RESUMO
Myofibroblastoma (MFB) of the breast is a rare benign neoplasm, which exhibits several morphologic variants and presents diagnostic dilemmas for pathologists. Here, we describe a case of a 42-year-old female patient diagnosed as epithelioid MFB. This painless tumor was well-circumscribed and found in the left breast for three months. Histologically, this tumor was predominantly composed of epithelioid cells, which arranged as single cells or small clusters, and formed a cellular nodule. Tumor stroma was collagenized, with scattered myxoid areas. This case was misinterpreted as invasive lobular carcinoma in the original diagnosis. Immunohistochemical profile demonstrated positivity for desmin, SMA, calponin, CD34 and hormone receptors, whereas pan-CK, CK7, CK8, CK34bE12, CK5/6, EMA, p63 and S-100 were negative, confirming the diagnosis of epithelioid MFB. Awareness of this unusual variant and careful integration of clinicopathologic findings would be critical to diagnosis this challenging lesion and avoid potential diagnostic pitfalls.
RESUMO
Hepatic epithelioid hemangioendothelioma (HEHE) is a rare category of vascular tumor with uncertain malignant potential. It commonly presents nonspecific and variable clinical manifestations, ranging from asymptomatic to hepatic failure. In addition, laboratory measurements and imaging features also lack specificity in the diagnosis of HEHE. The aim of the present study is to highlight the dilemma and challenges in the preoperative diagnosis of HEHE, and to enhance awareness of the range of hepatobiliary surgery available in patients with multiple hepatic nodular lesions on imaging. In these patients, HEHE should at least be considered in the differential diagnosis.
Assuntos
Hemangioendotelioma Epitelioide/diagnóstico , Neoplasias Hepáticas/diagnóstico , Adulto , Antígenos CD34/análise , Biomarcadores Tumorais/análise , Biópsia , Feminino , Hemangioendotelioma Epitelioide/diagnóstico por imagem , Hemangioendotelioma Epitelioide/patologia , Hemangioendotelioma Epitelioide/cirurgia , Hepatectomia , Humanos , Imuno-Histoquímica , Neoplasias Hepáticas/diagnóstico por imagem , Neoplasias Hepáticas/patologia , Neoplasias Hepáticas/cirurgia , Molécula-1 de Adesão Celular Endotelial a Plaquetas/análise , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Valor Preditivo dos Testes , Tomografia Computadorizada por Raios X , UltrassonografiaAssuntos
Granuloma de Células Plasmáticas/diagnóstico por imagem , Hepatopatias/diagnóstico por imagem , Diagnóstico Diferencial , Diafragma/diagnóstico por imagem , Granuloma de Células Plasmáticas/patologia , Humanos , Hepatopatias/patologia , Neoplasias Hepáticas/diagnóstico , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Tomografia Computadorizada por Raios XRESUMO
BACKGROUND: Neuroendocrine carcinoma is rare with a proportion of less than 2% in gallbladder malignancies, cases of gallbladder neuroendocrine cell carcinoma coexisting with adenocarcinoma are exceptionally rare, and the prognosis is dismal. METHODS: Herein, we presented an unusual case of poorly differentiated gallbladder neuroendocrine cell carcinoma coexisting with poorly differentiated adenocarcinoma who survived 20 months after the multimodal treatment (MT) of extended surgery and postoperative chemotherapy. RESULTS: Our result indicated that for advanced gallbladder neuroendocrine cell carcinoma coexisting with adenocarcinoma, MT including extended surgical approach combined with postoperative chemotherapy may contribute to a relatively good survival outcome. CONCLUSION: MT may contribute to a relatively good survival outcome for advanced gallbladder neuroendocrine cell carcinoma coexisting with gallbladder adenocarcinoma.