Real-World clinical features and survival outcomes associated with primary gastrointestinal natural killer/T-cell lymphoma from 1999 to 2020.

BACKGROUND: Primary gastrointestinal natural killer (NK)/T-cell lymphoma (PGINKTL) is a rare T-/NK-cell lymphoma subtype, and the clinical features and survival outcomes remain largely unknown. METHODS: To summarize the clinical features and survival outcomes of PGINKTL, PGINKTL cases diagnosed at our hospital from May 1999 to December 2020 were reviewed; and the clinical data, information on treatment strategies, and survival were collected. Survival analysis was performed using the Kaplan-Meier method and multivariable Cox proportional hazards regression. We constructed a nomogram to visualize the survival prediction of PGINKTL. The discriminative ability and calibration of the nomogram for prediction were tested using the concordance index (C-index) and calibration plots. RESULTS: The cohort included 81 cases, the median age was 36 years (range, 7-80 years), and the male-to-female ratio was 1.7:1. The most common clinical symptom at the time of diagnosis was abdominal pain (71.6%). The most common lesion site was the colon (59.3%). During a median follow-up period of 37.7 months, the median overall survival (OS) time of 81 patients was 4.0 months (95% confidence interval [CI], 3.1-4.9 months), and the 2-year OS rate was 30.7% (95% CI, 20.3%-40.1%). The multivariate analyses indicated that patients with an Eastern Cooperative Oncology Group (ECOG) performance status (PS) score ≥2, serum lactic dehydrogenase (LDH) level ≥ the upper limit normal (ULN), and perforation had worse OS. We used these data to establish a nomogram to predict survival for PGINKTL. The nomogram displayed good accuracy, with a C-index of 0.726. CONCLUSION: The clinical features and poor outcomes of PGINKTL, which is a rare and fatal lymphoma type, are presented. The proposed nomogram provides an individualized estimate of survival for these patients. In the future, the study focused on exploring a better treatment strategy to improve survival is required in PGINKTL.

Influencing factors of quality of life and correlation among quality of life and its influencing factors in aged patients with coronary heart disease / 心血管康复医学杂志

Objective:To explore influencing factors of quality of life (QOL)in aged patients with coronary heart disease (CHD)and perform correlation analysis among quality of life and its influencing factors.Methods:A total of 70 aged CHD patients treated in our hospital from 2011 to 2015 were selected and followed up.All patients received evaluation of Chinese Questionnaire of Quality of life in Chinese patients with cardiovascular diseases (CQQC ). CQQC score was compared between patients with different gender,age,course of disease,body mass index (BMI) and number of complications.Spearman correlation analysis was used to analyze the correlation between influencing factors of QOL and CQQC score.Results:There was no significant difference in CQQC score between male and fe- male patients (P=0.697).CQQC scores of patients with age 60~70 years,course of disease 15 years,BMI>30 kg/m2 and complications,P50 scores,scores of 60~70 years were significantly higher than those of>70 years (85.42% vs.31.82%),scores of course of disease 15 years (79.55% vs. 3.85%),scores of BMI30 kg/m2 (62.22% vs.20.00%) in aged CHD patients,P<0.01 all.Conclusion:Quality of life in CHD patients are mainly affected by age,course of disease and body mass index etc.So attention should be paid to follow-up,guiding therapy and intervening lifes- tyle in order to improve patients'quality of life.