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1.
J Parasit Dis ; 45(1): 252-257, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-33746411

RESUMO

Nematodes of the Ancylostomidae family consist of important parasitic species. The control of such parasitosis represents an important challenge, given the constant high rate of reinfection of some hosts, among which the domestic dog, as well as the high environmental contamination. Another factor that can have a negative influence is the toxicity of the chemicals used for environmental decontamination, highlighting the need to design research to identify new control strategies for this parasitosis, among which the use of plant extracts. Thus, the objective of this research was to evaluate the toxicity and ovicidal activity of hydroalcoholic extracts obtained by percolation of three plants: Tagetes minuta L., Euphorbia milli var splendens (Bojer ex Hook.) Ursch & Leandri and Synadenium carinatum Boiss, against Ancylostoma spp. In addition, these extracts were tested at different concentrations for toxicity against Artemia salina L. and Allium cepa L. It was observed that the hydroalcoholic extract of all plant species evaluated induced moderate ovicide activity at all the tested concentration, with emphasis on E. milii, which was the only plant species that presented significantly low toxicity in the concentration of 12.5 µL/mL when compared to the other species evaluated.

2.
J Nat Prod ; 80(12): 3120-3127, 2017 12 22.
Artigo em Inglês | MEDLINE | ID: mdl-29182338

RESUMO

Twelve new furanocassane diterpenoids, sucupiranins A-L (1-12), and three known compounds (13-15) were isolated from the seeds of Bowdichia virgilioides. The structures of the compounds were elucidated via 1H and 13C NMR analysis, including 2D NMR (1H-1H COSY, HSQC, HMBC, and NOESY); HRMS data; and X-ray crystallographic analysis. The absolute configurations were defined using their electronic circular dichroism (ECD) spectra by applying the exciton chirality method to the bis-p-bromobenzoate of compound 13. Sucupiranin J (10) inhibited lipopolysaccharide-induced nitric oxide production (IC50 30.6 µM), whereas sucupiranins J (10), K (11), and 13 exhibited weak antimalarial activity against Plasmodium falciparum K1 with IC50 values of 32.2, 23.5, and 22.9 µM and selectivity indices of 4.3, 1.9, and >12.0 (MRC-5/K1), respectively.


Assuntos
Diterpenos/química , Fabaceae/química , Sementes/química , Antimaláricos/química , Antimaláricos/farmacologia , Cristalografia por Raios X/métodos , Diterpenos/farmacologia , Lipopolissacarídeos/farmacologia , Espectroscopia de Ressonância Magnética/métodos , Óxido Nítrico/metabolismo , Plasmodium falciparum/efeitos dos fármacos
3.
Artigo em Inglês | MEDLINE | ID: mdl-26075002

RESUMO

Hebanthe paniculata roots (formerly Pfaffia paniculata and popularly known as Brazilian ginseng) show antineoplastic, chemopreventive, and antiproliferative properties. Functional properties of these roots and their extracts are usually attributed to the pfaffosidic fraction, which is composed mainly by pfaffosides A-F. However, the therapeutic potential of this fraction in cancer cells is not yet entirely understood. This study aimed to analyze the antitumoral effects of the purified pfaffosidic fraction or saponinic fraction on the human hepatocellular carcinoma HepG2 cell line. Cellular viability, proliferation, and apoptosis were evaluated, respectively, by MTT assay, BrdU incorporation, activated caspase-3 immunocytochemistry, and DNA fragmentation assay. Cell cycle was analyzed by flow cytometry and the cell cycle-related proteins were analyzed by quantitative PCR and Western blot. The cells exposed to pfaffosidic fraction had reduced viability and cellular growth, induced G2/M at 48 h or S at 72 h arrest, and increased sub-G1 cell population via cyclin E downregulation, p27(KIP1) overexpression, and caspase-3-induced apoptosis, without affecting the DNA integrity. Antitumoral effects of pfaffosidic fraction from H. paniculata in HepG2 cells originated by multimechanisms of action might be associated with cell cycle arrest in the S phase, by CDK2 and cyclin E downregulation and p27(KIP1) overexpression, besides induction of apoptosis through caspase-3 activation.

4.
Rev. patol. trop ; 42(2): 209-216, abr.-jun. 2013. tab
Artigo em Português | LILACS | ID: lil-696200

RESUMO

Diversos inquéritos coproparasitológicos têm destacado Ancylostoma spp. como sendo a espéciede helmintos que mais frequentemente parasita o cão doméstico, podendo gerar uma série de danos ao hospedeiro como irritabilidade, anorexia, anemia severa e morte. Os ancilostomídeossão enteroparasitos que desenvolvem uma parte do seu ciclo de vida no solo, tratando-se de um curto período de maturação de ovos e eclosão e evolução de larvas. É fundamental que esses doisprocessos ocorram para que o parasito possa evoluir para a fase infectante em seus hospedeiros. No presente trabalho, objetivou-se avaliar, in vitro, a propriedade ovicida e larvicida de extratos vegetais de plantas tóxicas coletadas na região do Vale Paraíba ante a Ancylostoma spp. Foramobtidos extratos hidroalcoólicos de dez plantas pelo método de Soxhlet, que foram concentrados por evaporação do solvente, sendo a concentração final do extrato ajustada para 10por cento do extrato bruto. Amostras fecais de cães naturalmente infectados foram utilizadas, das quais foram purificadosovos de ancilostomídeos e, em paralelo, procedeu-se à cultura de larvas pelo método de Harada-Mori. Das plantas avaliadas, quatro apresentaram resultados promissores: Allamanda cathartica L. (Apocynaceae), Nerium oleander L. (Apocynaceae), Mirabilis jalapa L. (Nyctaginaceae) e Brugmansia suaveolens Willd. (Solanaceae). Merecem destaque as duas últimas, pois apresentaram 100por cento de atividade larvicida na diluição de 12,5mg/mL, demonstrando, desse modo, o potencial da aplicabilidade destes extratos na descontaminação ambiental no que diz respeito ao controle de larvas de Ancylostoma spp.


Assuntos
Animais , Cães , Ancylostoma/parasitologia , Poluição Ambiental , Extratos Vegetais/classificação , Inseticidas , Larvicidas
5.
J Appl Oral Sci ; 19(5): 476-82, 2011 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-21986652

RESUMO

OBJECTIVE: The objective of this study was to compare the antimicrobial effect of mouthwashes containing Calendula officinalis L., Camellia sinensis (L.) Kuntze and 0.12% chlorhexidine digluconate on the adherence of microorganisms to suture materials after extraction of unerupted third molars. MATERIAL AND METHODS: Eighteen patients with unerupted maxillary third molars indicated for extraction were selected (n=6 per mouthwash). First, the patients were subjected to extraction of the left tooth and instructed not to use any type of antiseptic solution at the site of surgery (control group). After 15 days, the right tooth was extracted and the patients were instructed to use the Calendula officinalis, Camellia sinensis or chlorhexidine mouthwash during 1 week (experimental group). For each surgery, the sutures were removed on postoperative day 7 and placed in sterile phosphate-buffered saline. Next, serial dilutions were prepared and seeded onto different culture media for the growth of the following microorganisms: blood agar for total microorganism growth; Mitis Salivarius bacitracin sucrose agar for mutans group streptococci; mannitol agar for Staphylococcus spp.; MacConkey agar for enterobacteria and Pseudomonas spp., and Sabouraud dextrose agar containing chloramphenicol for Candida spp. The plates were incubated during 24-48 h at 37ºC for microorganism count (CFU/mL). RESULTS: The three mouthwashes tested reduced the number of microorganisms adhered to the sutures compared to the control group. However, significant differences between the control and experimental groups were only observed for the mouthwash containing 0.12% chlorhexidine digluconate. CONCLUSIONS: Calendula officinalis L. and Camellia sinensis (L.) Kuntze presented antimicrobial activity against the adherence of microorganisms to sutures but were not as efficient as chlorhexidine digluconate.


Assuntos
Anti-Infecciosos/farmacologia , Calendula , Camellia sinensis , Clorexidina/farmacologia , Antissépticos Bucais/farmacologia , Suturas/microbiologia , Adolescente , Adulto , Aderência Bacteriana/efeitos dos fármacos , Candida/efeitos dos fármacos , Contagem de Colônia Microbiana , Humanos , Dente Serotino/cirurgia , Fitoterapia/métodos , Extratos Vegetais/farmacologia , Fatores de Tempo , Extração Dentária , Adulto Jovem
6.
J. appl. oral sci ; 19(5): 476-482, Sept.-Oct. 2011. ilus, tab
Artigo em Inglês | LILACS | ID: lil-600848

RESUMO

OBJECTIVE: The objective of this study was to compare the antimicrobial effect of mouthwashes containing Calendula officinalis L., Camellia sinensis (L.) Kuntze and 0.12 percent chlorhexidine digluconate on the adherence of microorganisms to suture materials after extraction of unerupted third molars. MATERIAL AND METHODS: Eighteen patients with unerupted maxillary third molars indicated for extraction were selected (n=6 per mouthwash). First, the patients were subjected to extraction of the left tooth and instructed not to use any type of antiseptic solution at the site of surgery (control group). After 15 days, the right tooth was extracted and the patients were instructed to use the Calendula officinalis, Camellia sinensis or chlorhexidine mouthwash during 1 week (experimental group). For each surgery, the sutures were removed on postoperative day 7 and placed in sterile phosphate-buffered saline. Next, serial dilutions were prepared and seeded onto different culture media for the growth of the following microorganisms: blood agar for total microorganism growth; Mitis Salivarius bacitracin sucrose agar for mutans group streptococci; mannitol agar for Staphylococcus spp.; MacConkey agar for enterobacteria and Pseudomonas spp., and Sabouraud dextrose agar containing chloramphenicol for Candida spp. The plates were incubated during 24-48 h at 37ºC for microorganism count (CFU/mL). RESULTS: The three mouthwashes tested reduced the number of microorganisms adhered to the sutures compared to the control group. However, significant differences between the control and experimental groups were only observed for the mouthwash containing 0.12 percent chlorhexidine digluconate. CONCLUSIONS: Calendula officinalis L. and Camellia sinensis (L.) Kuntze presented antimicrobial activity against the adherence of microorganisms to sutures but were not as efficient as chlorhexidine digluconate.


Assuntos
Adolescente , Adulto , Humanos , Adulto Jovem , Anti-Infecciosos/farmacologia , Calendula , Camellia sinensis , Clorexidina/farmacologia , Antissépticos Bucais/farmacologia , Suturas/microbiologia , Aderência Bacteriana/efeitos dos fármacos , Contagem de Colônia Microbiana , Candida/efeitos dos fármacos , Dente Serotino/cirurgia , Fitoterapia/métodos , Extratos Vegetais/farmacologia , Fatores de Tempo , Extração Dentária
7.
Braz. arch. biol. technol ; 53(3): 609-613, May-June 2010. graf, tab
Artigo em Inglês | LILACS-Express | LILACS | ID: lil-548581

RESUMO

This study aimed to investigate the effects of the administration of butanolic residue (BR) of Pfaffia paniculata by intraperitoneal route to Ehrlich ascitis tumor bearing mice. Initially, a toxicity study of P. paniculata BR was performed in which doses of 12.5; 25 and 50mg/Kg were administered by intraperitoneal injection for seven days to Swiss mice. The treatment did not show toxicity. Then, Swiss male mice received, by intraperitoneal injection, once a day, 12.5; 25 or 50mg/Kg of P. paniculata BR for seven days. This protocol started in the same day of tumor inoculation with 5X10(6) cells i.p. The treatment with butanolic residue of P.paniculata i.p caused a significant increase in the ascitic volume; however, a significant decrease in tumor cells number per ml (p<0.05) was observed in P. paniculata treated mice that was followed by a numerical (although non-significant) decrease in the total numbers of tumor cells in the collected ascitic fluid. These results indicated a tumor cell inhibitory effect by P. paniculata butanolic residue in this experimental system, and indicate that topical application of this residue can be useful to control the cancer growth.


Neste estudo, foi avaliado o efeito do tratamento intraperitoneal com Resíduo Butanólico de Pfaffia paniculata, sobre o crescimento do Tumor de Ehrlich, forma ascítica. Foram utilizados dois grupos de 15 camundongos cada, sendo um grupo controle e o outro grupo tratado com RB 50mg/Kg. Todos os animais foram inoculados intraperitonealmente, com 5X10(6) células tumorais O tratamento iniciou-se no mesmo dia da inoculação do tumor. Assim, os animais receberam diariamente, por via intraperitoneal, 0,1 ml de RB na concentrações 50 mg/Kg, ou PBS como controle. Após 7 dias da inoculação do tumor, os animais foram eutanasiados e foi colhido o fluído ascítico total, para a contagem do número de células tumorais presentes neste fluído e estudo da morfologia destas células . Neste experimento observou-se aumento significante da quantidade de fluido ascítico nos animais tratados com RB, e diminuição significativa em relação ao número de células tumorais/ml e células tumorais totais, presentes no fluído ascítico, comparativamente com os animais controle. Estes resultados sugerem efeito inibitório tópico do RB levando à morte as células neoplásicas.

8.
Exp Toxicol Pathol ; 62(2): 145-55, 2010 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-19427770

RESUMO

Pfaffia paniculata (Brazilian ginseng) roots and/or its extracts have shown anti-neoplastic, chemopreventive, and anti-angiogenic properties. The aim of this work was to investigate the chemopreventive mechanisms of this root in mice submitted to the infant model of hepatocarcinogenesis, evaluating the effects on cellular proliferation, apoptosis, and intercellular communication. Fifteen-day-old BALB/c male mice were given, i.p., 10mug/g of the carcinogen N-nitrosodiethylamine (DEN). Animals were separated into three groups at weaning and were given different concentrations of powdered P. paniculata root (0%, 2%, or 10%) added to commercial food for 27 weeks. Control group (CT) was not exposed to the carcinogen and was given ration without the root. After euthanasia, the animals' liver and body weight were measured. Liver fragments were sampled to study intercellular communication, molecular biology, and histopathological analysis. Cellular proliferation was evaluated by immunohistochemistry for PCNA, apoptosis was evaluated by apoptotic bodies count and alkaline comet technique, and intercellular communication by diffusion of lucifer yellow dye, immunofluorescence, western blot and real-time PCR for connexins 26 and 32. Chronic treatment with powdered P. paniculata root reduced cellular proliferation and increased apoptosis in the 2% group. Animals in the 10% group had an increase in apoptosis with chronic inflammatory process. Intercellular communication showed no alterations in any of the groups analyzed. These results indicate that chemopreventive effects of P. paniculata are related to the control of cellular proliferation and apoptosis, but not to cell communication and/or connexin expression, and are directly influenced by the root concentration.


Assuntos
Amaranthaceae/química , Apoptose/efeitos dos fármacos , Comunicação Celular/efeitos dos fármacos , Proliferação de Células/efeitos dos fármacos , Neoplasias Hepáticas Experimentais/prevenção & controle , Extratos Vegetais/farmacologia , Animais , Anticarcinógenos/farmacologia , Western Blotting , Ensaio Cometa , Conexinas/efeitos dos fármacos , Imunofluorescência , Imuno-Histoquímica , Neoplasias Hepáticas Experimentais/patologia , Masculino , Camundongos , Camundongos Endogâmicos BALB C , Fitoterapia/métodos , Raízes de Plantas/química , Reação em Cadeia da Polimerase Via Transcriptase Reversa
9.
Exp Toxicol Pathol ; 61(1): 75-82, 2009 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-18485683

RESUMO

Roots of Pfaffia paniculata have been well documented for multifarious therapeutic values and have also been used for cancer therapy in folk medicine. This study has been performed in a human breast tumor cell line, the MCF-7 cells. These are the most commonly used model of estrogen-positive breast cancer, and it has been originally established in 1973 at the Michigan Cancer Foundation from a pleural effusion taken from a woman with metastatic breast cancer. Butanolic extract of the roots of P. paniculata showed cytotoxic effect MCF-7 cell line, as determined with crystal violet assay, cellular death with acridine orange/ethidium bromide staining, and cell proliferation with immunocytochemistry of bromodeoxyuridine (BrdU). Subcellular alterations were evaluated by electron microscopy. Cells treated with butanolic extract showed degeneration of cytoplasmic components and profound morphological and nuclear alterations. The results show that this butanolic extract indeed presents cytotoxic substances, and its fractions merit further investigations.


Assuntos
Amaranthaceae , Neoplasias da Mama/ultraestrutura , Fitoterapia/métodos , Extratos Vegetais/farmacologia , Amaranthaceae/química , Bromodesoxiuridina , Butanóis , Linhagem Celular Tumoral , Proliferação de Células/efeitos dos fármacos , Feminino , Humanos , Imuno-Histoquímica , Microscopia Eletrônica de Transmissão , Raízes de Plantas/química
10.
Exp Toxicol Pathol ; 58(6): 427-31, 2007 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-17481871

RESUMO

Pfaffia paniculata (Brazilian ginseng) roots have been indicated for the treatment of several diseases. Our studies have shown that P. paniculata roots present antineoplastic effects and cancer chemopreventive activity in a mouse hepatocarcinogenesis model. The purpose of this study was to investigate the effects of the Brazilian ginseng on corneal angiogenesis in mice. We first conducted a toxicological study employing 250, 500, or 1000mg/kg/day of the methanolic extract of P. paniculata roots by gavage to BALB/c mice. Animals did not lose weight during the treatment nor presented histopathological alterations. The effect of this root on angiogenesis in the cornea of BALB/c mice was then assessed. Male mice were treated, by gavage, once a day, with doses of 250, 500, or 1000mg/kg of methanolic extract of P. paniculata powdered root for 10 days; filtered water was used as control. Corneal cauterization was accomplished by the contact of a silver nitrate crystal on the central area of the cornea, in the 5th day of treatment with P. paniculata, which continued thereafter; the animals were euthanized on the 6th day after cauterization. Newly formed blood vessels were filled with India ink, and the corneas were routinely processed. Blood vessels were quantified in an image analysis system. A smaller total area of neovascularization in the mouse cornea was observed in animals treated with 1000mg/kg of the methanolic extract of P. paniculata. These results indicate an antiangiogenic effect of this extract. The mechanisms of this antiangiogenic activity of P. paniculata should be further investigated.


Assuntos
Amaranthaceae/química , Inibidores da Angiogênese/uso terapêutico , Córnea/irrigação sanguínea , Neovascularização da Córnea/tratamento farmacológico , Panax , Extratos Vegetais/uso terapêutico , Administração Oral , Animais , Peso Corporal/efeitos dos fármacos , Cauterização/efeitos adversos , Neovascularização da Córnea/patologia , Relação Dose-Resposta a Droga , Masculino , Metanol/química , Camundongos , Camundongos Endogâmicos BALB C , Raízes de Plantas/química , Testes de Toxicidade
11.
Cancer Lett ; 238(1): 85-9, 2006 Jul 08.
Artigo em Inglês | MEDLINE | ID: mdl-16051424

RESUMO

We have previously reported a reduction in the accumulation of ascitic fluid in Ehrlich tumor-bearing mice following treatment with the powdered roots of Pfaffia paniculata. The aim of this study was to investigate which extracts from these roots presented antineoplastic properties. Thus, the effects of the ethanolic extract, butanolic residue, or aqueous residue from Pfaffia paniculata on animal survival and tumor growth in mice bearing this tumor were studied. Butanolic residue-treated mice survived longer than untreated mice. This result points to an antineoplastic effect exerted by the butanolic fraction from the roots of P. paniculata on this tumor model.


Assuntos
Amaranthaceae/química , Antineoplásicos Fitogênicos/uso terapêutico , Butanóis/química , Carcinoma de Ehrlich/tratamento farmacológico , Animais , Antineoplásicos Fitogênicos/química , Modelos Animais de Doenças , Ensaios de Seleção de Medicamentos Antitumorais , Etanol/química , Masculino , Camundongos , Transplante de Neoplasias , Extratos Vegetais/química , Extratos Vegetais/uso terapêutico , Raízes de Plantas/química , Solventes/química , Taxa de Sobrevida , Água/química
12.
Life Sci ; 78(12): 1287-92, 2006 Feb 16.
Artigo em Inglês | MEDLINE | ID: mdl-16214177

RESUMO

The roots of Pfaffia paniculata (Brazilian ginseng) have been indicated for the treatment of several diseases and as an analgesic and antiinflamatory drug. Treatment of mice with 200 mg/kg of the powdered root of P. paniculata reduced the Ehrlich ascitic volume [Matsuzaki, P., Akisue, G., Salgado Oloris, S.C., Gorniak, S.L., Zaidan Dagli, M.L., 2003. Effect of Pffafia paniculata (Brazilian ginseng) on the Ehrlich tumor on its ascitic form. Life Sciences, Dec 19; 74 (5), 573-579.]. One of the putative means to control the Ehrlich tumor growth is by increasing macrophage activity [Kleeb, S.R., Xavier, J.G., Frussa-Filho, R., Dagli, M.L.Z., 1997. Effect of haloperidol on the development of the solid Ehrlich tumor in mice. Life Sciences, 60 (4/5), 69-742.]. The aim of this study was to investigate experimentally the effects of the methanolic extract of P. paniculata roots on macrophage activity. Male mice received, by gavage, once a day, different doses (100, 250, or 500 mg/kg) of the methanolic extract of P. paniculata or filtered water, as control, for 10 days. Macrophage activity was evaluated through the phagocytosis index (PI), spreading index (SI), production of peroxide oxigen and nitric oxide. The peritoneal cells were activated with ip inoculation of Ehrlich ascitic cells, 24 h before the macrophage harvesting. The methanolic extract raised significantly the SI of mice from group of 500 mg/kg in comparison with the control group and group of 100 mg/kg. This raise of SI possibly induced the higher phagocytic activity observed in the experimental situation. Increased macrophage activity may be one of the effects contributing to inhibition of the Ehrlich ascitic tumor growth in mice.


Assuntos
Amaranthaceae , Carcinoma de Ehrlich/tratamento farmacológico , Macrófagos/fisiologia , Extratos Vegetais/uso terapêutico , Animais , Antineoplásicos/uso terapêutico , Carcinoma de Ehrlich/patologia , Divisão Celular/efeitos dos fármacos , Relação Dose-Resposta a Droga , Macrófagos/efeitos dos fármacos , Metanol , Camundongos , Camundongos Endogâmicos BALB C , Fitoterapia , Raízes de Plantas
13.
Cancer Lett ; 226(2): 107-13, 2005 Aug 26.
Artigo em Inglês | MEDLINE | ID: mdl-16039950

RESUMO

Studies have been demonstrating Pfaffia paniculata root (Brazilian ginseng) anticarcinogenic activities. We evaluated its chemopreventive effects on preneoplastic hepatic lesions. BALB/c aged-15 days received 10mug/g of diethylnitrosamine carcinogen, i.p. They were fed with the powdered root added to the diet: 0.5, 2 or 10% during 27 weeks. After being sacrificed, the macroscopic lesions in the livers were examined. Preneoplastic or neoplastic lesions were measured, quantified and classified morphologically. The treatment reduced the incidence, mean area and number of lesions, indicating an inhibitory effect of these roots on hepatocarcinogenesis promotion or progression steps.


Assuntos
Adenoma/prevenção & controle , Amaranthaceae , Neoplasias Hepáticas/prevenção & controle , Fitoterapia , Preparações de Plantas/uso terapêutico , Lesões Pré-Cancerosas/prevenção & controle , Adenoma/induzido quimicamente , Alquilantes/toxicidade , Animais , Dietilnitrosamina/toxicidade , Modelos Animais de Doenças , Feminino , Neoplasias Hepáticas/induzido quimicamente , Masculino , Camundongos , Camundongos Endogâmicos BALB C
14.
Life Sci ; 74(5): 573-9, 2003 Dec 19.
Artigo em Inglês | MEDLINE | ID: mdl-14623028

RESUMO

The roots of Pfaffia paniculata (Brazilian ginseng) have been indicated for the treatment of several diseases, among which the cancer. The purpose of this study was to investigate experimentally the possible antineoplastic effect of this root. Firstly, a toxicity study was performed in which the doses of 400 and 200 mg/Kg of the powdered root were administered by gavage for 10 days to BALB/cICB mice. The mice did not lose weight during the treatment. No increase in serum alanine-aminotransferase neither histopathological alteration (liver, kidney and spleen) was observed in mice treated with P. paniculata. The effect of this root on the ascitic Ehrlich tumor in BALB/cICB mice was then investigated. Male mice received, by gavage, once a day, 200 mg/Kg of the powdered root of P. paniculata or distilled water, as control, for 20 days. This protocol started 10 days before tumor inoculation with 5 x 10(6) cells i.p., and lasted until 10 days after. The ascitic tumor was evaluated by the quantification of the volume of the ascitic fluid, relative number of tumor cells and total number of tumor cells. A decrease in the total ascitic volume was observed in P. paniculata treated mice, that was followed by a numerical decrease in the total number of Ehrlich tumor cells. These results may indicate that P. paniculata anti-inflammatory effects were responsible by the decrease in the total ascitic fluid. In addition, the presence of tumor-cell inhibitory factors in P. paniculata roots is in agreement with other in vitro studies. The mechanisms of such tumor inhibition should be further investigated.


Assuntos
Amaranthaceae/química , Antineoplásicos Fitogênicos/farmacologia , Carcinoma de Ehrlich/tratamento farmacológico , Alanina Transaminase/sangue , Animais , Antineoplásicos Fitogênicos/toxicidade , Peso Corporal/efeitos dos fármacos , Carcinoma de Ehrlich/patologia , Masculino , Camundongos , Camundongos Endogâmicos BALB C , Raízes de Plantas/química
15.
Lecta-USF ; 20(1): 69-76, jan.-jun. 2002. ilus
Artigo em Português | LILACS | ID: lil-357226

RESUMO

Myracrodruon urundeuva Fr.All. é planta conhecida popularmente como aroeira-do-sertão. As cascas do caule empregadas em disenterias e em úlcera gastroduodenais foram estudadas morfológica e anatomicamente. Os dados obtidos facilitam sua indentificação.


Assuntos
Anacardiaceae , Farmacologia , Fitoterapia , Botânica , Estruturas Vegetais
16.
Lecta-USF ; 18(2): 9-32, jul.-dez. 2000. ilus, tab
Artigo em Português | LILACS | ID: lil-299890

RESUMO

Baccharis articulata Pers conhecida popularmente pelo nome de carqueja-doce é planta importante na medicina popular graças a sua fama como digestiva, tônica, afrodisíaca e diurética. Visando subsidiar trabalho de padronização e de indentificação da droga e do extrato fluido com ela elaborados, os autores procederam sua caracterização macroscópica e microscópica bem como a determinação de parâmetros físicos, químicos e cromatográficos. A presença de caule alado de estomato anomoóitico em ambas as faces epidérmicas, de pêlos glandulares dispostos em tufos e de canais esquizógenos ao lado da presença de flavonóides, óleos essenciais, saponinas, taninos e de esteróides constituem características importantes na diagnose da droga e do extrato fluido.


Assuntos
Extratos Vegetais , Plantas Medicinais , Cromatografia , Medicina Herbária , Farmacognosia
17.
Lecta-USF ; 16(2): 111-20, jul.-dez. 1998. tab
Artigo em Português | LILACS | ID: lil-268531

RESUMO

Com o objetivo de se observar a atividade moluscicida para o hospedeiro intermediário de Schistosoma mansoni foi realizado o estudo preliminar dos extratos aquosos a quente e a frio e fluidos de Pipper aduncun L., em caramujos adultos e embriöes de Biompharmalaria glabrata.


Assuntos
Biomphalaria , Extratos Vegetais/metabolismo , Caramujos
18.
Lecta-USF ; 15(1/2): 11-62, jan.-dez. 1997. ilus
Artigo em Português | LILACS | ID: lil-280208

RESUMO

Piper aduncum L. é uma piperácia de grande utilizaçäo na medicina e ampla distribuiçäo no Brasil. É conhecida pelos nomes: Aperta-Ruäo, Aperta-Joäo, Jaborandi do Mato, Pimenta do fruto ganchoso. Entre suas funçöes terapêuticas, é usada popularmente como estimulante hepático e cicatrizante. A planta tem porte arbustivo, com folhas alternas, lanceoladas simples.


Assuntos
Jaborandi/classificação , Medicina Tradicional , Conjuntivite de Inclusão/terapia , Diarreia/terapia , Gonorreia/terapia , Leucorreia/terapia
19.
Lecta-USF ; 14(2): 95-108, jul.-dez. 1996. ilus
Artigo em Português | LILACS | ID: lil-201433

RESUMO

Porophylum ruderale Cass, conhecido vulgarmente por arnica, foi objeto deste estudo no qual foram determinados alguns parâmetros para caracterizar a droga e o seu extrato fluido. Foram feitas análises morfo-histológicas da folha e do caule. Determinou-se o teor de óleo essencial das partes aéreas. Foram realizadas abordagens fitoquímicas da droga e do extrato fluido. O extrato fluido foi submetido à determinaçäo do resíduo seco e cinza. Foram também determinados os constantes físicos e os perfis cromatográficos do óleo essencial.


Assuntos
Arnica/anatomia & histologia , Óleos Vegetais/análise , Extratos Vegetais/química , Folhas de Planta/química , Caules de Planta/química , Cromatografia em Camada Delgada
20.
Lecta-USF ; 14(2): 109-19, jul.-dez. 1996. tab, ilus
Artigo em Português | LILACS | ID: lil-201434

RESUMO

Com o desenvolvimento da Fitoterapia, surgiu a necessidade de bom controle de qualidade da matéria-prima para a elaboraçäo de medicamentos confiáveis. Assim, para a caracterizaçäo do Capim limäo - Cymbopogon citratus (DC) Staph foram estabelecidos alguns parâmetros para padronizaçäo de drogas e extratos fluidos, formas estas muito utilizadas. Determinou-se o teor de óleo essencial mensalmente durante o período de um ano na folha fresca e estabeleceu-se a caracterizaçäo físico-química e cromatográfica correspondente.


Assuntos
Óleos Vegetais/análise , Extratos Vegetais , Folhas de Planta/química , Plantas Medicinais , Cromatografia em Camada Delgada
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