Using AutoCAD software to measure venous leg ulcers: a reproducibility assessment study.

OBJECTIVE: To assess the reproducibility of using AutoCAD software to measure the area of venous leg ulcers (VLUs). METHOD: Data from patients with VLUs were collected between March and July 2015, using data collection forms and photographing the different ulcers. A researcher and five nurses collected the data. The wounds were measured using AutoCAD software. Data were analysed using intraclass correlation coefficient (ICC), concordance correlation coefficient (CCC) and Bland-Altman analysis. RESULTS: A total of 21 patients with 36 VLUs were included in the study. A statistically significant difference (p<0.05) was observed between the areas of VLUs measured by the researcher and the evaluators. There was an excellent agreement when analysing the ICC [p=0.98; 95% CI (0.97-0.99); p <0.05] and the CCC [CCC=CI 0.97; 95% (0.95-0.98)]. There was no difference between the measurements of VLUs ≤10 cm2 (p=0.49) and those with an area >10cm2 (p=0.22). CONCLUSION: The use of AutoCAD software is appropriate for measuring VLUs and appears to be more accurate when used to measure VLUs with an area >10cm2.

The heritability of general cognitive ability increases linearly from childhood to young adulthood.

Although common sense suggests that environmental influences increasingly account for individual differences in behavior as experiences accumulate during the course of life, this hypothesis has not previously been tested, in part because of the large sample sizes needed for an adequately powered analysis. Here we show for general cognitive ability that, to the contrary, genetic influence increases with age. The heritability of general cognitive ability increases significantly and linearly from 41% in childhood (9 years) to 55% in adolescence (12 years) and to 66% in young adulthood (17 years) in a sample of 11 000 pairs of twins from four countries, a larger sample than all previous studies combined. In addition to its far-reaching implications for neuroscience and molecular genetics, this finding suggests new ways of thinking about the interface between nature and nurture during the school years. Why, despite life's 'slings and arrows of outrageous fortune', do genetically driven differences increasingly account for differences in general cognitive ability? We suggest that the answer lies with genotype-environment correlation: as children grow up, they increasingly select, modify and even create their own experiences in part based on their genetic propensities.

Genetic and environmental influences on age at sexual initiation in the Colorado Adoption Project.

Whereas the majority of research on adolescent sexual initiation has focused solely on environmental factors, the present study used behavioral genetic analyses to investigate the relative contributions of genetic and environmental influences. Structural equation models were fitted to data from adoptive and non-adoptive sibling pairs (231 biologically related pairs and 169 unrelated pairs) from the Colorado Adoption Project. Information from censored individuals who had not yet experienced sexual initiation was maximized by adapting the twin survival analysis method of Pickles et al. (Behav Genet 24(5):457-468, 1994) to accommodate adoptive and non-adoptive siblings. Point estimates of variance components from an ACE model, including additive genetic (A), shared environmental (C), and non-shared environmental (E) influences were 28%, 24%, and 48%, respectively. Despite the lower point estimate for shared environmental effects than additive genetic effects, a CE model provided the best fit to the data. However, because adoptive siblings provide a direct estimate of shared environmental influences there is greater power to detect shared environmental effects in adoption designs. Evidence for genetic influences from our data were somewhat lower than those obtained in previous twin studies, possibly reflecting a return to more socially conservative sexual attitudes, changing sexual behaviors, or ambiguities in the wording of questions commonly used in research on adolescent sexuality.

Reliability of sibling reports on parental drinking behaviors.

Questionnaire data from the Colorado Alcohol Research on Twins and Adoptees (CARTA) were analyzed to explore the reliability of sibling responses to items from the CARTA Family Alcoholism History Questionnaire (FHQ) concerning parental drinking behaviors. Subjects included 142 pairs of male and female, twin and nontwin siblings who reported on paternal and maternal problem drinking. FHQ items were summed to produce drinking-problem scales for fathers and mothers. There was generally good concordance across sibling reports of parental problem-drinking symptoms. There was a significant gender difference in that male offspring were more in agreement about their mothers' drinking behavior, while female offspring were more in agreement about their fathers' drinking behavior. For the most part, objective items, such as having two or more drunk-driving arrests, were more reliable (paternal kappa total = .56, maternal = .66) than subjective items, such as being happy only when drinking (paternal = .24, maternal = -.03). This evidence for reliability of sibling reports about parental drinking does seem to validate the use of such questionnaire data in alcohol studies.

Anticipated and subjective sensitivities to alcohol.

The development and maintenance of alcohol use patterns may depend, in part, on differences between how an individual anticipates he will respond to alcohol and how he appears to others when he is drinking. Such differences may introduce bias in decisions regarding which activities are safe while under the influence of an intoxicating amount of alcohol. This study of 387 participants of the Colorado Alcohol Research on Twins and Adoptees project examined the interrelationships of anticipated, subjective and observer-judged sensitivity to a blood alcohol concentrations of about 0.1 g/dl (approximated by breath alcohol concentration). Differences among the sensitivity measures were dependent upon recent alcohol drinking history and individual differences in actual sensitivity (as observer-rated). The results were consistent with hypotheses that people with little drinking experience may overestimate how intoxicated they will be, that heavier drinkers may develop chronic tolerance to the intoxicating effects and that denial may play a role in both subjective and anticipated sensitivity.