RESUMO
The absorption and elimination of a hospital pharmacy preparation of carbamazepine suspension have been investigated in a group of 6 new-born and 2 older infants. The results indicate that carbamazepine is adequately absorbed from the gastrointestinal tract and that blood carbamazepine levels which are therapeutic in older children or adults are maintained with doses of 5-8 mg/kg twice daily. Elimination half-lives in this group of infants, who were each receiving other anti-epileptic drugs, varied from 7.2 to 15.2 h. Carbamazepine may provide a useful alternative to phenytoin and phenobarbitone as maintenance oral therapy in the management of neonatal seizures. Further investigation of efficacy and safety in this age group is required.
Assuntos
Carbamazepina/uso terapêutico , Convulsões/tratamento farmacológico , Carbamazepina/administração & dosagem , Carbamazepina/sangue , Humanos , Recém-Nascido , Cinética , SuspensõesRESUMO
Previous models for febrile convulsions have used environmentally induced hyperthermia as the stimulus to induce convulsions. Changes in response to metrazole during yeast-induced fever in juvenile rats are reported here. Animals were more susceptible to metrazole during the rising phase of fever but showed some resistance to its convulsant effects once the fever was established and following defervescence. It is suggested that this may form the basis of a physiologically more appropriate model for the study of the pathogenesis of febrile convulsions.