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1.
J Nanosci Nanotechnol ; 18(7): 4714-4719, 2018 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-29442649

RESUMO

Co0 nanoparticles supported on TiO2 nanofibers (nanocomposite) were prepared using a simple electrospinning technique and In-Situ chemical reduction. The synthesized nanocomposite was used to generate hydrogen from ammonia borane (AB). Standard characterization techniques revealed dense distribution of Co0 nanoparticles (Co NPs) onto the TiO2 nanofibers (TiO2 NFs) in the prepared nanocomposite. The introduced nanocomposite has been showed a good catalytic activity as compared to those unsupported Co NPs. As, the hydrogen evolutions for the nanocomposite and Co NPs were 3 mol in 23 min and 47 min, respectively. Furthermore, both the nanocomposite concentration and the temperature have a significant catalytic activity in the AB dehydrogenation. The nanocomposite also showed low effective activation energy of ~26.03 KJ · mol-1.

2.
S Afr J Surg ; 54(1): 10-13, 2016 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-28240490

RESUMO

BACKGROUND: Intussusception is an important and one of the most commonly encountered diagnoses of intestinal obstruction in the paediatric age group. Ultrasound-guided hydrostatic reduction is an effective, nonoperative treatment modality for this condition and is associated with a high success rate. In addition, it is simple and safe as the entire procedure is carried out with real-time ultrasound, without the hazard of radiation. The aim of this study was to evaluate the effi cacy and safety of ultrasound-guided hydrostatic reduction in the management of intussusceptions in the paediatric age group. METHOD: A case study was carried out on 89 patients diagnosed with intussusception using high-resolution ultrasonography over a period of two years, spanning February 2012 to January 2014. Ultrasound-guided hydrostatic reduction was performed in 78 of these patients, and 11 patients were excluded owing to clinical contraindications. Follow-up ultrasound was performed after 24 hours to rule out recurrence. RESULTS: The disease was most prevalent in the age group 6-24 months. The ileocolic type was the most common. Mean duration (hours) was 17.02 ± 20.81 for time to presentation. Complete therapeutic reduction was achieved in 70 of the 78 cases, with a success rate of 90%. Two recurrences occurred in the following 24 hours, which were successfully reduced on the second attempt. Complications and mortality did not occur secondary to the procedure. CONCLUSION: Our study found that ultrasound-guided hydrostatic reduction is a simple, safe and effective nonoperative treatment for intussusceptions in the paediatric age group, and should be the fi rst line of management in appropriate patients.

3.
Phys Chem Chem Phys ; 17(14): 8596-603, 2015 Apr 14.
Artigo em Inglês | MEDLINE | ID: mdl-25738191

RESUMO

Silver nanoclusters were prepared in a soda-lime glass matrix through the ion-exchange (Ag(+)↔ Na(+)) method followed by thermal annealing in an air atmosphere. The nanoscale patterning of Ag nanoclusters embedded in a soda lime glass matrix in an air atmosphere at different annealing temperatures has been investigated. During annealing, Ag(+) is reduced to Ag(0) and subsequently forms silver nanoparticles inside the glass matrix. A blue shift of 20 nm has been observed as a function of the post annealing temperature. The photoluminescence intensity is highest for an annealing temperature of 500 °C for 1 h and continuously decreases as annealing temperature increases up to 600 °C. The presence of spherical nanoparticles with a maximum particle size of 7.2 nm has been observed after annealing at 600 °C for 1 hour, which is consistent with Mie theory based results.

4.
Int J Immunogenet ; 42(1): 46-51, 2015 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-25572425

RESUMO

Only 5-10% of people infected with Mycobacterium tuberculosis develop active tuberculosis which suggests a role of genetic variation in host immunity. Genetic variants in TLRs are potential indicator for host susceptibility and outcome of several diseases. We explored the association of nonsynonymous genetic variants (Met1Val) with Toll-like receptor 8 in Pakistani population. Genotypic and allelic distribution of TLR8 polymorphism (rs3764880) in patients with TB and healthy donors from different areas of southern Punjab, Pakistan, was determined. Results provide that our population is highly influenced by TLR8 Met1Val SNP for TB, and G allele appeared to increase TB susceptibility. Mutant genotype GG or G/- and G allele was significantly higher among all the categories of cases than in controls. Among different levels of bacillary load and genotypes, GG or G/- and G allele significantly supports the incidence of 2 + class for bacterial load.


Assuntos
Mycobacterium tuberculosis/imunologia , Receptor 8 Toll-Like/genética , Receptor 8 Toll-Like/imunologia , Tuberculose Pulmonar/imunologia , Adolescente , Adulto , Alelos , Carga Bacteriana/genética , Criança , Pré-Escolar , Feminino , Frequência do Gene , Estudos de Associação Genética , Predisposição Genética para Doença , Genótipo , Humanos , Masculino , Pessoa de Meia-Idade , Paquistão , Polimorfismo de Nucleotídeo Único/genética , Tuberculose Pulmonar/genética , Tuberculose Pulmonar/microbiologia , Adulto Jovem
5.
Curr Med Chem ; 21(26): 3081-94, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24934346

RESUMO

Transition metal-based compounds constitute a distinct class of chemotherapeutics extensively used in the clinic as antitumor and antiviral agents. However, drug resistance and side effects of established antitumor metallodrugs such as cisplatin [cis-diamminedichloroplatinum(II)] and its analogues, carboplatin and oxaliplatin, have limited their clinical utility. These limitations have prompted a search for more effective and less toxic metal-based antitumor agents. The unique properties of metal ions, such as redox transfer/electron shuttling, and versatile coordination geometries arising from various oxidation states, result in metal ions and complexes that have potential medicinal applications that could be complementary to organic compounds and which are widely sought in drug discovery efforts. This review summarizes the results that show that transition metal complexes exhibit antitumor effects that differ from cisplatin or its analogues.


Assuntos
Antineoplásicos/uso terapêutico , DNA/metabolismo , Neoplasias/patologia , Elementos de Transição/uso terapêutico , Animais , Antineoplásicos/metabolismo , Sobrevivência Celular/efeitos dos fármacos , Humanos , Neoplasias/tratamento farmacológico , Neoplasias/metabolismo , Oxirredução , Elementos de Transição/metabolismo
6.
Curr Med Chem ; 21(7): 911-31, 2014 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-24164193

RESUMO

Synthetic heterocyclic compounds have remarkable potential activity against diseases; thioamides, benzimidazoles, quinolones and derivatives with carboxylic acid and esters moieties have shown excellent activity against Mycobacterium tuberculosis. We reviewed antituberculosis activities of above compounds with reference to half maximal inhibitory concentration, minimum inhibitory concentration and structural-activity relationship which clearly indicate that electron-withdrawing groups are the main inducers of antimycobacterium activity. Comparison between clinically used drugs and new synthetic derivatives showed recent advances made in the last decade.


Assuntos
Antituberculosos/síntese química , Benzimidazóis/química , Ácidos Carboxílicos/química , Quinolonas/química , Tioamidas/química , Antituberculosos/química , Antituberculosos/farmacologia , Benzimidazóis/síntese química , Benzimidazóis/farmacologia , Ácidos Carboxílicos/síntese química , Ácidos Carboxílicos/farmacologia , Desenho de Fármacos , Ésteres , Mycobacterium tuberculosis/efeitos dos fármacos , Quinolonas/síntese química , Quinolonas/farmacologia , Tioamidas/síntese química , Tioamidas/farmacologia
7.
J Intellect Disabil Res ; 58(6): 560-71, 2014 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-23701497

RESUMO

PURPOSE: The purpose of this study was to examine the psychometric properties and the theoretical structure of the Parenting Stress Index-short form (PSI-SF) with Jordanian parents of children with autistic disorder. METHODS: Using a cross-sectional design for data collection, the convenience sample of the study was composed of 184 Jordanian parents of children with autistic disorder. The factor structure for the PSI-SF was examined using confirmatory and exploratory factor analyses. RESULTS: We found that the modified three-factor model (30 items) fits the data significantly better than the 36-item model. The results showed that the 12 items of the Parental Distress sub-scale support the original scale structure. However, items in the Parent-Child Dysfunctional Interaction and Difficult Child sub-scales did not show stability in their structure. The results in this study showed that the PSI-SF in its 30-item model has endorsed the necessary validity of the scale with parents of children with autistic disorder. The study provides information on the effects of Arab culture on the validity of PSI-SF. CONCLUSION: It is recommended to use the new factors structure of the PSI-SF with the 30 items in the studies that intend to examine the stress among parents with children with autistic disorder in the Arab world.


Assuntos
Transtornos Globais do Desenvolvimento Infantil/psicologia , Comparação Transcultural , Poder Familiar/psicologia , Psicometria/estatística & dados numéricos , Estresse Psicológico , Inquéritos e Questionários , Adulto , Idade de Início , Idoso , Criança , Transtornos Globais do Desenvolvimento Infantil/diagnóstico , Pré-Escolar , Características da Família , Feminino , Humanos , Jordânia , Masculino , Pessoa de Meia-Idade , Reprodutibilidade dos Testes , Adulto Jovem
8.
Recent Pat Biotechnol ; 8(1): 102-7, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-22642822

RESUMO

Artemisinin, a potent antimalarial natural products isolated from aerial parts of Artemisia annua L. Many patents have been reported that the demand for artemisinin is exponentially increasing year after year due to increased incidences of drug resistant malaria throughout the world. Leaf explants were used frequently as target tissue to generate transgenic of Artemisia. annua L. However, obtaining a large number of transgenic lines through out the year is a laborious and delicate process. To circumvent this, we have developed a highly efficient leaf explant based Agrobacterium mediated transformation of A. annua L. plant. The gus gene was used as screenable marker to assess and optimize the performance of T-DNA delivery. The age of explant, kind of bacterial inoculation, suspension duration, infection times and co-culture conditions were optimized. The co-culture was carried out with Agrobacterium tumefaciens strain EHA105 under desiccation condition in the dark at 25-28 0C for 2-4 days. Complete analysis of transgene insertion demonstrated that the optimized method of transformation from leaf explants of A. annua L. was efficient and highly reproducible.


Assuntos
Agrobacterium/metabolismo , Artemisia annua/metabolismo , Agrobacterium/genética , Artemisia annua/citologia , Técnicas de Cocultura , Glucuronidase/genética , Glucuronidase/metabolismo , Folhas de Planta/citologia , Proteínas de Plantas/genética , Proteínas de Plantas/metabolismo , Brotos de Planta/citologia , Plasmídeos/genética , Plasmídeos/metabolismo , Transformação Genética
9.
Int J Immunogenet ; 41(2): 105-11, 2014 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-23998736

RESUMO

Tuberculosis (TB) is a global public health problem and a source of preventable deaths each year, with 8.8 million new cases of TB and 1.6 million deaths worldwide. Pakistan ranks sixth on the list of 22 high-burden tuberculosis countries in the world. The transitions from infection to clinical disease are very few signifying that host-defence factors could lead to the development of active disease. Toll-like receptor (TLR) 2 polymorphisms have been associated with regulation of TLR expression and development of active TB. In this study, blood samples of 187 subjects including 100 healthy and 87 TB positive were collected from three districts of Pakistan. DNA was extracted from blood and TLR 2 (-196 to -174del) polymorphism was analysed by polymerase chain reaction (PCR). The results suggest that the frequency of -196 to -174del/del polymorphism of TLR2 was significantly higher in TB-positive patients compared with healthy. Results revealed that (-196 to -174del) polymorphism may increase the susceptibility to TB in healthy population of Pakistan. Moreover, males with heterozygous genotype (I/D) are more prone to TB than females with the same genotype. The occurrence of TB infection has been found positively associated with the age, suggesting that the population within the range of 21-45 years is more susceptible to Mycobacterium tuberculosis than other age groups studied. A significant association is also observed between smoking and the chances of developing TB, confirming that smoking strongly promotes its incidence.


Assuntos
Grupo com Ancestrais do Continente Asiático/genética , Receptor 2 Toll-Like/genética , Tuberculose Pulmonar/genética , Adolescente , Adulto , Estudos de Casos e Controles , Criança , Pré-Escolar , Feminino , Frequência do Gene , Predisposição Genética para Doença , Genótipo , Humanos , Masculino , Pessoa de Meia-Idade , Paquistão , Polimorfismo Genético , Adulto Jovem
10.
Nat Prod Res ; 25(1): 68-76, 2011 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-21240764

RESUMO

Two new compounds: 2-(3',4'-dihydroxyphenyl) ethyl-3-O-α-L-rhamnopyranosyl-4-O-p-hydroxyphenylacetyl-6-O-caffeoyl-ß-D-glucopyranoside and 2-(3',4'-dihydroxyphenyl) ethyl-3-O-α-L-rhamnopyranosyl-4-O-piperidine-3-carboxylic acid-6-O-caffeoyl-ß-D-glucopyranoside were isolated from the stem bark of Jacaranda mimosaefolia. In addition, the known compounds lupeol, betulinaldehyde, terminic acid, betulinic acid, maslinic acid, ß-sitosterol glucoside and isoacteoside were isolated and identified.


Assuntos
Bignoniaceae/química , Ácidos Cafeicos/química , Ácidos Cafeicos/isolamento & purificação , Glucosídeos/química , Glicosídeos/química , Glicosídeos/isolamento & purificação , Hemiterpenos/química , Fenóis/química , Casca de Planta/química , Glucosídeos/isolamento & purificação , Hemiterpenos/isolamento & purificação , Espectroscopia de Ressonância Magnética , Fenóis/isolamento & purificação
11.
Bioresour Technol ; 101(22): 8855-8, 2010 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-20621470

RESUMO

The main objective of this paper is to find the optimum operating condition to upgrade the EFB-derived pyrolysis oil (bio-oil) to liquid fuel, mainly gasoline using Taguchi Method. From the analysis that has been done, it is found that the optimum operating condition for heterogeneous catalytic cracking process is at 400 degrees C, 15min of reaction time using 30g of catalyst weight where operating at this condition produced the highest yield of gasoline fraction which is 91.67 wt.%. This observation proves that EFB-derived pyrolysis oil could be upgraded via heterogeneous catalytic cracking to produce gasoline.


Assuntos
Biocombustíveis , Frutas/química , Gasolina , Compostos Orgânicos/química , Catálise , Temperatura Alta , Soluções
12.
Eur J Ophthalmol ; 20(2): 283-9, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-20213619

RESUMO

PURPOSE: We modified the deep anterior lamellar keratoplasty big bubble technique to improve safety and ease of performance. METHODS: We describe a modification of the big bubble technique that involves injecting the air bubble through a peripheral corneal incision 1 mm from the limbus. The incision is made with a limbal relaxing incision knife. This is done before trephination of the recipient cornea, hence the name "early bubble." The goal of this technique is to reduce the risk of intraoperative corneal perforation and to obtain a large air bubble between Descemet membrane and the corneal stroma. We report outcomes of this technique in 21 eyes. RESULTS: At 6 months, 16 eyes showed a best-corrected visual acuity of 20/50; the remaining eyes had a best-corrected visual acuity of 20/80 or better. The postoperative corneal astigmatism was 3.6+/-0.9 diopters at 3 months and 3.15+/-0.67 diopters at 6 months. The rate of conversion to penetrating keratoplasty was 14%. CONCLUSIONS: We found that the "early bubble" technique improved the ease of performance, safety, and predictability of deep anterior lamellar keratoplasty.


Assuntos
Ar , Doenças da Córnea/cirurgia , Transplante de Córnea/métodos , Doenças da Córnea/patologia , Substância Própria , Transplante de Córnea/tendências , Lâmina Limitante Posterior , Seguimentos , Humanos , Injeções , Complicações Intraoperatórias/prevenção & controle , Complicações Pós-Operatórias/prevenção & controle , Técnicas de Sutura , Fatores de Tempo , Resultado do Tratamento , Acuidade Visual
13.
J Ocul Pharmacol Ther ; 25(6): 513-7, 2009 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-19929596

RESUMO

BACKGROUND: We studied the effect of an intracameral bevacizumab injection on the corneal endothelium and iris neovessels (INV). METHODS: Ten eyes were studied in 10 patients with an average age of 52.1 +/- 13.17 years. Patients underwent intracameral bevacizumab injections at a concentration of 1.25 mg/0.05 mL. Intraocular pressure, best-corrected visual acuity, gonioscopy, neovascular membrane extent, anterior segment photography, iris fluorescein angiography, pachymetry, and specular microscopy were recorded preoperatively and postoperatively. RESULTS: The minimum follow-up period was 4 months. INVs started to regress within the first 2 days after the injection and regressed completely by the end of the fourth week. Reduction in INV leakage started 1 week after injection, and resolved in 8 eyes (80%) by the end of the fourth week. Intraocular pressure dropped significantly from 17.8 +/- 4.8 mmHg to 16.6 +/- 2.8 mmHg over 4 weeks. The mean endothelial cell loss was 3.95% +/- 6.78%. CONCLUSIONS: An intracameral bevacizumab injection proved to be safe for corneal endothelial cells.


Assuntos
Inibidores da Angiogênese/farmacologia , Segmento Anterior do Olho/efeitos dos fármacos , Anticorpos Monoclonais/farmacologia , Neovascularização Patológica/tratamento farmacológico , Adolescente , Adulto , Inibidores da Angiogênese/administração & dosagem , Inibidores da Angiogênese/efeitos adversos , Segmento Anterior do Olho/irrigação sanguínea , Anticorpos Monoclonais/administração & dosagem , Anticorpos Monoclonais/efeitos adversos , Anticorpos Monoclonais Humanizados , Bevacizumab , Epitélio Posterior/efeitos dos fármacos , Epitélio Posterior/metabolismo , Feminino , Seguimentos , Humanos , Injeções Intraoculares , Pressão Intraocular/efeitos dos fármacos , Iris/irrigação sanguínea , Iris/efeitos dos fármacos , Masculino , Pessoa de Meia-Idade , Adulto Jovem
14.
Med J Malaysia ; 59(2): 146-52, 2004 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-15559162

RESUMO

Cervical spine injuries such as subluxation and fracture dislocation have long been known to result in severe consequences, as well as the trauma management itself. The injury to the region has been identified as one of the major causes of death in Malaysian motorcyclists involved in road crashes, besides head and chest injuries (Pang, 1999). Despite this, cervical spine injury in motorcyclists is not a well-studied injury, unlike the whiplash injury in motorcar accidents. The present study is a retrospective study on the mechanisms of injury in cervical spine sustained by Malaysian motorcyclists, who were involved in road crash using an established mechanistic classification system. This will serve as an initial step to look at the cervical injuries pattern. The information obtained gives engineer ideas to facilitate design and safety features to reduce injuries. All cervical spine injured motorcyclists admitted to Hospital Kuala Lumpur between January 1, 2000 and December 31, 2001 were included in the present study. Based on the medical notes and radiological investigations (X-rays, CT and MRI scans), the mechanisms of injuries were formulated using the injury mechanics classification. The result shows that flexion of the cervical vertebrae is the most common vertebral kinematics in causing injury to motorcyclists. This indicates that the cervical vertebrae sustained a high-energy loading at flexion movement in road crash, and exceeded its tolerance level. The high frequency of injury at the C5 vertebra, C6 vertebra and C5-C6 intervertebral space are recorded. Classification based on the Abbreviated Injury Scale (AIS) is made to give a view on injury severity, 9.1% of the study samples have been classified as AIS code 1, 51.5% with AIS 2 and 21.2% with AIS 3.


Assuntos
Acidentes de Trânsito/estatística & dados numéricos , Vértebras Cervicais/lesões , Motocicletas , Traumatismos da Coluna Vertebral/epidemiologia , Escala Resumida de Ferimentos , Adolescente , Adulto , Diagnóstico por Imagem , Feminino , Humanos , Malásia/epidemiologia , Masculino , Estudos Retrospectivos , Fatores de Risco , Traumatismos da Coluna Vertebral/diagnóstico , Traumatismos da Coluna Vertebral/fisiopatologia
15.
J Refract Surg ; 19(5): 516-27, 2003.
Artigo em Inglês | MEDLINE | ID: mdl-14518740

RESUMO

PURPOSE: To assess whether topography-driven laser in situ keratomileusis (LASIK) can correct induced corneal irregular astigmatism. METHODS: A prospective non-comparative case series of 41 eyes (38 patients) with irregular astigmatism following corneal refractive surgery, included two groups: Group 1 (26 eyes) with a defined topographic pattern and Group 2 (15 eyes) with no pattern. Ablation was performed using the Technolas 217C excimer laser with a software ablation program (TOPOLINK) based on corneal topography. Uncorrected and best spectacle-corrected visual acuity, manifest and cycloplegic refraction, corneal topography, superficial corneal surface quality, and image distortion were measured. RESULTS: At 6 months follow-up in Group 1 eyes (defined topographic pattern) mean preoperative BSCVA improved from 0.16 +/- 0.11 LogMAR (0.4 to 0) to 0.09 +/- 0.10 LogMAR (0.2 to 0) (P = .001) (safety index of 1.1). In Group 2 eyes (no pattern), mean preoperative BSCVA was 0.18 +/- 0.11 LogMAR (0.4 to 0), similar to the postoperative BSCVA of 0.17 +/- 0.10 LogMAR (0.3 to 0) (safety index of 0.98). Mean postoperative UCVA was > or = 0.3 LogMAR in 25 eyes (96.2%) in Group 1 (efficacy index of 0.8) and 7 eyes (46.6%) in Group 2 (efficacy index of 0.5). Both superficial corneal surface quality and image distortion significantly improved in Group 1; there were no significant changes in Group 2. We reoperated nine eyes (21.9%). CONCLUSIONS: Topographic-assisted LASIK was helpful in selected cases where irregular astigmatism showed a pattern. It was ineffective in undefined irregular astigmatism. Partial correction of the irregularity and regression of the obtained effect was common.


Assuntos
Astigmatismo/cirurgia , Substância Própria/cirurgia , Topografia da Córnea/métodos , Ceratomileuse Assistida por Excimer Laser In Situ/métodos , Adulto , Substância Própria/patologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias , Estudos Prospectivos , Refração Ocular/fisiologia , Reoperação , Segurança , Resultado do Tratamento , Acuidade Visual/fisiologia
16.
J Refract Surg ; 18(6): 697-707, 2002.
Artigo em Inglês | MEDLINE | ID: mdl-12458863

RESUMO

PURPOSE: To evaluate the efficacy, predictability, and safety of the Artisan iris claw phakic intraocular lens for the correction of high primary and secondary hyperopia. METHODS: Fifty-seven eyes were divided into two groups: 29 eyes had primary hyperopia (mean refraction 6.06 +/- 1.26 D, and 28 eyes had secondary hyperopia, (mean refraction 5.88 +/- 1.88 D) induced or residual following a previous corneal refractive procedure. Consecutive implantation of the Artisan iris claw phakic intraocular lens was performed. Main outcome measures recorded were BSCVA, UCVA, refraction, and astigmatic change, intraocular inflammation, and endothelial cell loss. RESULTS: Primary hyperopic group: Preoperatively, mean UCVA was 0.4 +/- 0.7 and mean BSCVA was 0.2 +/- 0.6. After implantation, mean UCVA was 0.3 +/- 0.6 and BSCVA was 0.1 +/- 0.6. Mean cycloplegic residual spherical refractive error after surgery was 0.10 +/- 0.57 D (range -1 to +2 D). Mean surgically induced astigmatism was 1.48 +/- 0.89 D. Safety index was 1.11. Efficacy index was 0.83. Secondary hyperopic group: Preoperatively, mean UCVA was 0.5 +/- 0.7 and mean BSCVA was 0.2 +/- 0.6. Postoperatively, mean UCVA was 0.4 +/- 0.7 and mean BSCVA was 0.2 +/- 0.6. Mean cycloplegic residual spherical refractive error was 0.55 +/- 1.49 D. Mean surgically induced astigmatism was 1.85 +/- 1.19 D. Safety index was 1.05. Efficacy index was 0.7. Postoperative iridocyclitis was observed in one eye (3.4%) in the primary group and in three eyes (10.7%) in the secondary group. Overall corneal endothelial cell loss at 1 year of follow-up was 9.4%. CONCLUSION: The Artisan iris claw phakic intraocular lens was reasonably safe and predictable for correcting high hyperopia.


Assuntos
Hiperopia/etiologia , Hiperopia/cirurgia , Procedimentos Cirúrgicos Oftalmológicos/efeitos adversos , Procedimentos Cirúrgicos Refrativos , Adulto , Astigmatismo/etiologia , Astigmatismo/fisiopatologia , Contagem de Células , Epitélio Posterior/patologia , Migração de Corpo Estranho/fisiopatologia , Humanos , Pressão Intraocular , Iridociclite/etiologia , Iridociclite/patologia , Implante de Lente Intraocular/efeitos adversos , Implante de Lente Intraocular/instrumentação , Lentes Intraoculares , Pessoa de Meia-Idade , Pupila , Refração Ocular , Segurança , Espalhamento de Radiação , Resultado do Tratamento , Acuidade Visual
17.
J Cataract Refract Surg ; 28(1): 67-75, 2002 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-11777712

RESUMO

PURPOSE: To evaluate anterior chamber phacoemulsification as an alternative to an endocapsular procedure. SETTING: Instituto Oftalmológico de Alicante, Alicante, Spain. METHODS: In this prospective randomized masked clinical trial, 60 eyes of 30 patients had cataract extraction by phacoemulsification. A conventional stop-and-chop technique was used in 30 eyes; the other 30 had surgery by the phaco-out technique in which the nucleus was prolapsed into the anterior chamber using extensive hydrodissection. Copious sodium hyaluronate 3.0%-chondroitin sulfate 4.0% (Viscoat) and hydroxypropyl methylcellulose were used to protect the cornea and iris. The phaco time and power, postoperative inflammation, corneal edema (clinically and by pachymetry), and endothelial cell count between groups preoperatively and postoperatively were compared. All patients completed a 3-month follow-up. Postoperative examinations were at 3 days, 2 weeks, and 1 and 3 months. RESULTS: The mean nuclear hardness was 2.67 +/- 0.61 (SD) in the stop-and-chop group and 2.65 +/- 0.71 in the phaco-out group. The power-to-time ratio was 18.47 and 18.80, respectively. The mean endothelial cell loss was 11.18% +/- 4.24% in the stop-and-chop group and 11.20% +/- 5.60% in the phaco-out group. There were no significant differences between groups in any parameter (P >.05, independent-sample t test). CONCLUSION: Phacoemulsification in the anterior chamber was as safe as endocapsular phacoemulsification using a stop-and-chop technique. This technique is fast and easier to learn than endocapsular phacoemulsification.


Assuntos
Câmara Anterior/cirurgia , Facoemulsificação/métodos , Idoso , Idoso de 80 Anos ou mais , Contagem de Células , Epitélio Posterior/patologia , Feminino , Humanos , Pressão Intraocular , Implante de Lente Intraocular , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Segurança , Fatores de Tempo , Resultado do Tratamento , Acuidade Visual
19.
Gastroenterology ; 121(4): 792-8, 2001 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-11606492

RESUMO

BACKGROUND & AIMS: In developing countries where Helicobacter pylori infection is widespread, posttherapeutic recurrence rates may be high. Many of the limited studies available have methodological problems and show varied recurrence rates. We determined late recrudescence rates, true reinfection, and ulcer recurrence. METHODS: One hundred five Bangladeshi patients with H. pylori infection and duodenal ulcer disease were treated with a triple therapy. Follow-up included 13C-urea breath tests, endoscopy, and biopsy-based tests. In reinfected patients, genomic typing compared pretherapeutic and posttherapeutic strains. RESULTS: Recrudescence, associated with nitroimidazole-based treatment, occurred in 15 of 105 patients (14%) within the first 3 months, but only 8 of 105 patients tested positive 4 weeks after therapy ended. True reinfection was diagnosed in 11 of 105 patients between 3 and 18 months after therapy. The annual reinfection rate was 13%, based on a total follow-up of 84.7 patient years. Ulcer relapse occurred in 2 of 15 (13%) recrudescence cases and in 6 of 11 (55%) reinfection cases, but also in 4 of 73 (5%) H. pylori-negative patients. CONCLUSIONS: In Bangladesh, late recrudescence of H. pylori after eradication therapy occurs within the first 3 months. The reinfection rate is high and might influence cost-benefit analyses for determining diagnostic and therapeutic procedures.


Assuntos
Antiulcerosos/uso terapêutico , Países em Desenvolvimento , Infecções por Helicobacter/fisiopatologia , Helicobacter pylori , Compostos Organometálicos/uso terapêutico , Ureia/análise , Adulto , Amoxicilina/uso terapêutico , Bangladesh/etnologia , Índice de Massa Corporal , Testes Respiratórios , Isótopos de Carbono , Feminino , Seguimentos , Infecções por Helicobacter/tratamento farmacológico , Infecções por Helicobacter/patologia , Humanos , Masculino , Metronidazol/uso terapêutico , Omeprazol/uso terapêutico , Cooperação do Paciente , Úlcera Péptica/epidemiologia , Ranitidina/uso terapêutico , Recidiva , Tinidazol/uso terapêutico
20.
Med J Malaysia ; 56(1): 77-81, 2001 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-11503301

RESUMO

Lower limb injuries are the main cause of temporary and permanent disability among motorcyclists in Malaysia. They cause non-fatal but serious injuries requiring hospitalisation. Detailed studies on factors influencing lower limb injuries are justified in an attempt to reduce the occurrence of these injuries. This study presents a computer simulation of the crash behaviour of the basket of a small-engined motorcycle with the lower limb using finite element (FE) methods. The results suggest that the extensive deformation of the motorcycle basket may reduce the risk of injury to the lower limb. The behaviour of the basket during collision is analogous to the crumple zone of automobiles.


Assuntos
Acidentes de Trânsito , Traumatismos da Perna/etiologia , Motocicletas , Humanos
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