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1.
Niger J Clin Pract ; 24(2): 233-239, 2021 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-33605914

RESUMO

Background: Antibiotic use in research volunteers partaking in dental studies varies widely, as inclusion and exclusion criteria used in participant selection lack strict rules. Aim: We aimed to investigate the most appropriate ending time of amoxicillin therapy in healthy subjects before their recruitment and participation in oral histology trials. A cross-sectional design study was conducted in Istanbul, Turkey, between October 2018 and June 2019. Subjects and Methods: Study participants who had undergone a previous course of amoxicillin were divided into three groups according to the amount of time since their last antibiotic dose: group I, within 1 month; group II, within 4-6 months; and group III, within 7-12 months. Periodontal parameters were measured, and smear samples were obtained from buccal mucosa and keratinized gingiva. Gingival biopsies were taken from the upper premolars. Genetic damage and histopathological damage were analyzed with Feulgen reaction and with hematoxylin-eosin staining. Data were analyzed using the Mann-Whitney U, Kruskal-Wallis, and the Pearson Chi-square tests. Results: There were no significant differences in the periodontal parameters and sociodemographic characteristics between the groups (P > 0.05). Higher genetic and histopathological damage scores were observed in group I, which were significantly different compared to the other groups (P < 0.05). No significant differences were observed between groups II and III (P > 0.05). Conclusions: When selecting healthy participants for oral histology trials, at least 3 months should pass after the final dose of amoxicillin is taken to avoid negative effects on gingival tissue and smear samples.

2.
Niger J Clin Pract ; 23(10): 1345-1355, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-33047690

RESUMO

Background: Several studies have demonstrated an association between obesity, periodontitis, and exercise. Aims: This study aimed to investigate the effects of regular exercise on obese women with periodontal disease, using serum, saliva, and gingival crevicular fluid (GCF) samples. A before-after study design was adopted to evaluate the effects of 12 weeks of regular exercise on obese women grouped according to periodontal status, without a control group (no exercise). The study sample comprised of 15 patients without periodontitis (NP group) and 10 patients with chronic periodontitis (CP group), from whom periodontal parameters were measured and serum, saliva, and GCF samples were collected. Body mass index (BMI), anthropometric measurements, somatotype-motoric tests, and maximal oxygen consumption (VO2max) were recorded at baseline and after exercise. Subjects and Methods: Med Calc was used for statistical analysis. Results: After exercise, a significant decrease in BMI and a significant increase in VO2max were observed in both groups. A significant decrease in probing depth and clinical attachment loss, serum leptin, GCF tumor necrosis factor-α(TNF-α) and leptin, and a significant increase in GCF resistin were observed in the CP group. A significant decrease in serum TNF-α and leptin levels and a significant increase in serum resistin and GCF TNF-α, leptin, resistin, and adiponectin levels were observed in the NP group. Significant correlations between bleeding on probing and levels of interleukin-1ß and leptin in GCF were observed in the CP group. Conclusions: This study showed that regular exercise exerts different impacts with respect to clinical and biochemical aspects of periodontal and systemic conditions in obese women.


Assuntos
Adipocinas/metabolismo , Periodontite Crônica/complicações , Periodontite Crônica/metabolismo , Exercício Físico/fisiologia , Líquido do Sulco Gengival/química , Obesidade/complicações , Saliva/química , Adipocinas/sangue , Adulto , Índice de Massa Corporal , Estudos de Casos e Controles , Periodontite Crônica/sangue , Feminino , Humanos , Interleucina-1beta/sangue , Interleucina-1beta/metabolismo , Pessoa de Meia-Idade , Obesidade/sangue , Obesidade/metabolismo , Bolsa Periodontal/metabolismo , Resistina/sangue , Resistina/metabolismo , Fator de Necrose Tumoral alfa/sangue , Fator de Necrose Tumoral alfa/metabolismo
3.
Phys Chem Chem Phys ; 20(44): 28124-28134, 2018 Nov 14.
Artigo em Inglês | MEDLINE | ID: mdl-30387488

RESUMO

Motivated by the increasing number of studies on optoelectronic applications of van der Waals (vdW) heterostructures, we have investigated the electronic and optical properties of monolayer gallium nitride (MGaN) and boron phosphide (MBP) heterobilayers by using first-principle calculations based on density functional theory. We have ensured the dynamical stability of the structures by considering their binding energies and phonon spectra. We show that the magnitude and status (direct or indirect) of the band gap are strongly dependent on the stacking pattern of the heterobilayers. Furthermore, we have investigated the band splittings in the presence of an external electric field which show the effect of the field on the band alignment of the structure. We have also shown the band gap, charge redistributions and work function of the structures are highly dependent on the magnitude and direction of the electric field such that its magnitude yields indirect to direct band gap transitions around |E⊥| ∼ 0.7 V Å-1 at the Γ point and the order of the band gap is varied according to the direction of the electric field. Moreover, we examine optical properties of MGaN/MBP heterobilayers as part of DFT calculations. The band gap and work function being tunable with changes in the external field together with the prominent absorption over the UV range make the MGaN/MBP heterobilayer a feasible candidate for optoelectronic applications.

4.
J Periodontal Res ; 52(3): 532-539, 2017 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-27734498

RESUMO

BACKGROUND AND OBJECTIVE: Inflammation is a common feature of both peripheral arterial disease (PAD) and periodontal disease. The aim of this study was to evaluate the relationship between PAD and periodontal disease by examining the levels of inflammatory cytokines (pentraxin 3 and interleukin 1ß) and high sensitive C-reactive protein from gingival crevicular fluid and serum. MATERIAL AND METHODS: A total of 60 patients were included in this cross-sectional study. Patients were divided into two groups based on ankle-brachial index values: with PAD (test group) and non-PAD (control group). Demographic evaluations, clinical periodontal examinations and biochemical analysis for pentraxin 3, interleukin 1ß and high sensitive C-reactive protein were performed to compare the two groups. RESULTS: There were no significant differences with respect to gender, age, body mass index, or smoking history (duration, amount) between the two groups (p > 0.05). There were no significant differences between the two groups in terms of clinical periodontal parameters (p > 0.05). Neither gingival crevicular fluid nor serum levels of the cytokines showed differences between the two groups. Logistic regression analysis revealed that, after adjusting for confounding factors (age, gender, diabetes, hypertension and body mass index), periodontitis raised the odds ratio for having PAD to 5.842 (95% confidence interval: 1.558-21.909). CONCLUSION: Although there were no significant differences with respect to clinical periodontal parameters and biochemical analyses between the study group and control, periodontitis did raise the odds ratio for having PAD. To clarify this possible relationship, future prospective studies are needed.


Assuntos
Proteína C-Reativa/análise , Líquido do Sulco Gengival/química , Interleucina-1beta/análise , Doenças Periodontais/complicações , Doença Arterial Periférica/complicações , Componente Amiloide P Sérico/análise , Índice Tornozelo-Braço , Estudos de Casos e Controles , Estudos Transversais , Feminino , Humanos , Interleucina-1beta/sangue , Modelos Logísticos , Masculino , Pessoa de Meia-Idade
5.
Eur J Dent ; 10(3): 432-434, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27403067

RESUMO

The total removal of a lesion via excisional biopsy causes gingival recession, resulting in dentin hypersensitivity and esthetical problems. In this case report, a gingival recession defect resulting from an excisional biopsy was treated with a free gingival grafting procedure performed during the same appointment, and its 12-year follow-up was presented. A 44-year-old female patient was presented to our clinic with a firm, pedunculated, red gingival enlargement located on the labial surface of lower incisors. The exposed root surface, after the excisional biopsy, was covered with a free gingival graft. The lesion was pathologically diagnosed as pyogenic granuloma, and in the early postoperative phase, no recurrence was observed, but partial root coverage was determined. At 6-month follow-up, root coverage resulting from "creeping attachment" was observed, and this situation was maintained throughout the 12-year follow-up period. Repetitious postoperative discomfort and emotional stress for the patient may be avoided with a timesaving single appointment performing excisional biopsy and free gingival graft. Free gingival grafting procedure was used for this purpose not only to cover exposed root surfaces but also to eliminate dentin hypersensitivity and make oral hygiene procedures more effective.

6.
Clin Adv Periodontics ; 5(3): 160-164, 2015 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32689712

RESUMO

INTRODUCTION: Root canal perforation during endodontic therapy is one of the most commonly encountered clinical situations that necessitates interdisciplinary therapy. CASE PRESENTATION: This case report presents the use of periodontal and prosthodontic teamwork to treat severely deteriorated anterior esthetics caused by an iatrogenically induced marginal tissue recession defect. CONCLUSION: In the case of deterioration of anterior dental esthetics, an interdisciplinary approach can successfully restore both esthetics and function, as observed in this case report.

7.
J Periodontol ; 85(8): e287-94, 2014 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-24669848

RESUMO

BACKGROUND: The aim of the present study is to examine whether anxiety and depression scale scores change with regard to clinical periodontal status and to investigate the association between the levels of stress-related hormones in gingival crevicular fluid (GCF) and extent/severity of periodontal disease. METHODS: One hundred twenty participants who fulfilled the study inclusion criteria were chosen. Patients with chronic periodontitis (CP) and those with healthy periodontal tissues/mild gingivitis were included. The clinical examinations were performed on the day after the psychologic evaluations which included anxiety and depression measurements. GCF sampling was undertaken the following day. Commercially available enzyme-linked immunosorbent assay kits were used to determine GCF cortisol and dehydroepiandrosterone (DHEA) levels. Study groups were assigned as follows: group 1, non-periodontitis; group 2, localized CP; and group 3, generalized CP. RESULTS: There were no significant differences with respect to age, sex, education, income level, occupation, or smoking history among the groups (P >0.05). There were no significant differences between the non-periodontitis and CP groups for any of the psychosocial scales (P >0.05). Group 3 had significantly higher mean DHEA scores compared with group 1 (P <0.05); however, the median cortisol scores showed no statistically significant differences among the three groups (P >0.05). CONCLUSIONS: Anxiety/depression scores and GCF cortisol levels did not show any difference with regard to clinical periodontal status. However, a significant association was found between elevated levels of GCF DHEA and the severity of periodontitis.


Assuntos
Desidroepiandrosterona/análise , Líquido do Sulco Gengival/química , Hidrocortisona/análise , Índice Periodontal , Adulto , Ansiedade/metabolismo , Ansiedade/psicologia , Periodontite Crônica/metabolismo , Periodontite Crônica/psicologia , Estudos Transversais , Índice de Placa Dentária , Depressão/metabolismo , Depressão/psicologia , Escolaridade , Feminino , Gengivite/metabolismo , Gengivite/psicologia , Humanos , Renda , Masculino , Pessoa de Meia-Idade , Ocupações , Perda da Inserção Periodontal/metabolismo , Perda da Inserção Periodontal/psicologia , Bolsa Periodontal/metabolismo , Bolsa Periodontal/psicologia , Fumar , Estresse Fisiológico/fisiologia , Estresse Psicológico/metabolismo , Adulto Jovem
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