RESUMO
We report the results of a comparative study of the biological activity of a series of gold(i), palladium(ii) and ruthenium(ii) complexes containing deprotonated thio- and selenoureato ligands. A library of compounds was prepared and characterised by spectroscopic methods and the solid-state structures of several derivatives were determined by single crystal X-ray diffraction. The in vitro activity of these compounds was evaluated in mammary and ovarian carcinoma, acute lymphatic and acute and chronic myeloid leukemia cell lines. At lower concentrations Ru- and Pd-containing compounds displayed stronger anti-cancer effects than the gold compounds. In all cases, the selenium derivatives proved to be more active than the corresponding sulfur compounds.
RESUMO
A series of both mono- and dinuclear gold(I) phosphine complexes containing monoanionic seleno- and thiosemicarbazones as ligands were prepared and fully characterized by spectroscopic methods and, in some cases, by single crystal X-ray diffraction. The in vitro anti-malaria activity of some of these compounds was investigated in chloroquine sensitive strains of Plasmodium falciparum. The IC(50) results show that the sulfur containing compounds exhibit activity similar to that of chloroquine, whilst the selenium derivatives display only moderate anti-malaria activity.
Assuntos
Antimaláricos/farmacologia , Compostos Organometálicos/farmacologia , Plasmodium falciparum/efeitos dos fármacos , Antimaláricos/síntese química , Antimaláricos/química , Cristalografia por Raios X , Relação Dose-Resposta a Droga , Ouro/química , Ligantes , Modelos Moleculares , Estrutura Molecular , Compostos Organometálicos/síntese química , Compostos Organometálicos/química , Testes de Sensibilidade Parasitária , Fosfinas/química , Selênio/química , Estereoisomerismo , Relação Estrutura-Atividade , Tiossemicarbazonas/químicaRESUMO
Some indium(III), antimony(III) and bismuth(III) dihalide complexes containing deprotonated, tridentate thio- and selenosemicarbazone ligands were prepared and were fully characterized by spectroscopic methods. In addition, the crystal structures of some of the compounds were obtained. TGA and DSC analyses were carried out on selected samples to assess their suitability as single-molecule precursors for metal selenide nanomaterials.
RESUMO
The title compound, [Au(2)Br(2)(C(27)H(26)P(2))], features linearly coordinated Au(I) atoms within P,Br-donor sets. The central portion of the mol-ecule is practically planar as quanti-fied by the Br-Auâ¯Au-Br torsion angle of -169.9â (2)°. The P-Au-Br chromophores are twisted with respect to each other [dihedral angle = 52.3â (6)°]. The benzene rings on each P atom lie on either side of this plane. The Au atoms are positioned at the periphery of the mol-ecule, which facilitates the formation of Auâ¯Au inter-actions [3.2575â (11)â Å] that result in the formation of supra-molecular chains along the b-axis direction. The Auâ¯Au inter-actions are responsible for the deviations from the ideal linear geometry for each Au atom.