[Risk of vitamin K antagonists in cases of cerebral microbleeds]. / Risico's van vitamine K-antagonisten bij cerebrale microbloedingen.

- Cerebral microbleeds are associated with a higher risk of intracerebral hemorrhage.- When microbleeds are detected, the possible underlying pathology should be considered; this includes cerebral amyloid angiopathy and other factors that increase the risk of haemorrhage, particularly hypertension. - No randomised trials have yet been conducted into haemorrhagic complications and cerebral infarctions in patients with microbleeds who take vitamin K antagonists. This means that it is not clear whether the intended prevention of cerebral infarctions outweighs the increased risk of haemorrhage associated with use of vitamin K antagonists by these patients.- When deciding whether or not an older patient should be given anticoagulants the following should be taken into consideration as well: comorbidities, polypharmacy, the risk of falls and the probability that the patient can be optimally titrated to vitamin K antagonists. - If there is an increased risk of intracerebral haemorrhage but anticoagulants are indicated, direct oral anticoagulants (DOACs) might be preferable to vitamin K antagonists in patients with a history of cerebral microbleeds.

Interdependence of clinical factors predicting cognition in children with tuberous sclerosis complex.

Cognitive development in patients with tuberous sclerosis complex is highly variable. Predictors in the infant years would be valuable to counsel parents and to support development. The aim of this study was to confirm factors that have been reported to be independently correlated with cognitive development. 102 patients included in this study were treated at the ENCORE-TSC expertise center of the Erasmus Medical Center-Sophia Children's Hospital. Data from the first 24 months of life were used, including details on epilepsy, motor development and mutation status. Outcome was defined as cognitive development (intellectual equivalent, IE) as measured using tests appropriate to the patients age and cognitive abilities (median age at testing 8.2 years, IQR 4.7-12.0). Univariable and multivariable regression analyses were used. In a univariable analysis, predictors of lower IE were: the presence of infantile spasms (ß = -18.3, p = 0.000), a larger number of antiepileptic drugs used (ß = -6.3, p = 0.000), vigabatrin not used as first drug (ß = -14.6, p = 0.020), corticosteroid treatment (ß = -33.2, p = 0.005), and a later age at which the child could walk independently (ß = -2.1, p = 0.000). An older age at seizure onset predicted higher IE (ß = 1.7, p = 0.000). In a multivariable analysis, only age at seizure onset was significantly correlated to IE (ß = 1.2, p = 0.005), contributing to 28% of the variation in IE. In our cohort, age at seizure onset was the only variable that independently predicted IE. Factors predicting cognitive development could aid parents and physicians in finding the appropriate support and schooling for these patients.

Radio-frequency spectroscopy of ultracold fermions.

Radio-frequency techniques were used to study ultracold fermions. We observed the absence of mean-field "clock" shifts, the dominant source of systematic error in current atomic clocks based on bosonic atoms. This absence is a direct consequence of fermionic antisymmetry. Resonance shifts proportional to interaction strengths were observed in a three-level system. However, in the strongly interacting regime, these shifts became very small, reflecting the quantum unitarity limit and many-body effects. This insight into an interacting Fermi gas is relevant for the quest to observe superfluidity in this system.

Interisotope determination of ultracold rubidium interactions from three high-precision experiments.

Combining the measured binding energies of four of the most weakly bound rovibrational levels of the 87Rb2 molecule with results of two other recent high-precision experiments, we obtain exceptionally strong constraints on the atomic interaction parameters in a highly model independent analysis. The comparison of (85)Rb and (87)Rb data, where the two isotopes are related by a mass scaling procedure, plays a crucial role. We predict scattering lengths, clock shifts, and Feshbach resonances with an unprecedented level of accuracy. Two of the Feshbach resonances occur at easily accessible magnetic fields in mixed-spin channels. One is related to a d-wave shape resonance.

Feshbach resonances in rubidium 87: precision measurement and analysis.

More than 40 Feshbach resonances in rubidium 87 are observed in the magnetic-field range between 0.5 and 1260 G for various spin mixtures in the lower hyperfine ground state. The Feshbach resonances are observed by monitoring the atom loss, and their positions are determined with an accuracy of 30 mG. In a detailed analysis, the resonances are identified and an improved set of model parameters for the rubidium interatomic potential is deduced. The elastic width of the broadest resonance at 1007 G is predicted to be significantly larger than the magnetic-field resolution of the apparatus. This demonstrates the potential for applications based on tuning the scattering length.