[An experimental study of the immunogenic and protective properties of Coxiella burnetii strain M-44 and a live enteral vaccine against Q fever]. / Eksperimental'noe izuchenie immunogennykh i protektivnykh svoistv shtamma M-44 Coxiella burnetii i zhivoi énteral'noi vaktsiny protiv likhorodki Ku.

High effectiveness of C.burnetii strain M-44 was confirmed in experimental studies on subcutaneously immunized guinea pigs ¿correction of pig] after their intratracheal infection with the virulent culture of the infective agent. The study revealed that the dose necessary for the enteral immunization of guinea pigs and monkeys was 10(4.8) -- 10(5.0) times less than that needed for the oral immunization of the animals. Live enteral vaccine obtained on the basis of this strain possessed sufficiently pronounced immunogenic and protective properties, protecting 75% of immunized monkeys from subcutaneous infection with C.burnetii virulent culture.

[The protective activity of the attenuated strain 15 of the Venezuelan equine encephalomyelitis virus in rodent infection via the respiratory tract]. / Protektivnaia aktivnost' attenirovannogo shtamma 15 virusa venesuél'skogo éntsefalomielita loshadei pri infitsirovanii gryzunov cherez dykhatel'nye puti.

Administration to rodents (Syrian hamsters, mice, guinea pigs, rabbits) of minimal doses of attenuated strain 15 VEE (up to 20 ImD50) provided protection against respiratory challenge with a highly virulent strain of Venezuelan equine encephalomyelitis virus. The protection is observed in a wide range of doses (up to LD50 hundreds and even thousands).

[The postvaccinal reaction in hamadryas baboons to the administration of attenuated strain 15 of the Venezuelan equine encephalomyelitis virus]. / Postvaktsinal'naia reaktsiia u pavianov gamadrilov na vvedenie attenuirovannogo shtamma 15 virusa venesuél'skogo éntsefalomieta loshadei.

Immunization of Papio hamadryas with attenuated VEE virus (strain 15) causes seroconversion in 100% of animals. Postvaccinal reaction such as viremia and short-lasting fever occurs in response to the injection of 10(3) ImD50 in about 30% of animals. CNS lesion symptoms characterizing infection of Papio hamadryas with natural Trinidad strain do not occur in response to injection with attenuated strain.