1.
J Org Chem
; 84(7): 4000-4008, 2019 04 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30864430
RESUMO
An "on water" organocatalytic cyanoarylmethylation of aryl acetonitrile to isatins is developed, giving products in high yields and up to excellent diastereoselectivities. A remarkable enhancement of reaction rates and diastereoselectivities by water was observed under mild conditions. Moreover, this approach provides a highly efficient and environmentally benign access to thermodynamic 3-hydroxy-3-cyanomethyl oxindoles.