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Chem Biol Interact ; 315: 108885, 2020 Jan 05.
Artigo em Inglês | MEDLINE | ID: mdl-31678112


BACKGROUND: Although more restrictive alcohol control policies (e.g., higher alcohol taxes) are related to lower levels of alcohol consumption, little is known about the relationship between alcohol policies and rates of alcohol-attributable cancer. METHODS: State alcohol policy restrictiveness, as measured by a validated policy scale, were related to state rates of six alcohol attributable cancers in the U.S. from 2006 to 2010 in a lagged, cross-sectional linear regression that controlled for a variety of state-level factors. Cancer mortality rates were from the Center for Disease Control and Prevention's Alcohol-Related Disease Impact application, which uses population-attributable fraction methodology to calculate mortality from cancers of the esophagus, larynx, liver, oropharynx, prostate (male only) and breast (female only). RESULTS: More restrictive state alcohol policies were associated with lower cancer mortality rates for the six cancer types overall (beta [ß] -0.33; 95% confidence interval [CI] -0.59, -0.07), and among men (ß -0.45; 95% CI -0.81, -0.10) and women (ß -0.21; 95% CI -0.40, -0.02). A 10% increase in the restrictiveness of alcohol policies (based on the mean APS among states) was associated with an 8.5% decrease in rates of combined alcohol-attributable cancers. In all analyses stratified by cancer subtype and sex, the associations were in the hypothesized direction (i.e., more restrictive state policy environments were associated with lower rates of alcohol-attributable cancers), with the exception of laryngeal cancer among women. CONCLUSION: Strengthening alcohol policies is a promising prevention strategy for alcohol-related cancer.

Consumo de Bebidas Alcoólicas/efeitos adversos , Etanol/efeitos adversos , Neoplasias/mortalidade , Adulto , Estudos Transversais , Feminino , Humanos , Masculino
Gulf J Oncolog ; 1(29): 22-30, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30956193


INTRODUCTION: Saudi Arabia faces a rapid growth in cancer cases and deaths despite the rapid development and expansion of its healthcare system. No applied national strategies exist, limiting cancer control efforts. Saudi Cancer Registry data lacks cancer specific mortality rates and available data to project the future cancer burden is inadequate. METHODS: This review paper examines the extent which cancer burden will increase by providing an estimate projection of cancer cases and deaths for the year 2025 and 2050. Current cancer burden and gaps are discussed. Saudi population projections were used to predict the burden of cancer types with the highest mortality. Rough estimates of the burden were calculated using incidence and mortality rates adopted from available UK cancer data and population figures from Office for National Statistics. FINDINGS: For most common cancers in Saudi Arabia, it is expected that the number of new cancer cases will reach 151,719 by the year 2025 and 30,718 cancer deaths are expected for the same year. Evidence from other countries' efforts to control cancer demonstrates reduced mortality and points out the substantial need to urgently update cancer control strategy. DISCUSSION AND CONCLUSION: Reviewing current trends in cancer burden in Saudi Arabia and projecting the future burden, especially of breast and colon cancers, proves the need to prioritize cancer control efforts. Planning a multidisciplinary evidence based national cancer control strategy will alleviate the burden and improve cancer outcomes.

Detecção Precoce de Câncer/métodos , Neoplasias/epidemiologia , Feminino , Humanos , Masculino , Arábia Saudita