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3.
Int J Dermatol ; 58(11): 1270-1276, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31347153

RESUMO

BACKGROUND: Primary cutaneous lymphomas (PCLs) and pseudolymphomas presenting as single pink-red nodules/tumors are highly unspecific and include a wide differential diagnosis. OBJECTIVE: To describe the dermoscopic characteristics of PCL/pseudolymphoma. METHODS: In this retrospective, case-control study, we evaluated the dermoscopic features of patients with solitary PCL/pseudolymphoma tumors and compared them to a control group of non-lymphomatous, nonpigmented, solitary tumors (e.g., basal cell carcinoma, amelanotic melanoma, etc). RESULTS: We included 14 patients with PCL/pseudolymphomas and 35 controls. T-cell and B-cell lymphoma proportions were 28.6% (n = 4) and 71.4% (n = 10), respectively. Compared to controls, most lymphomas presented dermoscopically with orange color (71.4% vs. 14.2%, P < 0.001), follicular plugs (85% vs. 2.8%, P < 0.001), and as  organized lesions (85% vs. 31.4%, P = 0.001). Coexistence of orange color and follicular plugs had an odds ratio (OR) of 2.8 (P < 0.001), highly suggestive of PCL . The kappa index for independent observers was 0.66, 0.49, 0.43 for orange background, follicular plugs, and organized lesion, respectively. Histopathologic correlation was performed in six PCL cases and showed dense diffuse and perifollicular lymphocytic infiltrate in all cases and keratin plugs in five of six cases, possibly correlating with the orange color and the follicular plugs, respectively. CONCLUSION: Primary cutaneous lymphomas/pseudolymphomas present with characteristic dermoscopic findings irrespective of immunohistochemical subtype.


Assuntos
Linfoma de Células B/diagnóstico por imagem , Linfoma Cutâneo de Células T/diagnóstico , Pseudolinfoma/diagnóstico por imagem , Neoplasias Cutâneas/diagnóstico por imagem , Pele/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Biópsia , Carcinoma Basocelular/diagnóstico por imagem , Estudos de Casos e Controles , Dermoscopia , Diagnóstico Diferencial , Feminino , Humanos , Linfoma de Células B/patologia , Linfoma Cutâneo de Células T/patologia , Masculino , Melanoma Amelanótico/diagnóstico por imagem , Pessoa de Meia-Idade , Pseudolinfoma/patologia , Estudos Retrospectivos , Pele/diagnóstico por imagem , Neoplasias Cutâneas/patologia
6.
Dermatol Pract Concept ; 6(3): 47-9, 2016 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-27648383

RESUMO

Superficial angiomyxomas (SA) of the skin are rare benign cutaneous tumors of soft tissue composed of prominent myxoid matrix and numerous blood vessels. SA are more common in males [1] and they are usually located on the trunk but can also appear on the lower limbs, head, neck and genitalia [2,3]. Treatment is surgical, the total excision is curative, but local recurrence is possible [4]. Herein we present a 72-year-old patient with a history of melanoma in situ, with a new lesion on the lower back.

7.
J Am Acad Dermatol ; 70(6): 1045-9, 2014 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-24656727

RESUMO

BACKGROUND: Infantile hemangiomas have a dramatic response to propranolol, a nonselective beta-blocker. However, this treatment is not risk-free and many patients are excluded because of respiratory comorbidities. Atenolol is a cardioselective beta-blocker that may have fewer adverse events. OBJECTIVE: We sought to evaluate the effectiveness of atenolol against propranolol in a noninferiority trial. METHODS: In all, 23 patients met the inclusion criteria and were randomized to receive either atenolol or propranolol. Thirteen patients were treated with atenolol and 10 with propranolol. Follow-up was made at baseline, 2 weeks, 4 weeks, and then monthly for 6 months. RESULTS: Patients treated with atenolol had a complete response of 53.8% and 60% with propranolol, respectively. These results were nonsignificant (P = .68). Relevant adverse events were not reported. LIMITATIONS: The reduced number of patients could have influenced our results. CONCLUSION: Atenolol appears to be as effective as propranolol. We did not find significant differences between these results or any adverse events.


Assuntos
Antagonistas Adrenérgicos beta/uso terapêutico , Atenolol/uso terapêutico , Hemangioma Capilar/tratamento farmacológico , Propranolol/administração & dosagem , Neoplasias Cutâneas/tratamento farmacológico , Relação Dose-Resposta a Droga , Esquema de Medicação , Feminino , Seguimentos , Hemangioma Capilar/congênito , Hemangioma Capilar/patologia , Humanos , Lactente , Recém-Nascido , Masculino , Medição de Risco , Neoplasias Cutâneas/patologia , Fatores de Tempo , Resultado do Tratamento
8.
Indian J Dermatol ; 59(1): 24-9, 2014 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-24470656

RESUMO

BACKGROUND: Onychomycosis of the fingernails and toenails is generally caused by dermatophytes and yeasts. Toenail mycoses involve mainly dermatophytes but when Candida is also involved, the strain most commonly isolated worldwide is C. albicans. AIMS: To determine Candida strains prevailing in onychomycosis. MATERIALS AND METHODS: A retrospective, observational and descriptive study of fungal cultures retrieved from the registry of the microbiology laboratory of the Pontificia Universidad Católica was performed. Specimens obtained from patients attending the healthcare network between December 2007 and December 2010 was analyzed. STATISTICAL ANALYSIS: A descriptive statistical analysis was performed. RESULTS: Candida was retrieved from 467 of 8443 specimens (52% fingernails and 48% toenails). Cultures were negative in 5320 specimens (63.6%). Among Candida-positive cultures, parapsilosis was the most commonly isolated strain with 202 cases (43.3%). While isolates of Candida guillermondii were 113 (24.2%), those of Candida albicans were 110 (23.6%), those of spp. were 20 (4.3%) and there were 22 cases of other isolates (4.71%). Among the 467 patients with positive cultures for Candida, 136 (29,1%) were men and 331 (70,9%) were women. All patients were older than 18 years old. Clinical files were available for only 169 of the 467 patients with positive cultures for Candida. For those, age, gender, underlying illnesses and use of immunossupresive agents during the trial was reviewed. CONCLUSIONS: The present study shows that both C. parapsilosis as well as C. guillermondii appear as emerging pathogens that would be in fact taking the place of C. albicans as the most commonly isolated pathogen in patients with Candida onychomycosis. The relative percentage of C parapsilosis increases every year. Identification of Candida strains as etiological agents of nail candidiasis becomes relevant to the management both nail as well as systemic candidiasis, in view of the resistance to conventional treatments readily reported in the literature.

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