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1.
Int. braz. j. urol ; 45(3): 495-502, May-June 2019. tab, graf
Artigo em Inglês | LILACS-Express | ID: biblio-1012326

RESUMO

ABSTRACT Background: Our study investigates whether Native Thiol, Total Thiol and disulphide levels measured in serum of patients with prostate cancer and prostatitis and of healthy subjects, have any role in differential diagnosis. Materials and Methods: Patients followed up for histopathologically verified diagnosis of prostate cancer and prostatitis in 2016-2017 at the Medicalpark Gaziantep Hospital Urology Clinic were included in the study. Native Thiol (NT), Total Thiol (TT), Dynamic Disulphide (DD) levels in serum were measured by a novel automated method. Results: NT, TT, DD, NT / TT ratios, DD / TT ratio and DD / NT ratio were measured as 118.4 ± 36.8μmoL / L, 150.3 ± 45.3μmoL / L, 15.9 ± 7μmoL / L, 78.8 ± 7μmoL / L, 10.5 ± 3.5μmoL / L, 13.8 ± 5.8μmoL / L respectively in patients with prostate cancer; as 116.4 ± 40.5μmoL / L, 147.5 ± 50.1μmoL / L, 15.5 ± 8.7μmoL / L, 79.7 ± 9μmoL / L, 10.1 ± 4.5μmoL / L, 13.5 ± 7.2μmoL / L in patients with prostatitis and as 144.1 ± 21.2μmoL / L, 191 ± 32.3μmoL / L, 23.4 ± 10.1μmoL / L, 76.1 ± 98.3μmoL / L, 11.9 ± 4.1μmoL / L, 16.4 ± 6.9μmoL / L in healthy subjects. Significant difference was detected between groups of NT, TT and DD levels (p = 0.008, p = 0.001, p = 0.002). No significant difference was detected in terms of the NT / TT, DD / TT and DD / NT rates (p = 0.222, p = 0.222, p = 0.222). Conclusions: Serum NT, TT, DD levels in patients with prostatitis and prostate cancer were found significantly lower compared to the control group. This indicates that just as inflammation, prostate cancer also increases oxidative stress on tissues.

2.
Asian Cardiovasc Thorac Ann ; 27(4): 251-255, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-30818961

RESUMO

BACKGROUND: Recently, the role of inflammation in coronary artery disease and the association of inflammatory biomarkers with adverse outcomes have been investigated in many studies. We investigated the relationship between high serum mobility group box 1 protein levels and established risk factors for coronary artery disease. METHODS: Fifty-five patients who presented to our Cardiovascular Surgery Clinic and subsequently underwent coronary artery bypass surgery for coronary artery disease and 50 healthy subjects presenting to the cardiology outpatient clinic without any cardiovascular problem were included in the study. The mean age was 61.47 ± 9.38 years for patients and 58.20 ± 10.15 years for controls. RESULTS: There was no statistically significant difference between groups with respect to age or sex. Family history of coronary artery disease, aspirin use, hypertension, and type 2 diabetes were significantly more prevalent in the patient group versus the control group. A significant difference was found between patients and healthy controls with respect to high mobility group box 1 protein levels ( p = 0.001). CONCLUSIONS: Serum high mobility group box 1 protein was significantly increased in patients with coronary artery disease in comparison to healthy subjects. No associations were found between high mobility group box 1 protein level and certain risk factors for coronary artery disease.


Assuntos
Doença da Artéria Coronariana/sangue , Proteína HMGB1/sangue , Idoso , Biomarcadores/sangue , Estudos de Casos e Controles , Angiografia Coronária , Ponte de Artéria Coronária , Doença da Artéria Coronariana/diagnóstico por imagem , Doença da Artéria Coronariana/cirurgia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Fatores de Risco , Regulação para Cima
3.
Int Braz J Urol ; 45(3): 495-502, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30676303

RESUMO

BACKGROUND: Our study investigates whether Native Thiol, Total Thiol and disulphide levels measured in serum of patients with prostate cancer and prostatitis and of healthy subjects, have any role in differential diagnosis. MATERIALS AND METHODS: Patients followed up for histopathologically verified diagnosis of prostate cancer and prostatitis in 2016-2017 at the Medicalpark Gaziantep Hospital Urology Clinic were included in the study. Native Thiol (NT), Total Thiol (TT), Dynamic Disulphide (DD) levels in serum were measured by a novel automated method. RESULTS: NT, TT, DD, NT / TT ratios, DD / TT ratio and DD / NT ratio were measured as 118.4 ± 36.8µmoL / L, 150.3 ± 45.3µmoL / L, 15.9 ± 7µmoL / L, 78.8 ± 7µmoL / L, 10.5 ± 3.5µmoL / L, 13.8 ± 5.8µmoL / L respectively in patients with prostate cancer; as 116.4 ± 40.5µmoL / L, 147.5 ± 50.1µmoL / L, 15.5 ± 8.7µmoL / L, 79.7 ± 9µmoL / L, 10.1 ± 4.5µmoL / L, 13.5 ± 7.2µmoL / L in patients with prostatitis and as 144.1 ± 21.2µmoL / L, 191 ± 32.3µmoL / L, 23.4 ± 10.1µmoL / L, 76.1 ± 98.3µmoL / L, 11.9 ± 4.1µmoL / L, 16.4 ± 6.9µmoL / L in healthy subjects. Significant difference was detected between groups of NT, TT and DD levels (p = 0.008, p = 0.001, p = 0.002). No significant difference was detected in terms of the NT / TT, DD / TT and DD / NT rates (p = 0.222, p = 0.222, p = 0.222). CONCLUSIONS: Serum NT, TT, DD levels in patients with prostatitis and prostate cancer were found significantly lower compared to the control group. This indicates that just as inflammation, prostate cancer also increases oxidative stress on tissues.


Assuntos
Dissulfetos/sangue , Neoplasias da Próstata/sangue , Prostatite/sangue , Compostos de Sulfidrila/sangue , Idoso , Análise de Variância , Biomarcadores Tumorais/sangue , Estudos de Casos e Controles , Diagnóstico Diferencial , Humanos , Masculino , Pessoa de Meia-Idade , Estresse Oxidativo/fisiologia , Neoplasias da Próstata/diagnóstico , Prostatite/diagnóstico , Valores de Referência , Reprodutibilidade dos Testes , Estudos Retrospectivos , Medição de Risco , Fatores de Risco , Estatísticas não Paramétricas
4.
Gene ; 688: 140-150, 2019 Mar 10.
Artigo em Inglês | MEDLINE | ID: mdl-30529510

RESUMO

Moringa oleifera (Moringaceae) is a plant known for having high antioxidant potency, anticancer, hepatoprotective, cardioprotective etc. and many more activities. Besides these, Moringaceae has the potential for attenuating the male sexual dysfunction. Reactive oxygen species/ROS were increased in cryptorchidism and therefore cause infertility by damaging sperm DNA and germ cell apoptosis. There was an increase in heat shock proteins (HSP) in cells, which is affected by heat shock. In the present study, the antioxidant effects of two different doses of M. oleifera Lam Extract (MOLE) on experimentally induced cryptorchid testes of rats was investigated. Forty two male rats (16 days old) were divided into four groups: a normal control group, a cryptorchidism-induced control group and two cryptorchidism-induced groups treated orally with either 400 or 800 mg/kg MOLE for 2 weeks. Our study showed that there were ruptures from interstitial spaces, separation of the germ cells from basal membrane, falling of the germ cells into the lumen, perivascular fibrosis, oedema, increased level of HSP70, apoptosis, malondialdehyde (MDA) and decrease in the level of superoxide dismutase (SOD) after the cryptorchidism. We found that pathological damages, oxidative stress, expression of the HSP70 and germ cell apoptosis were decreased in treated groups with MOLE. In brief, we can say that aqueous extract of M. oleifera reduces the oxidative stress in a unilateral cryptorchidism induced rats, and it might attenuate histopathological damages, HSP expression and germ cell apoptosis.


Assuntos
Apoptose/efeitos dos fármacos , Células Germinativas/efeitos dos fármacos , Proteínas de Choque Térmico HSP70/metabolismo , Moringa oleifera/química , Extratos Vegetais/farmacologia , Animais , Antioxidantes/farmacologia , Criptorquidismo/metabolismo , Células Germinativas/metabolismo , Masculino , Malondialdeído/metabolismo , Modelos Animais , Estresse Oxidativo/efeitos dos fármacos , Ratos , Ratos Sprague-Dawley , Espermatozoides/efeitos dos fármacos , Espermatozoides/metabolismo , Superóxido Dismutase/metabolismo
5.
Agri ; 28(1): 9-17, 2016 Jan.
Artigo em Turco | MEDLINE | ID: mdl-27225607

RESUMO

OBJECTIVES: The aim of the present study was to compare preventive effects of 10% povidone-iodine, and combination of 2-propanol and benzalkonium chloride skin antiseptics on contamination of epidural catheter tip. METHODS: Included were 160 patients aged 18-65 years with American Society of Anesthesiologists (ASA) physical status classifications of I-II. Patients were randomized. Povidone-iodine was administered to group P (n=80) prior to insertion of antibiotic prophylaxis catheter; 2-propanol and benzalkonium chloride was administered to group B. Swabs obtained before and after administration of antiseptics were sent for culture. Antiseptics were applied to skin prior to catheter removal, as well as 48 hours after insertion. In sterile conditions, 2-3 cm pieces of catheter tips were sent to laboratory. Preoperative and postoperative complete blood count, body temperature, and signs of postoperative localized skin infection were recorded. RESULTS: Leukocyte, neutrophil, and lymphocyte counts were all within normal ranges in preoperative and postoperative. Swab cultures obtained following use of antiseptics were positive in 6 group P patients; coagulase-negative Staphylococcus was found in 5 patients, E. coli in 1, and were negative in group B. Difference between groups was statistically significant (p=0.013). Epidural catheter tip cultures were negative. CONCLUSION: Combination of 2-propanol and benzalkonium chloride was determined to be more effective in reducing skin flora around epidural catheter insertion site.


Assuntos
Anti-Infecciosos Locais/administração & dosagem , Compostos de Benzalcônio/administração & dosagem , Povidona-Iodo/administração & dosagem , Infecção da Ferida Cirúrgica/prevenção & controle , 2-Propanol/administração & dosagem , Administração Cutânea , Adolescente , Adulto , Idoso , Analgesia Epidural , Cateterismo Periférico , Desinfecção , Contaminação de Equipamentos/prevenção & controle , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Resultado do Tratamento , Adulto Jovem
6.
Turk J Med Sci ; 45(6): 1214-9, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26775373

RESUMO

BACKGROUND/AIM: To compare the effects of tramadol-only treatment and tramadol + gabapentin treatment in patients who had received an epidural steroid injection. MATERIALS AND METHODS: Forty patients with hernia disc-originated acute lumbar discogenic pain were evaluated. All patients received a single dose of steroid and local anesthesia mixture epidurally via the lumbar approach. In both groups, Group T (tramadol, n = 20) and Group TG (tramadol + gabapentin, n = 20), the injection dose was adjusted to 4 mL of triamcinolone acetonide and 0.25% bupivacaine mixture. Orally, 75 mg/day tramadol or 75 mg/day tramadol + 900 mg/day gabapentin were added to the treatment. Leukocyte, erythrocyte sedimentation rate, C-reactive protein, and urine serotonin levels were measured prior to and after treatment. The effectiveness of the treatment was evaluated byvisual analog scale (VAS), Oswestry Disability Index (ODI), and straight leg elevation test (SLET). RESULTS: Similar improvements in VAS, ODI, and SLET values were observed in both groups in the second week. The inflammation markers were not different after treatment, neither within the groups nor between the groups. CONCLUSION: This study revealed that tramadol + gabapentin treatment was not superior to tramadol treatment.


Assuntos
Aminas/administração & dosagem , Analgésicos/administração & dosagem , Ácidos Cicloexanocarboxílicos/administração & dosagem , Deslocamento do Disco Intervertebral/tratamento farmacológico , Dor Lombar/tratamento farmacológico , Tramadol/administração & dosagem , Ácido gama-Aminobutírico/administração & dosagem , Administração Oral , Adulto , Anestésicos Locais/uso terapêutico , Bupivacaína/uso terapêutico , Avaliação da Deficiência , Quimioterapia Combinada , Feminino , Gabapentina , Glucocorticoides/administração & dosagem , Humanos , Injeções Epidurais , Vértebras Lombares , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Método Simples-Cego , Triancinolona Acetonida/administração & dosagem , Escala Visual Analógica
7.
Arch Gynecol Obstet ; 286(1): 43-9, 2012 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-22298205

RESUMO

OBJECTIVE: Low pseudocholinesterase (PChE) activity accompanies pregnancy, liver disease, renal failure, and certain drug therapies. The aim of this study was to investigate a possible relationship among PChE and plasma insulin levels, lipid profile, and inflammatory response ingestational diabetes. METHODS: This study included 165 women aged 20­40 years. Subjects were divided into four groups as follows:Control group, 29 non-pregnant healthy women; GroupNGT, 61 healthy pregnant women (normal glucose tolerance);Group GD, 62 pregnant women with gestational diabetes; and Group AGT, 13 pregnant women with abnormal glucose tolerance. Gestational ages were between 34 and 40 weeks. Plasma PChE, triglyceride, high-/lowdensity lipoprotein (HDL, LDL), glycated hemoglobin A1c(HbA1c), insulin, C-reactive protein (CRP), and white blood cell (WBC) levels were measured in all subjects. RESULTS: There were no statistically significant differences in plasma PChE, insulin, and LDL levels between the groups. Plasma triglyceride, HbA1c, WBC, and CRP levels were significantly higher in Group GD and Group AGT compared to the other groups (P\0.000). There was a positive correlation between increased PChE and LDL,while a negative correlation was observed between PChE and triglyceride in Group GD. There was a positive correlation between increased CRP and HbA1c and a negative correlation among CRP and LDL and triglyceride in Group GD. CONCLUSION: PChE activity was not significantly different between the groups. However, there was a positive correlation between PChE and LDL levels in pregnant women with GD, suggesting that LDL levels in pregnant women with GD may help to predict the risk of prolonged apnea in situations in which PChE activity cannot be measured.


Assuntos
Butirilcolinesterase/sangue , Diabetes Gestacional/sangue , Lipoproteínas LDL/sangue , Triglicerídeos/sangue , Adulto , Análise de Variância , Proteína C-Reativa/metabolismo , Feminino , Teste de Tolerância a Glucose , Hemoglobina A Glicada/metabolismo , Humanos , Insulina/sangue , Contagem de Leucócitos , Lipoproteínas HDL/sangue , Gravidez , Estudos Prospectivos , Estatísticas não Paramétricas , Adulto Jovem
8.
J Obstet Gynaecol Res ; 37(1): 45-50, 2011 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-21040211

RESUMO

AIM: The aim of this study was to evaluate maternal and fetal serum levels of homocysteine, folic acid, vitamin B12 and placental tissue levels of homocysteine and their association with severity of pre-eclampsia. MATERIAL & METHODS: A case-control study, performed by a single center, included 26 pregnant women with mild pre-eclampsia, 26 pregnant women with severe pre-eclampsia and 26 healthy pregnant women. Maternal blood was collected before delivery and fetal blood was collected from the umbilical cord at delivery. Placental tissue samples were obtained after delivery of placenta. Homocysteine, folic acid, vitamin B12 levels in serum and homocysteine levels in placental tissue homogenates were analyzed by immunochemiluminescent assay. RESULTS: Homocysteine levels in both maternal and fetal serum were significantly higher in the severe pre-eclampsia group compared to mild pre-eclampsia and control groups. However, homocysteine levels in both maternal and fetal serum were not significantly different between mild pre-eclampsia and control groups. No significant differences were observed in folic acid and vitamin B12 levels in both maternal and fetal serum between the groups. Homocysteine levels in placental tissue homogenates were too low to be measured in the three groups (<2 µmol/l). CONCLUSION: Maternal and fetal serum homocysteine levels were found to be significantly higher in severe pre-eclampsia group compared to mild pre-eclampsia and control groups suggesting that elevated serum levels of homocysteine might be associated with severity of pre-eclampsia. On the other hand it seems like elevated serum homocysteine levels were not associated with deficiency of folic acid and vitamin B12.


Assuntos
Sangue Fetal/metabolismo , Ácido Fólico/metabolismo , Homocisteína/metabolismo , Placenta/metabolismo , Pré-Eclâmpsia/sangue , Pré-Eclâmpsia/metabolismo , Vitamina B 12/metabolismo , Adulto , Estudos de Casos e Controles , Feminino , Ácido Fólico/sangue , Homocisteína/sangue , Humanos , Hiper-Homocisteinemia/epidemiologia , Estado Nutricional , Gravidez , Índice de Gravidade de Doença , Vitamina B 12/sangue
9.
Mikrobiyol Bul ; 43(1): 133-9, 2009 Jan.
Artigo em Turco | MEDLINE | ID: mdl-19334390

RESUMO

Laboratory diagnosis of hepatitis C virus (HCV) infection is based on the detection of anti-HCV antibodies by enzyme immunoassay (EIA) or chemiluminescence immunoassay (CIA) techniques. However, a consensus related to the problem of low titer (Serum/Cut-off; S/C= 1.0) anti-HCV antibodies is still lacking. This study was aimed to evaluate the clinical status of the patients with low titer anti-HCV antibodies detected by third generation anti-HCV tests during january 2007-December 2007. Two hundred and fifteen sera with anti-HCV S/C values between 1-5, detected by a commercial test system (Vitros EC Immunodiagnostic System, 3rd generation anti-HCV test, Ortho-Clinical Diagnostics, USA) with a sensitivity of 100% and specificity of 99.7%, as indicated by the supplier, were included to the study. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were determined by using chemiluminescence assay (Roche Diagnostics, Germany) and HCV-RNA was detected by real-time PCR (Flurion HCV QNP 2.1). Hundred and thirty six (63.3%) of the patients were female and 79 (36.7%) were male. The mean age of the patients was 50.2 +/- 18.9 years. In 18 (8.3%) patients ALT and/or AST levels were high and two of them were infected with hepatitis A while the remaining two with hepatitis B virus. HCV-RNA positivity (15.6 x 10(6); 4.3 x 10(5) and 2.6 x 10(3) IU/ml, respectively) was detected in three patients (1.4%) with S/C values of 3.69, 4.46 and 4.59, respectively. These three patients were older than 50 years, had high ALT levels and were chronic renal failure patients undergoing dialysis for at least one year. It was observed that after 4-6 weeks anti-HCV titers increased (S/C values were 15.1, 6.5 and 11.8, respectively) in the serum samples of these patients. The data obtained from this study emphasizes the problem of low titer positive anti-HCV results. It could be concluded that in case of low titer anti-HCV values, the result should be confirmed by RIBA, although its use is a matter of debate due to its low sensitivity, and HCV-RNA tests. Based on these data it seemed that changing the anti-HCV S/C ratio would not be a solution for the problem of low titer anti-HCV positive results.


Assuntos
Anticorpos Anti-Hepatite C/sangue , Hepatite C/diagnóstico , Adolescente , Adulto , Idoso , Alanina Transaminase/sangue , Aspartato Aminotransferases/sangue , Criança , Diagnóstico Diferencial , Feminino , Hepacivirus/genética , Hepacivirus/imunologia , Hepacivirus/isolamento & purificação , Humanos , Técnicas Imunoenzimáticas , Medições Luminescentes , Masculino , Pessoa de Meia-Idade , Reação em Cadeia da Polimerase , RNA Viral/isolamento & purificação
10.
Tohoku J Exp Med ; 218(1): 57-62, 2009 May.
Artigo em Inglês | MEDLINE | ID: mdl-19398874

RESUMO

In developing countries, rheumatic valve disease (RVD) is still prevalent. Management of RVD depends on symptomatology, physical examination and echocardiographic evaluation, all of which, however, might be inadequate. Reliable biomarkers to establish severity of RVD and predict complications would be highly beneficial. Urotensin II is regarded as a cardiovascular autacoid/hormone, and its role in cardiovascular diseases is emerging. We hypothesized urotensin II might have pathophysiological roles in RVD. We investigated 71 patients with RVD (mean age 40 +/- 12 years, 17 female patients) and 25 normal subjects (mean age 40 +/- 7 years, 8 female patients). We assessed their New York Heart Association (NYHA) functional class, RVD severity and pulmonary artery pressure (PAP), and measured plasma urotensin II levels. Mitral regurgitation (r = 0.226, p = 0.02), tricuspid regurgitation (r = 0.238, p = 0.02), PAP (r = 0.320, p = 0.01), and NYHA class (r = 0.213, p = 0.03) correlated positively with urotensin II levels. There was positive correlation between urotensin II levels and severity of mitral regurgitation (r = 0.248, p = 0.01) and tricuspid regurgitation (r = 0.326, p = 0.001). In linear regression analysis, only PAP was predictive of urotensin II (beta = 0.3; p = 0.02). In conclusion, this is the first study showing that plasma urotensin II is elevated in chronic RVD, associated with severe mitral and tricuspid valve regurgitation. Furthermore, urotensin II level is correlated with NYHA functional class, and the increase in PAP is predictive of plasma urotensin II.


Assuntos
Biomarcadores/sangue , Cardiopatia Reumática/sangue , Urotensinas/sangue , Adulto , Pressão Sanguínea/fisiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Insuficiência da Valva Mitral/sangue , Insuficiência da Valva Mitral/patologia , Insuficiência da Valva Mitral/fisiopatologia , Cardiopatia Reumática/patologia , Cardiopatia Reumática/fisiopatologia , Insuficiência da Valva Tricúspide/sangue , Insuficiência da Valva Tricúspide/patologia , Insuficiência da Valva Tricúspide/fisiopatologia
11.
Arch Gynecol Obstet ; 279(3): 321-7, 2009 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-18607612

RESUMO

OBJECTIVE: Flutamide is an effective drug in treatment of hirsutism. Hepatotoxicity occasionally may occur with therapeutic doses (750-1500 mg/day), 3 months after initiation of treatment. Monitoring of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels is recommended to obviate serious hepatotoxicity. MATERIALS AND METHODS: Two hundred and fourteen patients with mean age of 20.9+/-2.34 years suffering from hirsutism were included in the study. Of these 214 women, 117 had diagnosis of polycystic ovarian syndrome (PCOS), and 97 had diagnosis of idiopathic hirsutism. Thirty age-matched (mean age 20.3+/-2.0 years) normal women without signs of hirsutism and with normal menstrual cycle served as control group. Hirsutism was assessed using modified Ferriman-Gallwey method at the beginning and at the end of the treatment. Serum levels of luteinizing hormone (LH), follicle stimulant hormone (FSH), prolactin (PRL), estradiol (E2), androstenodion (A), testosterone (T), dehydrotestosterone (DHT), dehydroepiandrosterone sulfate (DHEAS), dehydroepiandrosterone (DHEA), 17-hydroxyprogesterone (17-P), sex hormone binding protein (SHBG), and ACTH were measured. Pelvic ultrasonography was performed for diagnosis of PCOS. Fifty-seven patients with PCOS (group 1) were given flutamide 125 mg/day + oral contraceptive. Sixty patients with PCOS (group 2) were given flutamide 250 mg/day + oral contraceptive. Forty-seven patients with IH (group 3) were given flutamide 125 mg/day alone, and 50 patients with IH (group 4) were given flutamide 250 mg alone. Thirty women in control group (group 5) were given placebo only. ALT and AST levels were measured in the beginning of the treatment, and repeated after 3, 6, 9 and 12 months. RESULTS: No incidence of increase in AST or ALT levels (>or= 45 U/L) was observed in any of the groups. No evidence of hepatotoxicity in any of the 214 hyperandrogenic women was observed on low-dose flutamide for 1 year. CONCLUSION: We conclude that flutamide in a dosage of 125 or 250 mg daily is a safe drug in the long-term treatment of hirsutism. The follow-up of patients receiving flutamide can be done by monitoring AST or ALT levels for hepatotoxicity.


Assuntos
Antagonistas de Androgênios/efeitos adversos , Doença Hepática Induzida por Substâncias e Drogas , Flutamida/efeitos adversos , Hirsutismo/tratamento farmacológico , Adolescente , Adulto , Alanina Transaminase/sangue , Antagonistas de Androgênios/administração & dosagem , Aspartato Aminotransferases/sangue , Relação Dose-Resposta a Droga , Feminino , Flutamida/administração & dosagem , Hirsutismo/sangue , Humanos , Hepatopatias/sangue , Hepatopatias/enzimologia , Adulto Jovem
12.
Arch Gynecol Obstet ; 279(2): 119-23, 2009 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-18488237

RESUMO

OBJECTIVE: To determine the effects of fasting during the month of Ramadan on fetal development and maternal serum cortisol and lipid profile. METHODS: This study was performed in Obstetrics and Gynecology Department of Gaziantep University Hospital, between 23 September 2006 and 23 October 2006 (during the month of Ramadan). Thirty-six consecutive healthy women with uncomplicated pregnancies of 20 weeks or more, who were fasting during Ramadan, were included in the study group (group 1). The control group (group 2) consisted of 29 healthy pregnant women, who were not fasting during the study period. For evaluating Ramadan's effect on fetus, Doppler ultrasonography was performed on all subjects in the beginning and then once a week until the end of Ramadan for the following measurements: increase of fetal biparietal diameter (BPD), increase of fetal femur length (FL), increase of estimated fetal body weight (EFBW), fetal biophysical profile (BPP), amniotic fluid index (AFI), and umbilical artery systole/diastole (S/D) ratio. Maternal serum cortisol, triglyceride, total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), very low density lipoprotein (VLDL), and LDL/HDL ratio were also evaluated before and after Ramadan. RESULTS: No significant difference was found between the two groups for the fetal age, maternal weight gain (kilogram), estimated fetal weight gain (EFWG), fetal BPP, AFI, and umbilical artery S/D ratio. In the fasting group, the maternal serum cortisol levels on day 20 were significantly higher than the initial levels obtained 1 week prior to Ramadan (p < 0.05). Although no significant increases were observed in total cholesterol and triglyceride levels in the fasting group, these increases were significantly higher than those in the control group (p < 0.05). LDL and VLDL levels showed a non-significant decrease at the end of the Ramadan. HDL levels showed a slight increase, but LDL/HDL ratios were significantly decreased in fasting group (p < 0.05). CONCLUSION: The results of this study showed that maternal serum cortisol level was elevated while LDL/HDL ratio were decreased in healthy women with uncomplicated pregnancies of 20 weeks or more, who were fasting during Ramadan. No untoward effect of Ramadan was observed on intrauterine fetal development.


Assuntos
Jejum/efeitos adversos , Desenvolvimento Fetal/fisiologia , Hidrocortisona/sangue , Islamismo , Lipídeos/sangue , Adulto , Colesterol/sangue , Feminino , Peso Fetal , Idade Gestacional , Férias e Feriados , Humanos , Lipoproteínas HDL/sangue , Lipoproteínas LDL/sangue , Gravidez , Triglicerídeos/sangue , Ganho de Peso
13.
Arh Hig Rada Toksikol ; 59(4): 283-7, 2008 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-19064366

RESUMO

Various effects of exposure to volatile organic compounds (VOC) have recently become an important issue because of their widespread use in industry. The aim of this study was to determine the effect of volatile organic solvents commonly used in textile paint industry on free radical levels and the antioxidant enzyme system in textile workers. The study included twenty exposed workers and twenty controls. Blood samples were taken after an overnight fast of 10 to 12 hours. Malondialdehyde (MDA) and total antioxidant capacity (TAC) were studied in serum while super oxide dismutase (SOD) activity was studied in erythrocytes. Statistical analysis was performed using the ANOVA and Kruskall-Wallis analysis tests. MDA and SOD were significantly higher in textile workers than in controls (p<0.01). In contrast, no significant difference was observed between them for TAC (p>0.05).Elevated MDA levels in textile workers may indicate increased lipid peroxidation as a result of long-term exposure to organic solvents, whereas elevated SOD activity suggests that the antioxidant system was activated to counter lipid peroxidation. The results suggest that textile workers occupationally exposed to volatile organic solvents make a risk group and require more frequent periodic examinations.


Assuntos
Antioxidantes/metabolismo , Peroxidação de Lipídeos , Malondialdeído/sangue , Exposição Ocupacional , Superóxido Dismutase/sangue , Indústria Têxtil , Compostos Orgânicos Voláteis/efeitos adversos , Adulto , Radicais Livres/metabolismo , Humanos , Masculino
14.
J Obstet Gynaecol Res ; 34(4): 494-8, 2008 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-18937702

RESUMO

AIM: The aim of the present study was to determine whether fasting during Ramadan causes ketonemia and/or ketonuria and their effects on fetal intrauterine development. METHODS: Thirty-six consecutive healthy women with uncomplicated pregnancies of >or=20 weeks of gestation who were fasting during Ramadan were included in the study group (group 1). The control group (group 2) consisted of 29 healthy pregnant women who were not fasting. Doppler ultrasonography was performed in all subjects in the beginning and at the end of Ramadan to evaluate the changes in the following measurements: fetal biparietal diameter; fetal femur length; and estimated fetal body weight. Fetal biophysical profile, amniotic fluid index, and umbilical artery systole/diastole ratio were measured in the beginning and at the end of Ramadan. Effects of fasting on the mother were evaluated by measuring serum concentrations of 3ss hydroxybutyrate and glucose, and urinary concentration of ketone. Subjects with any of the followings were excluded: diabetes; thyroid dysfunction; Cushing's syndrome; adrenal disease; pre-eclampsia; and multiple pregnancy. RESULTS: The mean duration of fasting in the study group was 18 +/- 2.1 days. The mean maternal glucose level was significantly lower in the study group than in the control group (P = 0.003). No statistically significant differences were found between the two groups in the comparisons of other parameters. CONCLUSION: We concluded that fasting during Ramadan does not lead to maternal ketonemia or ketonuria in pregnant women. In addition, fasting during Ramadan has no significant adverse effect on intrauterine fetal development or the fetus's health.


Assuntos
Jejum/fisiologia , Desenvolvimento Fetal/fisiologia , Islamismo , Adulto , Feminino , Peso Fetal/fisiologia , Feto , Humanos , Gravidez , Estudos Prospectivos
15.
Ann N Y Acad Sci ; 1100: 179-84, 2007 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-17460176

RESUMO

Lipoprotein(a) [Lp(a)] is known to be a risk factor for atherosclerotic disease in middle-aged men, but the role of Lp(a) in women and in the elderly is less clear. In most studies, excess Lp(a) is not associated with increased risk for persons >65 years of age. This study examined the strength of association of a number of risk factors to coronary artery disease (CAD) in groups of men <65 years (n = 108) and >65 of age (n = 66) with angiographically documented significant narrowing of coronary arteries. Serum Lp(a) concentrations were determined; elevated Lp(a) is positively associated with CAD for men <65 years (adjusted OR: 2.45, P <0.05) but not for men >65 of age (adjusted OR: 0.56, P = NS). For middle-aged men, elevated Lp(a) appears to be an independent risk factor for premature CAD, and the importance of Lp(a) as a risk factor appears to decrease with age. These data suggest that the utility of Lp(a) lipoprotein levels in predicting the risk of CAD in older men is limited. Factors, such as age; sex; levels of total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides; carotid-wall thickness; smoking status; the presence or absence of diabetes and systolic and diastolic hypertension; body mass index (BMI); and other traditional risk factors, must be evaluated together to determine the risk of CAD for the entire population.


Assuntos
Aterosclerose/diagnóstico , Aterosclerose/genética , Lipoproteína(a)/sangue , Fatores Etários , Idoso , Colesterol/metabolismo , LDL-Colesterol/metabolismo , Doença das Coronárias/diagnóstico , Doença das Coronárias/genética , Dissulfetos/química , Humanos , Hipertensão/diagnóstico , Hipertensão/genética , Masculino , Pessoa de Meia-Idade , Fatores de Risco , Triglicerídeos/metabolismo
16.
Med Princ Pract ; 16(2): 137-41, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-17303950

RESUMO

OBJECTIVE: To investigate the levels of serum cortisol, dehydroepiandrosterone sulfate (DHEA-S), nitric oxide (NO) and adrenomedullin (AM) in schizophrenic patients. SUBJECTS AND METHODS: Sixty-six male patients with chronic schizophrenia and 28 normal male subjects participated in this study. The duration of disease was 145 +/- 120 (mean +/- SD) months. Serum levels of cortisol and DHEA-S were measured by electrochemiluminescence; plasma nitrite levels as an index of NO were measured with the Griess reaction, while plasma AM concentration was measured by using high-performance liquid chromatography. RESULTS: Patients (12.48 +/- 3.2 microg/dl), as compared to controls (10.31 +/- 3.1 microg/dl), had higher levels of baseline cortisol (p < 0.05). DHEA-S levels were lower in patients though this did not reach statistical significance (302 +/- 156 microg/dl compared to control, 322 +/- 96 microg/dl, p > 0.05). The mean levels of plasma AM and NO in the schizophrenic group (44.33 +/- 5.07 pmol/l and 36.27 +/- 17.6 micromol/l) were significantly higher than the levels in the control group (14.56 +/- 4.03 pmol/l and 32.54 +/- 7.14 micromol/l; p < 0.001, p < 0.03, respectively). There was a positive association between duration of disease and cortisol/DHEA-S ratio and cortisol level. CONCLUSION: The data show that schizophrenia is associated with abnormal levels of cortisol, DHEA-S, NO and AM.


Assuntos
Adrenomedulina/sangue , Desidroepiandrosterona/sangue , Hidrocortisona/sangue , Óxido Nítrico/sangue , Esquizofrenia/sangue , Adulto , Estudos de Casos e Controles , Cromatografia Líquida de Alta Pressão , Doença Crônica , Humanos , Masculino , Estatísticas não Paramétricas
19.
Clin Lab ; 52(1-2): 49-56, 2006.
Artigo em Inglês | MEDLINE | ID: mdl-16506364

RESUMO

Osteoporosis is a major problem in contemporary society. However, there is not enough data on multiparity and osteoporosis from developing and/or undeveloped countries on a large scale. Selection of participants in this study was aimed at the detection of bone status in healthy (normal bone mineral density) postmenopausal (n = 46, 55.3 +/- 6.7 years) and osteoporotic postmenopausal women (n: 33) of similar age. Bone mineral density (BMD) was evaluated using dual energy X-ray absorptiometry. At the DEXA evaluation, 33 women had osteoporotic (T score below -2.5) and 46 had normal BMD values. The number of pregnancies was found to range from 3 to 12 (with an overall mean of 6.7 +/- 2.5), while 2.6 +/- 1.9 (range, 1-7) were miscarriages in all of the 33 postmenopausal osteoporotic women. Serum homocysteine (t-Hcy) and urinary deoxypyridinoline (DPD) levels were significantly higher in osteoporotic postmenopausal women (11.96 +/- 3.84 micromol/L, 15.4 +/- 7.0 nM/mM cr) than in non-osteoporotic postmenopausal women (10.93 +/- 3.6 micromol/L, 10.6 +/- 9.1 nM/mM cr), p < 0.05, p < 0.01, respectively. Surprisingly, in postmenopausal osteoporotic women the homocysteine (t-Hcy) levels were positively associated with the number of deliveries (multiparity; 6.7 +/- 2.5), and positively associated with the number of curettages (2.6 +/- 1.9), r = 0.401, p < 0.038 and r = 0.520, p < 0.029, respectively. The mechanism linking serum t-Hcy to the number of pregnancies is unclear, and the relationship may only be by chance. In conclusion, the present study firstly suggests that the number of pregnancies has an effect on the t-Hcy levels. In addition, our study indicates that there is a significant negative correlation between the number of pregnancies and the lumbar spine BMD.


Assuntos
Densidade Óssea/fisiologia , Países em Desenvolvimento , Homocisteína/sangue , Osteoporose/fisiopatologia , Paridade/fisiologia , Pós-Menopausa/fisiologia , Absorciometria de Fóton , Aminoácidos/urina , Análise Química do Sangue , Feminino , Humanos , Região Lombossacral/fisiologia , Pessoa de Meia-Idade , Osteoporose/sangue , Gravidez , Turquia
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