RESUMO
Multiple natural and mixed foci of Q fever have been revealed at the territory of six administrative regions of the western part of the Ukraine. Coxiella burnetii strains have been isolated from small animals and ticks, the specific features of their ecology in Poles'e and forest-steppe zones have been determined. The necessity of the study of natural foci of Q fever at not yet surveyed territories for at least 3-4 years has been substantiated.
Assuntos
Febre Q/epidemiologia , Animais , Animais Domésticos/microbiologia , Animais Selvagens/microbiologia , Anticorpos Antibacterianos/sangue , Especificidade de Anticorpos , Coxiella burnetii/imunologia , Coxiella burnetii/isolamento & purificação , Reservatórios de Doenças/estatística & dados numéricos , Reservatórios de Doenças/veterinária , Ecologia , Feminino , Cobaias , Humanos , Masculino , Febre Q/imunologia , População Rural/estatística & dados numéricos , Estudos Soroepidemiológicos , Carrapatos/microbiologia , Ucrânia/epidemiologiaAssuntos
Febre Q/diagnóstico , Doenças dos Trabalhadores Agrícolas/diagnóstico , Animais , Anticorpos Antibacterianos/sangue , Especificidade de Anticorpos , Bovinos , Doenças dos Bovinos/diagnóstico , Coxiella burnetii/imunologia , Humanos , Febre Q/veterinária , Estudos Retrospectivos , Testes Sorológicos/métodos , UcrâniaAssuntos
Adamantano/uso terapêutico , Antivirais/uso terapêutico , Hidrocarbonetos Aromáticos com Pontes/uso terapêutico , Fluorenos/uso terapêutico , Naftalenos/uso terapêutico , Naftoquinonas/uso terapêutico , Infecções por Orthomyxoviridae/tratamento farmacológico , Adamantano/análogos & derivados , Animais , Antivirais/toxicidade , Relação Dose-Resposta a Droga , Avaliação Pré-Clínica de Medicamentos , Glioxal/análogos & derivados , Glioxal/uso terapêutico , Dose Letal Mediana , Masculino , Camundongos , Tetra-Hidronaftalenos , Fatores de TempoRESUMO
The antiviral, viricidal, and interferon-inducing activities of florenal (bisulphite derivative of 2-flourenylglyoxal) and its influence on RNA and protein synthesis were studied. The drug inhibited replication of A/WSN and A/Englang/42/72 influenza viruses in chick embryos infected with low doses of the viruses (10--1000 EID50), induced interferon production in cell culture and in chick embryos (16 and 32 units/ml, respectively) and showed viricidal activity in vitro. Florenal in concentrations 50 microgram/ml or higher reduced the level of RNA and protein synthesis both in non-infected and infected cells within the first 4--5 hours after its administration. It was not effective against influenza infection of white mice caused by A/England/42/72 virus.
Assuntos
Antivirais , Antivirais/uso terapêutico , Fluorenos/farmacologia , Vírus da Influenza A/efeitos dos fármacos , Indutores de Interferon , Adamantano/análogos & derivados , Adamantano/farmacologia , Animais , Antivirais/farmacologia , Células Cultivadas , Embrião de Galinha , Relação Dose-Resposta a Droga , Fluorenos/uso terapêutico , Glioxal/análogos & derivados , Glioxal/farmacologia , Masculino , Camundongos , Infecções por Orthomyxoviridae/tratamento farmacológico , Biossíntese de Proteínas , RNA/biossíntese , Replicação Viral/efeitos dos fármacosRESUMO
The results of the study of rimantadine effectiveness in a viral-bacterial infection in white mice caused by a mixture of influenza A2 virus (10 LD50) and hemolytic streptococcus group A (350 million bacteria). The drug showed no prophylactic or therapeutic effect in the mixed infection, whereas in influenza infection in the animals which served as a positive control rimantadine had marked antiviral activity (P less than 0.001). It is assumed that the lack of the drug effectiveness against the mixed infection is due to the formation in the animals of virus-microbe complexes which are conducive to an increase of infectious virus titers and virus resistance to various treatments.