Patient-reported outcome measures in knee injuries rehabilitation: A protocol for intervention.

Different musculoskeletal conditions affect people all over the world and were considered by the WHO to be the main cause of disability in 4 of 6 regions in 2017, with an increase in the associated burden and the impact they have on today's society. One of these conditions is related to the knee, which is associated with complex and vulnerable injuries associated with ligaments, menisci, and cartilage. After surgery, there is a reflex inhibition of motor neurons and immobilization, there is rapid atrophy and weakness in the different associated muscles, affecting proprioception, strength and muscle function, compromising quality of life. The aim of this article is to describe a protocol for a rehabilitation program after surgery for people with knee injuries. An experimental study will be carried out with 75 patients, with control and experimental groups. In both groups, initial measurements will be compared with measurements after the program, at different times. It is hoped that this study will generate significant information on rehabilitation intervention for people with knee injuries.

Radiofrequency driving antitumor effect of graphene oxide-based nanocomposites: a Hill model analysis.

Aim: This report proposes using the Hill model to assess the benchmark dose, the 50% lethal dose, the cooperativity and the dissociation constant while analyzing cell viability data using nanomaterials to evaluate the antitumor potential while combined with radiofrequency therapy. Materials & methods: A nanocomposite was synthesized (graphene oxide-polyethyleneimine-gold) and the viability was evaluated using two tumor cell lines, namely LLC-WRC-256 and B16-F10. Results: Our findings demonstrated that while the nanocomposite is biocompatible against the LLC-WRC-256 and B16-F10 cancer cell lines in the absence of radiofrequency, the application of radiofrequency enhances the cell toxicity by orders of magnitude. Conclusion: This result points to prospective studies with the tested cell lines using tumor animal models.

Sobrevivência aos Cânceres Ósseos e Reinserção Social / Survivorship to Osteosarcomas and Social Reinsertion / Supervivencia de los Cánceres de Hueso y Reinserción Social

Introdução: Pacientes com cânceres ósseos representam uma população singular com necessidades psicossociais pouco estudadas. Objetivo: Compreender o processo e o impacto da reinserção social para a vida cotidiana de adolescentes e adultos jovens após o tratamento e seguimento oncológico de cânceres ósseos. Método: Pesquisa qualitativa e exploratória, utilizando referencial metodológico da tradição hermenêutica com produção de dados por meio de entrevistas semiestruturadas com 12 sobreviventes de cânceres ósseos. Resultados: O material empírico foi organizado em três categorias: Reinserção social na família, Reinserção social na escola e Inserção na vida sociolaboral. Os desafios da reinserção social na família, escola e vida laboral de adolescentes e adultos jovens após o tratamento de câncer ósseo envolvem um complexo sentido de enfrentamento dos estigmas e limitações impostas pela doença e seu tratamento. Conclusão: As percepções e experiências dos sobreviventes ao câncer ósseo apontam para a vida social como um lugar de desafios e incertezas, perdas e lutos. É de extrema importância a existência de apoio multiprofissional especializado, assim como apoios familiar e social, para que esse grupo consiga suportes material e humano para enfrentar as mudanças decorrentes do tratamento oncológico

Introduction: Patients with bone cancer are a unique population with poorly investigated psychosocial needs. Objective: To understand the process and impact of social reintegration on the daily lives of adolescents and young adults after treatment and oncological follow-up of bone cancers. Method: Qualitative, exploratory, hermeneutic-based investigation with data obtained from semistructured interviews with 12 bone cancer survivors. Results: The empirical material was organized into three categories: Social reintegration into the family, Social reintegration at school and Insertion into social-labor life, which are challenging and involve a complex concept of coping with the stigmas and limitations imposed by the disease and its treatment. Conclusion: The emotions and experiences of cancer survivors indicate social life as a place of challenges and uncertainties, losses and grief. It is extremely important to count with specialized multidisciplinary support, as well as family and social background to enable this group to face cancer treatment related challenges

Introducción: Los pacientes con cáncer de huesos representan una población con necesidades psicosociales poco estudiadas. Objetivo: Comprender el proceso y el impacto de la reinserción social en la vida cotidiana de los adolescentes y adultos jóvenes después del tratamiento y seguimiento oncológico de los cánceres de huesos. Método: Investigación cualitativa y exploratoria, con referente metodológico de la tradición hermenéutica. La producción y el análisis de datos se basaron en 12 entrevistas semiestructuradas con sobrevivientes de cáncer de huesos. Resultados: El material empírico se organizó en tres categorías: Reinserción social en la familia, Reinserción social en la escuela e Inserción en la vida sociolaboral. Los desafíos de la reinserción social en la vida familiar, escolar y laboral de los adolescentes y jóvenes después del tratamiento del cáncer de huesos implican un sentido complejo de enfrentamiento de los estigmas y limitaciones que impone el cáncer y su tratamiento. Conclusión: Las emociones y experiencias de los sobrevivientes de cáncer apuntan a la vida social como un lugar de desafíos y choques, pérdida y duelo. Es de suma importancia contar con un apoyo multidisciplinario especializado, familiar y social, para que este grupo pueda obtener apoyo material y humano para enfrentar los cambios derivados del tratamiento del cáncer

Indução de dislipidemia em ratos Wistar e comparação do tratamento com sinvastatina e quercetina / Dyslipidemia induction in Wistar rats with comparison of treatment with sinvastatin and quercetin

A Dislipidemia causa diversas doenças cardiovasculares e metabólicas, e as estatinas são seu tratamento padrão. Alternativas para o tratamento têm sido estudadas para reduzir efeitos colaterais. O flavonoide quercetina mostrou um potencial efeito antioxidante e redutor de colesterol. Objetivou-se analisar a diferença entre o tratamento atual com sinvastatina e outro com quercetina. 25ratos Wistar foram divididos em 5 grupos: G1 com dieta padrão; G2 recebendo dieta hiperlipídica (DH); G3 DH e 10mg/Kg de sinvastatina; G4 DH e 2mg/Kg de quercetina após 10 dias da dieta; G5 DH e 2mg/Kg de quercetina desde o início. Todos foram mantidos por 90 dias até eutanásia, quando coletou-se tecidos e sangue para análise.Encontrou-se uma maior proporção de diabetes (GLI>6Mmol/dl) no G2 quando comparado ao G3 e G5. Além da glicemia, G2 teve maiores valores de triglicerídeos e do índice TG-HDL, porém não apresentaram diferença significativa entre os demais

Dyslipidemia causes diverse cardiovascular and metabolic diseases, and statins are its standard treatment. Alternatives treatments to reduce side effects are in study. The flavonoid quercetin showed a potential antioxidant and cholesterol lowering effect. The aim was to analyze the difference between the current treatment with simvastatin and other with quercetin. 25 Wistar rats were divided into 5 groups: G1 with standard diet; G2 receiving hyperlipidic diet (HD); G3 HDand 10mg / kg simvastatin; G4 HD and 2 mg / kg quercetin after 10 days of diet; G5 HD and 2mg / kg quercetin from the beginning. All groups were kept for 90 days until euthanasia, when tissue and blood were collected for analysis. A higher proportion of diabetes (GLI>6Mmol / dl) was found in G2 compared to G3 and G5. In addition, G2 had higher levels of triglycerides and TG-HDL, but lack a significant difference between the others