1.
J Org Chem
; 78(20): 10240-50, 2013 Oct 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24060201
RESUMO
A simple and straightforward approach to access C4-substituted-3,4-dihydroquinazolines has been achieved, where copper-catalyzed activation of α-amino peroxide and hydroxide intermediates to iminium ion precursors has been realized as an important step. Reactions of these intermediates with alkynes, indoles, pyrrole, and silylenol ether afforded the structurally diverse C4-substituted-3,4-dihydroquinazoline derivatives in good yields.