RESUMO
The currently used pertussis vaccines are highly efficacious; however, neonates are susceptible to whooping cough up to the sixth month. In agreement, DTP-immunized neonate mice were not protected against intracerebral challenge with Bordetella pertussis. Neonate mice immunized with either DTP or a recombinant-BCG strain expressing the genetically detoxified S1 subunit of pertussis toxin do not show a humoral immune response against PT. On the other hand, rBCG-Pertussis induces higher PT-specific IFN-ã production and an increase in both IFN-ã+ and TNF-á+-CD4+-T cells than the whole cell pertussis vaccine and confers protection against a lethal intracerebral challenge with B. pertussis
Assuntos
Masculino , Feminino , Humanos , Animais , Recém-Nascido , Camundongos , Bordetella pertussis , Vacina BCG , Vacina contra Coqueluche , Vacina contra Difteria, Tétano e CoquelucheRESUMO
No presente estudo, avaliamos a importancia clinico-epidemiologica da genotipagem do VHC em 130 pacientes com diagnostico histologico de hepatite cronica C e sua influencia na resposta terapeutica sustentada. Nao se observou associacao entre os genotipos e os aspectos clinico-epidemiologicos como sexo, idade, vias de trasmissao, presenca ou nao de cirrose e tempo de infeccao. Dos 130 pacientes, 113 foram submetidos a tratamento com...