RESUMO
The cathepsin D concentration in 18 women with benign breast pathology has a cut-off value of 43 pmol/mg of protein. High values have been detected in two cases of chronic mastitis. These high values of cathepsin D were found in a study of 62 patients suffering from breast cancer and are independent of the hormone dependent state of the tumour. The cathepsin D concentration may have a prognostic function in breast cancer determination, as high concentrations are found in combination with other prognostic factors such as clinical stage, size of the tumour, state of the axillary lymph nodes and in the histological differentiation grade, where from a statistical point of view, the combination is important.
Assuntos
Biomarcadores Tumorais/metabolismo , Neoplasias da Mama/metabolismo , Catepsina D/metabolismo , Adulto , Idoso , Neoplasias da Mama/patologia , Neoplasias da Mama/secundário , Carcinoma Intraductal não Infiltrante/metabolismo , Carcinoma Intraductal não Infiltrante/patologia , Carcinoma Intraductal não Infiltrante/secundário , Feminino , Humanos , Metástase Linfática , Pessoa de Meia-Idade , PrognósticoRESUMO
PIP: A clinical study to quantify estrogen receptors in tissues from malignant and benign breast tumors was conducted on 61 patients in the hospital "La Paz" of Madrid, Spain. 42 tumors were malignant, and 19 benign. The McGuire technique, based on the property of receptor protein to combine with tritiated estradiol-17 B, was used. Among the 42 biopsies with malignant histology 25 had significant quantities of estrogen receptors. Among the 19 biopsies with benign histology, only 3 had positive receptors. Endocrine treatment for such cases usually consists in administration of antiestrogens. The article also contains a brief review of the latest published literature on the subject.^ieng