[New opportunities of antithrombotic therapy in patients with type 2 diabetes mellitus and stable coronary heart disease for reducing the cardiovascular risk and cardiovascular complications: THEMIS, THEMIS-PCI trials].

Patients with diabetes mellitus (DM) and coronary heart disease belong to a group with a very high risk of developing cardiovascular disease. In patients with coronary atherosclerosis, DM increases the risk of ischemic events by 2-4 times. Apparently, increased antithrombotic therapy has an advantage in patients with DM who have had myocardial infarction. However, until recently it was not clear there is such an advantage in patients with DM and stable coronary artery disease without prior myocardial infarction. The addition of ticagrelol to monotherapy of acetylsalicylic acid reduces the risk of major cardiovascular events in patients with type 2 DM and stable coronary artery disease undergoing percutaneous coronary intervention, if patients have a high risk of ischemic events.

[Effect of carbohydrates on possible utilization of wastes from antibiotic-manufacturing plants in the construction industry]. / O vliianii uglevodov na vozmozhnos't utilizatsii otkhodov proizvodstva antibiotikov v stroite'lnoi industrii.

Utilization of antibiotic manufacture waste containing a certain amount of carbohydrates in concrete preparation requires their control. It was shown that the content of not more than 0.5 per cent of carbohydrates in the waste had no unfavourable effect on the concrete hardening.

[Utilization of modified waste from the antibiotic industry for the production of construction materials]. / Utilizatsiia modifitsirovannykh otkhodov proizvodstva antibiotikov dlia polucheniia stroitel'nykh materialov.

Possible utilization of treated streptomycin fermentation broth modified with waste hydrochloric acid solution followed by lime neutralization was studied. Such a complex additive to concrete increased its strength by 36-41 per cent. With saving cement by 7 per cent the concrete strength increased by 22-29 per cent as compared to the control samples. Therefore, utilization of antibiotic industry waste in production of building material allowed not only to improve its quality but also to lower the environmental pollution.

[Utilization of mycelial waste of antibiotic production in the technology of kilned construction materials]. / Utilizatsiia mitselial'nykh otkhodov proizvodstva antibiotikov v tekhnologii obzhigovykh stroitel'nykh materialov.

At present the main part of the mycelial waste of antibiotic production is collected in sludge lagoones, discarded to the sewage treatment system or burnt. The mycelial waste is one of the causes of the environmental pollution. It contains a significant quantity of valuable substances, such as lipids, carbohydrates, proteins and amino acids. The inorganic portion of the waste includes the compounds of calcium, magnesium, sodium, iron, silicium and phosphorus. The levels of the above substances in the mycelial waste allow using it as organic mineral additives in making expanded clay aggregate gravel with the use of low quality clay and loam. It may be also used as the burn-out of the raw material charge in making burnt bricks and other burnt building materials. By its calorific value the mycelial waste is equal to brown coal or peat. It was shown that the structural and mechanical properties of the mixtures of the mycelium and clay depended on the moisture content of the composition and the proportion of its components. The mycelial waste provided a decrease in the optimal temperature of burning by 40-50 degrees C. The production tests at the expanded clay aggregate plants showed that the bulk weight of expanded clay aggregate might be lowered by 50-100 kg/m3 and the usual additives with the use of petroleum products might be completely excluded from the technological process. The use of the mycelial waste for manufacture of burnt building materials provides saving of the fuel energy sources and improvement of the quality of the finished product. It is also important from the ecological viewpoint.