Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 20
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
J Am Vet Med Assoc ; 253(1): 73-83, 2018 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-29911943

RESUMO

OBJECTIVE To compare outcomes of dogs treated surgically for oral, nontonsillar, squamous cell carcinomas (SCCs) and fibrosarcomas (FSAs) with outcomes of dogs treated with a combination of surgery and postoperative radiotherapy; to explore whether postoperative, hypofractionated radiotherapy improved outcomes of dogs with incomplete excisions; and to identify prognostic factors associated with outcome. DESIGN Retrospective cohort study. ANIMALS 87 client-owned dogs that had undergone maxillectomy or mandibulectomy for treatment of oral SCC or FSA between 2000 and 2009. PROCEDURES Medical records were retrospectively reviewed. Survival analysis was performed with Kaplan-Meier and Cox regression analyses to evaluate potential prognostic factors associated with patient outcome. RESULTS Median survival time (MST) for all 87 dogs was 2,049 days, but was not reached for dogs with SCC, and was only 557 days for dogs with FSA; tumor type was a significant predictor of survival time. Dogs undergoing postoperative radiotherapy after incomplete excision of oral SCCs had a significantly longer MST (2,051 days) than did dogs with incompletely excised tumors and no radiotherapy (MST, 181 days). Postoperative radiotherapy of dogs with incompletely excised FSAs did not appear to offer protective value (MST, 299 days with radiotherapy and 694 days without radiotherapy). CONCLUSIONS AND CLINICAL RELEVANCE Wide-margin surgical excision should be considered the gold-standard treatment for dogs with oral SCC or FSA. For dogs with oral SCCs without clean surgical margins, survival times may be improved by providing postoperative, hypofractionated radiotherapy.


Assuntos
Carcinoma de Células Escamosas/veterinária , Doenças do Cão/mortalidade , Fibrossarcoma/veterinária , Neoplasias Bucais/veterinária , Recidiva Local de Neoplasia/veterinária , Animais , Carcinoma de Células Escamosas/mortalidade , Estudos de Coortes , Terapia Combinada , Doenças do Cão/radioterapia , Doenças do Cão/cirurgia , Cães , Feminino , Fibrossarcoma/mortalidade , Masculino , Neoplasias Bucais/mortalidade , Recidiva Local de Neoplasia/mortalidade , Estudos Retrospectivos , Análise de Sobrevida , Resultado do Tratamento , Reino Unido
3.
PLoS One ; 12(8): e0181928, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28763490

RESUMO

Extremely brachycephalic, or short-muzzled, dog breeds such as pugs, French bulldogs, and bulldogs are prone to the conformation-related respiratory disorder-brachycephalic obstructive airway syndrome (BOAS). Affected dogs present with a wide range of clinical signs from snoring and exercise intolerance, to life-threatening events such as syncope. In this study, conformational risk factors for BOAS that could potentially aid in breeding away from BOAS were sought. Six hundred and four pugs, French bulldogs, and bulldogs were included in the study. Soft tape measurements of the head and body were used and the inter-observer reproducibility was evaluated. Breed-specific models were developed to assess the associations between the conformational factors and BOAS status based on functional grading. The models were further validated by means of a BOAS index, which is an objective measurement of respiratory function using whole-body barometric plethysmography. The final models have good predictive power for discriminating BOAS (-) and BOAS (+) phenotypes indicated by the area under the curve values of >80% on the receiver operating curves. When other factors were controlled, stenotic nostrils were associated with BOAS in all three breeds; pugs and bulldogs with higher body condition scores (BCS) had a higher risk of developing BOAS. Among the standardized conformational measurements (i.e. craniofacial ratio (CFR), eye width ratio (EWR), skull index (SI), neck girth ratio (NGR), and neck length ratio (NLR)), for pugs EWR and SI, for French bulldogs NGR and NLR, and for bulldogs SI and NGR showed significant associations with BOAS status. However, the NGR in bulldogs was the only significant predictor that also had satisfactory inter-observer reproducibility. A NGR higher than 0.71 in male bulldogs was predictive of BOAS with approximately 70% sensitivity and specificity. In conclusion, stenotic nostrils, BCS, and NGR were found to be valid, easily applicable predictors for BOAS (+).


Assuntos
Obstrução das Vias Respiratórias/veterinária , Craniossinostoses/veterinária , Doenças do Cão/diagnóstico , Obstrução das Vias Respiratórias/diagnóstico , Obstrução das Vias Respiratórias/genética , Animais , Cruzamento , Craniossinostoses/diagnóstico , Craniossinostoses/genética , Doenças do Cão/genética , Cães , Feminino , Masculino , Variações Dependentes do Observador , Pletismografia Total , Análise de Regressão , Reprodutibilidade dos Testes , Fatores de Risco , Especificidade da Espécie , Síndrome
4.
Vet Surg ; 46(2): 271-280, 2017 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-28146288

RESUMO

OBJECTIVE: To determine prognostic indicators for the surgical treatment of brachycephalic obstructive airway syndrome (BOAS) and to compare the prognosis of 2 multilevel surgical procedures. STUDY DESIGN: Prospective clinical study. SAMPLE POPULATION: Client-owned pugs, French bulldogs, and bulldogs (n = 50). METHODS: Noninvasive whole-body barometric plethysmography (WBBP) was used to assess respiratory function before, 1 month and 6 months after upper airway corrective surgery. Postoperatively, BOAS indices (ie, ascending severity score generated from WBBP data, 0%-100%) that equaled to or exceeded the cut-off values of BOAS in the diagnostic models were considered to have a "poor prognosis." A multivariate logistic regression was used to assess predictors for prognosis. RESULTS: The median BOAS indices decreased after surgery (from 76% to 63%, P < .0001), although dogs with indices in this range would still be considered clinically affected. Age (odds ratios [OR] = 0.96, 95% confidence interval [CI]: 0.93-0.99, P < .05), body condition (OR = 0.06, 95% CI: 0.01-0.39, P < .01), laryngeal collapse (OR = 6.1, 95% CI: 1-37.22, P < .05), and surgical techniques (OR = 7.94, 95% CI: 1.17-54.01, P < .05) were associated with postoperative prognosis. The multivariate model suggests modified multilevel surgery (MMS) may have a better outcome than traditional multilevel surgery (TMS) (P = .034). The positive predictive value of the logistic model was 84% (95% CI: 68-94%) and the area under the receiver operating characteristic (ROC) curve was 89% (95% CI: 78-99%, P <.0001). CONCLUSIONS: Younger age, normal body condition, presence of laryngeal collapse, and treatment with TMS were negative prognostic factors after surgical treatment of BOAS. MMS is recommended, particularly in dogs with a higher probability of poor prognosis.


Assuntos
Obstrução das Vias Respiratórias/veterinária , Craniossinostoses/veterinária , Doenças do Cão/cirurgia , Obstrução das Vias Respiratórias/cirurgia , Animais , Craniossinostoses/cirurgia , Cães , Feminino , Masculino , Linhagem , Complicações Pós-Operatórias , Prognóstico , Estudos Prospectivos , Curva ROC , Testes de Função Respiratória/veterinária
5.
PLoS One ; 10(6): e0130741, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26079684

RESUMO

Brachycephalic obstructive airway syndrome (BOAS) is an important health and welfare problem in several popular dog breeds. Whole-body barometric plethysmography (WBBP) is a non-invasive method that allows safe and repeated quantitative measurements of respiratory cycles on unsedated dogs. Here respiratory flow traces in French bulldogs from the pet population were characterised using WBBP, and a computational application was developed to recognise affected animals. Eighty-nine French bulldogs and twenty non-brachycephalic controls underwent WBBP testing. A respiratory functional grading system was used on each dog based on respiratory signs (i.e. respiratory noise, effort, etc.) before and after exercise. For development of an objective BOAS classifier, functional Grades 0 and I were considered to have insignificant clinical signs (termed here BOAS-) and Grades II and III to have significant signs (termed here BOAS+). A comparison between owner-perception of BOAS and functional grading revealed that 60 % of owners failed to recognise BOAS in dogs that graded BOAS+ in this study.WBBP flow traces were found to be significantly different between non-brachycephalic controls and Grade 0 French bulldogs; BOAS- and BOAS+ French bulldogs. A classifier was developed using quadratic discriminant analysis of the respiratory parameters to distinguish BOAS- and BOAS + French bulldogs, and a BOAS Index was calculated for each dog. A cut-off value of the BOAS Index was selected based on a receiver operating characteristic (ROC) curve. Sensitivity, specificity, positive predictive value, and negative predictive value of the classifier on the training group (n=69) were 0.97, 0.93, 0.95, and 0.97, respectively. The classifier was validated using a test group of French bulldogs (n=20) with an accuracy of 0.95. WBBP offers objective screening for the diagnosis of BOAS in French Bulldogs. The technique may be applied to other brachycephalic breeds affected by BOAS, and possibly to other respiratory disease in dogs.


Assuntos
Obstrução das Vias Respiratórias/veterinária , Craniossinostoses/veterinária , Doenças do Cão/patologia , Pletismografia Total/veterinária , Obstrução das Vias Respiratórias/patologia , Animais , Estudos de Casos e Controles , Craniossinostoses/patologia , Cães , Feminino , Masculino , Pletismografia Total/métodos , Testes de Função Respiratória , Índice de Gravidade de Doença , Síndrome
6.
BMC Vet Res ; 9: 121, 2013 Jun 19.
Artigo em Inglês | MEDLINE | ID: mdl-23777563

RESUMO

BACKGROUND: There are a number of different methods that can be used when estimating the size of the owned cat and dog population in a region, leading to varying population estimates. The aim of this study was to conduct a systematic review to evaluate the methods that have been used for estimating the sizes of owned cat and dog populations and to assess the biases associated with those methods.A comprehensive, systematic search of seven electronic bibliographic databases and the Google search engine was carried out using a range of different search terms for cats, dogs and population. The inclusion criteria were that the studies had involved owned or pet domestic dogs and/or cats, provided an estimate of the size of the owned dog or cat population, collected raw data on dog and cat ownership, and analysed primary data. Data relating to study methodology were extracted and assessed for biases. RESULTS: Seven papers were included in the final analysis. Collection methods used to select participants in the included studies were: mailed surveys using a commercial list of contacts, door to door surveys, random digit dialled telephone surveys, and randomised telephone surveys using a commercial list of numbers. Analytical and statistical methods used to estimate the pet population size were: mean number of dogs/cats per household multiplied by the number of households in an area, human density multiplied by number of dogs per human, and calculations using predictors of pet ownership. CONCLUSION: The main biases of the studies included selection bias, non-response bias, measurement bias and biases associated with length of sampling time. Careful design and planning of studies is a necessity before executing a study to estimate pet populations.


Assuntos
Gatos , Cães , Animais de Estimação , Animais , Viés , Métodos Epidemiológicos/veterinária , Humanos , Propriedade/estatística & dados numéricos
7.
BMC Vet Res ; 9: 17, 2013 Jan 22.
Artigo em Inglês | MEDLINE | ID: mdl-23339769

RESUMO

BACKGROUND: Feline injection site sarcomas (FISS) are aggressive neoplasms that have been associated with vaccination. In North America the incidence estimates have varied from 1 case of FISS per 1,000-10,000 cats vaccinated. The aim of this study was to estimate the incidence of FISS in the United Kingdom (UK) in 2007. The ratio of FISS to vaccines sold in the UK was also estimated.Fourteen FISS were diagnosed by a convenience sample of 34 small animal veterinary practices in the United Kingdom in 2007 and were used as the numerator for the incidence estimates. Denominator data was obtained from the computer systems of each practice. Considering that a single cause relationship with vaccination is not proven, three different denominators (number of cats registered, the number of cat consultations undertaken and the number of vaccination visits for cats at the practices) were used to express the potential variation in risk. RESULTS: The incidence risk of FISS per year was estimated to be 1/16,000 -50,000 cats registered by practices, 1/10,000-20,000 cat consultations and 1/5,000-12,500 vaccination visits. CONCLUSION: When interpreting these findings, it needs to be taken into consideration that this sample of practices and their cats may not be representative of veterinary practices and cats at risk of FISS in the UK. However it can still be concluded with reasonable certainty that the incidence of FISS in the UK is very low.


Assuntos
Doenças do Gato/epidemiologia , Injeções/veterinária , Sarcoma/veterinária , Neoplasias de Tecidos Moles/veterinária , Animais , Doenças do Gato/etiologia , Gatos , Incidência , Injeções/efeitos adversos , Fatores de Risco , Sarcoma/epidemiologia , Sarcoma/etiologia , Neoplasias de Tecidos Moles/epidemiologia , Neoplasias de Tecidos Moles/etiologia , Reino Unido/epidemiologia , Vacinas/efeitos adversos
8.
Vet Ophthalmol ; 14(3): 146-52, 2011 May.
Artigo em Inglês | MEDLINE | ID: mdl-21521437

RESUMO

OBJECTIVE: To investigate ophthalmic and cone-derived electrodiagnostic findings in outbred Miniature Long-haired Dachshunds (MLHD) homozygous for a mutation in the RPGRIP1 gene previously associated with cone-rod dystrophy 1 (cord1). ANIMALS: A total of 36 MLHD homozygous for the RPGRIP1 mutation and 23 dogs clear of the mutation (control group). PROCEDURES: The dogs underwent ophthalmic examination and photopic electroretinogram (ERG) recordings. RESULTS: None of the control dogs presented with clinical or ophthalmic signs consistent with cord1. Amongst the dogs homozygous for the mutation one presented with bilateral symmetrical total retinal atrophy. None of the other dogs in this group showed signs consistent with cord1. Photopic ERG recordings were available in 23 control dogs and 34 dogs homozygous for the mutation. Photopic a- and b-waves following four light stimuli (3 cdS/m(2) ) at a rate of 5.1 Hz were not significantly different between groups. The amplitudes of the 30 Hz flicker (128 flashes, 3 cdS/m(2) ) response were significantly reduced in the dogs homozygous for the PRGRIP1 mutation. The difference in age between the two groups did not significantly affect the difference. CONCLUSION: Homozygosity of the RPGRIP1 mutation does not invariably result in early onset cord1. However, cone derived ERG recordings show evidence of a reduced cone or inner retinal function in homozygous but clinically normal MLHD. Modifying genes that have yet to be identified may influence an individual dog's risk of developing the blinding cord1 and also the age of onset and rate of progression.


Assuntos
Doenças do Cão/genética , Cães/genética , Eletrorretinografia/veterinária , Proteínas/metabolismo , Retinite Pigmentosa/veterinária , Animais , Estudos de Casos e Controles , Doenças do Cão/patologia , Predisposição Genética para Doença , Genótipo , Homozigoto , Mutação , Proteínas/genética , Retinite Pigmentosa/genética , Retinite Pigmentosa/patologia
9.
J Small Anim Pract ; 51(7): 376-81, 2010 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-20626784

RESUMO

OBJECTIVES: To estimate breed-specific risk of death due to, and prevalence of, gastric dilatation-volvulus (GDV) in UK pedigree dogs. METHODS: Data were available on the reported cause of and age at death and occurrence of and age at diagnosis of disease from the 2004 purebred dog health survey. A total of 15,881 dogs of 165 breeds had died in the previous 10 years; GDV was the cause of death in 65 breeds. There were 36,006 live dogs of 169 breeds of which 48 breeds had experienced > or =1 episodes of GDV. Prevalence ratios were used to estimate breed-specific GDV mortality and morbidity risks. RESULTS: Gastric dilatation-volvulus was the cause of death for 389 dogs, representing 2.5% (95% CI: 2.2-2.7) of all deaths reported and the median age at death was 7.92 years. There were 253 episodes in 238 live dogs. The median age at first diagnosis was five years. Breeds at greatest risk of GDV mortality were the bloodhound, Grand Bleu de Gascogne, German longhaired pointer and Neapolitan mastiff. Breeds at greatest risk of GDV morbidity were the Grand Bleu de Gascogne, bloodhound, otterhound, Irish setter and Weimaraner. CLINICAL SIGNIFICANCE: These results suggest that 16 breeds, mainly large/giant, are at increased risk of morbidity/mortality due to GDV.


Assuntos
Tamanho Corporal/fisiologia , Doenças do Cão/mortalidade , Dilatação Gástrica/veterinária , Linhagem , Volvo Gástrico/veterinária , Fatores Etários , Animais , Cães , Feminino , Dilatação Gástrica/mortalidade , Masculino , Prevalência , Fatores de Risco , Volvo Gástrico/mortalidade , Reino Unido/epidemiologia
10.
J Small Anim Pract ; 51(2): 113-8, 2010 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-20136998

RESUMO

OBJECTIVES: To describe the frequency of caesarean sections in a large sample of pedigree dogs in the UK. METHODS: Data on the numbers of litters born in the previous 10 years were available from a cross-sectional study of dogs belonging to breed club members (2004 Kennel Club/BSAVA Scientific Committee Purebred Dog Health Survey). In this survey 151 breeds were represented with data for households that had reported on at least 10 litters (range 10-14,15): this represented 13,141 bitches which had whelped 22,005 litters. The frequency of caesarean sections was estimated as the percentage of litters that were reported to be born by caesarean section (caesarean rates) and are reported by breed. The dogs were categorised into brachycephalic, mesocephalic and dolicocephalic breeds. RESULTS: The 10 breeds with the highest caesarean rates were the Boston terrier, bulldog, French bulldog, mastiff, Scottish terrier, miniature bull terrier, German wirehaired pointer, Clumber spaniel, Pekingese and Dandie Dinmont terrier. In the Boston terrier, bulldog and French bulldog, the rate was > 80%. CLINICAL SIGNIFICANCE: These data provide evidence for the need to monitor caesarean rates in certain breeds of dog.


Assuntos
Cesárea/veterinária , Tamanho da Ninhada de Vivíparos , Linhagem , Animais , Animais Recém-Nascidos , Cruzamento , Cesárea/estatística & dados numéricos , Estudos Transversais , Cães , Feminino , Masculino
11.
Vet Anaesth Analg ; 37(1): 1-6, 2010 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-20017813

RESUMO

OBJECTIVE: To evaluate the sedative effects of intravenous (IV) medetomidine (1 microg kg(-1)) and butorphanol (0.1 mg kg(-1)) alone and in combination in dogs. STUDY DESIGN: Prospective, blinded, randomized clinical trial. ANIMALS: Sixty healthy (American Society of Anesthesiologists I) dogs, aged 6.2 +/- 3.2 years and body mass 26 +/- 12.5 kg. METHODS: Dogs were assigned to four groups: Group S (sodium chloride 0.9% IV), Group B (butorphanol IV), Group M (medetomidine IV) and Group MB (medetomidine and butorphanol IV). The same clinician assessed sedation before and 12 minutes after administration using a numerical scoring system in which 19 represented maximum sedation. Heart rate (HR), respiratory rate, pulse quality, capillary refill time and rectal temperature were recorded after each sedation score assessment. Sedation scores, sedation score difference (score after minus score before administration) and patient variables were compared using one-way anova for normally distributed variables and Kruskal-Wallis test for variables with skewed distributions and/or unequal variances. Where significance was found, further evaluation used Bonferroni multiple comparisons for pair-wise testing. RESULTS: Breed, sex, neuter status, age and body mass did not differ between groups. Sedation scores before substance administration were similar between groups (p = 0.2). Sedation scores after sedation were significantly higher in Group MB (mean 9.5 +/- SD 5.5) than in group S (2.5 +/- 1.8) (p < 0.001), group M (3.1 +/- 2.5) (p < 0.001) and group B (3.7 +/- 2.0) (p = 0.003). Sedation score difference was significantly higher in Group MB [7 (0-13)] than in Group S [0 (-1 to 4)] (p < 0.001) and Group M [0 (0-6)] (p < 0.001). HR decreased significantly in Groups M and MB compared with Group S (p < 0.05). CONCLUSION AND CLINICAL RELEVANCE: Low-dose medetomidine 1 microg kg(-1) IV combined with butorphanol 0.1 mg kg(-1) IV produced more sedation than medetomidine or butorphanol alone. HR was significantly decreased in both medetomidine groups.


Assuntos
Anestesia Intravenosa/veterinária , Anestésicos Combinados/administração & dosagem , Butorfanol/administração & dosagem , Hipnóticos e Sedativos/administração & dosagem , Medetomidina/administração & dosagem , Anestésicos Combinados/farmacologia , Animais , Temperatura Corporal/efeitos dos fármacos , Butorfanol/farmacologia , Sedação Consciente/veterinária , Cães , Feminino , Frequência Cardíaca/efeitos dos fármacos , Hipnóticos e Sedativos/farmacologia , Infusões Intravenosas/veterinária , Masculino , Medetomidina/farmacologia , Taxa Respiratória/efeitos dos fármacos , Método Simples-Cego
12.
Vet Anaesth Analg ; 37(1): 7-13, 2010 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-20017814

RESUMO

OBJECTIVE: To determine in dogs the effects of medetomidine and butorphanol, alone and in combination, on the induction dose of alfaxalone and to describe the induction and intubation conditions. STUDY DESIGN: Prospective, randomized, blinded clinical trial. ANIMALS: Eighty-five client-owned dogs (ASA 1 or 2). METHODS: Subjects were block randomized to treatment group according to temperament. The treatment groups were: medetomidine 4 microg kg(-1) (M), butorphanol 0.1 mg kg(-1) (B), or a combination of both (MB), all administered intramuscularly. After 30 minutes, a sedation score was assigned, and alfaxalone 0.5 mg kg(-1) was administered intravenously over 60 seconds by an observer who was unaware of treatment group. Tracheal intubation conditions were assessed and, if tracheal intubation was not possible after 20 seconds, further boluses of 0.2 mg kg(-1) were given every 20 seconds until intubation was achieved. Induction dose and adverse events (sneezing, twitching, paddling, excitement, apnoea and cyanosis) were recorded; induction quality and intubation conditions were scored and recorded. RESULTS: The mean dose of alfaxalone required for induction was similar for groups M and B: 1.2 +/- 0.4 mg kg(-1). The mean dose requirement for group MB (0.8 +/- 0.3 mg kg(-1)) was lower than groups M and B (p < 0.0001). Induction dose was not influenced by temperament or level of sedation. Induction and intubation scores did not differ between treatment groups. Adverse events were noted in 16 dogs; there was no association with treatment group, temperament or level of sedation. CONCLUSIONS AND CLINICAL RELEVANCE: Medetomidine and butorphanol administered in combination reduce the anaesthetic induction dose of alfaxalone compared to either agent alone. This difference should be taken into account when using this combination of drugs in a clinical setting.


Assuntos
Anestesia Endotraqueal/veterinária , Anestesia Intravenosa/veterinária , Anestésicos Combinados , Anestésicos/administração & dosagem , Butorfanol , Medetomidina , Medicação Pré-Anestésica/veterinária , Pregnanodionas/administração & dosagem , Anestésicos Combinados/administração & dosagem , Animais , Cães , Feminino , Intubação Intratraqueal/veterinária , Masculino , Método Simples-Cego
13.
J Am Anim Hosp Assoc ; 45(1): 3-13, 2009.
Artigo em Inglês | MEDLINE | ID: mdl-19122058

RESUMO

Clinical and metabolic variables were evaluated in 14 Labrador retrievers with exercise-induced collapse (EIC) before, during, and following completion of a standardized strenuous exercise protocol. Findings were compared with previously reported variables from 14 normal Labrador retrievers that participated in the same protocol. Ten of 14 dogs with EIC developed an abnormal gait during evaluation, and these dogs were significantly more tachycardic and had a more severe respiratory alkalosis after exercise compared to the normal dogs. Muscle biopsy characteristics and sequential lactate and pyruvate concentrations were normal. Genetic testing and linkage analysis excluded malignant hyperthermia as the cause of EIC. Common causes of exercise intolerance were eliminated, but the cause of collapse in EIC was not determined.


Assuntos
Doenças do Cão/fisiopatologia , Cães/fisiologia , Condicionamento Físico Animal/efeitos adversos , Animais , Biópsia/veterinária , Análise Química do Sangue , Temperatura Corporal , Carnitina/análise , Carnitina/sangue , Carnitina/urina , Doenças do Cão/genética , Cães/genética , Feminino , Masculino , Hipertermia Maligna/veterinária , Músculo Quadríceps/cirurgia , Descanso/fisiologia , Canal de Liberação de Cálcio do Receptor de Rianodina/genética
14.
J Feline Med Surg ; 11(2): 53-9, 2009 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-18602328

RESUMO

Medical records of 92 cats presented with clinical signs of spinal cord disease, which had undergone magnetic resonance imaging (MRI), were reviewed. The cats were grouped into seven categories based upon the diagnosis suggested by results of MRI, cerebrospinal fluid analysis and other diagnostic procedures: neoplastic (n=25), inflammatory or infectious (n=13), traumatic (n=8), vascular (n=6), degenerative (n=5), anomalous (n=3) and those with an unremarkable MRI (n=32). There were two independent predictors of abnormal MRI findings: severity of clinical signs and presence of spinal pain. Abnormal MRI findings and speed of onset of disease were significantly associated with survival. For the 32 cats with unremarkable MRI findings, only nine died due to spinal disease and, therefore, the median survival time (MST) was not reached (lower 95% confidence interval (CI)=970 days). For the 60 cats with abnormal MRI findings, 37 died due to their disease and the MST was 138 days (95% CI: 7-807).


Assuntos
Doenças do Gato/diagnóstico , Doenças do Gato/epidemiologia , Imagem por Ressonância Magnética/veterinária , Doenças da Medula Espinal/veterinária , Animais , Doenças do Gato/mortalidade , Gatos , Líquido Cefalorraquidiano , Feminino , Modelos Logísticos , Masculino , Dor/diagnóstico , Dor/veterinária , Prognóstico , Estudos Retrospectivos , Doenças da Medula Espinal/diagnóstico , Doenças da Medula Espinal/epidemiologia , Análise de Sobrevida
15.
Vet Anaesth Analg ; 35(3): 208-19, 2008 May.
Artigo em Inglês | MEDLINE | ID: mdl-18282256

RESUMO

OBJECTIVE: To determine the haemodynamic effects of halothane and isoflurane with spontaneous and controlled ventilation in dorsally recumbent horses undergoing elective surgery. STUDY DESIGN: Prospective randomized clinical trial. ANIMALS: Twenty-five adult horses, body mass 487 kg (range: 267-690). METHODS: Horses undergoing elective surgery in dorsal recumbency were randomly assigned to one of four treatment groups, isoflurane (I) or halothane (H) anaesthesia, each with spontaneous (SB) or controlled ventilation (IPPV). Indices of cardiac function and femoral arterial blood flow (ABF) and resistance were measured using transoesophageal and transcutaneous Doppler echocardiography, respectively. Arterial blood pressure was measured directly. RESULTS: Four horses assigned to receive isoflurane and spontaneous ventilation (SBI) required IPPV, leaving only three groups for analysis: SBH, IPPVH and IPPVI. Two horses were excluded from the halothane groups because dobutamine was infused to maintain arterial blood pressure. Cardiac index (CI) was significantly greater, and pre-ejection period (PEP) shorter, during isoflurane compared with halothane anaesthesia with both spontaneous (p = 0.04, p = 0.0006, respectively) or controlled ventilation (p = 0.04, p = 0.008, respectively). There was an association between CI and PaCO(2) (p = 0.04) such that CI increased by 0.45 L minute(-1)m(-2) for every kPa increase in PaCO(2). Femoral ABF was only significantly higher during isoflurane compared with halothane anaesthesia during IPPV (p = 0.0006). There was a significant temporal decrease in CI, but not femoral arterial flow. CONCLUSION: The previously reported superior cardiovascular function during isoflurane compared with halothane anaesthesia was maintained in horses undergoing surgery. However, in these clinical subjects, a progressive decrease in CI, which was independent of ventilatory mode, was observed with both anaesthetic agents. CLINICAL RELEVANCE: Cardiovascular function may deteriorate progressively in horses anaesthetized for brief (<2 hours) surgical procedures in dorsal recumbency. Although cardiovascular function is superior with isoflurane in dorsally recumbent horses, the need for IPPV may be greater.


Assuntos
Anestesia por Inalação/veterinária , Anestésicos Inalatórios/farmacologia , Halotano/farmacologia , Cavalos , Isoflurano/farmacologia , Animais , Velocidade do Fluxo Sanguíneo/efeitos dos fármacos , Pressão Sanguínea/efeitos dos fármacos , Feminino , Frequência Cardíaca/efeitos dos fármacos , Masculino , Respiração/efeitos dos fármacos , Fatores de Tempo
16.
Vet Anaesth Analg ; 34(3): 171-80, 2007 May.
Artigo em Inglês | MEDLINE | ID: mdl-17444930

RESUMO

OBJECTIVE: To evaluate a total intravenous anaesthetic technique in dogs undergoing craniectomy. STUDY DESIGN: Prospective clinical study. ANIMALS: Ten dogs admitted for elective surgical resection of rostro-tentorial tumours. METHODS: All dogs were premedicated with methadone, 0.2 mg kg(-1) intramuscularly 30 minutes prior to induction of anaesthesia. Anaesthesia was induced with propofol administered intravenously (IV) to effect, following administration of lidocaine 1 mg kg(-1) IV and maintained with a continuous infusion of propofol at < or =0.4 mg kg(-1) minute(-1) during instrumentation and preparation and during movement of the animals to recovery. During surgery, anaesthesia was maintained using a continuous infusion of propofol at

Assuntos
Anestesia Intravenosa/veterinária , Anestésicos Intravenosos/administração & dosagem , Neoplasias Encefálicas/veterinária , Doenças do Cão/cirurgia , Cães/fisiologia , Alfentanil/administração & dosagem , Anestesia Intravenosa/métodos , Anestésicos Combinados/administração & dosagem , Animais , Pressão Sanguínea/efeitos dos fármacos , Neoplasias Encefálicas/cirurgia , Cães/cirurgia , Feminino , Frequência Cardíaca/efeitos dos fármacos , Intubação Intratraqueal/veterinária , Masculino , Propofol/administração & dosagem , Estudos Prospectivos
17.
Can Vet J ; 47(3): 234-40, 2006 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-16604979

RESUMO

The purpose of this study was to describe clients' level of compliance with reminders that are computer generated and to identify factors associated with owner response to a recall. Client response to a recall notice revealed that clients responded to reminders for vaccination about 3 times less often than for the other recall codes combined (dental procedures, laboratory tests, medical progress examinations, and neutering). These results suggest that veterinarians need to move away from annual vaccination reminders and toward the promotion of preventive veterinary services, such as annual wellness examinations, screening laboratory testing, and routine dental procedures. Once a practice has committed to and set up the required computer systems to promote preventive veterinary care, the stage is set for the implementation and monitoring of recommendations and reminders. This type of practice philosophy and marketing coincides perfectly with an approach to maximizing compliance in all aspects of veterinary medicine.


Assuntos
Cooperação do Paciente , Gerenciamento da Prática Profissional/normas , Sistemas de Alerta , Software , Medicina Veterinária/normas , Animais , Gatos , Cães , Humanos , Programas de Rastreamento/veterinária , Prevenção Primária , Prática Profissional/normas
18.
Vet Ophthalmol ; 9(1): 53-7, 2006.
Artigo em Inglês | MEDLINE | ID: mdl-16409246

RESUMO

OBJECTIVE: To investigate the effects of age, weight, gender, and of time of day on tear production in normal dogs. ANIMALS: studied One hundred ophthalmoscopically and systemically unremarkable dogs. PROCEDURE: Schirmer tear tests (STT) were performed every 2 h during the day on one randomly chosen eye of each of 100 dogs. RESULTS: There was a statistically significant effect of time of day and age on the STT measurement. The mean STT decreased by 0.4 mm for every 1 year that age increased (P=0.007). Mean STT values taken at 10:00 am were 0.7 mm lower than values taken at 4:00 pm (P=0.04). CONCLUSIONS: Tear production decreases with age in the normal dog. In this population of dogs the largest difference was between the 10:00 am and the 4:00 pm STT measurements, but this still only amounted to 0.7 mm. This value is unlikely to be of clinical significance in the diagnosis of keratoconjunctivitis sicca (KCS).


Assuntos
Lágrimas/metabolismo , Fatores Etários , Animais , Peso Corporal/fisiologia , Ritmo Circadiano , Doenças do Cão/diagnóstico , Cães , Feminino , Ceratoconjuntivite Seca/diagnóstico , Ceratoconjuntivite Seca/veterinária , Masculino , Fatores Sexuais
19.
J Am Vet Med Assoc ; 226(4): 567-74, 2005 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-15742698

RESUMO

OBJECTIVE: To describe the degree of and variability in the level of client compliance and identify determinants of client compliance with short-term administration of antimicrobial medications to dogs. DESIGN: Prospective study. SAMPLE POPULATION: 90 owners of dogs prescribed antimicrobials. PROCEDURE: Eligible clients were invited to participate when antimicrobial medications were dispensed. Data were collected during a follow-up appointment by use of a client questionnaire, residual pill count, and return of an electronic medication monitoring device. Attending veterinarians also completed a questionnaire that asked them to predict client compliance. Methods of assessing compliance were compared with nonparametric tests. Generalized estimating equations were used to investigate potential determinants of compliance. RESULTS: Median compliance rates of 97% of prescribed container openings, 91% of days when the correct number of doses were given, and 64% of doses given on time as assessed by the electronic medication monitoring devices were significantly lower than the median compliance rates of 100% for client self-report of missing doses and pill count. Veterinarians were unable to predict client compliance. The dosage regimen significantly determined compliance. Clients giving antimicrobials once or twice daily were 9 times more likely to be 100% compliant, compared with 3 times daily dosing. CONCLUSIONS AND CLINICAL RELEVANCE: The combination of reported missed doses and pill counts was a significant predictor of compliance as measured by electronic monitoring. Electronic monitoring caps provided useful information only when they were used appropriately. Asking clients about missed doses and performing pill counts are the most practical assessments of compliance in practice.


Assuntos
Antibacterianos/uso terapêutico , Infecções Bacterianas/veterinária , Doenças do Cão/tratamento farmacológico , Cooperação do Paciente , Autorrevelação , Animais , Antibacterianos/administração & dosagem , Infecções Bacterianas/tratamento farmacológico , Cães , Esquema de Medicação/veterinária , Humanos , Monitorização Fisiológica/métodos , Monitorização Fisiológica/veterinária , Probabilidade , Estudos Prospectivos
20.
J Am Vet Med Assoc ; 221(3): 389-92, 2002 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-12164536

RESUMO

OBJECTIVE: To compare blood glucose (BG) concentrations measured with a portable blood glucose meter in blood samples obtained with a marginal ear vein (MEV) nick technique, from a peripheral venous catheter, and by direct venipuncture in healthy cats and cats with diabetes mellitus. DESIGN: Prospective study. ANIMALS: 1 0 healthy cats and 11 cats with diabetes mellitus. Procedure-On day 1, blood samples were collected every hour for 10 hours by the MEV nick technique and from a peripheral venous catheter. On day 2, blood samples were collected every hour for 10 hours by the MEV nick technique and by direct venipuncture of the medial saphenous vein. RESULTS: For all cats, mean BG concentration for samples collected by the MEV nick technique was not significantly different from mean concentration for samples obtained from the peripheral venous catheter. For healthy cats, mean BG concentration for samples collected by the MEV nick technique was not significantly different from mean concentration for samples obtained by direct venipuncture. For cats with diabetes mellitus, mean BG concentration for samples collected by the MEV nick technique was significantly different from mean concentration for samples obtained by direct venipuncture; however, for the range of concentrations examined, this difference was not clinically important. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that for the range of concentrations examined, the MEV nick technique is a reasonable alternative to venous blood collection for serial measurement of BG concentrations in cats.


Assuntos
Glicemia/análise , Coleta de Amostras Sanguíneas/veterinária , Doenças do Gato/sangue , Diabetes Mellitus/veterinária , Orelha Externa/irrigação sanguínea , Animais , Coleta de Amostras Sanguíneas/instrumentação , Coleta de Amostras Sanguíneas/métodos , Estudos de Casos e Controles , Gatos , Diabetes Mellitus/sangue , Estudos Prospectivos , Manejo de Espécimes/métodos , Manejo de Espécimes/veterinária
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA