Urinary Versus Recombinant Gonadotropins for Ovarian Stimulation in Women Undergoing Treatment with Assisted Reproductive Technology.

Globally, about 10%-15% couples are affected by infertility, with major role being played by the couple's lifestyle. Several gonadotropin preparations (urinary, purified urinary, recombinant, and biosimilars) are available for use. Purified urinary formulations offer numerous advantages over their predecessor, including lesser injection dose required, ability to be administered subcutaneously, less batch-to-batch variability, better efficacy, ability to individualize protocols as per patient's need, better control of developing follicles, less risk of multiple pregnancies, and hyperstimulation. Published results of Cochrane reviews and meta-analysis show no difference in efficacy or safety between urinary and recombinant gonadotropins. In the absence of any significant difference, cost plays an important role in deciding choice of gonadotropins. In this article, we have reviewed the results of comparative clinical trials, Cochrane analysis, and meta-analysis to derive consensus statements regarding efficacy, safety, and cost implications of urinary versus recombinant gonadotropin preparations.

Broad ligament cystic lymphangioma: a case report.

INTRODUCTION: Cystic lymphangiomas are uncommon tumors that can arise from any part of the body. They can pose a diagnostic and therapeutic challenge. They are more common in infants and children than adults. Broad ligament cystic lymphangioma is extremely rare. CASE PRESENTATION: A 70-year-old multiparous woman presented with an abdominal mass of 20-year duration. A large cystic swelling was detected on computed tomography scan that was found to arise from the left adnexal region. This 19 kg lesion was found arising from the broad ligament. It was successfully removed. A detailed pathological study, including immunohistochemistry, was required to diagnose the lesion as a cystic lymphangioma. CONCLUSION: Lymphangiomas should be treated with total surgical excision. Broad ligament lymphangiomas are extremely rare but must be considered as a differential diagnosis of cystic lesions in that region.

An autopsy study of relationship between perinatal stomach capacity and birth weight.

BACKGROUND: Aspiration pneumonia is a common complication of overfeeding in neonates. Since overfeeding may be related to neonatal stomach capacity, it was considered worthwhile to obtain such data. AIMS: To measure the capacity of stomach obtained from fresh stillbirths and liveborn infants at autopsy and correlate the same with their birth weights. METHODS: Stomach capacity was measured at autopsy in 63 stillborn and 37 newborn infants with birth weights ranging from 500 g to 3500 g. RESULTS: Stomach capacity had a significant positive correlation with birth weight (r = 0.56, p < 0.001). A formula and a nomogram have been derived to estimate stomach capacity from birth weight. There was no significant difference in stomach capacity between liveborn and stillborn infants in any of the weight groups, except in the 1501-2000 g weight group (p < 0.001). CONCLUSIONS: Our results have provided normative data on stomach capacity across a wide birth weight range in the perinatal period.

New manifestations of Neu-Laxova syndrome.

We report on a newborn boy with Neu-Laxova syndrome and spina bifida, bilateral cryptorchidism, and shallow orbital cavities. Association of these manifestations in Neu-Laxova syndrome is the first to be reported in the literature. This is the first report of Neu-Laxova syndrome from India.