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1.
Recurso educacional aberto em Português | CVSP - Brasil | ID: cfc-367845

RESUMO

O programa vai falar sobre os potenciais beneficios do café para a saúde, das pesquisas recentes como a que aponta que a cafeína pode ter efeitos benéficos em pessoas com a doença de Parkinson e outros estudos que mostram como a substância pode estar relacionada a benefícios para a saúde e prevenção de algumas doenças. O programa também vai ensinar a identificar o café saudável, falar da quantidade que pode ser consumida e tirar outras dúvidas sobre o assunto. Para saber mais sobre o tema, a apresentadora Marcela Morato conversa com a nutricionista e coordenadora do Núcleo de Café da Universidade Federal do Rio de Janeiro (UFRJ), Adriana Farah. Participante: Priscila Soares, barista.


Assuntos
Café , Cafeína , Estimulantes do Sistema Nervoso Central
2.
Arch Oral Biol ; 93: 56-65, 2018 09.
Artigo em Inglês | MEDLINE | ID: mdl-29807235

RESUMO

OBJECTIVE: The efficacy of a red propolis hydro-alcoholic extract (RP) in controlling Streptococcus mutans biofilm colonization was evaluated. The effect of RP on dental demineralization was also investigated. METHODS: Chemical composition was determined by High Performance Liquid Chromatography (HPLC). Minimum Inhibitory and Bactericidal Concentration (MIC and MBC, respectively) were investigated against Streptococcus mutans (ATCC 25175). The cytotoxic potential of 3% RP in oral fibroblasts was observed after 1 and 3 min. Bovine dental enamel blocks (N = 24) were used for S. mutans biofilm formation (48 h), simulating 'feast or famine' episodes. Blocks/biofilms were exposed 2×/day, for 3 days, to a cariogenic challenge with sucrose 10% (5 min) and treated (1 min) with: 0.85% saline solution (negative control), 0.12% Chlorhexidine (CHX, positive control for biofilm colonization), 0.05% Sodium Fluoride (NaF, positive control to avoid demineralization) and 3% RP. Biofilms were assessed for viability (CFU/mL), and to observe the concentration of soluble and insoluble extracellular polysaccharides (SEPS and IEPS). Dental demineralization was assessed by the percentage of surface hardness loss (%SHL) and through polarized light microscopy (PLM). RESULTS: The RP presented 4.0 pH and ºBrix = 4.8. The p-coumaric acid (17.2 µg/mL) and luteolin (15.23 µg/mL) were the largest contents of phenolic acids and flavonoids, respectively. MIC and MBC of RP were 293 µg/mL and 1172 µg/mL, respectively. The 3% RP showed 43% of viably cells after 1 min. Lower number (p < 0.05) of viable bacteria (CFU/mL) was observed after CHX (1.8 × 105) followed by RP (1.8 × 107) treatments. The lowest concentration (µg/CFU) of SEPS (12.6) and IEPS (25.9) was observed in CHX (p < 0.05) followed by RP (17.1 and 54.3), and both differed from the negative control (34.4 and 63.9) (p < 0.05). Considering the %SHL, all groups differed statistically (p < 0.05) from the negative control (46.6%); but NaF (13.9%), CHX (20.1%) and RP (20.7%) did not differ among them (p > 0.05). After all treatments, suggestive areas of caries lesions were observed by PLM, which were lower for CHX and NaF. CONCLUSION: The 3% RP reduced S. mutans colonization, decreased concentration of extracellular polysaccharides and reduced dental enamel demineralization.


Assuntos
Biofilmes/efeitos dos fármacos , Esmalte Dentário/efeitos dos fármacos , Própole/farmacologia , Streptococcus mutans/efeitos dos fármacos , Desmineralização do Dente/microbiologia , Animais , Bovinos , Cromatografia Líquida de Alta Pressão , Dureza , Concentração de Íons de Hidrogênio , Técnicas In Vitro , Incisivo , Polissacarídeos/metabolismo , Distribuição Aleatória , Propriedades de Superfície
3.
Z Naturforsch C J Biosci ; 58(7-8): 590-3, 2003.
Artigo em Inglês | MEDLINE | ID: mdl-12939049

RESUMO

The quinic acid derivatives (including 4-feruoyl quinic and 5-ferruoyl quinic acids characterized for first time in propolis samples) and other phenolic compounds were quantified in thirteen Brazilian propolis samples by HPLC analysis. For chemometrical analysis, the distribution of quinic acid derivatives and other phenolic compounds were considered. The results suggest that the Brazilian propolis with floral origin from Citrus sp. have the highest concentration of the quinic acid derivatives (between 11.0 to 58.4 mg/mg of the dried crude hydroalcoholic extract) and therefore would probably show a more effective hepatoprotective activity.


Assuntos
Fenóis/isolamento & purificação , Própole/química , Ácido Quínico/isolamento & purificação , Brasil , Cromatografia Líquida , Geografia , Fenóis/química , Própole/isolamento & purificação , Ácido Quínico/química
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