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1.
Eur Rev Med Pharmacol Sci ; 28(5): 1920-1930, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38497875

RESUMO

OBJECTIVE: Thyroid hormones are essential for regulating metabolism, reproduction, and growth. Hypothyroidism is connected with lower sperm count and motility, leading to male infertility. Oxidative stress is likely to be linked to this interaction. Melatonin, being known as an oxidative scavenger, may offer a feasible treatment method for reproductive dysfunction accompanying hypothyroidism in adult male rats. The purpose of this investigation was to determine the mechanism by which melatonin treatment affected spermatogenic and steroidogenic function in an experimental model-induced hypothyroidism in adult male rats. MATERIALS AND METHODS: Twenty-one male albino adult rats weighing between 150 and 210 g were used in this experiment. Rats were split into three groups and studied for 11 weeks. The control euthyroid group, in which rats received 0.9% Sodium Chloride (NaCl) solution by intraperitoneal injection [solvent for 6-propyl 2-thouracil (PTU)], 6 days/week for 8 weeks; the PTU-induced hypothyroid group, in which chemical thyroidectomy was induced by intraperitoneal injection of PTU at a dose of 10 mg/kg body weight, 6 days/week for 8 weeks; and the melatonin-treated hypothyroid group, which received 3 mg/kg melatonin intraperitoneally daily for 21 days plasma free Triiodothyronine (T3), free Thyroxin (T4), thyroid stimulating hormone (TSH), free testosterone, Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and prolactin were measured. Also, semen analysis, testicular tissue malondialdehyde (MDA), and tumor necrosis factor-α (TNF-α) were accessed. RESULTS: The results indicated that melatonin significantly increased sperm viability and motility compared to the untreated PTU-induced hypothyroid group (p<0.001). Testicular MDA and TNF-α showed a significant decrease in the melatonin-treated hypothyroid group compared with the PTU-induced hypothyroid group (p<0.05). In addition, plasma testosterone levels were significantly increased, accompanied by a significant reduction of plasma prolactin levels compared to the untreated hypothyroid group (p<0.05 for both). CONCLUSIONS: Based on the study findings, melatonin could mitigate gonadal dysfunction induced by hypothyroidism by improving several components of semen analysis, such as sperm motility and sperm viability, as well as by enhancing testosterone production focusing on oxidative and inflammatory stress as the underlying mechanisms.


Assuntos
Hipotireoidismo , Melatonina , Masculino , Animais , Ratos , Propiltiouracila/toxicidade , Melatonina/farmacologia , Prolactina , Fator de Necrose Tumoral alfa , Sêmen , Motilidade dos Espermatozoides , Hipotireoidismo/induzido quimicamente , Hipotireoidismo/tratamento farmacológico , Testosterona
2.
Eur Rev Med Pharmacol Sci ; 27(21): 10247-10254, 2023 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-37975349

RESUMO

OBJECTIVE: The quantitative measurement of handgrip strength is important in assessing and charting the progress of patients with neuromuscular diseases. The aim of this research was to determine the intra-rater and inter-rater reliability and the validity of the Squegg digital dynamometer. SUBJECTS AND METHODS: Twenty-one females and nine male participants with an age range between 18 and 40 years volunteered for the study. Three testers each took three measurements with a Squegg device and a Jamar dynamometer using standardized measurement techniques. Intra- and inter-tester reliability were calculated using the intra-class correlation coefficient (ICC). To investigate the relationship between hand measures and isometric handgrip strength, the Pearson correlation coefficient test was used. To determine the agreement between the two devices, a Bland Altman plot was constructed, and the concurrent validity of Squegg was calculated. RESULTS: The intra-rater reliability coefficients for both Jamar and Squegg were greater than 0.99 for all three testers, indicating excellent intra-rater reliability. The inter-rater reliability of Jamar (ICC=0.93) and Squegg (ICC=0.87) was excellent. With an ICC of 0.844 and an r-value of 0.720, Squegg with Jamar demonstrates good validity and statistical significance (p=0.001). CONCLUSIONS: The isometric handgrip strength and hand measures showed a moderate correlation in the study population. The Squegg isometric handgrip dynamometer has good concurrent validity and great intra- and inter-rater reliability in healthy individuals. The validity of Squegg in patients with neuromuscular diseases that affect hand function has to be investigated further.


Assuntos
Força da Mão , Doenças Neuromusculares , Feminino , Humanos , Masculino , Adolescente , Adulto Jovem , Adulto , Reprodutibilidade dos Testes , Dinamômetro de Força Muscular , Nível de Saúde
3.
Eur Rev Med Pharmacol Sci ; 27(14): 6480-6488, 2023 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-37522659

RESUMO

OBJECTIVE: The long-term consequences of congenital diaphragmatic hernia (CDH), which include altered lung functions and compromised cardiopulmonary capacity, impact functional performance and quality of life. This study investigates the effects of virtual reality-based exercise programs on pulmonary functions, cardiopulmonary capacity, functional performance, and quality of life in children with repaired CDH. PATIENTS AND METHODS: A randomized controlled clinical trial was performed. Fifty-two children with repaired CDH (aged 6-10 years) were enrolled and randomly allocated to virtual reality-based exercises plus traditional physical therapy (VR-EX group, n = 26) or traditional physical therapy alone (control group, n = 26). Interventions were conducted three times a week for 12 weeks. Pulmonary functions, cardiopulmonary capacity, functional performance, and quality of life were assessed before and after the intervention. RESULTS: The VR-EX group demonstrated significantly enhanced post-treatment pulmonary functions and cardiopulmonary capacity compared to the control group after accounting for the pre-treatment values (p < 0.05). In addition, the values in functional performance and quality of life measures showed significantly larger improvements in the VR-EX group (p < 0.05). CONCLUSIONS: Children with repaired CDH may benefit more from VR-based exercises when combined with traditional physical therapy than from traditional physical therapy alone regarding their pulmonary functions, cardiopulmonary capacity, functional performance, and quality of life.

4.
Eur Rev Med Pharmacol Sci ; 27(12): 5370-5377, 2023 06.
Artigo em Inglês | MEDLINE | ID: mdl-37401271

RESUMO

OBJECTIVE: This study aimed to evaluate the physical therapists' knowledge and awareness of breast cancer, treatment modalities, contraindications, and clinical guidelines. SUBJECTS AND METHODS: A cross-sectional survey was conducted from December 2020 to May 2021 in Saudi Arabia. The sample size was determined using the Raosoft sample size calculator, which indicated the need for 67 participants. All physical therapists of both sex in private and public hospitals in Ha'il and non-Ha'il regions were included in the study. Data was collected by a structured Google form questionnaire, consisting of 4 main domains with a maximum score of 43. RESULTS: 57 physical therapists participated in the current study, out of which 31 were from the Ha'il region (42.1% male, 57.9% female) with a mean age of 29±7 years and a mean experience 6±7years. The referral of breast cancer patients was only 22.8%. Interestingly only 22.8% of the hospital has specific setups for oncology rehabilitation, and 12.3% have reported positive about continuing professional development (CPDs) workshops for breast cancer organized by their hospitals. 5.3% of patients with breast cancer are aware of the benefit of oncology rehabilitation, while 22.8% of patients come for follow-up sessions in the rehabilitation department. According to multiple regression, only gender was statistically significant for prediction, p<0.05. Females increased the mean score by 5.996 more than males. Female therapists are 38.2% more aware than males. CONCLUSIONS: Although physical therapists have a low level of knowledge and an average level of awareness, with a higher number of women than men, attitudes toward physical therapy are quite high, and the profession is practiced exceptionally well.


Assuntos
Neoplasias da Mama , Fisioterapeutas , Humanos , Masculino , Feminino , Adulto Jovem , Adulto , Arábia Saudita , Estudos Transversais , Inquéritos e Questionários , Conhecimentos, Atitudes e Prática em Saúde
5.
Eur Rev Med Pharmacol Sci ; 27(2): 483-492, 2023 01.
Artigo em Inglês | MEDLINE | ID: mdl-36734719

RESUMO

OBJECTIVE: Bee venom (BV) phonophoresis has been recommended as a non-invasive treatment for a variety of inflammatory conditions and for reducing post-operative pain. This study aimed at evaluating the impact of bee venom phonophoresis around incisions and on selected acupuncture points for the treatment of pain, inflammation, and mobility of the hip following inguinal hernioplasty. PATIENTS AND METHODS: Sixty-six male patients who had acute pain and decreased mobility of the hip after having an indirect unilateral inguinal hernioplasty with a mesh participated in this study. Patients were randomly assigned into two equal groups of 33. The bee venom phonophoresis group (Group A) received low-intensity pulsed ultrasound using BV gel, and the control group (Group B) received low-intensity pulsed ultrasound using only plain gel without BV gel. Both groups received the same regular medical care and 5 minutes of therapy each, three times a week, for three weeks postoperative. The visual analogue scale (VAS), serum C-reactive protein (CRP), and hip ROM measurements were used to assess the acute pain, inflammation, and ROM pre-application (pre-treatment) and post-3 weeks of treatment (post-treatment) for both groups. RESULTS: The findings have exhibited an extremely significant difference in VAS, CRP, and hip ROM measurements in the BV phonophoresis group compared to that of the control group (p < 0.05). CONCLUSIONS: BV delivered by phonophoresis around incisions and on selected acupuncture points has a beneficial effect in the treatment of pain, inflammation, and mobility of the hip following inguinal hernioplasty with mesh.


Assuntos
Dor Aguda , Venenos de Abelha , Hérnia Inguinal , Masculino , Humanos , Método Simples-Cego , Herniorrafia , Resultado do Tratamento , Inflamação , Hérnia Inguinal/cirurgia
6.
Eur Rev Med Pharmacol Sci ; 27(3): 845-851, 2023 02.
Artigo em Inglês | MEDLINE | ID: mdl-36808329

RESUMO

OBJECTIVE: Adhesive capsulitis is a common health concern affecting shoulder mobility, which targets around 5% of populations worldwide, consequently affecting their quality of life. The aim of this study was to ascertain the effects of combining suprascapular nerve block and low-power laser therapy on pain intensity, mobility, disability, and quality of life in adhesive capsulitis. PATIENTS AND METHODS: Between December 2021 and June 2022, 60 patients with adhesive capsulitis were enrolled in the study. They were randomly allocated into three groups, 20 each. The first group was employed for laser therapy 3 sessions a week for 8 weeks (LT group). The second group was employed for nerve block one time (NB group). The third group was recruited for nerve block intervention one time in addition to laser therapy 3 sessions a week for 8 weeks (LT+NB group). VAS, SPADI, SF-36, and shoulder range of motion were assessed pre- and post-8-week intervention. RESULTS: Of 60 patients that started the study, 55 patients have completed the study program. No significant differences were noticed between LT, NB, and LT+NB groups before intervention (VAS at rest, p = 0.818, VAS at motion, p = 0.878, SPADI, p = 0.919, SF-36 (PCS), p = 0.731, SF-36 (MCS), p = 0.936, shoulder flexion, p = 0.441, shoulder abduction, p = 0.722, shoulder internal rotation, p = 0.396, and shoulder external rotation, p = 0.263). However, noteworthy differences were identified between LT, NB, and LT+NB groups (VAS at rest, p < 0.001, VAS at motion, p < 0.001, SPADI, p = 0.011, SF-36 (PCS), p = 0.033, SF-36 (MCS), p = 0.007, shoulder flexion, p < 0.001, shoulder abduction, p < 0.001, shoulder internal rotation, p < 0.001, and shoulder external rotation, p < 0.001). CONCLUSIONS: Both treatment modalities whether low-power laser therapy or suprascapular nerve block have beneficial effects in the treatment of adhesive capsulitis. The combination of both interventional modalities has beneficial effects in the treatment of adhesive capsulitis more than laser therapy or suprascapular nerve block alone. Accordingly, this combination should be recommended in pain management of musculoskeletal disorders, particularly adhesive capsulitis.


Assuntos
Bursite , Terapia a Laser , Bloqueio Nervoso , Articulação do Ombro , Humanos , Dor de Ombro/terapia , Qualidade de Vida , Resultado do Tratamento , Bursite/terapia , Amplitude de Movimento Articular
7.
Eur Rev Med Pharmacol Sci ; 26(21): 7779-7787, 2022 11.
Artigo em Inglês | MEDLINE | ID: mdl-36394725

RESUMO

OBJECTIVE: The current study aimed at determining the difference in hamstring tightness between dominant and non-dominant legs and to detect the correlation between LBP and hamstring tightness. PATIENTS AND METHODS: One hundred females with hamstring tightness of at least 15 degrees have been included in the study. Hamstring shortening was examined by the Active Knee Extension test (AKE) and Straight Leg Raising test (SLR), whilst the functional disability' degree was measured by Oswestry Disability Index (ODI). RESULTS: The straight leg raising and the AKE of the dominant leg were significantly more flexible than the non-dominant ones. There was a weak positive non-significant correlation between ODI and AKE of the dominant side (r = 0.162, p = 0.1) and the non-dominant side (r = 0.071, p = 0.48). There was a weak negative non-significant correlation between ODI and SLR of the dominant side (r = - 0.29, p = 0.77) and the non-dominant side (r = - 0.53, p = 0.6). CONCLUSIONS: There was no relation between the degree of hamstring tightness and LBP in female students at Jouf University.


Assuntos
Músculos Isquiossurais , Dor Lombar , Doenças Musculares , Humanos , Feminino , Dor Lombar/epidemiologia , Universidades , Incidência , Arábia Saudita/epidemiologia , Estudantes
8.
Eur Rev Med Pharmacol Sci ; 26(21): 7788-7796, 2022 11.
Artigo em Inglês | MEDLINE | ID: mdl-36394727

RESUMO

OBJECTIVE: This study aimed to evaluate the efficacy of a combination of MIRE exposure and Tai Chi exercise on balance and fall risk in community-dwelling older adults with lower-extremity disease (LED). PATIENTS AND METHODS: In this double-blinded randomized controlled study, 49 older adults were randomly allocated into the MIRE group (n=25), in which the participants were exposed to 30 min of MIRE and performed 40-45 min of Tai Chi exercise, three sessions/week; and the sham group (n=24), in which the participants only performed the Tai Chi exercise. We measured the ankle/brachial index (ABI), as well as scores of the Berg balance scale (BBS), Tinetti clinical scale (TCS), and Timed Up and Go Test (TUG) before and after 3-months of intervention. RESULTS: A significant increase in ABI and scores of BBS, and TCS, was observed, along with a significant decrease in TUG scores in the MIRE group. The sham group showed a significant increase in the ABI, and TCS score, and a significant decrease in the TUG score, with a non-significant change in the BBS score. Comparison between both study groups illustrated that the patients in the MIRE group experienced improved balance and decreased fall risk. CONCLUSIONS: Three months of MIRE exposure and Tai Chi exercise improved balance and reduced the risk of falls in community-dwelling older adults with LEDs.


Assuntos
Tai Chi Chuan , Humanos , Idoso , Vida Independente , Equilíbrio Postural , Estudos de Tempo e Movimento , Extremidade Inferior
9.
Eur Rev Med Pharmacol Sci ; 26(19): 6911-6918, 2022 10.
Artigo em Inglês | MEDLINE | ID: mdl-36263570

RESUMO

OBJECTIVE: There is no evidence that exercise training program is effective in improving aerobic capacity, musculoskeletal abnormalities, and quality of life in asthmatic children with cerebral palsy (CP). Therefore, the effects of intermittent aerobic training on exercise capacity, pulmonary function, and gait parameters in asthmatic CP children have been evaluated in the current study. PATIENTS AND METHODS: This clinical trial included thirty-six asthmatic CP children between January and December 2021. Their ages were between 7 and 12 years old. They were randomly allocated to the intermittent aerobic exercise group (IAEG) and a control group (CG), with 18 per each group. The children have been recruited for the 10-week interventional program. The 6-minute walk test (6MWT), forced vital capacity (FVC), forced expiratory volume in one second (FEV1), stride length, cadence, gait speed, and pediatric asthma quality of life (PAQLQ) were all measured before and after treatment. RESULTS: Pre-post analysis in the IAEG showed noteworthy changes (6MWT, p=0.005; FVC, p=0.002; FEV1, p<0.001; overall score of PAQLQ, p<0.001; stride length, p<0.001; cadence, p<0.001; and gait speed, p˂0.001), while the control group showed non-significant changes (p>0.05). There were noteworthy differences between IAEG and CG post-treatment (6MWT, p=0.019; FVC, p=0.031; FEV1, p<0.001; overall score of PAQLQ, p=0.031; stride length, p<0.001; cadence, p=0.009; and gait speed, p<0.001) in favor of the IAEG. CONCLUSIONS: Depending on the study findings, 10 weeks of intermittent aerobic exercise may improve exercise capacity, pulmonary function, gait parameters, and quality of life in asthmatic CP children. Based on what we found, this protocol should be used in pulmonary rehabilitation programs for children with CP who have breathing problems.


Assuntos
Asma , Paralisia Cerebral , Humanos , Criança , Tolerância ao Exercício , Paralisia Cerebral/terapia , Qualidade de Vida , Asma/terapia , Marcha , Terapia por Exercício/métodos
10.
Eur Rev Med Pharmacol Sci ; 26(17): 6098-6106, 2022 09.
Artigo em Inglês | MEDLINE | ID: mdl-36111910

RESUMO

OBJECTIVE: Several researchers have evaluated the impact of exercise training on patients with chronic kidney disease (CKD). However, few studies have evaluated the impact of concurrent training (aerobic and resisted exercise) on non-dialysis days on the functional capacity and quality of life (QOL) of such patients. Our current study evaluated the effects of concurrent training on functional capacity and QOL of patients with CKD. PATIENTS AND METHODS: Forty-three patients, aged ≥ 25 years, were recruited in this randomized study. They were divided into intervention and control groups (22 per group). The intervention group received concurrent aerobic and resistance exercises (three sessions per week for twelve weeks on alternative days). The control group continued their regular lifestyle practices and medical treatment without any exercise intervention. Before and after twelve weeks of training, the participant's functional capacity and quality of life (QOL) were measured. RESULTS: Compared to the control group, the intervention group displayed a significant improvement in the distance walked in the 6-minute walk test and sit-to-stand test (STS1/s and STS-60) with p<0.001; furthermore, a significant improvement was observed in physical function, body pain, general health, role functioning/physical, vitality, and social functioning (p<0.05) of QOL assessed with the SF-36 questionnaire. CONCLUSIONS: The twelve-week concurrent aerobic and resistance exercise training had a positive impact on functional capacity and QOL in CKD patients. Concurrent exercise training should be recommended as an interventional modality in physical therapy and rehabilitation protocols in CKD patients.


Assuntos
Insuficiência Renal Crônica , Treinamento de Força , Adulto , Exercício Físico , Terapia por Exercício/métodos , Humanos , Qualidade de Vida , Insuficiência Renal Crônica/terapia
11.
Eur Rev Med Pharmacol Sci ; 26(14): 4951-4958, 2022 07.
Artigo em Inglês | MEDLINE | ID: mdl-35916790

RESUMO

OBJECTIVE: In healthy adults, the short-term effects of sleep disruption include disorders of mood, impaired coping ability, deficits in cognition, and reduced quality of life. Increased physical activity may improve sleep duration and quality. The aim was to investigate the physical activity level and sleep quality and their relationship among a cohort of healthy females in Egypt. PATIENTS AND METHODS: We conducted a cross-sectional, self-reported survey. 688 healthy young adult females aged 18-45 years without a prior history of chronic disease were recruited for this study. Demographic data as well as physical activity (International Physical Activity Questionnaire) and sleep quality (Pittsburgh Sleep Quality Index) were collected. RESULTS: 73.5% reported poor sleep quality, which was worse for housewives. 50.4% of participants were either obese or overweight. Approximately 29.7% of the participants were physically inactive. High physical activity levels were associated with higher sleep efficiency compared to moderate physical activity (p=0.01). However, high physical activity resulted in poorer sleep quality overall (p=0.001). CONCLUSIONS: The majority of participants reported poor sleep quality and high levels of physical activity, but the relationship between physical activity and sleep quality was not clear. Poor sleep quality in our study is one of, if not the highest, reported in the literature for a similar age range in females.


Assuntos
Qualidade de Vida , Distúrbios do Início e da Manutenção do Sono , Estudos Transversais , Egito , Exercício Físico , Feminino , Humanos , Sono , Adulto Jovem
12.
Braz J Biol ; 84: e257021, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35703637

RESUMO

The aim of this paper is to better understand the dynamics of crystallogenic and starting activity in biological fluids of patients throughout surgery and the late postoperative phase in alveococcosis. Samples of saliva from 22 individuals with alveococcosis were included in the research. Biological fluid samples were taken at the time of admission and before the patient was discharged. Following that, slides were made utilizing the teziocrystalloscopy method, which incorporates the investigation of the crystal forming activity of mixed saliva with its starting characteristics using a 0.9 percent sodium chloride solution as the foundation ingredient. Using our own set of criteria, we evaluated the outcomes of crystalloscopic and tezigraphic experiments. Specrophotometric examination of tezigraphic and crystalloscopic facies was done using a PowerWave XS microplate spectrophotometer at wavelengths of 400, 350, and 300 nm to augment the results from ocular morphometry of dried saliva micro slides. Surgical therapy results in a partial normalization of physical and chemical parameters, as well as the composition of the patient's biological fluids after the patient is discharged from the hospital.


Assuntos
Equinococose , Humanos , Saliva
13.
Eur Rev Med Pharmacol Sci ; 26(10): 3506-3513, 2022 05.
Artigo em Inglês | MEDLINE | ID: mdl-35647831

RESUMO

OBJECTIVE: Chronic low-grade inflammation has emerged as a key contributor to the pathogenesis of Polycystic Ovary Syndrome (PCOS). In this regard, the present study examined the potential effects of aerobic exercise on interleukin-6 (IL6), tumor necrosis factor (TNF), and C-reactive protein (CRP) in PCOS women. PATIENTS AND METHODS: This was a randomized clinical trial that included 40 females aged 25-35 years diagnosed with PCOS. The participants were divided into two groups equal in number: the aerobic exercise group (AEM), and the metformin group (M). The AEM group performed aerobic exercise three times a week for 12 weeks in addition to metformin treatment. The M group received metformin only. Participants were assessed for IL-6, TNF-α, and CRP at baseline and after 12 weeks of intervention. RESULTS: The findings showed a significant reduction in IL-6, TNF-α, and CRP values in both AEM and M groups (p=0.001, p=0.01, respectively) after the end of the 12 weeks of the intervention. However, the participants who received aerobic exercise plus metformin, group AEM, showed a greater reduction in IL-6, TNF-α, and CRP (p=0.01, p = 0.01 and p=0.001, respectively). CONCLUSIONS: Aerobic exercise is effective in lowering IL-6, TNF-α, and CRP in polycystic ovarian women. Further clinical trials are recommended to assess the potential effects of aerobic exercise on PCOS-associated risk factors.


Assuntos
Exercício Físico , Metformina , Síndrome do Ovário Policístico , Biomarcadores , Proteína C-Reativa/análise , Feminino , Humanos , Inflamação/tratamento farmacológico , Interleucina-6/metabolismo , Metformina/uso terapêutico , Síndrome do Ovário Policístico/terapia , Fator de Necrose Tumoral alfa/metabolismo
14.
Eur Rev Med Pharmacol Sci ; 26(11): 3950-3957, 2022 06.
Artigo em Inglês | MEDLINE | ID: mdl-35731065

RESUMO

OBJECTIVE: The present study investigated the efficacy of a program of aerobic exercise on pulmonary functions in adult males with hemophilia A (HA). PATIENTS AND METHODS: 40 patients with HA who met the eligibility criteria (40 HA; age range: 20-39 years) were invited to participate in the study. The patients were divided into two groups, 20 per each. Participants in the study group (A) underwent selected physical therapy program, along with aerobic training sessions on a cycle ergometer (50-60% heart rate reserve, moderate intensity), while the control group (B) underwent a selected physical therapy program only. The pulmonary functions (FVC, FEV1, FEV1/FVC, PEF, PIF, and MVV) were measured before and after treatment program. RESULTS: There were noteworthy statistical differences between pre- and post-measurements in the study group in all measured variables (p < 0.05). There were also significant statistical differences between the study and control groups in all measured variables post treatment (p < 0.05). CONCLUSIONS: This study has demonstrated that hemophilic A patients' pulmonary functions have improved significantly following aerobic exercise training. As a result, aerobic exercise can be used in addition to medical treatment for hemophilic A patients.


Assuntos
Terapia por Exercício , Exercício Físico , Adulto , Exercício Físico/fisiologia , Frequência Cardíaca , Humanos , Pulmão , Masculino , Testes de Função Respiratória , Adulto Jovem
15.
Braz J Biol ; 84: e260090, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35613214

RESUMO

Ophiactis savignyi could be discovered all over the world in tropical marine environments. People could have aided in the spread of O. savignyi, particularly in the western and eastern populations of Panama's Isthmus. The brittle star Ophiactis savignyi, often known as savigny's brittle star, coexists alongside the sponge Geodia corticostylifera. The focus of this research has been to assess the functional relevance of G. corticostylifera secondary metabolites as antifoulant against mussels, protection against generalist fish, and chemical cues to affiliated brittle stars. Both in flow-through and static seawater laboratory studies, O. savignyi which has previously been connected with sponges, was given both treated and control mimics at the same time. The sponge extract was also tested for its ability to protect fish against predators and fouling. Deterrence test using chemicals indicated that the normal level of the sponge extract may also suppress generalist fish predation in the field as well as the mussel Perna perna's normal attachment in clinical contexts. According to the findings, G. corticostylifera crude extract has many roles in the aquatic environments, apparently being accountable for this sponge's tighter relationship with O. savignyi, which protects the ophiuroid and inhibits epibionts on itself.


Assuntos
Geodia , Animais , Peixes , Humanos , Comportamento Predatório
16.
Braz J Biol ; 84: e260091, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35584460

RESUMO

Epilepsy is one of the most common neurological disorders affecting most social, economic and biological aspects of human life. Most patients with epilepsy have uncontrolled seizures and drug side effects despite the medications. Patients with epilepsy often have problems with attention, memory, and information processing speed, which may be due to seizures, underlying causes, or anticonvulsants. Therefore, improving seizure control and reducing or changing the anti-epileptic drugs can solve these problems, but these problems will not be solved in most cases. In this work, we looked at the effects of pioglitazone, a Peroxisome Proliferator-Activated Receptor agonist used to treat type 2 diabetes, on pilocarpine-induced seizures in mice. The Racine scale was used to classify pilocarpine-induced convulsions. After that, all of the animals were beheaded, and the brain and hippocampus were dissected. Finally, biochemical techniques were used to determine the levels of Malondialdehyde and Catalase activity, as well as Superoxide Dismutase and Glutathione Reductase in the hippocampus. The results of this investigation suggest that pioglitazone's antioxidant action may play a key role in its neuroprotective properties against pilocarpine-induced seizure neuronal damage.


Assuntos
Diabetes Mellitus Tipo 2 , Epilepsia , Animais , Antioxidantes , Epilepsia/induzido quimicamente , Epilepsia/tratamento farmacológico , Humanos , Masculino , Camundongos , Pilocarpina/uso terapêutico , Pilocarpina/toxicidade , Pioglitazona/efeitos adversos , Convulsões/induzido quimicamente , Convulsões/tratamento farmacológico
17.
Eur Rev Med Pharmacol Sci ; 26(4): 1091-1100, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-35253163

RESUMO

OBJECTIVE: The objective of this study was to evaluate how a Pilates-based core strengthening exercise program affected pain, lower limb muscle strength, functional status, and health-related quality of life in adolescents with patellofemoral pain syndrome (PFPS). MATERIALS AND METHODS: In this randomized controlled clinical trial, 34 teenagers with PFPS (ages 14-17) were randomly assigned to receive either a standard PT program (control group) or Pilates exercises plus the conventional program (study group). Both groups continued the treatment sessions for 3 months (3 sessions/week). Pain intensity, lower limb muscle strength (hip abductors and external rotators and knee extensors), functional status, and health-related quality of life were evaluated pre-and post-intervention. RESULTS: Pain intensity (p =.005) reduced significantly post-treatment in the study group as compared to the control group, when controlled for the pre-treatment value. Also, muscle strength of hip abductors (p =.002) external rotators (p < .001), knee extensors (p = .013), functional status (p = .002), and health-related quality of life (p < .001) increased significantly in the study group when compared to the control group. CONCLUSIONS: The results of this study show that Pilates-based core strengthening exercises can help adolescents with PFPS reduce pain, enhance muscle strength, and improve their functional status and quality of life.


Assuntos
Síndrome da Dor Patelofemoral , Adolescente , Terapia por Exercício/métodos , Humanos , Joelho , Força Muscular/fisiologia , Dor , Síndrome da Dor Patelofemoral/reabilitação , Qualidade de Vida , Ensaios Clínicos Controlados Aleatórios como Assunto
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