[Cognitive functions in late-onset psychosis]. / Sostoyanie kognitivnykh funktsii pri pozdnikh shizofrenicheskikh psikhozakh.

The review discusses cognitive functions in late-onset schizophrenia and very late-onset schizophrenia-like psychosis compared to cognition in normal aging, early-onset schizophrenia, and neurodegenerative diseases. The problem of the dynamics of the state of the cognitive functions in patients with late-onset schizophrenic psychoses is highlighted, and prospects for further research are discussed. Patients with late-onset schizophrenic psychosis are characterized by more pronounced cognitive deficits compared to normal aging, but less severe than cognitive changes observed in early-onset schizophrenia. Late-onset schizophrenia may be a heterogeneous condition in terms of cognitive dysfunction.

[Post stroke delirium]. / Postinsul'tnyi delirii

This review considers the issues of clinical typology of delirium (mental confusion), its etiology and pathogenesis. Based on these data, the peculiarities of treatment, prevention and rehabilitation of delirium are discussed. Attention is drawn to the risk factors of this disorder (potentially modifiable or non-modifiable), which are most important in treatment and prevention of delirium. The questions of rehabilitation measures are regarded. Section "Treatment" presents pharmacological and non-pharmacological approaches to treatment of delirium.

[Clinical characteristics of post-stroke anxiety disorders].

Authors studied 198 patients with first-ever cerebral stroke. Affective disorders, including depression, generalized anxiety disorder (GAD) and phobias, were identified in 71.2% of patients. The study demonstrated that the anxiety syndrome developed in the post-stroke period may be regarded as relatively independent. Some post-stroke anxiety disorders had different risk and pathogenetic factors. GAD is associated with young age and phobias are associated with female sex and inherited predisposition. In contrast to post stroke depression, anxiety-phobic disorders develop more frequently in patients with mild stroke.

[Clinical features of post stroke apathy].

An aim of the study was to evaluate clinical features and risk factors of post stroke apathy. The study included 209 patients with first-time stroke. Assessments of neurological and mental status were carried out on the 1st, 7th day, after 2 weeks, 1 month, 3, 6 and 12 months after stroke. The frequency of apathy was 28.2%. Three types of apathy were singled out: classical, depressive, and combined. Apathy was significantly associated with the older age of patients, right-sided brain lesion and worst recovery of neurological deficit. Patients with depressive apathy were significantly older than patients without apathy, classic apathy was more common in men, and depressive apathy - in women. Depressive apathy was significantly associated with small lesions, while classic or combined apathy was significantly associated with the average volume of lesions.

[Post stroke affective disorders].

We have studied 198 patients with first-ever stroke. The spectrum of affective disorders included depressions, generalized anxiety disorder, phobias. The study has demonstrated that mentioned post stroke affective disorders have different risk and pathogenetic factors. In stroke patients, affective disorders were caused by the damage of different brain areas. Depression was associated with the damage of left frontal/temporal cortical areas and left subcortical structures. On the contrary, anxiety disorders were associated with the damage of these structures in the right hemisphere.

[Interaction effect of serotonin transporter gene and brain-derived neurotrophic factor on the platelet serotonin content in stroke patients].

Platelet serotonin content in patients in the acute period of stroke is an important index of clinical changes during the post stroke period as well as a predictor of development of mental disorders. We studied the association between two polymorphisms (5-HTTLPR and Val66Met BDNF) and the platelet serotonin content in 47 patients with stroke. We also investigated the moderating effect of genetic variants on the association between platelet serotonin content and development of affective and anxiety disorders in stroke patients in the acute period of stroke. The interaction effect of two polymorphisms on levels of platelet serotonin was found. The lowest level was observed in patients with the diplotype LL*ValVal, the highest level--in the group of patients with the LL genotype and genotypes containing at least one copy of a Met allele. No moderating effect of genetic variants on the relationship between serotonin content and affective or anxiety disorder was found.

[Pathogenetic characteristics of post stroke affective disorders].

Fifty patients with affective disorders developed after first cerebral stroke were studied. A spectrum of affective disorders included post-stroke depressions, generalized anxiety disorders, anxiety-depressive disorders and pseudo post-stroke depressions. Platelet serotonin (PS) levels were measured in these patients as well. The levels of PS at the first three days after stroke and their changes towards the 28th day are associated with the development of post-stroke affective disorders. The development of anxiety-depressive disorders in the acute period of stroke is related to the localization of brain lesion focus. The low levels of PS in patients at the first three days after stroke may be the risk factor of delayed affective disorders development.

[Bioelectrical brain activity in different affective disorders in patients with cerebral stroke].

One hundred and forty-nine patients with ischemic stroke who had different affective disorders developed one year after stroke (depression, anxiety, depression-anxiety disorders) were included in the study. Based on the computer data analysis of EEG, we singled out the characteristics of bioelectrical brain activity in patients with different types of poststroke affective disorders in acute, early and late restorative periods.

[Depressive disorders in patients with cerebral stroke].

Different types of depression in patients who survived cerebral stroke and their influence on the rehabilitation process were studied. One hundred and fifteen patients were examined. The clinical heterogeneity of post-stroke depression was shown. A clinical analysis allowed to find different nosological and psychopathological forms of depressive disorders. Two main nosological forms of depression--reactive and endoreactive--were found. The liability to affective disorders exerts the influence on the development of depression; reactive depression is related with more severe functional damage. Depression, in particular reactive one, has an unfavorable effect on the rehabilitation of neurological deficit and ability to self-service.

[Diversity of wild and domestic pig populations estimated by a set of serum allotypes].

Variation of serum protein allotypes serving as genetic markers of the blood has been analyzed in 29 populations of the domestic pig and subspecies of the wild boar. The population biodiversity and genetic structure have been estimated by two methods: by the frequencies of allotype combinations and with the use of a map constructed in the space of two principal components. The results obtained are the basis for determining the characteristics of the microevolution of wild boars and formation of the breeds of domestic pigs.

[Age variation of the phenotypic expression and the inheritance of the IgG system of immunoglobulin allotypes in the pig]. / Vozrastnaia izmenchivost' fenotipicheskoi ékspressii i nasledovanie IgG-sistemy allotipov immunoglobulinov svin'i.

The specificity of phenotypic expression and inheritance of immunoglobulin allotypes IgG1a and IgG2b in pigs are discussed. It was shown that a negative state by both these allotypes is repeatedly found among newborn pigs but is extremely rare in pigs older than one month. A model, which simultaneously describes the genetic determination of allogroups formed by allotypes IgG1a and IgG2b and the dynamics of ontogenetic expression of individual genotype by system IgG with a result of a visually registered phenotype, was developed. Allele frequencies by system IgG were assessed in populations of domestic pigs of productive breeds, laboratory miniature pigs, and wild Eurasian pigs.

[Characteristics of some breeds of swine and populations of Georgian and Western Siberian wild boar by immunogenetic systems of blood serum proteins]. / Kharakteristika nekotorykh porod svinei i populiatsii dikogo kabana gruzii i zapadnoi sibiri po immunogeneticheskim sistemam syvorotochnykh belkov krovi.

A bank of reagents for hog serum protein allotypes has been created. All of these allotypes passed international comparison tests in 1987-1988. The bank can be used for typing the animals for four generally accepted (Gp, LpB, Lpr, and IgGH) and several experimental systems. In this study, immunogenetic characteristics of some pig breeds (Large White, Lithuanian White, Swedish Landrace, Kakhetinskaya, and Svanetskaya) bred in Georgia are compared with those of western Siberian breeds (Large White, Kemerovskaya, and Northern Siberian), and some foreign breeds, as well as with European, Caucasian, and Siberian subspecies of the wild boar.

[A2G--a new system of alpha-2-globulin allotypes in pig blood serum]. / A2G--novaia sistema allotipov alpha-2-globulinov syvorotki krovi svinei.

Combinations of four alpha-2-globulin allotypes were studied for their distribution in pigs of nine different breeds and hybrid groups. Based on this analysis, a new, previously unpublished polyallelic genetic system designated A2G was postulated. The complex alleles of this system control alpha-2-globulin allotypes and are suggested to be encoded by genes of two subloci. One of these subloci is virtually monomorphic, whereas the other has at least four allelic variants.

[Interaction of polymorphic systems in a population of Semirechenskaya swine breed]. / Vzaimodeistvie polimorfnykh sistem v populiatsii svinei semirechenskoi porody.

Associations between the alleles of nonlinked polymorphic genetic systems were studied in the population of the Semirechenskaya breed of pigs. The study of marker pairs of 21 genetic systems revealed that 7% of associations are statistically significant. Most of the associations detected are assumed to arise from breeding by commercial productivity traits and from the formation of an integral genotype adapted to conditions of artificial selection in the population.

[Dynamics and genetic determination of transformation of alpha macroglobulins allogroups in different populations of domestic pigs]. / Dinamika i geneticheskaia obuslovlennost' transformatsii allogrupp sistemy al'fa-makroglobulinov v raznykh populiatsiiakh domashnikh svinei.

The results of genetic studies of transformation of alpha-macroglobullin (AM) allogroups (i.e., fixed allotype combinations) in pigs are presented. Population and hybridization studies showed that the phenomenon discovered was based on activation/inactivation of the AMI allotype expression, which depended on the genetic environment and interlocus relationships. Genetic and selection bases, as well as the significance of the transformation phenomenon described, are discussed.