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1.
Dev Neuropsychol ; 46(1): 1-15, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33356560

RESUMO

The objective of the study was to determine the prevalence of low scores in a diverse Latin American population for two neuropsychological commonly used tests to evaluate executive functions and to compare the number of low scores obtained using normative data from a Spanish-speaking population from Latin America versus an English-speaking population from U.S.A. Healthy adults (N = 5402) were administered the Modified Wisconsin Card Sorting Test and Stroop Color-Word. Low scores on measures of executive functioning are common. Clinicians working with Spanish-speaking adults should take into account the higher probability of low scores on these measures to reduce false-positive diagnoses of cognitive deficits in an individual.

2.
Reumatol. clín. (Barc.) ; 16(2,pt.1): 87-91, mar.-abr. 2020. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-194325

RESUMO

INTRODUCCIÓN: Los congresos médicos representan una herramienta que favorece la actualización permanente del médico; su calidad es obligación de los colegios e instituciones. OBJETIVO: Evaluar el contenido académico de 4 congresos internacionales de Reumatología. MATERIALES Y MÉTODOS: Se utilizó como fuente de información los resúmenes publicados en los suplementos de la revista Reumatología Clínica, SE1 Vol. 12 del mes de febrero de 2016, el suplemento SE 1 Vol. 13 del mes de febrero de 2017, la aplicación para medios electrónicos del ACR/ARHP 2016 del Congreso Americano de Reumatología 2016 dedicado a los trabajos presentados en el XLIV Congreso Mexicano de Reumatología (CMR 44), XLV Congreso Mexicano de Reumatología (CMR 45) y del 2016 ACR/ARHP Annual Meeting (ACR 2016), y la página electrónica de archivos y resúmenes de EULAR 2017, respectivamente; de cada trabajo se obtuvo información referente a la principal patología referida, el tipo de información contenida y el tipo de trabajo. Cabe resaltar que algunos eran patologías o diseños combinados de los cuales se seleccionó el que a nuestro juicio era el más importante. RESULTADOS: Se presentaron 275, 340, 3275 y 4129 estudios en el CMR 44, CMR 45, ACR 2016, EULAR 2017, respectivamente. La artritis reumatoide fue la patología con mayor número de trabajos con 23, 26, 21 y 27% en el CMR 44, CMR 45 y ACR 2016 y EULAR 2017 respectivamente, seguida por informes sobre lupus eritematoso sistémico; en tercer lugar, en los congresos mexicanos destacan reportes sobre vasculitis, mientras en los congresos internacionales lo ocupan las espondiloartropatías. De resaltar que en el caso de artritis reumatoide los tópicos sobre clínica representan alrededor del 30% en los congresos mexicanos y ACR, y casi el 20% en EULAR. Los estudios observacionales representaron el 40% en los congresos mexicanos vs. 33% en el ACR 2016 y 55% en EULAR 2017, por otro lado, los estudios sobre ciencia básica fueron mínimos en los congresos mexicanos mientras que en ACR 2016 representan el 21% y en EULAR 12%. CONCLUSIONES: Los congresos de Reumatología constituyen fuente adecuada para la obtención de conocimientos basados en evidencia. Para estudios mexicanos requerimos de fomentar el esfuerzo de colaboración entre instituciones, que reditúen en mayor número de estudios controlados, ensayos clínicos y estudios básicos que apuntalen la calidad del congreso. Se debe hacer conciencia que hace falta mayor difusión del resto de enfermedades del aparato locomotor, y no solo las patologías autoinmunes, ya que las primeras constituyen un porcentaje importante de la práctica diaria


BACKGROUND: Medical meetings are a tool to help physicians advance and update their medical knowledge. Their quality is the responsibility of colleges and institutions. OBJECTIVE: To assess and compare the academic level of four different annual rheumatology meetings. MATERIAL AND METHODS: As a source of information, we used the abstracts published in the supplements of the journal Reumatología Clínica, SE1 Vol. 12, issued in February 2016, SE 1 Vol. 13 issued in February 2017, the electronic application of the 2016 ACR/ARHP of the 2016 American Congress of Rheumatology, devoted to the works presented at the 44th Mexican Congress of Rheumatology (CMR 44), the 45th Mexican Congress of Rheumatology (CMR 45), and the 2016 ACR/ARHP Annual Meeting (ACR 2016), as well as the Web page on the files and abstracts of EULAR 2017, respectively; from each work we compiled information on the major disease being referred to, the type of information provided and the type of report. We should point out that some were combined conditions or designs, from which we selected that which we considered to be the most important. RESULTS: In all, 275, 340, 3275 and 4129 studies were submitted to the XLIV Mexican Congress of Rheumatology, XLV Mexican Congress of Rheumatology, the 2016 ACR/ARHP Annual Meeting and EULAR 2017, respectively. Rheumatoid arthritis was the most common disorder, dealt with in 23%, 26%, 21% and 27% in CMR 44, CMR 45, 2016 ACR and EULAR 2017, respectively, followed by systemic lupus erythematosus; in third place, Mexican congresses reported trials related to systemic vasculitis, whereas spondylitis was the main subject of international congresses. In the case of rheumatoid arthritis, clinical topics accounted for 30% in the Mexican congresses and ACR, and nearly 20% in EULAR. Observational studies accounted for 40% in the Mexican congresses vs. 33% in 2016 ACR and 55% in EULAR 2017. Studies on basic science were minimal in the Mexican congress, whereas in 2016 ACR, they represented 21% and 12% in EULAR 2017. CONCLUSION: Rheumatology meetings constitute a tool to obtain adequate evidence-based medical knowledge in this important branch of medicine. For our Mexican Congress, we should encourage collaborative efforts between institutions, which will result in a greater number of controlled studies, clinical trials and basic studies that support the quality of the congress. We wish to emphasize that a greater diffusion of other musculoskeletal diseases is needed, not only autoimmune diseases, since the former represent an important percentage of the daily practice


Assuntos
Humanos , Reumatologia/normas , Indexação e Redação de Resumos/estatística & dados numéricos , Sociedades Médicas/normas , México , Europa (Continente) , Epigenômica
3.
Assessment ; : 1073191119897122, 2020 Jan 06.
Artigo em Inglês | MEDLINE | ID: mdl-31903778

RESUMO

This study is part of a larger project to generate norms for letter verbal fluency test (VFT) in 3,284 children from nine Latin American countries. The letter VFT (letters M, R, and P) was administered and multiple linear regressions, including age, age2, MPE (mean parental education), MPE2, sex, and interactions were used as predictors. Results showed significant differences across countries for all scores. Age affected scores linearly except for Ecuador (P-letter), in which a quadratic effect was found. Scores increased linearly as a function of MPE, with the exception of Mexico (R-letter), in which a quadratic effect was found. Age by MPE (M- and P-letters), and age by MPE2 (R-letter) interactions were found in Mexico. Sex had an impact on letter R in Cuba, and letter P in Ecuador and Paraguay. Age2 by sex interaction was found in Ecuador (P-letter). These norms will be useful for clinical neuropsychologists in these countries to evaluate their patients' verbal fluency.

4.
Reumatol Clin ; 16(2 Pt 1): 87-91, 2020.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-29891264

RESUMO

BACKGROUND: Medical meetings are a tool to help physicians advance and update their medical knowledge. Their quality is the responsibility of colleges and institutions. OBJECTIVE: To assess and compare the academic level of four different annual rheumatology meetings. MATERIAL AND METHODS: As a source of information, we used the abstracts published in the supplements of the journal Reumatología Clínica, SE1 Vol. 12, issued in February 2016, SE 1 Vol. 13 issued in February 2017, the electronic application of the 2016 ACR/ARHP of the 2016 American Congress of Rheumatology, devoted to the works presented at the 44th Mexican Congress of Rheumatology (CMR 44), the 45th Mexican Congress of Rheumatology (CMR 45), and the 2016 ACR/ARHP Annual Meeting (ACR 2016), as well as the Web page on the files and abstracts of EULAR 2017, respectively; from each work we compiled information on the major disease being referred to, the type of information provided and the type of report. We should point out that some were combined conditions or designs, from which we selected that which we considered to be the most important. RESULTS: In all, 275, 340, 3275 and 4129 studies were submitted to the XLIV Mexican Congress of Rheumatology, XLV Mexican Congress of Rheumatology, the 2016 ACR/ARHP Annual Meeting and EULAR 2017, respectively. Rheumatoid arthritis was the most common disorder, dealt with in 23%, 26%, 21% and 27% in CMR 44, CMR 45, 2016 ACR and EULAR 2017, respectively, followed by systemic lupus erythematosus; in third place, Mexican congresses reported trials related to systemic vasculitis, whereas spondylitis was the main subject of international congresses. In the case of rheumatoid arthritis, clinical topics accounted for 30% in the Mexican congresses and ACR, and nearly 20% in EULAR. Observational studies accounted for 40% in the Mexican congresses vs. 33% in 2016 ACR and 55% in EULAR 2017. Studies on basic science were minimal in the Mexican congress, whereas in 2016 ACR, they represented 21% and 12% in EULAR 2017. CONCLUSION: Rheumatology meetings constitute a tool to obtain adequate evidence-based medical knowledge in this important branch of medicine. For our Mexican Congress, we should encourage collaborative efforts between institutions, which will result in a greater number of controlled studies, clinical trials and basic studies that support the quality of the congress. We wish to emphasize that a greater diffusion of other musculoskeletal diseases is needed, not only autoimmune diseases, since the former represent an important percentage of the daily practice.

6.
Environ Sci Pollut Res Int ; 26(28): 28909-28918, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31385249

RESUMO

Milk can be considered as an indicator of the degree of environmental contamination of the place where it is produced and this is especially important when assessing its content in toxic metals. Therefore, 36 bovine milk samples from 7 farms with a semi-extensive grazing system were analysed, located in Asturias (Spain), in an area with high probability of being highly contaminated due to a mining zone, with important industrial activity and near high-density highway traffic. The samples were lyophilised to achieve total dehydration, further analysed using inductively coupled plasma mass spectrometry (ICP-MS). The metals titrated were aluminium (Al), arsenic (As), molybdenum (Mo) and mercury (Hg) in the lyophilised samples and subsequently extrapolated their values to whole milk. All samples analysed showed levels of Al and Mo above the limit of detection, with mean values of Al of 140.89 ± 157.07 in liquid milk and 1065.76 ± 1073.45 in lyophilised milk and Mo of 20.72 ± 14.61 µg/kg and 152.26 ± 96.82 µg/kg in whole and lyophilised milk. Only As was detected in four samples with mean values of 18.45 ± 6.89 and 166.45 ± 42.30 µg/kg in liquid and lyophilised milk, respectively, and no Hg was found in any of them. In no case do the values found indicate a significant hazard to the population and are in agreement with those found in other investigations. Although the various anthropogenic activities of the area (industrial, mining, traffic density) could, a priori, indicate a possibly contaminated area.


Assuntos
Alumínio/análise , Arsênico/análise , Poluição Ambiental/análise , Mercúrio/análise , Metais Pesados/análise , Leite/química , Molibdênio/análise , Animais , Bovinos , Monitoramento Ambiental/métodos , Feminino , Mineração , Espanha
7.
Int. j. psychol. psychol. ther. (Ed. impr.) ; 18(3): 357-370, oct. 2018. ilus
Artigo em Inglês | IBECS | ID: ibc-174411

RESUMO

Several studies suggest a link between fiction reading and Theory of Mind, a component of cognitive empathy which refers to the ability to understand other people’s mental and affective states. More frequent fiction readers perform better in tasks that require inference of intentions or emotions in others, like the Reading the Mind in the Eyes task. In addition, subjects who read a fiction text obtain better scores than controls reading non-fiction. Since most of this research has been conducted on caucasic subjects, cross-cultural replication of the effect is still needed. The present study is the first to investigate the subject in a Latin American sample (208 adults -137 females-, ranging from 18 to 59 years old (M= 27.66). We replicated the association between lifelong exposure to print fiction and performance in the Reading the Mind in the eyes task, but the effect was only significant in men. The association remained significant after controlling for age, education level and self-reported Trait Empathy scores. The results are congruent with the hypothesis that reading promotes Theory of Mind ability by engaging mentalizing processes in order to represent the thoughts and feelings of fictional characters. The sex difference we observed had not been reported before and requires further replication and analysis


No disponible


Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Teoria da Mente , Empatia , Leitura , Literatura , Teoria da Construção Pessoal , Afeto , Cognição , Distribuição por Sexo , Desenvolvimento da Personalidade , Argentina
8.
J Plant Physiol ; 231: 31-40, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30212659

RESUMO

Rhamnogalacturonan I (RG-I) is a domain of plant cell wall pectin. The rhamnogalacturonan lyase (RGL) enzyme (EC 4.2.2.23) degrades RG-I by cleaving the α-1,4 glycosidic bonds located between the l-rhamnose and d-galacturonic residues of the main chain. While RGL's biochemical mode of action is well known, its effects on plant physiology remain unclear. To investigate the role of the RGL enzyme in plants, we have expressed the Solyc11g011300 gene under a constitutive promoter (CaMV35S) in tomato cv. 'Ohio 8245' and evaluated the expression of this and other RGL genes, enzymatic activity and alterations in vegetative tissue, and tomato physiology in transformed lines compared to the positive control (plants harboring the pCAMBIA2301 vector) and the isogenic line. The highest expression levels of the Solyc11g011300, Solyc04g076630, and Solyc04g076660 genes were observed in leaves and roots and at 10 and 20 days after anthesis (DAA). Transgenic lines exhibited lower RGL activity in leaves and roots and during fruit ripening, whereas higher activity was observed at 10, 20, and 30 DAA than in the isogenic line and positive control. Both transgenic lines showed a lower number of seeds and fruits, higher root length, and less pollen germination percentage and viability. In red ripe tomatoes, transgenic fruits showed greater firmness, longer shelf life, and reduced shriveling than did the isogenic line. Additionally, a delay of one week in fruit ripening in transgenic fruits was also recorded. Altogether, our data demonstrate that the Solyc11g011300 gene participates in pollen tube germination, fruit firmness, and the fruit senescence phenomena that impact postharvest shelf life.


Assuntos
Frutas/crescimento & desenvolvimento , Genes de Plantas/fisiologia , Lycopersicon esculentum/genética , Pectinas/metabolismo , Proteínas de Plantas/genética , Polissacarídeo-Liase/genética , Frutas/enzimologia , Frutas/metabolismo , Perfilação da Expressão Gênica , Isoenzimas/genética , Isoenzimas/metabolismo , Isoenzimas/fisiologia , Lycopersicon esculentum/enzimologia , Lycopersicon esculentum/crescimento & desenvolvimento , Proteínas de Plantas/fisiologia , Plantas Geneticamente Modificadas , Pólen/genética , Pólen/metabolismo , Tubo Polínico/crescimento & desenvolvimento
9.
J Plant Physiol ; 229: 175-184, 2018 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-30121402

RESUMO

The enzyme rhamnogalacturonan lyase (RGL) cleaves α-1,4 glycosidic bonds located between rhamnose and galacturonic acid residues in the main chain of rhamnogalacturonan-I (RG-I), a component of the plant cell wall polymer pectin. Although the mode of action of RGL is well known, its physiological functions associated with fruit biology are less understood. Here, we generated transgenic tomato plants expressing the ß-glucuronidase (GUS) reporter gene under the control of a -504 bp or a -776 bp fragment of the promoter of a tomato RGL gene, Solyc11g011300. GUS enzymatic activity and the expression levels of GUS and Solyc11g011300 were measured in a range of organs and fruit developmental stages. GUS staining was undetectable in leaves and roots, but high GUS enzymatic activity was detected in flowers and red ripe (RR) fruits. Maximal expression levels of Solyc11g011300 were detected at the RR developmental stage. GUS activity was 5-fold higher in flowers expressing GUS driven by the -504 bp RGL promoter fragment (RGFL3::GUS) than in the isogenic line, and 1.7-fold higher when GUS gene was driven by the -776 bp RGL promoter fragment (RGLF2::GUS) or the constitutive CaMV35S promoter. Quantitative real-time polymerase chain reaction analysis showed that the highest expression of GUS was in fruits at 40 days after anthesis, for both promoter fragments. The promoter of Solyc11g011300 is predicted to contain cis-acting elements, and to be active in pollen grains, pollen tubes, flowers and during tomato fruit ripening, suggesting that the Solyc11g011300 promoter is transcriptionally active and organ-specific.


Assuntos
Lycopersicon esculentum/genética , Plantas Geneticamente Modificadas/metabolismo , Regiões Promotoras Genéticas/genética , Parede Celular/genética , Parede Celular/metabolismo , Frutas/genética , Frutas/metabolismo , Regulação da Expressão Gênica de Plantas/genética , Glucuronidase/genética , Glucuronidase/metabolismo , Proteínas de Plantas/genética , Proteínas de Plantas/metabolismo , Plantas Geneticamente Modificadas/genética , Sequências Reguladoras de Ácido Nucleico/genética , Sequências Reguladoras de Ácido Nucleico/fisiologia
10.
Appl Bionics Biomech ; 2018: 4196343, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29849758

RESUMO

The aim of the present work is to identify the reactions of the dental organs to the different forces that occur during chewing and the transcendence of the union and contact maintained by the dental tissues. The study used a lower first molar biomodel with a real morphology and morphometry and consisting of the three dental tissues (enamel, dentin, and pulp) each with its mechanical properties. In it, two simulations were carried out, as would the process of chewing a food. One of the simulations considers the contact between the enamel and the dentin, and the other does not take it into account. The results obtained differ significantly between the simulations that consider contact and those that do not, establishing the importance of taking this contact into account. In this way, the theories that establish horizontal and lateral occlusion forces are present during the functional chewing process which are viable to be correct. The case studies carried out present not only the reasons for the failure of enamel but also the failure of the restoration materials used. This reflection will allow the development of more adequate materials, mechanical design of prostheses, implants, and treatment.

11.
Sensors (Basel) ; 16(7)2016 Jul 05.
Artigo em Inglês | MEDLINE | ID: mdl-27399700

RESUMO

Sustainable mobility and smart mobility management play important roles in achieving smart cities' goals. In this context we investigate the role of smartphones as mobility behavior sensors and evaluate the responsivity of different attitudinal profiles towards personalized route suggestion incentives delivered via mobile phones. The empirical results are based on mobile sensed data collected from more than 3400 people's real life over a period of six months. The findings show which user profiles are most likely to accept such incentives and how likely they are to result in more sustainable mode choices. In addition we provide insights into tendencies towards accepting more sustainable route options for different trip purposes and illustrate smart city platform potential (for collection of mobility behavior data and delivery of incentives) as a tool for development of personalized mobility management campaigns and policies.

12.
Rev. colomb. cancerol ; 19(3): 150-155, jul.-set. 2015. tab
Artigo em Espanhol | LILACS | ID: lil-769088

RESUMO

El cáncer de mama en hombres es una enfermedad poco frecuente, en Colombia la incidencia estimada anual es de 1 caso por cada 1.000.000 de habitantes, lo cual es significativamente menor que en otros países. Objetivo: Describir la presentación clínica, histopatológica, tratamiento inicial y recaídas de pacientes de sexo masculino con diagnóstico de cáncer de mama en el Instituto Nacional de Cancerología entre el periodo 1996 a 2011. Resultados: La población del estudio fue de 27 pacientes. Los principales síntomas reportados por los pacientes fueron masa y dolor. La mayoría de los pacientes (89%) presentaban un estadio clínico localmente avanzado (IIIB y IV). El tipo histológico ductal NOS fue el más predominante (82%). Se encontró resultado de receptores hormonales en 22 de los 27 pacientes, de los cuales 19 (86%) eran positivos. El porcentaje de pacientes llevados a cirugía fue del 71% (20 pacientes), la técnica quirúrgica utilizada en 17 de los 20 pacientes fue la mastectomía radical modificada. En todos los pacientes sometidos a tratamiento quirúrgico fue realizado vaciamiento axilar y resección del CAP. La mediana de seguimiento de los pacientes fue de 8,9 meses. Dos pacientes presentaron recaída sistémica. Ninguno de los pacientes presentó recaída locorregional. Conclusión: Presentamos una serie de pacientes con cáncer de mama en hombres, lo cual es una entidad de baja incidencia. Nuestros pacientes se presentaron principalmente en estadio avanzado, en una proporción mayor a lo descrito en otras series latinoamericanas. Aunque la biología tumoral encontrada representa factores de buen pronóstico, no concuerda con el hecho de que la mayoría de tumores sean avanzados.


Breast cancer in men is a rare disease in Colombia, with an estimated annual incidence of 1 case per 1,000,000 habitants, which is significantly lower than in other countries. Objective: To describe the clinical presentation, histopathology, initial treatment and relapse of male patients diagnosed with breast cancer at the National Cancer Institute between 1996 and 2011. Results: The study population was 27 patients. The main symptoms reported by patients were mass and pain. Most patients (89%) had locally advanced clinical stage (IIIB and IV). NOS ductal histological type was the most prevalent (82%). Hormone receptor was found in 22 of 27 patients, of whom 19 (86%) were positive. The percentage of patients undergoing surgery was 71% (20 patients), and the surgical technique used in 17 of the 20 patients was modified radical mastectomy. Axillary dissection and resection of the CAP was performed on all patients who underwent surgical treatment. The median follow up of patients was 8.9 months. Two patients had systemic relapse. None of the patients had locoregional relapse. Conclusion: A case series is presented of male patients with breast cancer, which is a disease of low incidence. Our patients are mainly presented in advanced stages, a greater proportion than that described in other Latin American series. Although tumour biology found good prognostic factors, it is not consistent with the fact that most tumours are advanced.


Assuntos
Humanos , Masculino , Recidiva , Neoplasias da Mama , Diagnóstico , Homens , Terapêutica , Comportamento , Conhecimentos, Atitudes e Prática em Saúde
13.
Rev. colomb. cancerol ; 19(2): 61-70, abr.-jun. 2015. ilus, tab
Artigo em Espanhol | LILACS | ID: lil-765554

RESUMO

Objetivo: Describir las características clínico-patológicas, evolución postoperatoria y desenlaces oncológicos de los pacientes con diagnóstico de tumor retroperitoneal operados en el Instituto Nacional de Cancerología en un periodo de 11 años. Métodos: Se realizó un estudio descriptivo retrospectivo, incluyendo los pacientes operados en el INC entre los años 2000 y 2011. Resultados: En total fueron 101 pacientes. La mediana de la edad fue de 52 años con un 56,4% de mujeres. Entre los pacientes operados, 60,4% presentaban enfermedad primaria, el 23,8% enfermedad recurrente y 15,8% (n = 16) eran remitidos como irresecables. El principal método de imagen fue la tomografía abdominal helicoidal con doble contraste (89,1%). El tipo histológico más frecuente fue el liposarcoma bien diferenciado. Se alcanzó resección completa en el 74,3%, con resecciones viscerales en bloque en 68,3% de los pacientes. Se presentaron complicaciones intraoperatorias en 55,4% de los pacientes, siendo la más frecuente el sangrado. La mediana de seguimiento fue de 549 días, con una supervivencia global de 41,1% a 5 años. La recaída local fue de 54,2% y la progresión sistémica de 25%. Conclusión: Los tumores retroperitoneales son tumores raros que se suelen diagnosticar en estadio avanzado, tienen pobre pronóstico oncológico principalmente por alto porcentaje de recaída local. El manejo óptimo tiene como pilar la cirugía idealmente en centros de referencia. Inicia desde la sospecha diagnóstica e incluye el uso racional de imágenes, el análisis histológico por patólogos con experiencia, la planeación preoperatoria y la decisión de terapias neoadyuvantes o adyuvantes de acuerdo al tipo y estadio tumoral.


Objective: To describe the clinical-pathological features, postoperative and oncological outcomes of patients diagnosed with retroperitoneal soft tissue tumors operated at the National Cancer Institute (NCI), over a period of 11 years. Methods: A retrospective and descriptive study was performed that included patients operated in the NCI between years 2000 and 2011. Results: In total there were 101 patients. The median age was 52 years, with 56.4% of them women. Among the operated patients, 60.4% had primary disease, 23.8% recurrent disease, and 15.8% (n = 16) were submitted as unresectable. The main method of imaging was abdominal helical double-contrast tomography (89.1%). The most common histological type was well differentiated liposarcoma. Complete resection was achieved in 74.3%, with en bloc resections of involved structures in 68.3% of patients. Intraoperative complications occurred in 55.4% of patients, the most frequent being bleeding. Median follow-up was 549 days, with an overall survival of 41.1% at 5 years. Local recurrence was 54.2% and the systemic progression was 25%. Conclusion: Retroperitoneal tumors are rare tumors that are usually diagnosed in advanced stages. They have a poor prognosis, mainly due to a high rate of local relapse. The mainstay of optimal management is surgery, and starts from the suspected diagnosis, encompassing the rational use of images, histological analysis by experienced pathologists, preoperative planning, and the decision of neoadjuvant or adjuvant therapies according to the type and tumor stage.


Assuntos
Humanos , Pessoa de Meia-Idade , Neoplasias Peritoneais , Cirurgia Geral , Terapêutica , Sarcoma , Complicações Intraoperatórias , Neoplasias Abdominais , Oncologia
14.
Rev. colomb. cancerol ; 19(1): 18-28, ene.-mar. 2015. ilus, tab
Artigo em Espanhol | LILACS | ID: lil-765548

RESUMO

El tratamiento quirúrgico del cáncer de mama ha evolucionado, desde cirugías radicales que incluían la pared torácica hasta cirugías conservadoras de resección tumoral con margen oncológico seguro complementadas con radioterapia; estas se consideran alternativa a la cirugía radical. La supervivencia es similar en ambos procedimientos. Metodología: Estudio de cohorte retrospectivo que evaluó las características demográficas, patológicas y desenlaces clínicos, como recaída y mortalidad, en mujeres con cáncer invasivo, sometidas a cirugía conservadora entre 1998 y 2007 en el INC. Resultados: Se incluyeron 358 pacientes con edad promedio de 53 años y estados tumorales tempranos en su mayoría. Con mediana de seguimiento de cuatro anos se presentaron 40 recaídas entre locales, regionales y sistémicas con una tasa de recaída de 2,6 recaídas por 100 pacientes/año. Se presentó un mayor porcentaje de recaídas en estado clínico avanzado (p=0,022), tamaño tumoral mayor de 2 centímetros (p=0,02) y a mayor número de ganglios comprometidos en el vaciamiento axilar (p=0,004). La tasa de mortalidad fue 1,2 muertes por 100 pacientes/año. Los márgenes positivos se relacionaron con estado clínico avanzado (p=0,010) y las pacientes con márgenes positivos que recibieron manejo no quirúrgico presentaron un porcentaje mayor de recaída, comparado con las llevadas a cirugía (p=0,023). Esta diferencia se conservó al comparar manejo quirúrgico con no quirúrgico en márgenes positivos invasivos (p=0,037). Conclusiones: El estado clínico avanzado, se relacionó con márgenes positivos y recaída tumoral. El compromiso ganglionar axilar y el manejo no quirúrgico de los márgenes positivos determinaron un mayor porcentaje de recaída.


Surgical treatment for breast cancer has improved from radical surgery involving the chest wall, to conservative tumor resection surgery with oncologically safe margins. This latter, when supplemented with radiotherapy, is considered an alternative to radical surgery with similar survival for both procedures. Methodology: Retrospective observational study was performed to assess the clinical response in women older than 18 years with invasive cancer undergoing conservative surgery between 1998 and 2007. Results: A total 358 patients, with the majority in early tumor states were included for final revision. The mean age was 53 years. During a four year follow-up there were 40 local, regional and systemic relapses, with a progression rate of 2.6 relapses per 100 patients / year. There was a higher percentage of recurrence in advanced clinical status (P=.022), tumor size greater than 2 cm (P=.02), and greater number of lymph node involvement in the axillary clearance. Mortality rate was 1.2 deaths per 100 patients / year. Positive margins were associated with advanced clinical status (P=.010), and patients who received non-surgical management had a higher relapse rate compared with patients who had surgery (P=.023). This difference was maintained when comparing surgery with non-surgical management in invasive positive margins (P=.037). Conclusions: Advanced clinical stage was associated with positive margins and tumor relapse. Axillary lymph node involvement, and non-surgical management of surgical margins, resulted in a higher percentage of recurrence.


Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Recidiva , Cirurgia Geral , Neoplasias da Mama , Linfonodos , Sobrevida , Terapêutica , Mortalidade , Parede Torácica , Sobrevivência
15.
Rev. colomb. cancerol ; 18(3): 120-127, jul.-set. 2014. ilus, tab
Artigo em Espanhol | LILACS | ID: lil-726902

RESUMO

Objetivo: Establecer el tipo de complicaciones postquirúrgicas que presentaron las pacientes con cáncer de mama y otros tumores llevadas a mastectomía y reconstrucción mamaria inmediata o tardía durante una década en el Instituto Nacional de Cancerología (INC), así como su asociación con el retraso en el inicio de la terapia adyuvante y la relación entre quimioterapia neoadyuvante y la presencia de complicaciones. Materiales y métodos: Se realizó una revisión de las historias clínicas de las pacientes diagnosticadas con cáncer de mama, sarcoma mamario o tumor phillodes que fueron sometidas a mastectomía y reconstrucción mamaria inmediata o tardía durante el periodo 1998-2008. Resultados: Se identificaron 342 pacientes; el 76% de estas con carcinoma de mama localmente avanzado; el 60,53% de las pacientes presentó algún tipo de complicación temprana local; el 67,5% de las pacientes recibió quimioterapia neoadyuvante y el 60% presentaron complicación temprana local (sin significancia estadística). La tasa de tratamientos adyuvantes iniciados en relación a la presencia o no de complicaciones locales fue de 26,12 adyuvancias iniciadas por 100 pacientes/mes (IC95%: 22,2 a 30,7) en las que presentaron complicaciones tempranas locales vs. 55,06 adyuvancias iniciadas por 100 pacientes/mes (IC95%: 45,08 a 67,23) en las pacientes sin complicaciones locales (log-rank test, p =0,0079). Conclusiones: El uso de quimioterapia neoadyuvante aumenta el riesgo de complicaciones postoperatorias en pacientes con cáncer de mama sometidas a mastectomía y reconstrucción mamaria inmediata. Al igual que la presencia de complicaciones tempranas locales retarda el inicio de la quimioterapia adyuvante.


Objective: To establish the type of post surgical complications in patients with cancer and other tumors, taken to immediate or delayed mastectomy and breast cancer reconstruction over a decade in the National Cancer Institute (NCI); also, it's association with the late start of adjuvant therapy and the relationship between neoadjuvant chemotherapy and the presence of complications. Materials and methods: A review of the medical records of patients diagnosed with breast cancer, sarcoma, or phillodes breast tumor that were performed immediate or delayed mastectomy and breast reconstruction over the years 1998 to 2008. Results: 342 patients were identified. 76% of those with locally advanced breast carcinoma. 60.53% of patients had some form of early local complication. Immediate reconstruction showed a greater percentage of complication (63% vs 49%); 67.5% of the patients from this series received neoadjuvant chemotherapy and of those, 135 (60%) presented an early local complication. The rate of adjuvant treatments started in relation to the presence or absence of local complications was 26.12 adjuvants started by 100 patients/month (IC95%: 22.2 to 30.7) in patients with early local complications vs 55.06 adjuvants started by 100 patients/month (IC95%: 45.08 to 67.23) in patients with no local complications (log-rank test, p = 0.0079). Conclusions: The neoadjuvant chemotherapy increases de risk of postoperative complications in patients with breast cancer undergoing mastectomy and immediate breast reconstruction. As the presence of early local complications delay the onset of adjuvant chemotherapy.


Assuntos
Humanos , Feminino , Complicações Pós-Operatórias , Terapêutica , Neoplasias da Mama , Mamoplastia , Cirurgia Geral , Mama , Registros Médicos , Mastectomia
16.
Rev. colomb. cancerol ; 18(2): 78-82, abr.-jun. 2014. ilus, tab
Artigo em Espanhol | LILACS | ID: lil-726890

RESUMO

El cáncer de mama en hombres es una entidad rara y constituye menos del 1% de todos los tumores de mama. En Colombia la incidencia estimada anual es de 0.1 casos por 100.000. El pronóstico del cáncer de mama en hombres parece ser peor que el de mujeres en el mismo estadio y los factores involucrados parecen de tipo biológico. El tratamiento de estos tumores se ha extrapolado de la contraparte femenina ya que no hay ensayos clínicos controlados que lo avalen. El objetivo de la revisión fue buscar evidencia que comparara las características biológicas y el manejo de estos tumores en hombres y mujeres. Debido al número limitado de casos, los estudios publicados hasta el momento no permiten establecer evidencia contundente respecto al manejo de este cáncer en los hombres y las conductas se derivan de la literatura existente en mujeres.


Male Breast cancer is rare, and accounts for less than 1% of all breast cancers. In Colombia, the estimated annual incidence is 0.1 cases per 100,000 inhabitants. The prognosis seems to be worse in men than in women in the same stage and the factors involved seem to be biological. The treatment of these tumors has been extrapolated from the female counterpart; however no controlled clinical trials support this. The objective of the review was to look for evidence that compared biological characteristics and management of these tumors between men and women. In conclusion, due to the limited number of cases, the studies published to date do not present conclusive evidence regarding the management of this cancer in men. All therapeutic approaches are derived from the existing literature on women.


Assuntos
Humanos , Masculino , Prognóstico , Tamoxifeno , Condutas Terapêuticas , Neoplasias da Mama Masculina , Terapêutica
17.
Mycorrhiza ; 24 Suppl 1: S29-37, 2014 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-24522843

RESUMO

The quality of seedlings colonized by Tuber melanosporum is one of the main factors that contributes to the success or failure of a truffle crop. Truffle cultivation has quickly grown in European countries and elsewhere, so a commonly shared seedling evaluation method is needed. Five evaluation methods are currently published in the literature: three are used in Spain and two in France and Italy. Although all estimate the percentage colonization by T. melanosporum mycorrhizae, they do it in different ways. Two methods also estimate total number of mycorrhizae per seedling. Most are destructive. In this work, ten batches of holm oak seedlings inoculated with T. melanosporum from two different nurseries were evaluated by means of the five methods noted above. Some similarity was detected between the percentages of T. melanosporum mycorrhizae estimated by each method but not in their ability to assess the suitability of each batch. We discuss the advantages and disadvantages for each method and suggest approaches to reach consensus within the truffle culture industry for certifying mycorrhizal colonization by T. melanosporum and seedling quality.


Assuntos
Ascomicetos/fisiologia , Micorrizas/fisiologia , Quercus/microbiologia , Agricultura , Plântula/microbiologia
18.
Rev. colomb. cancerol ; 17(1): 3-10, ene.-mar. 2013. ilus, tab
Artigo em Espanhol | LILACS | ID: lil-729549

RESUMO

Objetivo: Describir las características epidemiológicas, clínicas y de tratamiento de los pacientes con tumores de tejidos blandos, melanoma y carcinomas escamocelulares del Servicio de Seno y Tejidos Blandos del instituto nacional de Cancerologìa con amputaciones mayores de extremidades entre los años 1998 y 2008. Métodos: Se revisaron 80 historias clínicas de pacientes adultos en quienes se realizó amputación mayor de una extremidad entre enero de 1998 y diciembre de 2008, en el Servicio de Seno y Tejidos Blandos del instituto nacional de Cancerología. Resultados: Se identificaron 24 pacientes con hemipelvectomía clásica, 22 con desarticulación de cadera, 19 con desarticulación interescapulotorácica, 8 con hemihemipelvectomía y 7 con desarticulación de hombro. los diagnósticos en orden de frecuencia fueron: sarcomas de tejidos blandos, 72,5%; carcinomas escamocelulares, 21,2%; melanoma, 6,2%. la intención de la cirugía fue curativa en 50% de los casos. En los pacientes en los cuales la intención de la cirugía fue paliativa, se presentó un mayor número de complicaciones, con significancia estadística solo para necrosis de los colgajos (22,5 vs. 5% p = 0,02). la supervivencia en los pacientes con intención curativa luego del primer año de cirugía fue de 67,5 vs. 42,5% para cirugía paliativa (p = 0,038). Conclusiones: En pacientes con tumores proximales de las extremidades con imposibilidad de cirugías preservadoras, las amputaciones mayores continúan siendo una opción terapéutica válida, a pesar de su alto índice de complicaciones.


Objective: To describe the epidemiological, clinical and treatment characteristics of patients with soft tissue tumours, melanoma, and squamous cell carcinomas of the Breast and Soft Tissue Department of the Instituto Nacional de Cancerología, who had major limb amputations between the years 1998 and 2008. Methods: a review was made of the clinical records of 80 patients in whom a major limb amputation was performed between January 1998 and December 2008 in the Breast and Soft Tissue Department of the Instituto Nacional de Cancerología. Results: Of the 80 patients studied, 24 had a classic hemipelvectomy, 22 with hip disarticulation, 19 with interscapular-thoracic disarticulation, 8 with hemi-hemipelvectomy, and 7 with shoulder disarticulation. The diagnoses, in order of frequency were: soft tissue sarcomas, 72.5%; squamous cell carcinomas, 21.2%; and melanoma, 6.2%. The intention of the surgery was curative in 50% of the cases. There was a greater number of complications in the patients where the intention of the surgery was palliative, with a significant significance only for necrosis of flaps (22.5% vs. 5% p=.02). The one-year survival in the patients with intention to cure surgery was 67.5% vs. 42.5% for palliative surgery (p=.038). Conclusions: in patients with tumours proximal to the limbs, where preservative surgery is impossible, major amputations continue to be a valid therapeutic option, despite its high rate of complications.


Assuntos
Humanos , Cirurgia Geral , Amputação , Neoplasias , Terapêutica , Registros , Oncologia
20.
Rev. Rol enferm ; 35(4): 276-278, abr. 2012. ilus
Artigo em Espanhol | IBECS | ID: ibc-100837

RESUMO

Se presenta un caso de úlcera de larga evolución (más de un año), que pasa por diferentes fases y tratamientos, Su origen fue provocado por una picadura de araña(AU)


A case of ulcer of long evolution (more than one year), what happens is presented by different phases and treatment, its origin was caused by a spider bite (AU)


Assuntos
Humanos , Úlcera/complicações , Úlcera/diagnóstico , Úlcera/enfermagem , Picaduras de Aranhas/complicações , Picaduras de Aranhas/diagnóstico , Picaduras de Aranhas/enfermagem , Cuidados de Enfermagem/tendências , Cuidados de Enfermagem , Úlcera/reabilitação , Picaduras de Aranhas/fisiopatologia
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