[Non-pigmented subungual malignancies--crux chirurgiae minoris]. / Nepigmentované subunguální malignity--kríz malé chirurgie.

BACKGROUND: Incidence of amelanotic subungual malignancies is small, but they are not extremely rare and are often omitted in the diagnostic algorithm of subungual lesions. METHODS: Retrospective analysis of four amelanotic subungual tumours--2 subungual melanomas and 2 spinocellular carcinomas. Diagnosis was made by surgeon and pathologist. RESULTS: We have observed frequent traumatic history, patients' symptomatology underrating, inconspicuous clinical manifestation with unusual macroscopic morphological features and a risk of diagnostic delay. CONCLUSION: It is necessary to consider possibility of subungual malignancies in diagnostic algorithm of nail unit pathologies. Early diagnosis enables the reduction of amputation rate. We recommend excision biopsy with low indication threshold. There is fatal risk of delayed diagnosis especially in subungual melanoma cases, and mostly mutilation risk in spinocellular carcinoma cases.

[Hodgkin's disease with epithelioid granulomatous reaction]. / Hodgkinova nemoc s epiteloidne granulomatózní reakcí.

Hodgkin's disease with a conspicuous presence of epithelioid-histiocytic elements was described as a particular subvariant of mixed type Hodgkin's disease. The authors presented four new cases. An additional increase of Langerhan's and interdigitating cells was observed in two cases, sarcoidosis-like granulomas with epithelioid and big multinucleated cells in the third. This female died and granulomas were found in several other organs. A prognostic relevance of this conspicuous reaction has not been clear for the time being. The mentioned patient deceased one year after the diagnosis had been settled, other three patients have been clinically well surviving 2-5 years.