[Synthesis of uracil and theophylline derivatives and study of their effect on glucose transport in rat hepatic cells]. / Sintez proizvodnykh uratsila i teofillina i issledovanie ikh vliianiia na transport gliukozy v kletki pecheni krys.

A series of uracil and theophyllin derivatives were synthesized. 4-Amino-1,3-dimethyl-5-nonanoylaminouracil displayed the most pronounced effect of the in vitro stimulation of the 2-deoxyglucose transport into hepatic rat cells.

[Effects of dalargin on the proliferative processes of the gastric epithelium under repeated action of different stressors]. / Vliianie dalargina na proliferativnye protsessy épiteliia zheludka pri povtornykh vozdeistviiakh razlichnykh strssorov.

Using radiography with H-thymidine method we studied the synthesis of DNA process in pyloric parts of stomach epithelium in white rats, which have been five-fold effected by different kinds of stressors against a background of dalargin injections. In the first hour after animals were stressed, DNA synthesis was depressed. Dalargin injections caused DNA synthesis normalization in the first hour after hypoxia and hyperthermia. Since 24 hours after hyperthermia and immobilization against a background of dalargin injections the normalization of DNA synthesis took place, and after hypoxia the post-stressing IMN activation was growing week. One of the mechanisms of dalargin correction of DNA synthesis breach under the influence of stressors is a stabilization of noradrenaline and histamine concentration in tissue of the stomach.

[Effects of dermorphin on processes of cell division in the corneal and tongue epithelium of white rats]. / Vliianie dermorfina na protsessy kletochnogo deleniia v épitelii rogovitsy i iazyka belykh krys.

The character of dermorphin influence on cell division in corneal and tongue epithelium of white rats was studied by the method of radioautography with 3H-thymidine. The effect of dermorphin was distinct from the effect of delta-receptors ligands on the cell division processes in corneal and tongue epithelium of experimental animals. The injection of dermorphin in dose 10 micrograms/kg compressed the DNA-synthesis in 4 and 24 hours since the moment of administration. The mitotic index increased in 4 hours and decreased in 24 hours.

[Insulin-dependent complement activity in the serum of patients with diabetes mellitus]. / Insulinz visimaia aktivnost' komplementa v syvorotke bol'nykh sakharnym diabetom.

Complement system was comparatively evaluated in 68 patients with diabetes mellitus and 104 healthy subjects. Hemolytic activity was examined for components C1, C2, C3, C4 and C5, and overall activity of the classic pathways was defined. The complement status appeared different for men and women. Females demonstrated hypofunction of the majority of the complement components, subcompensation in the absence of angiopathies, in decompensation complicated by angiopathies the activity was enhanced. In uneventful course of diabetes mellitus in males component C4 was activated remaining above normal though reduced in decompensation with angiopathies. High complement level in females could serve an aggravating factor, it depends on the dose of exogenic insulin.

[Effect of fluorine-containing ethers of permetrinic acid on inactivation kinetics of sodium influx into neuroblastoma cells (NEURO-2(alpha)]. / Vliianie ftorsoderzhashchikh éfirov permetrinovoi kisloty na kinetiku inaktivatsii natrievogo toka v kletkakh neiroblastomy (NEURO-2(alpha).

A synthesis of a number of esters of (+/-)-cis, trans-3-(2,2-dichlorovinyl) -2,2-dimethylcyclopropanecarboxylic acid with polyfluorinated alcohols was carried out. Their effect on kinetics of inactivation of sodium current in neuroblastoma (Neuro-2a) cells by the patch-clamp technique in the whole-cell configuration was investigated.

[L-pyroglutamyl-D-alanine amide normalizes the function of the developing brain damaged by antenatal alcoholization in rats]. / Normalizatsiia amido L-piroglutamil-D-alanina funktsii razvivaiushchegosia mozga, narushennykh antenatal'noi alkogolizatsiei krys.

The effects of the synthetic dipeptide, L-pyroglutamyl-D-alaninamide (LPDA) were studied in the experiments on offspring of alcoholized during the pregnancy (5 g/kg/day) females. This dipeptide, which revealed the nootropic activity in previous experiments, was injected to the pups in dose of 1 mg/kg from 8 to 19 days of life. LPDA was shown to prevent the delayed disturbances of learning in passive avoidance test, of extrapolatory behaviour in escape test, to attenuate the emotional hyperreactivity. LPDA normalized EEG power spectrum, decreased interhemispheric asymmetry. This substance attenuated the disbalance evoked by prenatal alcoholization.

Active immunization against bioregulators: behavioural and catecholamine changes in albino rats immunized against sydnophen.

Active immunization of white rats against the catecholamine analogue, sydnophen, results in physiological changes extending over two months. The levels of noradrenaline in blood, and dopamine in brain, were depressed, some behavioural activities were reduced and alcohol consumption was lowered. On this basis, active immunization against various bioregulators--a method of inverse regulation--shows promise as a method for achieving long-term adjustment of physiological status.

[Effects of sodium oxybutyrate on the level of catecholamines and serotonin and monoamine oxidase activity in patients with alcoholism]. / Vliianie natriia oksibutirata na urovni katekholaminov, serotonina i aktivnost' monoaminoksidazy u bol'nykh alkogolizmom.

Sodium salt of gamma-hydroxybutyric acid (Na-GHB) was administered to 37 drug-free alcoholic men in placebo controlled study. The psychotropic effect was evaluated using psychometric scale of 4 ranges. Changes in plasma levels of epinephrine, norepinephrine, dopamine, serotonin and platelet MAO-B activity were assessed. The psychotropic effect was observed in 27 (76%) patients. The baseline of dopamine concentration was significantly correlated with the expression of psychotropic effect. Na-GHB decreased dopamine concentration in responders. The possible involvement of dopaminergic system in the realization of psychotropic effect of Na-GHB was discussed.

[Various biochemical indicators in prenatally alcoholized rats]. / Nekotorye biokhimicheskie pokazateli u krys pri antenatal'noi alkogolizatsii.

A number of biochemical parameters have been determined which characterized the state of CNS and the structure of cell membranes in antenatally alcoholized animals. As compared with the control group the alcoholized animals had a significantly increased level of phosphatidyl inositol diphosphate in brain phospholipid fractions, while content of serotonin was reduced in their brain and increased in blood plasma; content of phosphatidyl serine and the cholesterol/phospholipids ratio were reduced in brain.

[Plasma levels of biogenic amines in patients with various forms of the alcohol abstinence syndrome]. / Soderzhanie biogennykh aminov v plazme krovi u bol'nykh s razlichnymi formami alkogol'nogo abstinentnogo sindroma.

Norepinephrine (NE), dopamine (DA) and serotonin (5-HT) blood plasma levels were measured in 40 alcoholic patients (2nd stage) during overt manifestations of the alcohol abstinence syndrome (AAS). Twenty-five healthy individuals served as controls. The patients were divided into four groups according to the structure of their AAS-related psychopathology and the progress of the disease. In the fast-progressive group with autonomic disorders prevalent in the AAS structure, the excitability, NE and DA levels were elevated. In the group with prevalent asthenic-neurotic and affective disorders, the 5-HT levels were lower than controls. The group with fast-progressive course of the disease and schizoaffective disorders had both the 5-HT and NE levels lowered. The authors discuss the possible impact of the results on perfectioning of the differential AAS therapies.

[Effect of magnolia vine lignans on cell division processes in the corneal and lingual epithelium of white rats subjected to long-term exposure to cold stress]. / Vliianie lignanov limonnika na protsessy kletochnogo deleniia épiteliia rogovitsy i iazyka belykh krys, podvergnutykh dlitel'nomu vozdeistviiu kholodovogo stressa.

A study was made of the possibility of correcting with shizandra lignans of the cell manifestations of disadaptation in animals exposed to chronic cold stress. The stress was simulated by a 1.5-hour cooling of the animals to 28-30 degrees C for 28 days. The cell disadaptation test was used for determination of the level of pathological mitoses (PM). The processes of cell division were evaluated with the aid of the mitotic index and radioautography of DNA synthesis. Administration of shizandra to the stress-exposed animals for 28 days averted the stress-induced elevation of the PM level in the corneal epithelium. The use of shizandra lignans also promoted the normalization of DNA synthesis and mitotic activity in the tissues under examination.

[Effect of chronic stress on cell division in corneal and tongue epithelia]. / Vliianie khronicheskogo stressovogo vozdeistviia na protsessy kletochnogo deleniia épiteliia rogovitsy i iazyka.

Chronic stress was simulated by daily 1.5-hour cooling of rats to 28-30 degrees C for 28 and 35 days. Stress development was marked by the decreased animals' weight, the reduction in the thymus weight, increase in the adrenal weight and lowered adrenaline content in the adrenals. Chronic stress resulted in a high level of pathological mitoses in the cornea. All series of experiments demonstrated DNA synthesis activation detectable by autoradiography. There were three variants of mitotic activity: the first one was characterized by "scissors" between high DNA synthesis and low mitotic activity, the second one by high DNA synthesis attended by mitotic activity normalization, and the third variant was marked by agreement between high DNA synthesis and high mitotic activity. A possible reason for the "scissors" between DNA synthesis and mitotic activity is discussed.