[Anti-somatostatin autoantibodies in the blood serum of patients with schizophrenia]. / Uroven' autoantitel k somatostatinu v syvorotke krovi bol'nykh shizofreniei.

Solid-phase IEA was used to measure the level of autoantibodies to somatostatin in the blood serum of 44 schizophrenics and 24 healthy donors. The patients suffering from schizophrenia manifested a higher (p less than 0.01) level of immune responsiveness of the blood serum to somatostatin (0.665 +/- 0.03) as compared to the control group (0.509 +/- 0.05). The main contribution to the differences between the groups as regards the parameter measured is made by patients with malignant (0.810 +/- 0.10) and paranoid (0.773 +/- 0.08) schizophrenia whereas the patients' subgroup with slow-progressive schizophrenia did not differ from normal regarding the level of autoantibodies to somatostatin in the serum (0.504 +/- 0.03). These tentative data agree with a hypothesis of the involvement of autoimmune processes into the development of schizophrenia.

[Specificity of electroencephalographic correlations of asthenic disorders in atypical juvenile asthenic-depressive conditions]. / K voprosu o spetsifichnosti élektroéntsefalograficheskikh korreliatov astenicheskikh rasstroistv pri atipichnykh iunosheskikh astenodepressivnykh sostoianiiakh.

Amplitude-interval factor analysis was made to study the EEG in young patients with atypical ++sub-depressive states (n-15) and depressive states (n-43) defined in the literature as "asthenic juvenile deficiency". It has been discovered that patients suffering from sluggish schizophrenia with prominent asthenic disorders differ from healthy test subjects, patients suffering from cyclothymia and those suffering from sluggish schizophrenia without well-defined asthenic symptomatology in significantly higher values of EEG factor related to the index, regularity and frequency of low-amplitude beta-activity as well as in the reduced values of the other EEG factor connected with the mean period of alpha-waves and with the theta-index. Based on the psychophysiological testing of structurally similar EEG factors, carried out earlier on healthy test subjects, the data obtained may be treated as reflection of the neurodynamic unbalance common to asthenic disorders in sluggish schizophrenia, which lies in abundance processes of cortical excitation and deficit of inhibitory processes of the active selective character. The intensity of depressive symptomatology correlated with relative deceleration of alpha-activity.

[Characteristics of the organization of the psychosocial and vocational rehabilitation of patients with juvenile schizophrenia (a clinico-psychological study of the slowly progressing form with a favorable outcome)]. / Osobennosti organizatsii sotsial'no-psikhologicheskoi i trudovoi reabilitatsii bol'nykh iunosheskoi shizofreniei (kliniko-psikhologicheskoe issledovanie maloprogredientnoi formy s blagopriiatnym iskhodom).

Clinical catamnestic and experimental psychologic techniques allowed the authors to single out a range of personality and psychosocial structures in patients with juvenile slow progredient neurosis-like schizophrenia with favorable outcome up to "virtual recovery". Influencing these structures with respect to the patients' age could promote their general and special activities, heighten their level and quality of adaptation to major spheres of social functioning. This provided a basis for establishing the major goals of social rehabilitative and psychic corrective aid to the juvenile patients.