Examining the immune signatures of SARS-CoV-2 infection in pregnancy and the impact on neurodevelopment: Protocol of the SIGNATURE longitudinal study.

The COVID-19 pandemic represents a valuable opportunity to carry out cohort studies that allow us to advance our knowledge on pathophysiological mechanisms of neuropsychiatric diseases. One of these opportunities is the study of the relationships between inflammation, brain development and an increased risk of suffering neuropsychiatric disorders. Based on the hypothesis that neuroinflammation during early stages of life is associated with neurodevelopmental disorders and confers a greater risk of developing neuropsychiatric disorders, we propose a cohort study of SARS-CoV-2-infected pregnant women and their newborns. The main objective of SIGNATURE project is to explore how the presence of prenatal SARS-CoV-2 infection and other non-infectious stressors generates an abnormal inflammatory activity in the newborn. The cohort of women during the COVID-19 pandemic will be psychological and biological monitored during their pregnancy, delivery, childbirth and postpartum. The biological information of the umbilical cord (foetus blood) and peripheral blood from the mother will be obtained after childbirth. These samples and the clinical characterisation of the cohort of mothers and newborns, are tremendously valuable at this time. This is a protocol report and no analyses have been conducted yet, being currently at, our study is in the recruitment process step. At the time of this publication, we have identified 1,060 SARS-CoV-2 infected mothers and all have already given birth. From the total of identified mothers, we have recruited 537 SARS-COV-2 infected women and all of them have completed the mental health assessment during pregnancy. We have collected biological samples from 119 mothers and babies. Additionally, we have recruited 390 non-infected pregnant women.

Intervención de la matrona hospitalaria en una gestante con mutilación genital femenina. A propósito de un caso / Intervention of the hospital midwife in the case of a pregnant women who had undergone female genital mutilation. A case study

La mutilación genital femenina, condenada por todos los países miembros de la Organización de las Naciones Unidas, se ha extendido alrededor del mundo como consecuencia de los flujos migratorios, y se realiza al amparo de una costumbre, tradición o cultura. En España está penada como delito de lesiones según el Código Penal vigente. Mediante un caso clínico se revisan las principales actuaciones de la matrona ante dicha lesión en una gestante en el trabajo de parto. Se exponen los datos recogidos en la exploración física y valoración según el modelo de Virginia Henderson, y se desarrolla un plan de cuidados completo. Del caso se puede concluir que, en el ámbito hospitalario, las matronas pueden y deben reforzar y completar el trabajo con estas mujeres y sus familias de informar, educar y fortalecer la decisión de no mutilar, el cual debería haber sido iniciado en el centro de salud (AU)

Female genital mutilation, condemned by all UN member countries has spread throughout the world as a result of migratory flows and is practiced under the guise of a custom, tradition or culture. In Spain, it is punishable as a personal injury offence under the current penal code. A clinical case study reviewed the main actions of the midwife in this kind of injury in a pregnant woman during labour. The data collected from the physical examination and the midwife's assessment according to the Virginia Henderson model are presented and a complete care plan developed. From the case it can be concluded that in the hospital area, midwives can and should reinforce and complete the work with these women and their families, of informing, educating and reinforcing the decision not to mutilate. This work should have been started in, the health centre (AU)

Intervention of the hospital midwife in the case of a pregnant women who had undergone female genital mutilation. A case study. / Intervención de la matrona hospitalaria en una gestante con mutilación genital femenina. A propósito de un caso.

Female genital mutilation, condemned by all UN member countries has spread throughout the world as a result of migratory flows and is practiced under the guise of a custom, tradition or culture. In Spain, it is punishable as a personal injury offence under the current penal code. A clinical case study reviewedthe main actions of the midwife in this kind of injury in a pregnant woman during labour. The data collected from the physical examination and the midwife's assessment according to the Virginia Henderson model are presented and a complete care plan developed. From the case it can be concluded that in the hospital area, midwives can and should reinforce and complete the work with these women and their families, of informing, educating and reinforcing the decision not to mutilate. This work should have been started in, the health centre.