Assuntos
Química Encefálica , Cromatografia Gasosa , Dronabinol/análise , Dronabinol/sangue , HumanosAssuntos
Proteínas Sanguíneas/metabolismo , Dronabinol/sangue , Animais , Ligação Competitiva , Masculino , Ligação Proteica , RatosRESUMO
Isotope effect studies on the metabolic dehydrogenation of delta 1-tetrahydrocannabinol in rats are described and it is shown that this process is confined to a very short period following i.v. administration. The implications of this finding are discussed.
Assuntos
Canabinoides/sangue , Canabinol/sangue , Dronabinol/sangue , Animais , Radioisótopos de Carbono , Ratos , TrítioRESUMO
Co-administration of cannabidiol with delta1-tetrahydrocannabinol was found to have no effect on the rate of disappearance of delta1-tetrahydrocannabinol from the blood of rats. The implications of this finding are discussed.
Assuntos
Canabidiol/farmacologia , Cannabis/metabolismo , Cannabis/farmacologia , Dronabinol/metabolismo , Animais , Canabidiol/sangue , Canabidiol/metabolismo , Dronabinol/sangue , Dronabinol/farmacologia , Interações Medicamentosas , Cinética , Masculino , RatosRESUMO
The co-administration of cannabinol with delta1-tetrahydrocannabinol accelerates the rate of clearance of delta1-tetrahydrocannabinol from rat blood. This increased rate of clearance appears to follow that of cannabinol. The implications of these findings are discussed.