Cognitive efficiency is associated with endogenous cytokine levels in patients with chronic hepatitis C.

The etiology of cognitive dysfunction in chronic hepatitis C (CHC) infection is unknown. Among the possibilities is cytokine activation, which has been associated with cognitive dysfunction in other chronic conditions. The purpose of this study was to investigate the relationship between endogenous IFN-alpha, IL-6, and TNF-alpha and cognitive functioning in CHC patients. Seventy-eight veterans with CHC underwent cognitive testing and measurement of serum cytokines. In patients with detectable IFN-alpha, higher levels of IL-6 and TNF-alpha were related to poorer cognitive functioning. Findings suggest CHC patients with immune responses characterized by elevated IFN-alpha may be at risk for cognitive difficulties.

Food Stamp Program participation but not food insecurity is associated with higher adult BMI in Massachusetts residents living in low-income neighbourhoods.

OBJECTIVE: Food-insecure populations employ multiple strategies to ensure adequate household food supplies. These strategies may increase the risk of overweight and obesity. However, existing literature reports conflicting associations between these strategies and BMI. The objective of the present study was to examine whether food insecurity and strategies for managing food insecurity are associated with BMI in adults. DESIGN, SETTING AND SUBJECTS: In 2005, RTI International and Project Bread conducted a representative survey of 435 adult residents of low-income census tracts in Massachusetts. Food insecurity was assessed using the US Department of Agriculture's eighteen-item Household Food Security Module. RESULTS: The prevalence of overweight and obesity was 51 % and 25 %, respectively. After adjusting for age, sex, sociodemographic characteristics and food insecurity, both participation in the Food Stamp Program (FSP) and participation in any federal nutrition programme 12 months prior to the survey were each associated with an approximate 3.0 kg/m2 higher adult BMI. In the subset of current FSP participants (n 77), participation for >or=6 months was associated with an 11.3 kg/m2 lower BMI compared with participation for <6 months. Respondents who consumed fast foods in the previous month had a mean BMI that was 2.4 kg/m2 higher than those who did not. Food insecurity was not associated with BMI after adjustment for sociodemographic characteristics and FSP participation. CONCLUSIONS: Participation in federal nutrition programmes and consumption of fast food were each associated with higher adult BMI independent of food insecurity and other sociodemographic factors. However, prolonged participation in the FSP was associated with lower BMI.

A simple index to measure hygiene behaviours.

BACKGROUND: Spot checks are becoming a popular method to assess hygiene behaviours; however, little is known about their repeatability or predictability. We evaluated the within-household repeatability of hygiene indices created from spot checks and their ability to predict incidence of diarrhoea in young Guatemalan children. METHODS: We observed hygiene behaviours in 588 households in four rural Guatemalan communities over 36 months. Four indices related to drinking water (DWI; score = 0-3), food (FI; score = 0-3), personal hygiene (PHI; score = 0-3), and domestic household hygiene (DHI; score = 0-6) and one summary hygiene index (SHI; range 0-15) were created. Morbidity of 694 children aged birth to 36 months living in the study households was assessed using biweekly recall. Intraclass correlation coefficients were calculated to assess within-household repeatability; the generalized estimating equations approach was employed to analyse diarrhoea morbidity. RESULTS: Households were observed a mean of 22.1 +/- 11.2 times. All indices decreased with duration of follow-up (SHI = -0.67 +/- 0.05 points/year; WI = -0.04 +/- 0.01; FI = -0.07 +/- 0.01; PHI = -0.21 +/- 0.01; DHI = -0.37 +/- 0.02; all P < 0.05). Intraclass correlations were low to moderate (SHI = 0.35-0.51; DWI = 0.17-0.21; FI = 0.16-0.18; PHI = 0.27-0.32; DHI = 0.27-0.38). Six separate spot checks would be needed to estimate a household's underlying level of hygiene within 20%. SHI and PHI scores were inversely associated with diarrhoea morbidity (both P < 0.05). CONCLUSIONS: Hygiene indices created using spot checks can be a rapid and efficient method for assessing hygiene and useful for predicting diarrhoea morbidity in young children. Multiple measures are required to accurately estimate the true hygiene pattern of a household.

Dietary lignans: potential role in cancer prevention.

Recent in vitro, animal, and epidemiological studies suggest that dietary lignans may be chemopreventive, potentially through anti-estrogenic, anti-angiogenic, pro- apoptotic, and anti-oxidant mechanisms. In this article, we review lignan food sources and metabolism, proposed anti-carcinogenic mechanisms, and the evidence for a role of lignans in breast, colon, and prostate cancer prevention from animal and epidemiologic literature. Although a number of in vitro and animal studies support a role for lignan-rich foods and purified lignans in the modulation of cancer events of the breast, prostate, and colon, epidemiological studies, sparse and often retrospective in nature, offer inconsistent findings. The most support for a role of lignans in cancer is observed for premenopausal breast cancer. Additional epidemiological studies that use a prospective design and well-developed food databases and questionnaires are needed to adequately evaluate the role of lignans in cancer prevention.