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1.
Cell Tissue Bank ; 2021 Aug 20.
Artigo em Inglês | MEDLINE | ID: mdl-34415474

RESUMO

To share our experience of establishing a bone bank in Pakistan, and the clinical use of these indigenously produced bone grafts. We retrospectively reviewed our experience of the procurement, processing, and storage of bone grafts at a bone bank in Karachi, Pakistan, the first bone bank to be established in a public sector hospital in Pakistan. The bone bank was established at Sindh Institute of Urology and Transplantation (SIUT), Karachi, in collaboration with Department of Orthopaedic Surgery, Dow University of Health Sciences/Civil Hospital, Karachi (CHK) in May, 2015. Since then, a large number of bone grafts from the tissue bank have been used for various orthopedic procedures. This paper describes the problems and challenges faced in establishing and running a tissue bank in a Muslim and a developing country and the progress of the bone bank over the first 4 years. A total of 93 bone grafts were retrieved and preserved in the bone bank over the 4-year period. Among these, 56 (60.2%) bones were retrieved from male donors and 37 (39.8%) from females. The mean age of all donors was 55.9 ± 15.34 years (range: 16-90 years). All bone donors were living patients. No c bones were obtained from deceased donors. Types of bone grafts included: femoral heads, 68; head with neck of femur, 19; radius and ulna, 1; lower femur, knee joint, lower leg and foot bones, 4; and skull bone, 1. All grafts were subjected to aerobic and anaerobic bacterial cultures, as well as fungal cultures. Microbiological contamination was observed in 18/93 (19.35%). All culture positive bones were discarded. Bone grafts issued from the bank and transplanted were 51/93 (54.8%) in all. Bone grafts were used in a variety of tumor and non-tumor orthopaedic procedures in CHK. Nine bone grafts were donated to the other hospitals to be used for revision total hip replacement and tumor surgeries. There were no service charges. Two patients (3.92%) developed infections postoperatively, one superficial and one deep. No other complications were noted. This is the preliminary report on the establishment and functioning of a bone bank in a public sector hospital in Pakistan. The favorable outcome has inculcated confidence in orthopedic surgeons for greater use of bone allografts for a variety of indications in this country.

2.
J Ayub Med Coll Abbottabad ; 33(2): 315-321, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34137552

RESUMO

BACKGROUND: Osteoarthritis is the most common degenerative disease of the synovial joints in the elderly population with hip osteoarthritis as the second most commonly affected joint. A multitude of conservative treatments is used for pain relief and functional improvement including acetaminophen, NSAID, intra-articular corticosteroid, and viscosupplementation (VS). Different preparations of VS based on different molecular weights are commercially available. No systematic review or meta-analysis regarding the use of intra-articular high molecular weight hyaluronic acid (HMWHA) injection for the hip joint was published before. This review analyzes the efficacy of intra-articular HMWHA for hip osteoarthritis. METHODS: PubMed, Google Scholar, Cochrane Library for randomized trials describing the efficacy of HMWHA for hip osteoarthritis was searched. The search terms were osteoarthritis, hip joint, outcomes, viscosupplementation, and high molecular weight hyaluronic acid in different combinations. Standardized mean difference (SMD) in VAS for pain relief and Lequesne index for functional outcomes while risk ratio (RR) for complications was used for data pooling. RESULTS: Four studies comprising 185 and 189 patients in HMWHA and control groups were included, respectively. SMD for VAS and Lequesne index was -0.056 and -0.114, respectively while RR for complication was 0.879. CONCLUSIONS: Intra-articular HMWHA injection provided pain relief, functional improvement, and no severe complications on immediate short term basis. However, the results do not favor treatment with HMWHA over other treatment methods. Randomized trials are further necessary to provide data regarding comparisons between HMWHA for hip osteoarthritis concerning clinicians' convenience, compliance, duration of relief, and cost-effectiveness.


Assuntos
Ácido Hialurônico/administração & dosagem , Osteoartrite do Quadril/tratamento farmacológico , Viscossuplementos/administração & dosagem , Idoso , Humanos , Ácido Hialurônico/química , Injeções Intra-Articulares , Peso Molecular , Osteoartrite do Quadril/fisiopatologia , Ensaios Clínicos Controlados Aleatórios como Assunto , Resultado do Tratamento , Escala Visual Analógica
3.
Cureus ; 12(9): e10361, 2020 Sep 10.
Artigo em Inglês | MEDLINE | ID: mdl-33062484

RESUMO

Metallosis is a very rare condition that poses a diagnostic challenge. Its precise incidence is not known and the condition should be suspected in patients who present with the clinical signs and symptoms discussed below. In particular, physicians and surgeons should pay special attention to whether metal prosthesis has been used for fracture repair or joint function. Here we report the case of a 40-year-old male who presented at an orthopedic surgery outpatient department in a tertiary care hospital with pain in the right distal thigh that had been ongoing for three months and swelling that had been ongoing for two months. According to the patient, he had received an operation for a right-sided distal femur fracture that was fixed with plate at a different hospital one year prior. Despite receiving all the appropriate physical exams and labs, and getting a radiologic workup, the diagnosis was unclear, and ultimately surgical exploration was conducted, which led to the diagnosis of metallosis. Although metallosis is a well-known complication, due to its rarity, physicians and surgeons often forget to keep metallosis as a differential that leads to diagnostic difficulties.

4.
Cureus ; 12(8): e9741, 2020 Aug 14.
Artigo em Inglês | MEDLINE | ID: mdl-32944456

RESUMO

Background The coronavirus disease 2019 (COVID-19) since the beginning has been a reason of fear among healthcare workers (HCWs) due to the increased mortality, especially in the HCWs themselves. In this survey study, we aimed to explore the predictive factors associated with fear faced by HCWs during the COVID-19 pandemic and to identify the areas which need to be addressed to reduce it. Methods On May 14, 2020, we conducted an observational, cross-sectional survey using a self-administered questionnaire, consisting of the following two parts: (1) focused on factors associated with HCWs' fear of getting an infection and being a source of carrying the infection to whom they care, and (2) focused on factors associated with HCWs' fear of uncertainty and lack of support from concerned health authorities. Results The mean age of the participants was 40.04 ± 12.92 years with 79.3% being males. More than half (51.1%) of the participants were consultants. The most important factors associated with fear included getting infected (84.8%), quarantined (69.6%), not getting medical treatment (62%), losing a life (56.8%), and infecting family members (94.2%). Another major factor associated with HCWs' fear was lack of support from concerned health authorities, 80.2% thought of solatium, and 71.7% believed that the job should be given to eligible family members of the deceased. More than 82.2% were concerned about health expenses and around 97.6% felt an additional health risk allowance should be given. Conclusion Our results indicate that the risk of getting infection to themselves and their families, along with a lack of support from concerned health authorities, was strongly associated with fear among HCWs. We hope through these findings that the concerned health authorities will take notice and do something in this regard by developing appropriate policies and measures to make sure that HCWs and their families are cared for if they get infected.

5.
Cureus ; 12(4): e7737, 2020 Apr 20.
Artigo em Inglês | MEDLINE | ID: mdl-32455057

RESUMO

Introduction Many countries including Pakistan are currently using face masks in their pandemic control plans. Being highly prevalent, the correct use of these masks is particularly important, as an incorrect use and disposal may actually increase the rate of transmission. The purpose of this study was to investigate the knowledge, attitude, and practices of healthcare workers (HCWs) in wearing a surgical face mask to limit the spread of the new coronavirus disease 2019 (COVID-19). Materials and Methods This survey was conducted by interviewing HCWs using a questionnaire consisting of the basic demographic characteristics, and the knowledge, attitude, and practices regarding the use of surgical face mask to limit the new COVID-19 exposure. Each correct answer was scored 1 and each incorrect answer scored 0. The total number of questions was 16, and the final score was calculated and then labeled according to the percentage (out of 16) of correct responses as good (>80%), moderate (60-80%), and poor (<60%). Results A total of 392 participants with a mean age of 42.37 ± 13.34 years (341 males and 51 females) were included in the study. The overall final results were good in 138 (35.2%), moderate in 178 (45.4%), and poor in 76 (19.3%). Around 43.6% of participants knew about the correct method of wearing the masks, 68.9% knew that there are three layers, 53% stated that the middle layer act as a filter media barrier, and 75.5% knew the recommended maximum duration of wearing it. The majority (88.2%) of participants knew that a cloth face mask is not much effective, around 79.8% knew that used face mask cannot be re-used, and 44.8% knew about the yellow-coded bag for disposal. Conclusions Knowledge, attitude, and practice of HCWs regarding the use of face masks were found to be inadequate. Studied HCWs had a positive attitude but moderate-to-poor level of knowledge and practice regarding the use of face mask. HCWs and general public awareness campaigns regarding the proper use of face mask by utilizing all social media available resources would be helpful during this pandemic.

6.
Cureus ; 11(9): e5614, 2019 Sep 10.
Artigo em Inglês | MEDLINE | ID: mdl-31720130

RESUMO

Background Crescent fracture-dislocation of sacroiliac joint is a type of lateral compression pelvic injury associated with instability. These fractures comprise 12% of lateral compression fractures. Objective The objective of this study is to share the experience and to assess the functional outcome of fixation in crescent fracture-dislocation. Methods We analyzed a descriptive case series with clinical data of 15 patients at the Department of Orthopedics Surgery at the Dr. Ruth K.M. Pfau Civil Hospital at Dow University of Health Sciences in Karachi, Pakistan, from January 2016 to August 2018. The patients were treated by closed and open fracture reduction and fixed with percutaneous screws and reconstruction plates. Results A total of 15 patients were included in this study with age ranging from 20 to 60 years (11 men [73%]; four women [27%]). According to the mechanism of injury, five (33%) had motorcycle accidents; four (27%) had collision while sitting in a car; three (20%) were pedestrians hit by a vehicle; four (27%) were injured while sitting in van; two (13%) had bus-related injury, and one (6.5%) presented with a history of wall collapse. Five (33%) patients had type I fractures, seven (47%) had type II fractures, and three (20%) had type III fractures Associated injuries were midshaft femur fracture in two patients, contralateral superior and inferior rami fracture in three patients, and open tibia fracture in one patient. All fractures were fixed with reconstruction plates and screws. Patients were kept as non-weight-bearing on the injured joint for three weeks, mobilized non-weight-bearing on the contralateral leg after three weeks, and partial weight-bearing was started at eight weeks; full weight-bearing was started after three months. Nine patients (60%) had excellent outcomes, three (20%) had a good outcome, and three (20%) had a poor outcome. Conclusion Crescent fracture-dislocations are unstable injuries. These fractures should have proper reduction and fixation that will reduce pain, malunion, and shortening.

7.
Cureus ; 11(6): e4832, 2019 Jun 04.
Artigo em Inglês | MEDLINE | ID: mdl-31403018

RESUMO

Gorham-Stout syndrome (GSS) is a rare disorder of complete bone resorption, characterized by lymphangiomatosis and angiomatosis of bone, with only around 200 cases reported from around the world till date. The diagnosis is made on clinical, radiological, and histopathological findings and exclusion of other common conditions, and treatment is based on the physician's judgment and tailored to the needs of the individual. With the etiology unknown, diagnosis mostly of exclusion, an unpredictable prognosis, and no standardized treatment formed, the disease poses a challenge to physicians in appropriately diagnosing and managing the patient. Herein, we present a case of an otherwise healthy 18-year-old female diagnosed with GSS of humerus following a fracture to her left arm. To our knowledge, this is the first case report of the disorder from Pakistan.

8.
Cureus ; 11(4): e4473, 2019 Apr 16.
Artigo em Inglês | MEDLINE | ID: mdl-31249751

RESUMO

Introduction Motorcycles are common in a developing nation like Pakistan. In addition to their benefits, motorcycles carry a high risk for accident and injury. Many factors can exacerbate the risk of motorcycle operation including the use of mobile phones while riding, a lack of knowledge of traffic rules, not following road rules or non-satisfactory vehicle health and road conditions. Along with these physical factors, some psychosocial aspects also impact risks, including aggressive behavior of drivers or variations in driving patterns associated with changes in driver mood. Objective We conducted this study to determine the association of rider/operator behavioral and psychosocial factors with motor vehicle crashes. Methods We conducted a cross-sectional study on the patients of Civil Hospital in Karachi, Pakistan aged between 15 to 65 years. Data were collected from 150 patients in the outpatient department and emergency room via a questionnaire assessing driver biodata, license details, socioeconomic status, and their behavioral and psychosocial conditions. Inclusion criteria were limited to patients with motorcycle accidents only; patients involved in accidents from any other form of vehicle were excluded. Result Of the 150 patients, 70% were reported varying their driving speed with fluctuating moods, 80% rode aggressively when they have any social or financial issue, and 57% became annoyed with another driver's behavior-all of which highlight the influence of psychosocial factors in motorcycle crashes. Concerning behavioral factors, 88% of drivers were involved in unofficial races, 44% reported overtaking slower drivers, and 80% violated traffic signals on a regular basis. These results suggest that behavioral and psychosocial factors have a major influence on the victims of motorcycle accidents and are an important cause of injury due to crashes. Conclusion Psychosocial and behavior aspects play a critical role in motorcycle accidents. Riders experiencing family-related or social-related stress and those with an aggressive personality are more prone to have a motorcycle accident than riders who do not have those stressors. Additional measures should be taken to raise awareness regarding these important contributing factors, including stress management in driving education.

9.
J Pak Med Assoc ; 69(Suppl 1)(1): S25-S28, 2019 02.
Artigo em Inglês | MEDLINE | ID: mdl-30697014

RESUMO

OBJECTIVE: To assess the Ponsetti technique's effectiveness in the treatment of talipes equinovarus. Methods: The cross-sectional study was conducted from January 2013 to March 2018in Naushehero Feroze disctrict of the province of Sindh, Pakistan, and data was assessed at the Department of Orthopaedic Surgery, Dow University of Health Sciences / Civil Hospital, Karachi. Children with talipes equinovarus were treated with Ponsetti casting. Results: Of the 86 patients, 53(68%) were boys and 33(32%) were girls. There were a total of 111 feet in the study. Once the foot reached neutral, percutaneous tenotomy of tendo achilles was done in 86)85%) of 111 feet. Seven (8%) patients had recurrence because of non-compliance in the maintenance phase. Overall, 17(19.7%) patients were lost to follow-up. Conclusion: Ponsetti casting was found to be a simple, effective and acceptable method of treatment for talipes equinovarus.


Assuntos
Tendão do Calcâneo/cirurgia , Moldes Cirúrgicos , Pé Torto Equinovaro/cirurgia , Órtoses do Pé , Procedimentos Ortopédicos , Tenotomia , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Paquistão , Cooperação do Paciente , Recidiva , Sapatos
10.
J Coll Physicians Surg Pak ; 16(1): 45-8, 2006 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-16441989

RESUMO

OBJECTIVE: To compare the proportion of early postoperative infection in clean orthopedic surgery after single dose of prophylactic antibiotic and multiple doses of prophylactic antibiotic. DESIGN: Interventional quasi-experimental study. PLACE AND DURATION OF STUDY: Department of Orthopedics, Abbasi Shaheed Hospital, Karachi from April 2004 to March 2005. MATERIAL AND METHODS: Two hundred patients of either age and gender, undergoing clean orthopedic surgery were equally divided into two groups A and B. Group A was given single dose of prophylactic antibiotic, while group B was given multiple doses of prophylactic antibiotic. Follow-up period was 28 days. All cases were evaluated for postoperative wound infection. Sampling technique was non-probability convenience. RESULTS: Mean age was 35.51+/-20.79 years in group A and 26.17+/-19.79 years in group B. However, there was a significantly higher proportion of male patients in group B than in group A (p=0.006). Statistical analysis showed no significant difference in the proportion of early postoperative infection cases between the two groups(p=0.270). Staphylococcus aureus was the commonest organism cultured from the wound discharge in our study followed by E. coli. Eight of our cases having postoperative wound infection showed no growth, out of which 7 were superficial and 1 was deep. There was no significant difference between the two groups regarding mean operating time and duration of stay in hospital. CONCLUSION: There was no statistically significant difference in the proportion of early postoperative infection cases between the two groups.


Assuntos
Antibacterianos/administração & dosagem , Antibioticoprofilaxia , Ceftazidima/administração & dosagem , Procedimentos Ortopédicos/efeitos adversos , Infecção da Ferida Cirúrgica/etiologia , Infecção da Ferida Cirúrgica/prevenção & controle , Adolescente , Adulto , Relação Dose-Resposta a Droga , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
11.
J Coll Physicians Surg Pak ; 15(12): 799-801, 2005 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-16398975

RESUMO

OBJECTIVE: To compare the time of union, degree of shortening and angulations in coronal and sagittal plane in children after applying Thomas splint and early hip spica for the treatment of isolated closed femoral shaft fractures. DESIGN: Interventional quasi-experimental study. PLACE AND DURATION OF STUDY: Orthopedic department of Abbasi Shaheed Hospital, Karachi from December 2002 to January 2004. SUBJECTS AND METHODS: A 100 patients of either gender selected by non-probability convenience with closed unilateral femoral shaft fracture were equally divided into 2 groups. Group A was treated with Thomas splint and Group B with early hip spica casting. Above mentioned variables were noted in both groups. RESULTS: In group A, there were 60% (n = 30) males and 40% (n = 20) females. In group B, there were 62% (n = 31) males and 38% (n = 19) females. Mean age was 6.94 + 2.75 years in group A and 5.48 + 2.67 years in group B. Time of union, degree of shortening and angulations in coronal and sagittal plane were not significantly different in two groups. Duration of stay in hospital was 4.82 + 2.4 days in group A and 3.68 + 2.11 days in group B. CONCLUSION: Results comparable to early hip spica cast can be obtained with Thomas splint in children with isolated closed femoral shaft fracture.


Assuntos
Moldes Cirúrgicos , Fraturas do Fêmur/terapia , Consolidação da Fratura , Contenções , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Resultado do Tratamento
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