Assuntos
Doadores de Sangue , Preservação de Sangue/normas , Eritrócitos/fisiologia , Hemólise/fisiologia , Desenho de Equipamento , Eritrócitos/diagnóstico por imagem , Humanos , Fragilidade Osmótica/fisiologia , Controle de Qualidade , U.R.S.S. , Ultrassonografia/instrumentação , Ultrassonografia/métodosRESUMO
The techniques employed to produce drug-containing liposomes and to control the disperse composition of the included preparation are discussed. The method of cryoradiation sterilization of liposomes containing different types of drugs is detailed. The applications of the described methodologies for obtaining the optimal technological parameters of liposome production are exemplified.
Assuntos
Tratamento Farmacológico/métodos , Lipossomos/uso terapêutico , Preparações Farmacêuticas/administração & dosagem , Tecnologia Farmacêutica/métodos , Portadores de Fármacos , Estabilidade de Medicamentos , Armazenamento de Medicamentos/métodos , Humanos , Lipossomos/síntese química , Lipossomos/farmacologia , Lipossomos/normas , Controle de Qualidade , Esterilização/métodos , U.R.S.S.RESUMO
The effect of ultrasound (frequency 0.88 MHz, intensity from 0.05 to 1 W/cm2) on alterations in antigenic activity has been investigated in vitro using ABO antigens of human erythrocytes. The existence of threshold doses of ultrasound influence has been found. These doses are shown to be independent of ultrasound intensity. The dependence of the effect on erythrocyte concentration has been established. Individual and group differences in the antigenic resistance to ultrasonic exposure in donors of groups A and B have been revealed. A drop in antigenic activity equal to 97% has been obtained.