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1.
PLoS One ; 14(11): e0224581, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31725753

RESUMO

AIMS: Cardiovascular manifestations are a major cause of mortality in Marfan syndrome (MFS). Animal models that mimic the syndrome and its clinical variability are instrumental for understanding the genesis and risk factors for cardiovascular disease in MFS. This study used morphological and ultrastructural analysis to the understanding of the development of cardiovascular phenotypes of the the mgΔloxPneo model for MFS. METHODS AND RESULTS: We studied 6-month-old female mice of the 129/Sv background, 6 wild type (WT) and 24 heterozygous animals from the mgΔloxPneo model. Descending thoracic aortic aneurysm and/or dissection (dTAAD) were identified in 75% of the MFS animals, defining two subgroups: MFS with (MFS+) and without (MFS-) dTAAD. Both subgroups showed increased fragmentation of elastic fibers, predominance of type I collagen surrounding the elastic fiber and fragmentation of interlaminar fibers when compared to WT. However, only MFS animals with spine tortuosity developed aortic aneurysm/dissection. The aorta of MFS+ animals were more tortuous compared to those of MFS- and WT mice, possibly causing perturbations of the luminal blood flow. This was evidenced by the detection of diminished aorta-blood flow in MFS+. Accordingly, only MFS+ animals presented a process of concentric cardiac hypertrophy and a significantly decreased ratio of left and right ventricle lumen area. CONCLUSIONS: We show that mgΔloxPneo model mimics the vascular disease observed in MFS patients. Furthermore, the study indicates role of thoracic spine deformity in the development of aorta diseases. We suggest that degradation of support structures of the aortic wall; deficiency in the sustenance of the thoracic vertebrae; and their compression over the adjacent aorta resulting in disturbed blood flow is a triad of factors involved in the genesis of dissection/aneurysm of thoracic aorta.


Assuntos
Aneurisma da Aorta Torácica , Síndrome de Marfan , Coluna Vertebral , Animais , Aorta Torácica/metabolismo , Aorta Torácica/patologia , Aorta Torácica/fisiopatologia , Aneurisma da Aorta Torácica/genética , Aneurisma da Aorta Torácica/metabolismo , Aneurisma da Aorta Torácica/patologia , Velocidade do Fluxo Sanguíneo , Modelos Animais de Doenças , Tecido Elástico/metabolismo , Feminino , Humanos , Síndrome de Marfan/genética , Síndrome de Marfan/metabolismo , Síndrome de Marfan/patologia , Camundongos , Camundongos Transgênicos , Coluna Vertebral/metabolismo , Coluna Vertebral/patologia
2.
Mod Pathol ; 31(8): 1318-1331, 2018 08.
Artigo em Inglês | MEDLINE | ID: mdl-29572500

RESUMO

Severe hemorrhagic events occur in a significant fraction of acute promyelocytic leukemia patients, either at presentation and/or early after starting therapy, leading to treatment failure and early deaths. However, identification of independent predictors for high-risk of severe bleeding at diagnosis, remains a challenge. Here, we investigated the immunophenotype of bone marrow leukemic cells from 109 newly diagnosed acute promyelocytic leukemia patients, particularly focusing on the identification of basophil-related features, and their potential association with severe bleeding episodes and patient overall survival.From all phenotypes investigated on leukemic cells, expression of the CD203c and/or CD22 basophil-associated markers showed the strongest association with the occurrence and severity of bleeding (p ≤ 0.007); moreover, aberrant expression of CD7, coexpression of CD34+/CD7+ and lack of CD71 was also more frequently found among patients with (mild and severe) bleeding at baseline and/or after starting treatment (p ≤ 0.009). Multivariate analysis showed that CD203c expression (hazard ratio: 26.4; p = 0.003) and older age (hazard ratio: 5.4; p = 0.03) were the best independent predictors for cumulative incidence of severe bleeding after starting therapy. In addition, CD203c expression on leukemic cells (hazard ratio: 4.4; p = 0.01), low fibrinogen levels (hazard ratio: 8.8; p = 0.001), older age (hazard ratio: 9.0; p = 0.002), and high leukocyte count (hazard ratio: 5.6; p = 0.02) were the most informative independent predictors for overall survival.In summary, our results show that the presence of basophil-associated phenotypic characteristics on leukemic cells from acute promyelocytic leukemia patients at diagnosis is a powerful independent predictor for severe bleeding and overall survival, which might contribute in the future to (early) risk-adapted therapy decisions.


Assuntos
Basófilos/patologia , Hemorragia/etiologia , Leucemia Promielocítica Aguda/patologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Linhagem da Célula , Criança , Pré-Escolar , Feminino , Humanos , Leucemia Promielocítica Aguda/complicações , Masculino , Pessoa de Meia-Idade , Fenótipo , Adulto Jovem
3.
Rev. dor ; 17(1): 19-23, Jan.-Mar. 2016. tab
Artigo em Inglês | LILACS-Express | LILACS | ID: lil-776639

RESUMO

RESUMO JUSTIFICATIVA E OBJETIVOS: Relacionar as variáveis biopsicossociais do Research Diagnostic Criteria for Temporomandibular Disorders com os grupos de pacientes com disfunção temporomandibular, com disfunção temporomandibular e migrânea e grupo controle. MÉTODOS: Estudo do tipo observacional transversal onde foram avaliados 280 pacientes consecutivos, divididos em 3 grupos: grupo I (140 indivíduos controle); grupo II (65 indivíduos com disfunção temporomandibular muscular) e grupo III (75 indivíduos com migrânea e disfunção temporomandibular muscular). Os critérios de exclusão foram indivíduos que apresentaram histórico clínico de processos inflamatórios musculares, espasmos musculares, contraturas e injúria traumática aguda na articulação temporomandibular. RESULTADOS: Os indivíduos do grupo III apresentaram associação com depressão grave (p<0,0001), grau 4 na variável intensidade da dor (p=0,004), sintomas físicos não específicos sem dor intensa (p<0,0001) e sintomas físicos não específicos com dor intensa (p<0,0001). Houve diferença significativa entre os gêneros feminino e masculino no grupo III (Z=2,59; p=0,001), evidenciando maior tempo de dor no gênero feminino. A porcentagem de mulheres no grupo III foi significativamente maior em relação aos homens (p=0,004). CONCLUSÃO: A relação entre as variáveis e os três grupos mostrou maior número de indivíduos acometidos com maior intensidade de sintomas no grupo III. Dessa forma, entende-se que a migrânea é uma condição mórbida frequentemente associada à disfunção temporomandibular, potencializando os sintomas descritos pelos pacientes. Há necessidade de avaliações clínicas multidisciplinares nesses indivíduos para que o tratamento seja otimizado, minimizando a morbidade e diminuindo os custos e o número de consultas prestadas aos pacientes.


ABSTRACT BACKGROUND AND OBJECTIVES: To relate biopsychosocial variables of Research Diagnostic Criteria for Temporomandibular Disorders to groups of patients with temporomandibular disorders, temporomandibular disorders and migraine and a control group. METHODS: This is a cross-sectional observational study where 280 consecutive patients were evaluated and distributed in three groups: group I (140 control individuals); group II (65 individuals with muscle temporomandibular disorders) and group III (75 individuals with migraine and muscle temporomandibular disorders). Exclusion criteria were individuals with clinical history of muscle inflammatory processes, muscle spasms, contractures and acute temporomandibular joint traumatic injury. RESULTS: Group III individuals had association with severe depression (p<0.001), level 4 in pain severity (p=0.004), unspecific physical symptoms without severe pain (p<0.0001) and unspecific symptoms with severe pain (p<0.00001). There has been significant difference between females and males in group III (Z=2.59; p=0.001), with longer pain duration among females. The percentage of females in group III was significantly higher as compared to males (p=0.004). CONCLUSION: The relationship between variables and the three groups has shown a higher number of individuals with more severe symptoms in group III. So, it is understood that migraine is a morbid condition often associated to temporo mandibular disorders, worsening symptoms referred by patients. There is the need for multidisciplinary evaluation of these individuals to optimize treatment and minimize morbidity, costs and the number of medical visits.

4.
Eur J Med Genet ; 59(2): 80-5, 2016 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-26791099

RESUMO

Okihiro syndrome, Duane-radial ray syndrome or acro-reno-ocular syndrome (OMIM #607323) are alternative denominations describing an extremely variable condition, characterized by several radial defects of the upper limbs associated with Duane anomaly. It is a rare autosomal dominant disorder determined by variants in the SALL4 gene which encodes a transcription factor with eight zinc finger motifs. Here we report a novel heterozygous frameshift variant, c.410dupG, present in a Brazilian family. The five affected individuals exhibit a broad spectrum of phenotypes, ranging from the severe one presented by the index case (grossly shortened and deformed forearm, markedly hypoplastic and appendicular thumb, malformed right foot and ear malformation), to the less conspicuous condition presented by his near relatives (usually only triphalangeal or hypoplastic thumbs, sometimes associated with ulnar deviation); Duane's anomaly, however, was not observed in any of the affected family members. The c.410dupG variant is predicted to result in the translation of a truncated protein with 180 amino acid residues, lacking seven of the eight zinc finger motifs, with the same size of the predicted products of the already reported c.496dupC variant, described in two unrelated cases. However, the phenotypes observed in the three families (the one here reported and other two with c.496dupC variant) are very different. The analysis of cases so far published does not permit to establish a clear or direct genotype-phenotype correlation, but the three more severe foot malformation cases are due to variants predicted to encode truncated proteins lacking seven ZFMs. This might indicate a possible correlation between foot malformation and reduced size of the protein, suggesting that the nonsense-mediated-decay mechanism might not be so effective as to eliminate all SALL4 variants harboring premature termination codons.


Assuntos
Síndrome da Retração Ocular/genética , Mutação da Fase de Leitura , Fatores de Transcrição/genética , Brasil , Análise Mutacional de DNA , Síndrome da Retração Ocular/patologia , Feminino , Humanos , Masculino , Linhagem , Penetrância
5.
Int. j. odontostomatol. (Print) ; 9(2): 295-300, ago. 2015. ilus
Artigo em Inglês | LILACS-Express | LILACS | ID: lil-764044

RESUMO

The objective was to investigate the prevalence of temporomandibular dysfunction ­TMD - in severe and moderate hemophiliac A and B patients and healthy men as control group. Hemophilia complication is chronic arthropathy that results from repeated joint bleeding, leading to limited movement. Limitation of jaw movement is present in patients with TMD. Hemophiliac patients were recruited in the Hemophilia outpatient clinic at Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP). The control group was composed of voluntary subjects recruited among medical and dental students of UNIFESP. Both groups were screened for TMD symptoms according to the European Academy of Craniomandibular Disorders questionnaire. The Research Diagnostic Criteria further evaluated those considered positive for TMD. The results showed a similar prevalence of TMD in the hemophiliac group compared to the control group (n= 38, n= 79; p= 0.7). There were no significant differences in severity of sign and symptoms between the groups. In conclusion, patients with hemophilia do not have a higher prevalence of temporomandibular disorders, indicating absence of hemorrhage in temporomandibular joint.


El objetivo fue investigar la prevalencia de trastornos temporomandibulares (TTM) entre pacientes hemofílicos A y B severos y moderados, y hombres sanos como grupo de control. Una complicación de la Hemofilia es la artropatía crónica como resultado de una hemorragia articular a repetición, limitando el movimiento en el tiempo. La limitación del movimiento de la mandíbula está presente en pacientes con TTM. Los pacientes hemofílicos fueron reclutados en la clínica de atención ambulatoria de hemofilia en Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP). El grupo control estaba compuesto por sujetos voluntarios reclutados entre los estudiantes de Medicina y Odontología de UNIFESP. Ambos grupos fueron evaluados por síntomas de TTM según cuestionario de trastornos craneomandibulares de la Academia Europea. Los criterios de diagnósticos de investigación evaluados se consideraron positivos para TTM. Los resultados mostraron una prevalencia similar de TTM en el grupo de hemofílicos en comparación con el grupo control (n= 38, n= 79; p= 0,7). No se encontraron diferencias significativas en la gravedad de los signos y síntomas entre los grupos. En conclusión, los pacientes con hemofilia no tienen una mayor prevalencia de trastornos temporomandibulares, indicando la ausencia de hemorragia en la articulación temporomandibular.

6.
Artigo em Inglês | MEDLINE | ID: mdl-26188733

RESUMO

OBJECTIVE: To investigate the correlation between pain measurements performed using a visual analogue scale (VAS) and pressure pain threshold (PPT) in individuals with temporomandibular disorders who underwent conservative treatment. STUDY DESIGN: This prospective study assessed 78 individuals diagnosed with myofascial pain, and the treatment consisted of counseling and self-care therapy sessions. Pain was assessed by means of a VAS and PPT at baseline (T0), after 15 to 30 days (T1), and after 75 to 90 days (T2). The participants were divided into two groups: "Compliant Group" and "Non-Compliant Group." The data were analyzed by means of Spearman's correlation test and Friedman's analysis of variance by ranks. RESULTS: Correlations were not identified between the VAS and PPT values at time points-T0, T1, or T2-in any group. CONCLUSION: Although, VAS and PPT represent subjective features, such as the perception of pain, the hypothesis that high pain intensity levels are equivalent to high pain sensitivity levels was not demonstrated.


Assuntos
Dor Facial/fisiopatologia , Dor Facial/terapia , Manejo da Dor/métodos , Limiar da Dor/fisiologia , Cooperação do Paciente , Transtornos da Articulação Temporomandibular/fisiopatologia , Transtornos da Articulação Temporomandibular/terapia , Adolescente , Adulto , Idoso , Aconselhamento , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Medição da Dor , Estudos Prospectivos , Autocuidado
7.
Int. j. odontostomatol. (Print) ; 9(1): 65-72, Apr. 2015. ilus
Artigo em Inglês | LILACS-Express | LILACS | ID: lil-747479

RESUMO

The aim of the study was to determine and classify the shape of the mandibular fossa and the corresponding condyle in different types, relating them to sex and symmetry, in adult human skulls, from lateral, posterior and superior views. The sample included 50 human skulls from 23 to 82 years old, 32 males and 18 females. The condyle and silicone casting molds of the fossa were photographed to assess shape in the three views. Shapes were classified, validated by intra- and inter-rater analysis and frequency, sex distribution and symmetry verified. Shapes were classified as rounded, angled, flattened and mixed types in the lateral and posterior views; and as biconvex, flat-convex, biflattened and mixed in the superior view. Rounded condyle and fossa were more frequent in the lateral (57% and 66% respectively) and posterior (53% and 83%) views. In the superior view, mixed shape presented higher frequency in condyle (59%) while in fossa the biconvex shape (46%) was most common. There was no significant difference in shape distribution by sex. The same shape (symmetry) or otherwise (non-symmetry) in right and left side condyle and fossa were separately assessed and showed various combinations.


El objetivo del estudio fue determinar y clasificar la forma de la fosa mandibular y cóndilo correspondiente en diferentes tipos, relacionándolos con el sexo y la simetría en cráneos humanos adultos en perspectivas laterales, posteriores y superiores. La muestra incluyó 50 cráneos humanos de 32 hombres y 18 mujeres entre 23 a 82 años. Fueron fotografiados el cóndilo y moldes de silicona de la fosa para evaluar la forma en los tres puntos. Se clasificaron las formas, validadas por el análisis intra e inter-evaluador, la frecuencia, distribución por sexo y simetría verificada. Las formas fueron clasificadas como redondeada, en ángulo, aplanada y mixtas en las vistas lateral y posterior; y como biconvexa, convexo-plana, y mixta en la vista superior. En las vistas laterales el cóndilo y la fosa redondeada fueron más frecuentes (57% y 66%, respectivamente), mientras que en la vista posterior (53% y 83%). En la vista superior, la forma mixta presentó mayor frecuencia en el cóndilo (59%), mientras que en la fosa la forma biconvexa (46%) fue más común. No hubo diferencia significativa en la distribución de laforma por sexo. La misma forma (simétrica o no-simétrica) en el cóndilo lateral derecho e izquierdo y la fosa fueron evaluadas por separado, y se observaron varias combinaciones.

8.
Anat Res Int ; 2014: 732720, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24527214

RESUMO

Objective. To characterize morphologically and ultrastructurally using light microscopy, the scanning electron microscopy and transmission electron microscopy the intima synovial of the temporomandibular joint (TMJ) of human fetuses between the 10th and the 38th week of development. Materials and Methods. The TMJ was dissected bilaterally in 37 human fetuses belonging to the Institute of Embryology of the University Complutense of Madrid and of the Federal University of São Paulo. Results. The outcome by light microscopy showed the morphology of the TMJ and that the formation of inferior joint cavity precedes the superior joint cavity and the presence of blood vessels in the synovial. Conclusion. By scanning and transmission electron microscopy we observed the presence of two well-defined cell types in the intima layer of synovial of the TMJ of human fetuses, macrophage-like type A cell and fibroblast-like type B cell, and the presence of the a third cell type, defined by the name of intermediate lining cell in the intima layer of the synovial.

9.
J Appl Genet ; 54(1): 35-41, 2013 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-23247912

RESUMO

Ring chromosome 10--r(10)--is a rare disorder, with 14 cases reported in the literature, but only two with breakpoint determination by high-resolution techniques. We report here on two patients presenting a ring chromosome 10, studied by G-banding, fluorescent in situ hybridization (FISH), multiplex ligation-dependent probe amplification (MLPA) and SNP-array techniques, in order to investigate ring instability and determine breakpoints. Patient 1 showed a r(10)(p15.3q26.2) with a 7.9 Mb deletion in 10q26.2-q26.2, while patient 2 showed a r(10)(p15.3q26.13) with a 1.0 Mb deletion in 10p15.3 and a 8.8 Mb deletion in 10q26.13-q26.3, both unstable. While patient 1 presented with clinical features usually found in patients with r(10) and terminal 10q deletion, patient 2 presented characteristics so far not described in other patients with r(10), such as Dandy-Walker variant, osteopenia, semi-flexed legs, and dermal pigmentation regions. Our data and the data from literature show that there are no specific clinical findings to define a r(10) syndrome.


Assuntos
Cromossomos Humanos Par 10/genética , Bandeamento Cromossômico , Deleção Cromossômica , Feminino , Humanos , Hibridização in Situ Fluorescente , Masculino , Reação em Cadeia da Polimerase Multiplex , Cromossomos em Anel
10.
Spec Care Dentist ; 31(2): 68-72, 2011.
Artigo em Inglês | MEDLINE | ID: mdl-21371068

RESUMO

Toriello Carey syndrome is a rare recessive autosomal disease whose clinical manifestations are more evident in males. Some authors report that the general characteristics of this disease are agenesis of the corpus callosum, mental disability, convulsions, atrial septal defect, pulmonary artery stenosis, pyloric stenosis, and hypospadias. Facial and cranial alterations may occur, including hypertelorism, telecanthus, divergent strabismus, malformed ears, anteverted nares, retrognathism, and cleft palate. This paper reports on a 13-year-old male with Toriello Carey syndrome and leucoderma, and describes his oral problems and his dental care.


Assuntos
Síndrome Acrocalosal/genética , Anormalidades Craniofaciais/genética , Assistência Odontológica para Pessoas com Deficiências , Deficiência Intelectual/genética , Anormalidades Múltiplas/genética , Síndrome Acrocalosal/patologia , Adolescente , Agenesia do Corpo Caloso , Anodontia/patologia , Dente Pré-Molar/anormalidades , Anormalidades Craniofaciais/patologia , Transtornos do Crescimento/genética , Transtornos do Crescimento/patologia , Humanos , Deficiência Intelectual/patologia , Masculino , Má Oclusão/patologia , Mordida Aberta/patologia , Higiene Bucal , Planejamento de Assistência ao Paciente , Síndrome
11.
Surg Radiol Anat ; 32(10): 951-6, 2010 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-20383501

RESUMO

PURPOSE: The aim of this study was to determine by computed tomography (CT) the interalveolar distance on mandible relative to the canine, first and second pre-molar, and the thickness of the cortical bone in the same region. METHODS: A hundred adult cadaveric dentate human hemi-mandibles were examined. A point (P) above the upper margin of the mental foramen was determined, the height at which monocortical screws are inserted to place miniplate according to the technique to treat mandibular fracture. Then, points A, B and C at the same height as point P, referring to the dental units namely canine, first and second pre-molars were marked to determine the CT cut level to measure cortical bone thickness and the interalveolar distance. RESULTS: The figures showed no statistically significant difference between the sides. The thickness of the vestibular cortical bone was less than 3.0 mm in 96% of the samples. In 91% of the samples the interalveolar distance between canine, first and second pre-molars was greater than 2 mm, a potentially safe condition to insert 2.0-mm diameter monocortical screws at the study points. CONCLUSIONS: The individual actual anatomy of the region where screws are to be inserted above the mental foramen is important to perform the technique safely. We believe that the minimal cortical thickness to obtain sufficient screw anchorage should be studied in order to determine the actually safe shortest screw length. It is important to minimize the risk of tooth root damage or nerve injury and the amount of titanium in the human tissues.


Assuntos
Mandíbula/diagnóstico por imagem , Adulto , Idoso , Idoso de 80 Anos ou mais , Humanos , Mandíbula/anatomia & histologia , Mandíbula/cirurgia , Fraturas Mandibulares/cirurgia , Pessoa de Meia-Idade , Tomografia Computadorizada por Raios X , Dente/diagnóstico por imagem
12.
Ital J Anat Embryol ; 114(4): 193-9, 2009.
Artigo em Inglês | MEDLINE | ID: mdl-20578675

RESUMO

Acute inflammatory response is one of the main defensive mechanisms of the lungs. This work tried to assess this response through an immunohistochemical analysis of rat lungs mechanically injured by open manipulation, analyzing the COX-2 inflammatory marker, in addition to performing a microscopic histological analysis using the hematoxylin and eosin stain. The correlation between this response and the degree of manipulation over different lengths of time and degrees of injury was also investigated. Sixteen rats were divided into four groups and subjected to anterior thoracotomy. The upper lobe of the right lung was compressed using a plastic Bulldog clamp for different time length according to group (5 minutes, 2 minutes, and three 10-second compressions with 10 second intervals). The control group was subjected to thoracotomy but their lungs were not compressed. The injured lobes were analyzed histologically and subjected to immunohistochemistry and the results were compared. There were no differences in the immunohistochemical patterns between the control and injured rats, but the histological patterns between them differed. In conclusion, the histological analysis shows that the degree of injury caused by clamping the pulmonary parenchyma increases as the time length of compression increases but this inflammatory response is not paralleled by modifications of the COX-2 marker at immunohistochemistry.


Assuntos
Lesão Pulmonar Aguda/enzimologia , Ciclo-Oxigenase 2/metabolismo , Mediadores da Inflamação/metabolismo , Pneumonia/enzimologia , Prostaglandinas/biossíntese , Lesão Pulmonar Aguda/complicações , Lesão Pulmonar Aguda/fisiopatologia , Animais , Biomarcadores/análise , Biomarcadores/metabolismo , Ciclo-Oxigenase 2/análise , Modelos Animais de Doenças , Imuno-Histoquímica , Pulmão/enzimologia , Pulmão/patologia , Pulmão/fisiopatologia , Masculino , Pneumonia/complicações , Pneumonia/fisiopatologia , Ratos , Ratos Wistar , Fatores de Tempo
13.
Ital J Anat Embryol ; 113(2): 91-5, 2008.
Artigo em Inglês | MEDLINE | ID: mdl-18702236

RESUMO

The objective of this paper was to study the morphology of the articular disc and analyze the immunohistochemical expression of the marker of type IV collagen in the articular disc of the temporomandibular joint (TMJ) of human fetuses of different gestational ages. Twenty TMJ from human fetuses aging from 21 to 24 weeks of intrauterine life were studied. The TMJ were supplied by the Federal University of Uberaba. The ages of the fetuses were determined by measuring the crown-rump length (CRL). Macroscopically, the fetuses were fixed in a formalin solution at 10% and dissected by removing the skin and the subcutaneous tissue, exposing the deep structures. An immunohistochemical marker of type IV collagen was used in order to characterize the presence of blood vessels in the central region of the temporomandibular joint disc. Analysis of the immunohistochemical marker of type IV collagen showed the presence of blood vessels in the central region of the temporomandibular disc in human fetuses.


Assuntos
Vasos Sanguíneos/embriologia , Colágeno Tipo IV/biossíntese , Neovascularização Fisiológica/fisiologia , Disco da Articulação Temporomandibular/irrigação sanguínea , Disco da Articulação Temporomandibular/embriologia , Especificidade de Anticorpos , Biomarcadores/análise , Biomarcadores/metabolismo , Vasos Sanguíneos/citologia , Vasos Sanguíneos/metabolismo , Colágeno Tipo IV/análise , Feto , Idade Gestacional , Humanos , Imuno-Histoquímica , Disco da Articulação Temporomandibular/metabolismo
14.
Eur J Radiol ; 61(1): 79-83, 2007 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-17049195

RESUMO

OBJECTIVE: In the last two decades, advances in the computerized tomography (CT) field revise the internal and medium ear evaluation. Therefore, the aim of this study is to analyze the morphology and morphometric aspects of the vestibular aqueduct on the basis of computerized tomography images (CTI). MATERIAL AND METHOD: Computerized tomography images of vestibular aqueducts were acquired from patients (n=110) with an age range of 1-92 years. Thereafter, from the vestibular aqueducts images a morphometric analysis was performed. Through a computerized image processing system, the vestibular aqueduct measurements comprised of its area, external opening, length and the distance from the vestibular aqueduct to the internal acoustic meatus. RESULTS: The morphology of the vestibular aqueduct may be funnel-shaped, filiform or tubular and the respective proportions were found to be at 44%, 33% and 22% in children and 21.7%, 53.3% and 25% in adults. The morphometric data showed to be of 4.86 mm(2) of area, 2.24 mm of the external opening, 4.73 mm of length and 11.88 mm of the distance from the vestibular aqueduct to the internal acoustic meatus, in children, and in adults it was of 4.93 mm(2), 2.09 mm, 4.44 mm, and 11.35 mm, respectively. CONCLUSIONS: Computerized tomography showed that the vestibular aqueduct presents high morphological variability. The morphometric analysis showed that the differences found between groups of children and adults or between groups of both genders were not statistically significant.


Assuntos
Antropometria/métodos , Interpretação de Imagem Assistida por Computador/métodos , Tomografia Computadorizada por Raios X/métodos , Aqueduto Vestibular/anatomia & histologia , Aqueduto Vestibular/diagnóstico por imagem , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Pessoa de Meia-Idade
15.
Cleft Palate Craniofac J ; 44(6): 678-82, 2007 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-18177190

RESUMO

Treacher Collins syndrome usually affects bilateral and symmetric structures that include the orbits, mandible, and ears. The purpose of this report is to describe a clinical case of the syndrome, focusing on the anatomy of the temporomandibular joint, which was assessed using the computed tomography method. Clinical examination included evaluation of mandibular dynamics, investigation of temporomandibular dysfunction, and measurement of bite force. Significant morphological and functional alterations were observed but without significant documented clinical consequences.


Assuntos
Disostose Mandibulofacial/complicações , Radiografia Dentária/métodos , Transtornos da Articulação Temporomandibular/diagnóstico por imagem , Transtornos da Articulação Temporomandibular/etiologia , Adolescente , Força de Mordida , Orelha Externa/anormalidades , Humanos , Masculino , Mandíbula/anormalidades , Mandíbula/diagnóstico por imagem , Mandíbula/fisiopatologia , Articulação Temporomandibular/diagnóstico por imagem , Transtornos da Articulação Temporomandibular/fisiopatologia , Tomografia Computadorizada por Raios X , Zigoma/anormalidades
16.
Einstein (Säo Paulo) ; 5(4): 333-336, 2007.
Artigo em Português | LILACS | ID: lil-485797

RESUMO

Objetivo: Estudar a morfologia do disco articular e analisar a expressãoimunoistoquímica do marcador de colágeno tipo VII no disco articular daarticulação temporomandibular de fetos humanos em diferentes idadesgestacionais. Métodos: Vinte articulações temporomandibulares defetos humanos entre 13 e 24 semanas de vida intra-uterina foram estudadas. As articulações temporomandibulares foram provenientesda coleção da Universidade Federal de Uberaba. As idades dos fetosforam determinadas pela mensuração do comprimento cabeça–nádega.Macroscopicamente, os fetos foram fixados em solução de formalina a10% e dissecados pela remoção da pele e tela subcutânea, expondo asestruturas profundas. Um marcador imunoistoquímico do colágeno tipoVII foi utilizado a fim de determinar sua presença na membrana basaldo disco articular da articulação temporomandibular. Resultados: Aanálise imunoistoquímica do marcador de colágeno tipo VII demonstroua presença desta proteína na região central e na porção superior dodisco articular da articulação temporomandibular de fetos humanos.Conclusão: A marcação de colágeno tipo VII no disco articular daarticulação temporomandibular no segundo trimestre de gestaçãodemonstrou que o disco articular, do ponto de vista biológico estrutural,é provido de membrana basal em suas porções central e superior.


Assuntos
Humanos , Masculino , Feminino , Membrana Basal , Colágeno , Embriologia , Imuno-Histoquímica , Articulação Temporomandibular
17.
Am J Orthod Dentofacial Orthop ; 129(6): 785-93, 2006 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-16769497

RESUMO

INTRODUCTION: Epidemiological studies have suggested an association between unilateral posterior crossbite (UPXB) and temporomandibular joint disc displacement. The purpose of this prospective study was to investigate articular disc positioning and its configuration in children with functional UPXB malocclusions and their counterparts with normal occlusions by using magnetic resonance imaging. METHODS: The study sample included 9 girls and 6 boys (mean age, 9.3 years; SD, 2.1) with complete UPXB involving 3 or more posterior teeth and functional shift from centric relation to intercuspal position (patient group). The control group consisted of 10 girls and 6 boys (mean age, 9.6 years; SD, 2.1) with normal occlusion. All participants had no signs or symptoms of temporomandibular disorder. Sagittal and frontal magnetic resonance images of the temporomandibular joint with the jaw in closed and open positions were made bilaterally. Three investigators independently interpreted the magnetic resonance images. RESULTS: No intergroup or intragroup differences regarding sex were found, and only 1 subject with articular derangement (disc displacement without reduction associated with disc distortion-folded disc) was found (patient group, same side of crossbite). CONCLUSIONS: These findings suggest that temporomandibular joint derangements and functional UPXB are independent occurrences, or that the magnitude of such derangements is still not normally detected by magnetic resonance imaging in children in this age range. Another explanation for posterior crossbite not being reflected in disc displacement is the potential compensatory asymmetrical condyle growth or articular fossa remodeling that can hold the articular disc in position.


Assuntos
Má Oclusão/complicações , Disco da Articulação Temporomandibular/patologia , Transtornos da Articulação Temporomandibular/complicações , Estudos de Casos e Controles , Relação Central , Distribuição de Qui-Quadrado , Criança , Oclusão Dentária Central , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Estudos Prospectivos
18.
Braz. j. morphol. sci ; 22(4): 233-238, Oct.-Dec. 2005. ilus
Artigo em Inglês | LILACS | ID: lil-468025

RESUMO

Ultrastructure of human fetuses temporomandibular joint is poorly understood specially by scanning electron microscopy and cryofracture techniques. In this work, the morphology of the temporomandibular joint (TMJ) articular disc and its insertions was examined in 12 human fetuses. Four TMJs were sectioned in the frontal and sagittal planes and five were cryofractured prior to examination using light and scanning electron microscopy. The three remaining TMJs were fixed, embedded in paraffin, sectioned and stained with HE and NMC trichrome. The articular disc inserted into the mandibular head, temporal bone, joint capsule and upper head of the lateral pterygoid muscle. The fibrous architecture of this disc was complex, with longitudinal fibers predominating in the upper and lower regions, and interposed transverse and oblique fibers predominating in the central region.


Assuntos
Humanos , Articulação Temporomandibular/fisiologia , Articulação Temporomandibular/ultraestrutura , Articulação Temporomandibular , Disco da Articulação Temporomandibular , Desenvolvimento Fetal , Feto , Microscopia Eletrônica de Varredura
19.
JBA, J. Bras. Oclusão ATM Dor Orofac ; 5(21): 139-144, jul.-ago. 2005. ilus, CD-ROM
Artigo em Português | BBO - Odontologia | ID: biblio-851519

RESUMO

Faz-se uma revisão de literatura da etiopatogenia da anquilose da articulação temporomandibular, suas classificações e uma análise comparativa das vantagens e desvantagens do tratamento cirúrgico com e sem interposição de material


Assuntos
Anquilose/terapia , Cirurgia Geral , Articulação Temporomandibular , Artroplastia/métodos
20.
Rev. Assoc. Paul. Cir. Dent ; 59(3): 223-226, maio-jun. 2005. ilus
Artigo em Português | LILACS, BBO - Odontologia | ID: lil-468229

RESUMO

Resumo: A dor de dente é uma queixa freqüente nos consultórios dentários. A maioria das odontalgias é de origem pulpar e/ou periodontal. Entretanto, algumas dores de origem não-odontogênica geram dificuldades no diagnóstico e, conseqüentemente, no tratamento indicado. Devemos considerar que a dor sentida no dente pode não ser de origem dental, caracterizando o fenômeno da dor referida. Dores de origem neural, cardíaca, psíquica, miofascial, cefálica e sinusal podem simular dor de dente. Portanto, o clínico deve estar atento para o reconhecimento da dor referida, pois nem sempre local e origem são coincidentes. O presente artigo revisa o conceito de odontalgias não-odontogênicas e aspectos relevantes associados.


Assuntos
Dor Facial/diagnóstico , Odontalgia
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