1.
Org Lett
; 26(6): 1201-1206, 2024 Feb 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38308848
RESUMO
We developed an asymmetric decarboxylative allylic alkylation of vinylethylene carbonates with α-fluoro pyridinyl acetates through a synergistic palladium/copper catalysis. This protocol provides chiral allylic alcohol with carbon-fluorine quaternary stereogenic centers in good yield with good enantioselectivities and excellent regioselectivities. The utility of this approach was further demonstrated via a gram-scale experiment and derivatizations of the product.