. The proposed method exhibited significantly better resolution enhancement and fewer artifacts compared with the other two networks. Our method outperformed the Gaussian method by an improvement of 0.111 ± 0.016 in the structural similarity index and 2.76 ± 0.98 dB in the peak signal-to-noise ratio. The blind/reference-less image spatial quality evaluator metric of the conventional Gaussian method and proposed method were 46.6 ± 4.2 and 34.1 ± 2.4, respectively.