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Appl Radiat Isot ; 178: 109965, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34688024


The positron emitters (18F-Sodium Fluoride (NaF)) and X-rays used in Positron emission tomography (PET) combined with computed tomography (PET/CT) imaging have a high radiation dose, which results in a high patient dose. The present research intends to determine the radiation dose and risks associated with PET/CT- 18F-Sodium fluoride examinations in patients. The 18F-NaF PET/CT was used to investigate the doses of 86 patients. Patient exposure parameters and ImPACT software were used to calculate mean effective doses. The administered activity of 185 MBq (5.0 mCi) per procedure has a mean and range based on the patient's BMI (BMI). The range of patient effective doses per procedure was found to be 4-10 mSv, with a radiation risk of 1 × 10-5 per procedure. Patient doses are determined by the patient's size, scanner type, imaging protocol, and reconstruction method. For further dose reduction, proper justification and radiation dose optimization is required.

Electromagn Biol Med ; : 1-10, 2021 Sep 20.
Artigo em Inglês | MEDLINE | ID: mdl-34541970


The study aimed to evaluate the possibility to perform electrochemotherapy using nanosecond pulsed electric field (nsPEF) and low electric field (LEF) monopolar electrical impulses to alleviate the problems of conventional electroporation. Two types of pulses have been used to treat MCF-7 human breast carcinoma cell line: very low voltage (electric field strength) long trains of short unipolar electric pulses, and low frequencies of extremely intense (40kV/cm), ultra-short (10ns) electric pulses. The electropermeabilization efficiency of the formed endocytotic vesicles was measured using the cloning efficacy test. The cell viability was decreased significantly at a repetition frequency begins from 0.01 Hz by ~35% and reached complete cell loss at 1 Hz of nanosecond pulses for cells treated before with monopolar pulses at 20 V/cm in the presence of BLM with 4 µM concentration. The uptake of non-permeant drugs has been done without plasma membrane permeabilization (classical electroporation), but by endocytosis. Nanosecond electric pulses can disrupt the membrane of endocytotic vesicles and release the cytotoxic drug bleomycin.

J Int Med Res ; 48(8): 300060520948754, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32811271


OBJECTIVE: This study was performed to obtain normative data of the distal femoral cartilage thickness in healthy adults by ultrasound. METHODS: This cross-sectional study included 72 healthy adults. The demographic characteristics of the participants were recorded, and the thickness of the femoral articular cartilage was measured using a 5- to 18-MHz linear probe. RESULTS: Significant statistical difference towards the male side at left medial condyle (P = 0.001) and left lateral condyle (P = 0.009). Weakly positive statistical difference was noted towards the male side at right medial condyle (P = 0.06) and right lateral condyle (P = 0.07). The femoral cartilage thickness in the study participants did not correlate with weight, body mass index, and age (P >0.05). Positive statistical correlation with height noted in right medial condyle, right lateral condyle, right intercondylar area, and left medial condyle. CONCLUSION: This study increases the pool of normative data of femoral cartilage thickness measurements. Additionally, the findings of this study emphasize the fact that women have thinner cartilage than men in four of the studied parameters.

Cartilagem Articular , Articulação do Joelho , Adulto , Cartilagem Articular/diagnóstico por imagem , Estudos Transversais , Feminino , Fêmur/diagnóstico por imagem , Humanos , Articulação do Joelho/diagnóstico por imagem , Masculino , Ultrassonografia
Am J Ther ; 23(6): e1560-e1567, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-25782568


This work investigates the effects of electroporation parameters on the transdermal delivery of insulin. Electroporation (EP) is known to induce temporal pores in the membrane, which are expected to enhance the diffusion of insulin through rabbits' skin. For such purpose, 5 different formulations of insulin and enhancers are applied to rabbit groups (5 rabbits each) with induced hyperglycemia in the presence of electroporative pulses. The blood sugar level (BSL) is followed up to 5-hour duration starting from the administration of the hyperglycemia-inducing factor. The effect of different electroporation parameters on BSL of rabbits is examined and compared with control groups. Results show that the increase in the number of pulses (from 15 up to 60 successive pulses) at an insulin concentration of 50 IU/mL, the increase in insulin concentration (from 50 to 70 IU/mL), and the decrease in applied field strength (from 200 to 100 V/cm) result in a significant decrease in BSL compared with control. Among all of the investigated formulations, the best performance is recorded for the insulin solution + EP (without enhancers) in almost all of the studied experimental conditions.

Eletroporação/métodos , Hipoglicemiantes/administração & dosagem , Insulina/administração & dosagem , Resinas Acrílicas/química , Administração Cutânea , Animais , Glicemia/efeitos dos fármacos , Óleo de Rícino/química , Sistemas de Liberação de Medicamentos , Feminino , Concentração de Íons de Hidrogênio , Hipoglicemiantes/uso terapêutico , Insulina/uso terapêutico , Iodo/química , Ácido Oleico/química , Coelhos