RESUMO
Herein, we describe a novel posterior lumbar interbody fusion (PLIF) technique with annulus fibrosus (AF) release and the use of expandable cages (called "anterior-release PLIF" [ARPLIF]). In this technique, posterior column osteotomy (PCO) and AF release provide excellent intervertebral mobility. AF release involves circumferentially peeling off the AF above or below the endplate between the fixed vertebrae under radiographic guidance without cutting the AF and anterior longitudinal ligament. Subsequently, high-angle variable-angle expandable cages are used to simultaneously expand both sides before inserting the percutaneous pedicle screws and correcting to achieve good local lumbar lordosis. PCO and AF release achieve excellent intervertebral mobility. Intervertebral mobility and simultaneous expansion of both cages disperse the force on the endplates, reducing cage subsidence, and the high-angle cages facilitate high intervertebral angle creation. The novel ARPLIF intervertebral manipulation technique can promote good local lumbar lordosis formation.
RESUMO
Introduction: Posterior lumbar interbody fusion (PLIF) is a common treatment for nerve root disease associated with lumbar foraminal stenosis or lumbar spondylolisthesis. At our institution, PLIF is usually performed with high-angle cages and posterior column osteotomy (PLIF with HAP). However, not all patients achieve sufficient segmental lumbar lordosis (SLL). This study determined whether the location of PLIF cages affect local lumbar lordosis formation. Methods: A total of 59 patients who underwent L4/5 PLIF with HAP at our hospital, using the same titanium control cage model, were enrolled in this cohort study. The mean ratio of the distance from the posterior edge of the cage to the posterior wall of the vertebral body/vertebral length (RDCV) immediately after surgery was 16.5%. The patients were divided into two groups according to RDCV <16.5% (group P) and ≥16.5% (group G). The preoperative and 6-month postoperative slip rate (%slip), SLL, local disk angle (LDA), ratio of disk height/vertebral height (RDV), 6-month postoperative RDCV, ratio of cage length/vertebral length (RCVL), and ratio of posterior disk height/anterior disk height at the fixed level (RPA) were evaluated via simple lumbar spine X-ray. The preoperative and 6-month postoperative Japanese Orthopedic Association (JOA) and low back pain visual analog scale (VAS) scores were also evaluated. Results: Groups G and P included 31 and 28 patients, respectively. The preoperative %slip, SLL, LDA, RDV, JOA score, and low back pain VAS score were not significantly different between the groups. In groups G and P, 6-month postoperative %slip, SLL, LDA, RDV, RDCV, RCVL, and RPA were 3.3% and 7.9%, 18.6° and 15.4°, 9.7° and 8.0°, 36.6% and 40.3%, 21.1% and 10.1%, 71.4% and 77.0%, and 56.1% and 67.7%, respectively. The 6-month postoperative SLL, LDA, RDV, RDCV, RCVL, and RPA significantly differed (p=0.03, 0.02, 0.02, <0.001, <0.001, and <0.001, respectively). Conclusions: Anterior PLIF cage placement relative to the vertebral body is necessary for good SLL in PLIF.
RESUMO
Introduction: Pedicle screws (PSs) or lateral mass screws (LMSs) are used in posterior cervical spine fixation. The former are more firmly fixed but are associated with the risk of neurovascular injury and should be inserted using intraoperative imaging or navigation, which may prolong the surgical duration and is not feasible in all hospitals. This prospective clinical study aimed to evaluate the outcomes of LMS insertions without fluoroscopic guidance and screw loosening rates at 6 months postoperatively using computed tomography (CT). Methods: We examined 38 patients who underwent posterior cervical spine fusion using 206 LMSs in the C3-C6 range between January 2018 and July 2021. The direction of screw insertion followed the Magerl method, and we inserted screws as bicortically as possible without intraoperative imaging. The screw position was examined using CT at 1 week postoperatively. Screw insertion angles, bicortical insertion rate, facet violation, and neurovascular injury were evaluated. Screw loosening with unicortical and bicortical screws (US and BS, respectively) was investigated using CT at 6 months postoperatively. Results: The average LMS length was 14.1 mm. The average axial and sagittal angles were 33.9° and 29.2°, respectively. Among the 206 LMSs inserted, 167 were BS; of these, 94.6% had screw length protrusion of 0-2 mm. Facet violation was observed in 3.4% of all screws but without neurovascular injury. Six months postoperatively, loosening of 25 screws (12.1%) occurred, including 17 (18.3%) USs and 8 (8.39%) BSs. The screw loosening rate was significantly higher in US than for BS (43.6% [17/39] vs. 4.8% [8/167], P<0.01). Conclusions: Over 80% of LMSs were inserted bicortically without intraoperative imaging. By devising the screw length selection process, we inserted for screw loosening was more common in US and more likely at the fixed end.
RESUMO
BACKGROUND CONTEXT: Revision surgery after laminoplasty is rarely performed, and there are few reports of this procedure in the English literature. PURPOSE: To evaluate the reasons why patients underwent revision surgery after laminoplasty and to discuss methods of preventing the need for revision surgery. A literature review with a comparative analysis between previous reports and present cases was also performed. STUDY DESIGN: Case report and literature review. PATIENT SAMPLE: Five patients who underwent revision surgery after laminoplasty. OUTCOME MEASURES: Diagnosis was based on the preoperative computed tomography and magnetic resonance imaging findings. Neurologic findings were evaluated using the Japanese Orthopedic Association score. METHODS: A total of 237 patients who underwent cervical laminoplasty for cervical spondylotic myelopathy from 1990 to 2010 were reviewed. Patients with ossification of the posterior longitudinal ligament, renal dialysis, infection, tumor, or rheumatoid arthritis were excluded. Five patients who underwent revision surgery for symptoms of recurrent myelopathy or radiculopathy were identified, and the clinical courses and radiological findings of these patients were retrospectively reviewed. RESULTS: The average interval from the initial surgery to revision surgery was 15.0 (range 9-19) years. The patients were four men and one woman with an average age at the time of the initial operation of 49.8 (range 34-65) years. Four patients developed symptoms of recurrent myelopathy after their initial surgery, for the following reasons: adjacent segment canal stenosis, restenosis after inadequate opening of the lamina with degenerative changes, and trauma after inadequate opening of the lamina. One patient developed new radiculopathy symptoms because of foraminal stenosis secondary to osteoarthritis at the Luschka and zygapophyseal joints. All patients experienced resolution of their symptoms after revision surgery. CONCLUSIONS: Revision surgery after laminoplasty is rare. Inadequate opening of the lamina is one of the important reasons for needing revision surgery. Degenerative changes after laminoplasty may also result in a need for revision surgery. Surgeons should be aware of the degenerative changes that can cause neurologic deterioration after laminoplasty.
Assuntos
Vértebras Cervicais/cirurgia , Laminoplastia/métodos , Radiculopatia/cirurgia , Espondilose/cirurgia , Adulto , Idoso , Vértebras Cervicais/patologia , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Radiculopatia/patologia , Reoperação , Estudos Retrospectivos , Espondilose/patologia , Resultado do TratamentoRESUMO
BACKGROUND: The incidence of neurological deficits is reportedly low after sacrificing the affected nerve root during spinal schwannoma treatment. Although the incidence has been widely reported, the operative method for nerve root resection has been not clarified. To evaluate the safety of pure nerve root resection, we focused on solitary spinal schwannomas below the thoracolumbar level and investigated the effect of affected nerve resection. METHODS: Twenty-three spinal schwannoma patients were retrospectively examined. The mean age at surgery was 53 years. We investigated preoperative symptoms, duration of the disorder, postoperative neurological deficits, and clinical outcomes. In addition, we measured tumor size on computed tomography after myelography or on magnetic resonance images using image-analysis software. We retrospectively assessed correlations among duration of symptoms, tumor size, and postoperative neurological deficits. RESULTS: The tumors comprised 19 intradural schwannomas and 4 dumbbell-shaped schwannomas. No postoperative neurological deficits were observed in the intradural schwannoma patients. In contrast, three of the four dumbbell-shaped schwannoma patients experienced postoperative neurological deficits. Among these three patients, two recovered quickly whereas one never recovered. The mean duration of the disorder was 29 months. The postoperative modified JOA score (13.0) was significantly improved compared with the preoperative score (8.9). The mean maximum tumor sizes were 97.2 mm(2) for the intradural schwannomas and 884.0 mm(2) for the dumbbell-shaped schwannomas. There were no correlations among tumor size, duration of the disorder, and postoperative neurological deficits. CONCLUSIONS: On the basis of this study, we recommend pure single nerve resection for treatment of intradural spinal schwannomas before such tumors progress and involve other normal roots, because postoperative neurological deficits did not occur in our intradural schwannoma patients, irrespective of tumor size, when this procedure was used. However, dumbbell-shaped schwannoma patients should be carefully treated operatively, because high incidence of postoperative neurological deficits can be expected.
Assuntos
Condução Nervosa/fisiologia , Neurilemoma/cirurgia , Neoplasias do Sistema Nervoso Periférico/cirurgia , Raízes Nervosas Espinhais/cirurgia , Adolescente , Adulto , Idoso , Eletromiografia , Feminino , Seguimentos , Humanos , Vértebras Lombares , Masculino , Pessoa de Meia-Idade , Mielografia , Neurilemoma/diagnóstico , Neurilemoma/fisiopatologia , Neoplasias do Sistema Nervoso Periférico/diagnóstico , Neoplasias do Sistema Nervoso Periférico/fisiopatologia , Período Pós-Operatório , Estudos Retrospectivos , Raízes Nervosas Espinhais/fisiopatologia , Vértebras Torácicas , Resultado do Tratamento , Adulto JovemRESUMO
STUDY DESIGN: Marrow mesenchymal cells (MSCs) contain stem cells and possess the ability to regenerate bone, cartilage, and fibrous tissues. Here, we applied this regenerative ability to intervertebral disc regeneration therapy in an attempt to develop a new spinal surgery technique. OBJECTIVE: We analyzed the regenerative restoration ability of autologous MSCs in the markedly degenerated intervertebral discs. SUMMARY OF BACKGROUND DATA: Fusion for lumbar intervertebral disc instability improves lumbago. However, fused intervertebral discs lack the natural and physiologic functions of intervertebral discs. If intervertebral discs can be regenerated and repaired, then damage to adjacent intervertebral discs can be avoided. We verified the regenerative ability of MSCs by animal studies, and for the first time, performed therapeutic intervertebral disc regeneration therapy in patients and obtained favorable findings. METHODS: Subjects were 2 women aged 70 and 67 years; both patients had lumbago, leg pain, and numbness. Myelography and magnetic resonance imaging showed lumbar spinal canal stenosis, and radiograph confirmed the vacuum phenomenon with instability. From the ilium of each patient, marrow fluid was collected, and MSCs were cultured using the medium containing autogenous serum. In surgery, fenestration was performed on the stenosed spinal canal and then pieces of collagen sponge containing autologous MSCs were grafted percutaneously to degenerated intervertebral discs. RESULTS: At 2 years after surgery, radiograph and computed tomography showed improvements in the vacuum phenomenon in both patients. On T2-weighted magnetic resonance imaging, signal intensity of intervertebral discs with cell grafts was high, thus indicating high moisture contents. Roentgenkymography showed that lumbar disc instability improved. Symptom was alleviated in both patients. CONCLUSION: The intervertebral disc regeneration therapy using MSC brought about favorable results in these 2 cases. It seems to be a promising minimally invasive treatment.
Assuntos
Degeneração do Disco Intervertebral/cirurgia , Disco Intervertebral/fisiologia , Vértebras Lombares/cirurgia , Transplante de Células-Tronco Mesenquimais , Regeneração/fisiologia , Idoso , Células Cultivadas , Feminino , Humanos , Disco Intervertebral/cirurgia , Vértebras Lombares/diagnóstico por imagem , Imageamento por Ressonância Magnética , Radiografia , Transplante AutólogoRESUMO
The objective of the study was to investigate the comorbidity of degenerative spondylolisthesis (DS), in elderly cervical spondylotic myelopathy (CSM) patients in our hospital, and the correlation between surgical results and preoperative DS. There are few studies on the outcome of laminoplasty for CSM with DS. A total of 49 elderly patients (>65 years old) who eventually had surgical treatment for CSM were evaluated. A slippage displacement of more than 2.5 mm at least at one level was classified to have a positive DS on flexion/extension radiographs (DS group). A slippage displacement less than 1.0 mm was considered a negative DS (non-DS group). Seventeen patients who had slippage of 1.0-2.5 mm were excluded from the study. The DS group (n = 15) included cases with DS at preoperation, while the remaining cases (n = 17) belonged to the non-DS group. The flexion/extension radiographs of the two groups were compared for range of motion and clinical results at 3 years after the operation. Of all elderly patients, 30.6% had DS. There was no significant difference between the two groups based on the clinical results. The range of motion of all cervical spines (DS group and non-DS group) was significantly limited. However, there was no significant difference between the two groups. New postoperative DS appeared in four patients, of which two were from the DS group and two from the non-DS group. These data suggest that degenerative spondylolisthesis does not influence surgical results in elderly cervical spondylotic myelopathy patients.
Assuntos
Vértebras Cervicais/cirurgia , Laminectomia/métodos , Espondilolistese/cirurgia , Espondilose/cirurgia , Idoso , Idoso de 80 Anos ou mais , Vértebras Cervicais/diagnóstico por imagem , Distribuição de Qui-Quadrado , Humanos , Radiografia , Amplitude de Movimento Articular , Espondilolistese/diagnóstico por imagem , Espondilose/diagnóstico por imagem , Resultado do TratamentoRESUMO
BACKGROUND: Wires and cables have been used extensively for spinal sublaminar wiring, but damages to the spinal cord due to compression by metal wires have been reported. We have used more flexible ultra-high-molecular-weight polyethylene cable (Tekmilon tape) instead of metal wires since 1999 and have obtained good clinical outcomes. Although the initial strength of Tekmilon tape is equivalent to metal wires, the temporal changes in the strength of Tekmilon tape in the body should be investigated to show that sufficient strength is maintained over time until bone union is complete. METHODS: Tekmilon tape was embedded into the paravertebral muscle of 10-week-old male Japanese white rabbits. Samples were embedded for 0, 1, 3, 6 or 12 months. At the end of each period, sequential straight tensile strength and sequential knot-pull tensile strength were measured. FINDINGS: The initial strength of Tekmilon tape in muscle tissue was maintained over time, with 92% straight tensile strength and 104% knot-pull tensile strength at 6months, and values of 77% and 100% at 12 months, respectively. Since single knot is clinically relevant, it is very important that the knot-pull tensile strength did not decrease over a 12-month period. This suggests that temporal changes in the tensile strength of Tekmilon tape are negligible at 1 year. INTERPRETATION: Tekmilon tape maintains sufficient strength in vivo until bone union has occurred. It is useful for sublaminar wiring instead of metal materials due to its flexibility and strength and may reduce the risk of neurological damage.
Assuntos
Materiais Biocompatíveis/química , Músculo Esquelético/cirurgia , Polietilenos/química , Próteses e Implantes , Desenho de Equipamento , Análise de Falha de Equipamento , Resistência à Tração , Fatores de TempoRESUMO
BACKGROUND: Raloxifene acts like estrogen in preventing bone loss in postmenopausal women, but it selectively activates biological responses in bone tissue. It has a direct effect on osteoblasts' differentiation and bone formation in bone marrow culture. However, the point at which raloxifene has an effect on bone marrow-derived mesenchymal stem cells (MSCs), regardless of sex difference, is not known. The purpose of this study was to examine the osteogenic effect of raloxifene on MSCs derived from female and male rats and to assess the sex difference of raloxifene with or without osteogenic supplements (OSs) in the regulation of bone formation. METHODS: Female and male rat bone marrow cells were cultured with or without OSs. In each experimental group, 10-6 M or 10-8 M raloxifene was added. As a control, cells were cultured without raloxifene. Histologically, mineralization was assessed by alizarin red S staining. Biochemically, alkaline phosphatase (ALP) activity, calcium content, and osteocalcin content were assessed. RESULTS: On histological analysis, mineralized nodules were seen on alizarin red S staining in the groups treated with OS. On the biochemical analysis, OS increased ALP activity, calcium content, and osteocalcin content. Among female groups with OSs, 10-6 M raloxifene significantly increased ALP activity, calcium content, and osteocalcin content compared with the controls. Among male groups, raloxifene had negligible effects. CONCLUSIONS: 10-6 M Raloxifene had no ossification-inducing effect on female MSCs, but it had an ossification-promoting effect; it had no osteogenic effect on male MSCs. Therefore, raloxifene has a sex difference with regard to its osteogenic effect on MSCs. Moreover, combined treatment with raloxifene plus OS has an effect on female MSCs. These results provide a useful insight into the possible influence of raloxifene after MSC transplantation in clinical practice.
Assuntos
Calcificação Fisiológica/efeitos dos fármacos , Diferenciação Celular/efeitos dos fármacos , Células-Tronco Mesenquimais/efeitos dos fármacos , Cloridrato de Raloxifeno/farmacologia , Moduladores Seletivos de Receptor Estrogênico/farmacologia , Animais , Células da Medula Óssea , Células Cultivadas , Feminino , Masculino , Ratos , Fatores SexuaisRESUMO
STUDY DESIGN: A prospective research. OBJECTIVE: Compare the reliability of post-tetanic motor-evoked potential (p-MEP) monitoring in the detection of motor injury during spinal surgery with that of conventional MEP (c-MEP). SUMMARY OF BACKGROUND DATA: Myogenic MEPs are sensitive to suppression by anesthetics and neuromuscular blockade. Recently, we reported a new technique for MEP recording, called "p-MEP" in which MEP amplitude can be enlarged by tetanic stimulation of peripheral nerve before transcranial stimulation in comparison with that of c-MEP. The purpose of this study is to compare the reliability of p-MEP monitoring in the detection of motor injury during spinal surgery with that of c-MEP. METHODS: Eighty patients undergoing elective spinal surgery were enrolled in the study. Both c-MEP and p-MEP monitoring were performed throughout the operation in each patient. For recording c-MEPs, transcranial electrical train of five pulses stimulation with an interstimulus interval of 2 milliseconds was performed and compound muscle action potentials were bilaterally recorded from abductor pollicis brevis, abductor hallucis, tibialis anterior, and soleus muscles. For recording p-MEPs, tetanic stimulation (50 Hz, 50 mA, 5 sec) was applied to the left median nerve and bilateral tibial nerves 1 second before transcranial stimulation and compound muscle action potentials were recorded from the same muscles. The false positive, false negative, and accuracy of MEP monitoring in the detection of change in motor function were compared between p-MEP and c-MEP. RESULTS: At the baseline, success rates of baseline c-MEP and p-MEP recording were 66.3% (53/80) and 92.5% (74/80), respectively. The false positive, false negative, and accuracy of p-MEP monitoring were 0%, 0%, and 100%, respectively, whereas c-MEP were 4%, 20%, and 95%, respectively. CONCLUSION: The results indicate that p-MEP is a more reliable method to detect changes in motor function during spinal surgery under general anesthesia in comparison with c-MEP.
Assuntos
Anestesia Geral/normas , Potencial Evocado Motor/fisiologia , Monitorização Intraoperatória/normas , Doenças da Medula Espinal/fisiopatologia , Doenças da Medula Espinal/cirurgia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Anestesia Geral/métodos , Criança , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Monitorização Intraoperatória/métodos , Estudos Prospectivos , Reprodutibilidade dos Testes , Adulto JovemRESUMO
OBJECT: The purpose of this study was to investigate the prevalence of developmental canal stenosis in patients with cervical spondylotic myelopathy (CSM), and the correlation between surgical results and degree of developmental canal stenosis. METHODS: A total of 112 patients who eventually had surgical treatment for CSM were evaluated. Male patients whose sagittal spinal diameter was < 14 mm and females whose sagittal diameter was < 13 mm even at one level were classified as having developmental canal stenosis. Two groups of patients were used in this study; the "positive" group (57 cases) included patients with developmental canal stenosis preoperatively, whereas the "negative" group (55 cases) excluded such patients. Lateral functional radiographs obtained in patients in the 2 groups were compared for range of motion and clinical results. RESULTS: Developmental canal stenosis was found in 50.9% of all cases. Based on clinical results, there was no significant difference between the 2 groups. CONCLUSIONS: Patients with CSM showed a high incidence of preoperative developmental canal stenosis. However, there were no significant differences in clinical results between patients with and without this disorder. These results indicate that developmental canal stenosis is not a factor that influences surgical results.
Assuntos
Vértebras Cervicais , Osteofitose Vertebral/cirurgia , Estenose Espinal/epidemiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Estudos de Coortes , Feminino , Humanos , Laminectomia , Masculino , Pessoa de Meia-Idade , Prevalência , Recuperação de Função Fisiológica , Estudos Retrospectivos , Osteofitose Vertebral/complicações , Osteofitose Vertebral/patologia , Estenose Espinal/patologia , Resultado do TratamentoRESUMO
BACKGROUND: Recently, we reported a new technique to augment motor-evoked potentials (MEPs) under general anesthesia, posttetanic MEP (p-MEP), in which tetanic stimulation of the peripheral nerve before transcranial stimulation enlarged amplitudes of MEPs from the muscle innervated by the nerve subjected to tetanic stimulation. In the present study, we tested whether tetanic stimulation of the left tibial nerve can also augment amplitudes of MEPs from the muscles which are not innervated by the nerve subjected to tetanic stimulation. METHODS: Thirty patients undergoing spinal surgery under propofol-fentanyl anesthesia with partial neuromuscular blockade were examined. For conventional MEP (c-MEP) recording, transcranial stimulation with train-of-five pulses was delivered to C3-4, and the compound muscle action potentials were bilaterally recorded from the abductor pollicis brevis, abductor hallucis (AH), tibialis anterior, and soleus muscles. For p-MEP recording, tetanic stimulation (50 Hz, 50 mA of stimulus intensity) with a duration of 5 s was applied to the left tibial nerve at the ankle 1 s before transcranial stimulation. Transcranial stimulation and recording of compound muscle action potentials were performed in the same manner as c-MEP recording. Amplitudes of c-MEP and p-MEP were compared using Wilcoxon's signed rank test. RESULTS: Amplitudes of p-MEPs from the left AH muscle innervated by the left tibial nerve with tetanic stimulation were significantly larger compared with those of c-MEPs. Amplitudes of p-MEPs from the bilateral abductor pollicis brevis and soleus muscles and right AH and tibialis anterior muscles, which were not innervated by the left tibial nerve with tetanic stimulation, were also significantly larger compared with those of c-MEPs. CONCLUSION: In patients under propofol and fentanyl anesthesia with partial neuromuscular blockade, the application of tetanic stimulation to the left tibial nerve augmented the amplitudes of MEPs from the muscles without tetanic nerve stimulation and those with stimulation.
Assuntos
Encéfalo/fisiologia , Potencial Evocado Motor , Músculo Esquelético/fisiologia , Nervo Tibial/fisiologia , Potenciais de Ação , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Estimulação Elétrica , Extremidades , Feminino , Fentanila/farmacologia , Humanos , Masculino , Pessoa de Meia-Idade , Músculo Esquelético/inervação , Bloqueio Neuromuscular , Propofol/farmacologiaRESUMO
STUDY DESIGN: A retrospective study comparing cervical laminoplasty with or without muscle release for the treatment of cervical myelopathy resulting from athetoid cerebral palsy. OBJECTIVE: To assess the effectiveness of muscle release in the treatment of athetoid cerebral palsy. SUMMARY OF BACKGROUND DATA: While anterior and/or posterior spinal fusion has been generally accepted as necessary in surgical treatment for cervical myelopathy due to athetoid cerebral palsy, several studies have shown relatively favorable results following laminoplasty. Better results can be obtained by combining muscle release. METHODS.: Study participants were 10 patients who underwent cervical laminoplasty combined with muscle release (mean age, 44.6 years) and 15 patients who underwent cervical laminoplasty alone (mean age, 48.2 years). Therapeutic outcomes 1 year after surgery, as assessed by Kurokawa's methods and JOA scores, were compared between groups. RESULTS: Recovery rate 1 year after surgery was significantly higher for the muscle release group than for the control group. In both groups, recovery rates were significantly better for patients who could walk before surgery. CONCLUSIONS: Cervical laminoplasty combined with muscle release for the treatment of cervical myelopathy due to athetoid cerebral palsy is effective in simplifying postoperative therapy and improving JOA scores.
Assuntos
Paralisia Cerebral/cirurgia , Vértebras Cervicais/cirurgia , Descompressão Cirúrgica/métodos , Laminectomia/métodos , Músculo Esquelético/cirurgia , Compressão da Medula Espinal/cirurgia , Adulto , Idoso , Paralisia Cerebral/complicações , Paralisia Cerebral/fisiopatologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Compressão da Medula Espinal/etiologia , Compressão da Medula Espinal/fisiopatologiaRESUMO
The in vivo osteogenic potential of autogenous cultured bone/ceramic constructs in large animals or humans is unknown, and thus we performed a preliminary study of this issue prior to clinical application. All autogenous cultured-bone/ceramic constructs at 3 weeks after implantation in dogs showed obvious histological bone formation within the ceramic pores. In many pores, the HE staining of decalcified specimens revealed thick lamellar bone formation on the pore surface of ceramic. On the surface of bone tissue, numerous active cuboidal osteoblasts were evident. Biochemically, high alkaline phosphatase activity was detected in all dogs. Histological examination of the constructs at 8 weeks postimplantation showed lamellar bone formation with vascular system invasion into the pores, and regenerated hematopoietic bone marrow was often detected in association with the new bone in grafting of human cultured bone/ceramic constructs. Trilineage hematopoietic cells (i.e., granulocytic, erythroblastic, and megakaryocytic cells) were identified in the ceramic pores. Biochemically, high alkaline phosphatase activity and significant human osteocalcin content was detected in the constructs. Based on these findings, in the near future, this technique (grafting of patient-derived cultured bone/HA constructs) will be able to be applied to various bone reconstruction surgical treatments.
Assuntos
Materiais Biocompatíveis/metabolismo , Regeneração Óssea/fisiologia , Osso e Ossos/metabolismo , Cerâmica/metabolismo , Fosfatase Alcalina/metabolismo , Animais , Materiais Biocompatíveis/química , Células da Medula Óssea/citologia , Células da Medula Óssea/metabolismo , Substitutos Ósseos/química , Substitutos Ósseos/metabolismo , Células Cultivadas , Cães , Feminino , Humanos , Masculino , Teste de Materiais , Osteocalcina/metabolismoRESUMO
STUDY DESIGN: Case report. OBJECTIVES: To describe a rarely reported type of upper thoracic spinal cord injury without vertebral bony lesion in two cases with multiple trauma. SUMMARY OF BACKGROUND DATA: Because it is supported by the stiffness of the rib cage, the upper thoracic spine has greater stability than the cervical and lumbar regions, and thus its fracture or fracture dislocation is less frequent. Nevertheless, when fracture or fracture dislocation of upper thoracic spine occurs, spinal cord involvement and severe concomitant injuries are frequently associated. METHODS: Two cases who were suspected to have thoracic spinal cord injuries were referred to our emergency center: a 19-year-old girl presented with paraparesis after her motorcycle collided with a truck, and a 63-year-old male involved in an industrial accident presented with paraplegia. RESULTS: Radiograph and computed tomography scan showed no abnormality or dislocation in the vertebral bodies in these two cases, although the upper thoracic spinal cord injuries were suspected by clinical features. Magnetic resonance images detected abnormal signals, suggesting spinal cord injuries, and these signals each emanated from levels that coincided with the observed clinical features. CONCLUSIONS: Transient subluxation or displacement might have caused the upper thoracic spinal cord injuries after the support of the rib cages was temporarily lost on application of excessive force, although such findings could not be confirmed by imaging procedures.
Assuntos
Traumatismos da Medula Espinal/diagnóstico , Vértebras Torácicas/diagnóstico por imagem , Acidentes de Trabalho , Acidentes de Trânsito , Adulto , Traumatismos do Braço/complicações , Feminino , Hemotórax/diagnóstico , Hemotórax/etiologia , Humanos , Luxações Articulares/complicações , Luxações Articulares/diagnóstico , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Paraparesia/diagnóstico , Paraparesia/etiologia , Paraplegia/diagnóstico , Paraplegia/etiologia , Recuperação de Função Fisiológica , Fraturas das Costelas/complicações , Fraturas das Costelas/diagnóstico , Traumatismos da Medula Espinal/complicações , Traumatismos da Medula Espinal/terapia , Tomografia Computadorizada por Raios XRESUMO
STUDY DESIGN: An analysis of lateral radiographs in the upright, flexion-extension position. OBJECTIVES: To document and define the differences in cervical flexion-extension kinematics as they relate to changes of alignment in upright cervical lordosis. SUMMARY OF BACKGROUND DATA: No previous study has reported the association between sagittal plane cervical rotation kinematics and changes of alignment in upright cervical lordosis. METHODS: Lateral radiographs were classified into five groups (Group A, lordosis; Group B, straight; Group C, kyphosis; Group D, S-curve with lordotic upper cervical and kyphotic lower cervical spine; and Group E, S-curve with kyphotic upper cervical and lordotic lower cervical spine) by changes of alignment in upright position. Sagittal cervical rotation angles were measured by a computer-assisted method in the fully flexed and extended positions. RESULTS: Group A revealed the largest angle of lordosis at extension and the smallest angle of kyphosis at flexion, whereas Group C revealed the smallest angle of lordosis at extension and the largest angle of kyphosis at flexion. When Group D adopted the flexion-extension position, the curvature of the upper cervical spine was the same as Group A, whereas the lower cervical spine showed the same curve as Group C. Similarly, the cervical rotation kinematics in Group E were a combination of motion of upper cervical spine in Group C and that of lower spine in Group A. CONCLUSION: The results suggest that alterations in the static alignment of the cervical curvature cause alterations in the dynamic kinematics of the cervical spine during cervical flexion-extension. This information should aid in the interpretation of kinematic studies of the cervical spine.