Modelo campo de salud para el estudio de la hipertensión arterial en estudiantes universitarios / Health field model for the study of arterial hypertension in university students

Introducción: el modelo campo de salud se agrupa en cuatro segmentos; biología humana [BH], medio ambiente [MA], Estilos de vida [EV] y servicios de salud [SS] descrito por primera vez por Mack Lalonde, es un instrumento para un análisis integral de la hipertensión arterial [HTA]. Objetivo: analizar las divisiones del campo de salud y su asociación con la HTA en estudiantes universitarios. Material y métodos: se trata de un estudio no experimental, descriptivo, transversal y prospectivo; muestra por conveniencia de 200 estudiantes universitarios. Se utilizó cuestionario Simão (2005) y medidas antropométricas y medición de la presión arterial [PA]. Estadística descriptiva y no paramétrica x2 y U de Mann Whitney. Resultados: la división del campo de salud con mayor prevalencia fueron los SS (62%). Hubo asociación estadísticamente significativa en presión arterial sistólica [PAS] con la BH (x2=9.53, gl=2, p=.009) y MA (x2=6.79, gl=2, p=.034) y en presión arterial diastólica [PAD] con BH (x2=6.13, gl=2, p=.047) y MA (x2=6.79, gl=2, p=.05). Conclusiones: el modelo de Lalonde permite valorar los factores causales y la prevalencia de la HTA en estudiantes universitarios.

Introduction: the health field model is grouped into four segments: human biology [HB], environment [E], lifestyles [LS] and health services [HS]. First described by Mack Lalonde, is an instrument for a comprehensive analysis of arterial hypertension [HBP]. Objective: analyze the divisions of the health field and its association with the HBP in university students. Material and methods: this is a non experimental, descriptive, cross-sectional and prospective study; convenience sample of 200 college students. A Simão questionnaire (2005), anthropometric measurements and measurement of blood pressure [BP] were used. Descriptive and non-parametric statistics x2 and Mann Whitney's U. Results: the division of the health field with the highest prevalence was the HS (62%). There was a statistically significant association in systolic blood pressure [SBP] with HB (x2=9.53, gl=2, p=.009) and E (x2=6.79, gl=2, p=.034) and in diastolic blood pressure [DBP] with HB (x2=6.13, gl=2, p=.047) and E (x2=6.79, gl=2).05. Conclusion: Lalonde model allows us to assess the causal factors and the prevalence of hypertension in university students.

Synaptic activity protects against AD and FTD-like pathology via autophagic-lysosomal degradation.

Changes in synaptic excitability and reduced brain metabolism are among the earliest detectable alterations associated with the development of Alzheimer's disease (AD). Stimulation of synaptic activity has been shown to be protective in models of AD beta-amyloidosis. Remarkably, deep brain stimulation (DBS) provides beneficial effects in AD patients, and represents an important therapeutic approach against AD and other forms of dementia. While several studies have explored the effect of synaptic activation on beta-amyloid, little is known about Tau protein. In this study, we investigated the effect of synaptic stimulation on Tau pathology and synapses in in vivo and in vitro models of AD and frontotemporal dementia (FTD). We found that chronic DBS or chemically induced synaptic stimulation reduced accumulation of pathological forms of Tau and protected synapses, while chronic inhibition of synaptic activity worsened Tau pathology and caused detrimental effects on pre- and post-synaptic markers, suggesting that synapses are affected. Interestingly, degradation via the proteasomal system was not involved in the reduction of pathological Tau during stimulation. In contrast, chronic synaptic activation promoted clearance of Tau oligomers by autophagosomes and lysosomes. Chronic inhibition of synaptic activity resulted in opposite outcomes, with build-up of Tau oligomers in enlarged auto-lysosomes. Our data indicate that synaptic activity counteracts the negative effects of Tau in AD and FTD by acting on autophagy, providing a rationale for therapeutic use of DBS and synaptic stimulation in tauopathies.

Ambient Computing to Support the Association of Contextual Cues with Medication Taking / Cómputo Ambiental para Facilitar la Asociación de Pistas Contextuales con la Toma de Medicamento

The most common reason for non-adherence to medication among older adults is forgetfulness. Contextual cues, such as daily routines, serve as implicit situational information that increases the retrieval process of the intended action. The main contribution is an overview of the process and the technical details of Ambient Computing displays we developed to help seniors use contextual cues to remember actions associated with medication intake (i.e. remember to take medications or remember having taken them earlier). Through a qualitative study, we obtained evidence about the potential of our technological approach to make seniors more responsible and independent for taking medications.

Las razones más comunes para que adultos mayores no se apeguen a la medicación es el olvido. Las rutinas de vida diaria sirven como pistas contextuales que mejoran el proceso cognitivo relacionado con recordar realizar una acción planeada. Nuestro propósito es presentar el proceso de desarrollo, así como detalles técnicos, de Sistemas de Cómputo Ambiental que proveen pistas contextuales al adulto mayor para ayudarle a recordar acciones de su medicación (e.g., recordar medicarse o recordar que se medicaron). Mediante un estudio cualitativo, obtuvimos evidencia del potencial de nuestra tecnología para que el adulto mayor sea más responsable e independiente para medicarse.

Tratamiento conservador del dolor neuropático: el aporte de la fisioterapia / No disponible

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Pharmacognostical studies of the plant drug Mimosae tenuiflorae cortex.

The bark of the Mimosa tenuiflora (Willd.) Poiret (Leguminoseae) tree, known as tepescohuite in Mexico, is commonly used in this country and in Central America to elaborate different products for the treatment of skin burns and lesions. The cicatrizing properties of extracts obtained from this bark have been scientifically studied, attributing the main biological activity to its tannin and saponin content. Studies include clinical trials of phytodrugs based on Mimosae tenuiflora bark extracts for treatment of venous leg ulcerations. Recent commercialization of the plant drug Mimosae tenuiflorae cortex requires pharmacognostical information to develop quality-control methods for raw materials and extracts produced with this plant drug. The present paper reports a group of ethnobotanical, morphological, chemical, and molecular studies performed with Mimosae tenuiflora materials obtained by collection in the southeastern Mexican state of Chiapas. Macro- and micro-morphological parameters were established to authenticate the genuine drug that allowed detection of adulterants usually found in commercial samples of this plant material. These morphological characteristics can be used for rapid identification of the drug and are particularly useful in the case of powdered materials. The chemical studies performed demonstrated that tannins represent the major component group in the bark. Its content in genuine tepescohuite is 16% and is mainly composed of proanthocyanidins, a condition permitting a tannin-based chemical-control method for fingerprinting the plant drug. Contrariwise, the saponin concentration in Mimosae tenuiflora bark is extremely low, and its isolation and content evaluation represent a complex procedure that is unsuitable for routine control purposes. Finally, random amplified DNA (RAPD) analysis results a useful tool for obtaining DNA specific markers of Mimosae tenuiflora species which should be useful in future studies involving raw material authentication by molecular methods.

[Effectiveness of (67)Ga scintigraphy in the diagnosis of lymphoma relapse]. / Efectividad de la gammagrafía con 67Ga en el diagnóstico de recidiva de linfomas.

PURPOSE: To establish the clinical effectiveness of 67Ga in lymphoma recurrence. PATIENTS AND METHODS: Thirty-nine patients were assessed on 43 occasions (31 for Hodgkin's disease and 12 for non-Hodgkin's lymphoma) either for a suspected recurrence or to monitor the evolution of the disease. A computed tomography (CT) and a 67Ga whole body scan were performed. Independent observers who did not know the definitive diagnosis performed the CT and 67Ga readings. The gold standard was the biopsy results or the follow-up during a 12 months period. RESULTS: Recurrence was confirmed in 17 cases, while 26 continued to have complete remission. Using 67Ga resulted in true positive (TP), 24 true negative (TN), 2 false positive (FP) and 2 false negative (FN) results with a sensitivity of 0.88 (15/17), specificity of 0.92 (24/26), positive predictive value (PPV) of 0.88 (15/17) and negative predictive value (NPV) of 0.92 (24/26), while CT produced 12 TP, 20 TN, 6 FP and 5 FN, with a sensitivity of 0.7 (12/17), specificity of 0.77 (20/26), PPV of 0.88 (12/18) and NPV of 0.92 (20/25). CONCLUSIONS: 67Ga is a useful indicator and has better diagnostic effectiveness than CT for both the confirmation and exclusion of lymphoma recurrence.

Efectividad de la gammagrafía con 67Ga en el diagnóstico de recidiva de linfomas / Effectiveness of 67Ga scintigraphy in the diagnosis of lymphoma relapse

Objetivo: Establecer los parámetros de efectividad clínica del 67Ga en el diagnóstico de confirmación o exclusión de recidiva de linfomas. Pacientes y Métodos: Se han estudiado retrospectivamente, 39 pacientes en 43 ocasiones (31 linfomas Hodgkin y 12 no Hodgkin) evaluados, bien por sospecha de recaída o por seguimiento de su enfermedad. Se realizó tomografía computarizada (TC) tóraco-abdominal y estudio con 67Ga (8 mCi) (cuerpo completo y SPET torácico y abdominal). La lectura de TC y 67Ga se realizó de forma ciega e independiente. El gold standard fue la biopsia y/o el seguimiento por un período mínimo de 1 año. Resultados: En 17 casos se confirmó la recidiva, mientras que 26 continuaron en remisión completa. El 67Ga tuvo 15 VP, 24 VN, 2 FP y 2 FN, mientras que la TC tuvo 12 VP, 20 VN, 6 FP y 5 FN. Para el 67Ga la sensibilidad fue de 0,88 (IC95 per cent: 0,64-0,98), la especificidad de 0,92 (0,74-0,99), el valor predictivo positivo de 0,88 (0,64-0,98) y el valor predictivo negativo de 0,92 (0,75-0,99), mientras que la TC tuvo 0,7 (0,44-0,89), 0,77 (0,56-0,91), 0,66 (0,41-0,87) y 0,8 (0,59-0,93), respectivamente. Conclusiones: Los resultados señalan que los datos de efectividad clínica del 67Ga en la confirmación o exclusión de recidiva de linfoma son adecuados y superiores a los de TC, por lo que debería incluirse en el control rutinario de estos pacientes (AU)

The use of transcutaneous acupoint electrical stimulation for preventing nausea and vomiting after laparoscopic surgery.

UNLABELLED: Nonpharmacologic techniques may be effective in preventing postoperative nausea and vomiting (PONV). This sham-controlled, double-blinded study was designed to examine the antiemetic efficacy of transcutaneous acupoint electrical stimulation (TAES) in a surgical population at high risk of developing PONV. We studied 221 outpatients undergoing laparoscopic cholecystectomy with a standardized general anesthetic technique in this randomized, multicenter trial. In the TAES group, an active ReliefBand(Woodside Biomedical, Inc., Carlsbad, CA) device was placed at the P6 acupoint, whereas in the Sham and Placebo groups, an inactive device was applied at the P6 acupoint and at the dorsal aspect of the wrist, respectively. The ReliefBand was applied after completion of electrocautery and remained in place for 9 h after surgery. The incidence of PONV and need for "rescue" medication were evaluated at predetermined time intervals. TAES was associated with a significantly decreased incidence of moderate-to-severe nausea as denoted on the Functional Living Index-Emesis score for up to 9 h after surgery (5%-11% for the TAES group vs 16%-38% [P < 0.05] and 15%-26% [P < 0.05] for Sham and Placebo groups, respectively). TAES was also associated with a larger proportion of patients free from moderate to severe nausea symptoms (73% vs 41% and 49% for Sham and Placebo groups, respectively; P < 0.05). However, there were no statistically significant differences among the three groups with regard to incidence of vomiting or the need for rescue antiemetic drugs. We conclude that TAES with the ReliefBand at the P6 acupoint reduces nausea, but not vomiting, after laparoscopic cholecystectomy. IMPLICATIONS: Transcutaneous acupoint electrical stimulation at the P6 acupoint reduced postoperative nausea, but not vomiting, in outpatients undergoing laparoscopic cholecystectomy procedures.

Development of a conceptual model for vertical flow wetland metabolism.

Four parallel vertical constructed wetlands, with a total area of 556 m2, are used to treat domestic wastewater, coming from a community of 550 inhabitants. The system includes pre-treatment with an anaerobic filter and post-treatment with chlorine, before discharging the effluent to the ocean. Four native species of macrophytes were planted: Paspalum penisetum, Typha sp, Conocarpres erectus and Scirpus lacustris. In situ measurements of gas content were performed for each bed during an operation cycle. After a feeding discharge, an unaltered sample of sand from each bed was taken, and a respirometric test was implemented to measure the metabolic activity in terms of oxygen consumption kinetics, CO2 production and organic matter degradation. The results were used to develop a conceptual model of the microbiologic metabolism for the process of organic matter removal from wastewater. Sorption in the bed is the main mechanism for organic matter removal from the wastewater, with subsequent biological oxidation during the resting period. The degradation rate for dissolved organic matter is found to be dependent on its concentration and on oxygen content in the gaseous phase. During the days of major activity, the oxygen content was not fully recovered when a new discharge occurred, finding anaerobic activity within the bed.

Removal of hydrogen sulphide BOD from brackish water using vertical flow wetlands in a Caribbean environment.

Wastewater from a 550-inhabitant community had been treated and discarded using an anaerobic filter. Due to seawater intrusion in the aquifer that supplies the water, high concentrations of hydrogen sulphide were detected in the effluent. A vertical flow wetland was designed in 1998 for treating this effluent. Four parallel reed beds with a total area of 556 m2 were constructed. During the first months of operation, a mean BOD5 removal efficiency of 91% was obtained, with loads to the wetland system up to 4 g/m2/d of grease and oils (G&O). In 1999, problems of soil clogging were found due to high G&O content in the wastewater, with loads up to 15 g/m2/d of G&O, which highly influenced the hydraulic conductivity of the beds, generating the clogging problems. The low hydraulic conductivity and the high effluent G&O content, caused low BOD5 and COD removal efficiencies. As G&O accumulated in the soil, the removal efficiencies decreased. Despite the clogging problems, there has been a high sulphide removal throughout the system operation. The wetlands removed sulphides successfully, under loads up to 20 g S=/m2/d. Four native species of macrophytes were planted: Paspalum penisetum, Typha sp, Conocarpres erectus and Scirpus lacustris. All of them but Typha sp. were established in the system.

El renograma diurético en la estrategia diagnóstica de la hidronefrosis prenatal / The diuretic renography in the diagnostic strategy of prenatal hidronephrosis

Objetivo: Comprobar la utilidad del renograma diurético con 99mTc-MAG3 en pacientes con diagnóstico prenatal de hidronefrosis ante la sospecha de obstrucción del tracto urinario. En un neonato con dilatación del tracto urinario superior, la dificultad se plantea en diferenciar una verdadera obstrucción de una dilatación sin obstrucción. Material y métodos: Estudio retrospectivo que incluye 40 pacientes consecutivos, de los 181 recién nacidos con diagnóstico prenatal de hidronefrosis durante el período comprendido entre enero de 1993 y diciembre de 1998. La edad media de realización del primer renograma fue 2,6 meses. Resultados: El diagnóstico final correspondió (excluidos previamente los reflujos vésico-ureterales) a: estenosis pieloureteral (EPU) 16, megaureter 15, ureterocele 3 y ectasia simple 6. En la mayoría de los pacientes se adoptó un tratamiento conservador, sin embargo, diecisiete precisaron tratamiento quirúrgico por el elevado riesgo de daño renal permanente. Conclusiones: 1) La EPU es la causa más frecuente de hidronefrosis neonatal (HN) y por tanto de solicitud de renogramas diuréticos. Debido a que es la entidad con mayor tasa de intervenciones quirúrgicas (por el alto riesgo de daño renal permanente) es donde el renograma con 99mTcMAG3 tiene mayor influencia en la decisión terapéutica, identificando quienes y cuando deben ser operados. 2) La indicación quirúrgica de la HN esta basada en los parámetros del renograma diurético y/o en la aparición de sintomatología. En nuestra serie de pacientes intervenidos ninguno de los que mostraban una función renal diferencial <20 por ciento respecto al contralateral, mostró una recuperación tras la cirugía (control a los 6 meses post-intervención) (AU)

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Fast-track cardiac anesthesia: use of remifentanil combined with intrathecal morphine as an alternative to sufentanil during desflurane anesthesia.

UNLABELLED: The purpose of this cardiac fast-track study was to evaluate the use of remifentanil (R) combined with intrathecal (IT) morphine as an alternative to sufentanil (S) during desflurane anesthesia with respect to postoperative pain control. Prior to entering the operating room, patients in the R group (n = 20) received morphine, 8 microg/kg IT. Anesthesia was induced using a standardized anesthetic technique in all patients. In the R group, anesthesia was maintained with R, 0.1 microg. kg(-1). min(-1) in combination with desflurane 3-10%. In the S group (n = 20), patients received S 0.3 microg. kg(-1). h(-1) and desflurane 3-10%. There were no differences between the two groups with respect to time from arrival in the intensive care unit to tracheal extubation (5.1 +/- 4.3 h vs 5.8 +/- 6.7 h for R and S groups, respectively). After extubation, patients in the R group had significantly lower visual analog pain scores, reduced patient-controlled analgesic requirements, and greater satisfaction with their perioperative pain management, compared with patients in the S group. We conclude that R combined with IT morphine provided superior pain control after cardiac surgery compared with a S-based general anesthetic technique. IMPLICATIONS: As part of a cardiac fast-tracking program involving desflurane anesthesia, the use of intrathecal morphine in combination with a remifentanil infusion provided improved postoperative pain control, compared with IV sufentanil alone.

A comparison of the costs and efficacy of ondansetron versus dolasetron for antiemetic prophylaxis.

UNLABELLED: The optimal dose and timing of 5-HT(3) antagonist administration for prophylaxis against postoperative nausea and vomiting (PONV) remains controversial. Although 5-HT(3) antagonists seem to be most effective when administered near the end of surgery, there are no data on the comparative efficacy or costs associated with the 5-HT(3) antagonists dolasetron and ondansetron when administered at the end of the operation. In this double-blinded study, 200 outpatients undergoing otolaryngologic procedures with a standardized general anesthetic received 4 (O4) or 8 mg (O8) of ondansetron or 12.5 (D12.5) or 25 mg (D25) of dolasetron IV within 30 min before the end of surgery. A blinded observer recorded the emetic episodes, maximum nausea score, recovery room resource and drug use, nursing time spent managing PONV, times to achieve discharge criteria from the Phase 1 and 2 recovery units, postdischarge emesis, and patient satisfaction. Total costs were calculated by using the perspective of a free-standing surgicenter. There were no differences in patient demographics, incidence of PONV, need for rescue medications, time spent in the recovery areas, unanticipated hospital admissions, or patient satisfaction among the four treatment groups. The mean total costs (95% confidence intervals) to prevent PONV in one patient were lowest in the D12.5 group: $23.89 (17.18-28.79) vs $37.81 (30.29-45.32), $33.91 (28.92-39.35), and $75.18 (61.13-89.24) for D25, O4, and O8, respectively. Excluding nursing labor costs did not alter this finding: $18.51 (14.18-22.85), $34.77 (28.03-41.49), $31.77 (28. 92-39.35), and $71.76 (58.17-85.35) for D12.5, D25, O4, and O8, respectively. We conclude that 12.5 mg of dolasetron IV is more cost effective than 4 mg of ondansetron IV for preventing PONV after otolaryngologic surgery and is associated with similar patient satisfaction. IMPLICATIONS: When administered at the end of surgery, 12.5 mg of dolasetron IV is as effective as 25 mg of dolasetron IV, 4 mg of ondansetron IV, and 8 mg of ondansetron IV in preventing emetic symptoms after otolaryngologic surgery and was associated with similar patient satisfaction at a reduced cost. There were no differences in the antiemetic efficacy of the 4 and 8 mg doses of ondansetron.

Fast-track cardiac anesthesia: a comparison of remifentanil plus intrathecal morphine with sufentanil in a desflurane-based anesthetic.

OBJECTIVE: To compare the effects of an intravenous remifentanil infusion plus intrathecal morphine with intravenous sufentanil infusion with respect to intraoperative hemodynamic variables, extubation times, and recovery profiles when administered as part of a desflurane-based fast-track anesthetic regimen for cardiac surgery. DESIGN: A prospective, randomized, nonblinded study. SETTING: University hospital. PARTICIPANTS: Forty patients undergoing elective primary coronary artery bypass graft, aortic valve replacement, or mitral valve replacement surgery. INTERVENTIONS: After a standardized anesthetic induction, anesthesia was maintained with a remifentanil infusion, 0.1 microg/kg/min, and desflurane, 3% to 10%, inspired (group I, n = 20) or a sufentanil infusion, 0.3 microg/kg/h, and desflurane, 3% to 10%, inspired (group II, n = 20). Patients receiving remifentanil were administered intrathecal morphine, 8 microg/ kg, for postoperative analgesia. MEASUREMENTS AND MAIN RESULTS: Both anesthetic regimens provided comparable intraoperative hemodynamic stability and similar recovery profiles, with extubation times of 5.1 +/- 4.3 hours (group I) and 5.8 +/- 6.7 hours (group II). CONCLUSIONS: Use of remifentanil in combination with intrathecal morphine did not facilitate earlier tracheal extubation or improve intraoperative hemodynamic stability compared with sufentanil alone for fast-track cardiac anesthesia.

[Diuretic renography in the diagnostic approach of prenatal hydronephrosis]. / El renograma diurético en la estrategia diagnóstica de la hidronefrosis prenatal.

OBJECTIVE: To verify the utility of diuretic renography using 99mTc-MAG3 in the evaluation of the urinary tract obstruction in patients with prenatal diagnosis of hydronephrosis. In a neonate with upper urinary tract dilatation, it is difficult to differentiate a true obstruction from a dilated non-obstructed system. MATERIAL AND METHODS: The retrospective study (january 1993-december 1998) included 40 consecutive patients selected from 181 newborns with a prenatal diagnosis of hydronephrosis. The mean age of the performance of the first renography was 2.6 months. RESULTS: The final diagnosis (once the vesicoureteral reflux was ruled out) was: ureteropelvic junction obstruction (UPJ) 16, megaureter 15, ureterocele 3 and stasis 6. Conservative treatment was applied in most of the patients. Nevertheless, 17 of them needed surgical treatment due to the high risk of the permanent renal damage. CONCLUSIONS: 1) UPJ is the most frequent cause of neonatal hydronephrosis (NH) and consequently, of the request for diuretic renographies. The renography with 99mTc-MAG3 has the greatest influence in the therapeutic decision (identifying who should be operated on and when this should be done), due to the fact that it is the disease with the highest rate of surgical interventions. 2). The surgical indication in NH is based on the diuretic renography parameters and/or on the presence of symptomatology. In our series of surgical patients, none of those who had a differential renal function <20% with regard to the contralateral one showed recuperation after surgery (control 6 months later).

Comparison of adenosine and remifentanil infusions as adjuvants to desflurane anesthesia.

BACKGROUND: Because adenosine has been alleged to produce both anesthetic and analgesic sparing effects, a randomized, double-blinded study was designed to compare the perioperative effects of adenosine and remifentanil when administered as intravenous adjuvants during general anesthesia for major gynecologic procedures. METHODS: Thirty-two women were assigned randomly to one of two drug treatment groups. After premedication with 0.04 mg/kg intravenous midazolam, anesthesia was induced with 2 micro/kg intravenous fentanyl, 1.5 mg/kg intravenous propofol, and 0.6 mg/kg intravenous rocuronium, and maintained with desflurane, 2%, and nitrous oxide, 65%, in oxygen. Before skin incision, an infusion of either remifentanil (0.02 microg x kg(-1) x min(-1)) or adenosine (25 microg x kg(-1) x min(-1)) was started and subsequently titrated to maintain systolic blood pressure, heart rate, or both within 10-15% of the preincision values. RESULTS: Adenosine and remifentanil infusions were effective anesthetic adjuvants during lower abdominal surgery. Use of adenosine (mean +/- SEM, 166+/-17 microg x kg(-1) x min(-1)) was associated with a significantly greater decrease in systolic blood pressure and higher heart rate values compared with remifentanil (mean +/- SEM, 0.2+/-0.03 microg kg(-1) x min(-1)). Total postoperative opioid analgesic use was 45% and 27% lower in the adenosine group at 0-2 h and 2-24 h after surgery, respectively. CONCLUSIONS: Adjunctive use of a variable-rate infusion of adenosine during desflurane-nitrous oxide anesthesia was associated with acceptable hemodynamic stability during the intraoperative period. Compared with remifentanil, intraoperative use of adenosine was associated with a decreased requirement for opioid analgesics during the first 24 h after operation.

Prueba logoaudiométrica IU-PLI / UI-PLI logo-audiometric test

El proposito de este estudio fue estimar la validez de contenido y la confiabilidad por mitades de la prueba de logoaudiometria adaptada al español colombiano para la poblacion infantil de Santafe de Bogota de 3.5 a 10 años basada en la prueba Northwestern University Children's Perception of Speech: NU-CHIPS (Elliot y Katz, 1980). Esta investigacion se inscribe en el area de la medicion audiologica y adopto un diseño de tipo descriptivo correlacional. Se tomo una muestra de 64 niños, 47 con audición normal y 17 con hipoacusia neurosensorial bilateral entre moderada y severa. La prueba fue aplicada a esta poblacion en un contexto cerrado de respuesta. Los resultados obtenidos sugirieron un alto grado de validez mediante el balance fonetico del instrumento a traves de expertos y de la aplicacion empirica de la prueba piloto y la confiabilidad por la correlacion existente entre las variables analizadas a traves de las pruebas estadisticas correlacionales Spearman Brown y Kuder Richardson 20, los cuales no arrojaron diferencias significativas en la ejecucion de la prueba por los sujetos con relacion a los datos normativos de la prueba originalel propósito