RESUMO
This paper was designed to report the results of analysis of metoprolol succinate substance and tablets obtained from two manufacturers, Akrikhin (Russia) and AstraZeneca (Sweden). The analysis was performed by spectroscopy in the near IR region and followed by the chemometric treatment of the data obtained. The method was used to confirm the "identity" of metoprolol succinate tablets. The approach to distinguishing the differences between pharmaceutical dosage forms produced by different manufacturers is proposed. Also, the method for the qualitative determination of metoprolol succinate in the pharmaceutical formulations has been developed.
Assuntos
Medicamentos Falsificados/análise , Indústria Farmacêutica/normas , Metoprolol/análogos & derivados , Espectroscopia de Luz Próxima ao Infravermelho/métodos , Calibragem , Química Farmacêutica , Análise Discriminante , Metoprolol/análise , Metoprolol/normas , Farmacopeias como Assunto , Polônia , Controle de Qualidade , Federação Russa , Espectroscopia de Luz Próxima ao Infravermelho/instrumentação , Suécia , ComprimidosRESUMO
This paper reports the results of analysis of the metoprolol succinate tablets fabricated by two different manufacturers, Akrikhin (Russia) and AstraZeneka (Sweden) by near-IR spectroscopy in the combination with the chemometric processing of the data obtained (discriminative analysis). It is concluded that this method is applicable for the assessment of interlot dispersion of the metoprolol succinate tablets.