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1.
Ecol Evol ; 8(22): 11083-11099, 2018 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-30519427

RESUMO

The environmental variability at local scale results in different physiognomic types of mangrove forest. However, this variability has never been considered in studies of mangrove genetic variability. This study analyzed the genetic and morphological variability and structure of Rhizophora mangle at regional and local scales in the Yucatan Peninsula. Thirteen mangrove populations (eight scrub and five tall), located in seven sites, were sampled, and their morphological variability and relationship with the availability of phosphorus and salinity were analyzed. The diversity and genetic structure were estimated at different hierarchical levels with nine microsatellites, also Bayesian inference and Principal Coordinates Analysis were used. We found a great morphological variability of R. mangle that responded to local environmental variability and not to the precipitation gradient of the peninsula. The genetic diversity found in the peninsula was greater than that reported for other populations in Mexico and was grouped into two regions: the Gulf of Mexico and the Caribbean Sea. At a local scale, tall and scrub mangroves had significant genetic differentiation suggesting that ecological barriers promote genetic differentiation within sites. These results need to be considered in future population genetic studies and for mangrove management and conservation.

2.
Physiol Plant ; 2018 Aug 22.
Artigo em Inglês | MEDLINE | ID: mdl-30136347

RESUMO

Climate change is expected to increase the frequency of extreme climatic events, yet few studies have addressed the capacity of plant species to deal with such events. Species that are widespread are predicted to be highly plastic and able to acclimate to highly changing conditions. To study the plasticity in physiological responses of the widely distributed epiphyte Tillandsia utriculata, we transplanted individuals from a coastal scrub and broadleaf evergreen forest to a similar coastal scrub site and forest. After a 45-day acclimation, the plants were moved to a semi-controlled greenhouse at each site, and then subjected to a 20-day drought. Physiological variables were measured during the acclimation and the drought. The individuals of scrub and forest populations had similar relative water content and carbon assimilation in the contrasting conditions of the two transplantation sites despite the high discrepancy between the environments at their original site. Electron transport rates were higher in individuals from the scrub population. Electron transport rates were also higher than estimated from carbon assimilation, suggesting that photorespiration was present. The individuals of the coastal scrub population had a higher capacity to dissipate excess energy this way. The relative distance index of plasticity was high overall, indicating that some traits are highly plastic (titratable acidity, carbon assimilation) in order to maintain the stability of others (maximum quantum yield Fv /Fm and relative water content). We conclude that T. utriculata is a highly plastic species with a high capacity to tolerate extreme environmental changes over a short time.

3.
Eur J Gastroenterol Hepatol ; 30(8): 930-937, 2018 08.
Artigo em Inglês | MEDLINE | ID: mdl-29979644

RESUMO

BACKGROUND: Cirrhotic cardiomyopathy is characterized by an attenuated contractile response to stress. Long-term exposure of ß-adrenergic receptors to persistently high levels of catecholamines has been implicated in its pathogenesis. We hypothesized that ß-blockade with metoprolol could reverse the changes in heart function and morphology in cirrhotic cardiomyopathy. PATIENTS AND METHODS: In this prospective randomized trial, we included 78 patients aged between 18 and 60 years with abnormal cardiac output response under dobutamine stress echocardiography, without primary cardiac disease or a history of alcohol intake. Patients were assigned randomly to receive metoprolol or placebo for 6 months. The primary endpoint was the improvement in cardiac output response to stress, measured by an increase in the left ventricle stroke volume more than 30%. RESULTS: Three (7.3%) patients in the metoprolol group and nine (24.3%) patients in the placebo group showed improved stroke volume (P=0.057). Diastolic dysfunction was found in two (4.8%) patients before and in five (15.6%) patients after therapy in the metoprolol group, and in 10 (27%) patients before and nine (31%) patients after therapy in the placebo group (P=0.67). After treatment, no echocardiography parameter of morphology was significantly different between metoprolol or placebo groups. No significant differences were observed in noradrenaline, plasma renin activity, and troponin levels between groups. Cirrhosis-related clinical events, including hospitalizations and mortality, were not significantly different between the two groups. Six months of therapy with ß-blocker did not ameliorate heart function and morphology in patients with cirrhotic cardiomyopathy.


Assuntos
Antagonistas de Receptores Adrenérgicos beta 1/uso terapêutico , Cardiomiopatias/tratamento farmacológico , Cirrose Hepática/tratamento farmacológico , Metoprolol/uso terapêutico , Adolescente , Antagonistas de Receptores Adrenérgicos beta 1/efeitos adversos , Adulto , Biomarcadores/sangue , Brasil , Débito Cardíaco/efeitos dos fármacos , Cardiomiopatias/diagnóstico por imagem , Cardiomiopatias/etiologia , Cardiomiopatias/fisiopatologia , Ecocardiografia sob Estresse , Feminino , Humanos , Cirrose Hepática/complicações , Cirrose Hepática/diagnóstico , Masculino , Metoprolol/efeitos adversos , Pessoa de Meia-Idade , Contração Miocárdica/efeitos dos fármacos , Norepinefrina/sangue , Estudos Prospectivos , Recuperação de Função Fisiológica , Renina/sangue , Fatores de Tempo , Resultado do Tratamento , Troponina/sangue , Função Ventricular Esquerda/efeitos dos fármacos , Remodelação Ventricular/efeitos dos fármacos , Adulto Jovem
4.
Rev. salud pública ; 19(3): 362-367, mayo-jun. 2017. tab
Artigo em Espanhol | LILACS-Express | ID: biblio-903116

RESUMO

RESUMEN Objetivo Evaluar la percepción de calidad de vida en habitantes de zonas mineras de explotación de carbón mineral y zonas agrícolas Materiales y Métodos Estudio de corte trasversal descriptivo en 228 individuos habitantes de municipios de explotación de carbón (n=151) y de municipios con actividades agrícolas (n=78). Quienes respondieron encuesta SF36 y test socio demográfico. Resultados Se encontró que la percepción de la calidad de vida relacionada con la salud es menor en los habitantes del área de explotación del carbón frente a los habitantes de zona agrícola solo con diferencia estadística en la percepción general de la escala y sin diferencia pro cada una de las escalas. Discusión La contaminación generada en zonas de explotación minera de carbón repercute en la salud de las personas y su percepción de calidad de vida, la evidencia es débil al no demostrar diferencias estadísticamente significativas por área en cada subescala y solo se demostró en percepción general.


ABSTRACT Objective To evaluate the perception of quality of life in inhabitants of mineral mining areas of mineral coal and agricultural areas. Materials and Methods Descriptive cross-sectional study of 229 individuals living in coal mining municipalities (n=151) and municipalities with agricultural activities (n=78). Those who answered SF36 survey and socio-demographic test. Results It was found that the perception of the health-related quality of life is lower in the inhabitants of the area of coal exploitation compared to the inhabitants of agricultural zone only with statistical difference in the general perception of the scale and with no difference pro each one of the scales. Discussion Pollution generated in coal mining areas has an impact on the health of people and their perception of quality of life. The evidence is weak in showing no statistically significant differences by area in each subscale and was only demonstrated in general perception.

5.
Rev Salud Publica (Bogota) ; 19(3): 362-367, 2017 May-Jun.
Artigo em Espanhol | MEDLINE | ID: mdl-30183941

RESUMO

OBJECTIVE : To evaluate the perception of quality of life in inhabitants of mineral mining areas of mineral coal and agricultural areas. MATERIALS AND METHODS : Descriptive cross-sectional study of 229 individuals living in coal mining municipalities (n=151) and municipalities with agricultural activities (n=78). Those who answered SF36 survey and socio-demographic test. RESULTS : It was found that the perception of the health-related quality of life is lower in the inhabitants of the area of coal exploitation compared to the inhabitants of agricultural zone only with statistical difference in the general perception of the scale and with no difference pro each one of the scales. DISCUSSION : Pollution generated in coal mining areas has an impact on the health of people and their perception of quality of life. The evidence is weak in showing no statistically significant differences by area in each subscale and was only demonstrated in general perception.

6.
Clin Exp Rheumatol ; 32(5): 754-9, 2014 Sep-Oct.
Artigo em Inglês | MEDLINE | ID: mdl-25152021

RESUMO

OBJECTIVES: This paper aims to perform global assessment of long-term cardiac function in juvenile idiopathic arthritis (JIA) patients under TNF blockage therapy. METHODS: Twenty-five polyarticular-course JIA patients pre-anti-TNF and 22 healthy controls underwent conventional/tissue Doppler echocardiography and cardiac biomarkers measurements (N-terminal pro-brain natriuretic peptide [NT-pro-BNP] and troponin T) at baseline (BL). Twenty-one JIA patients completed six evaluations during two consecutive years. Clinical/laboratorial evaluations were assessed before and during TNF blockage therapy. RESULTS: JIA patients and controls were comparable regarding current age (p=0.898) and female gender (p=0.38). At BL isovolumetric relaxation time of left ventricle (p=0.03), ventricular septum (VS), E' wave (p=0.014) and VS S wave velocity (p=0.03) were significantly reduced in JIA patients compared to controls. Frequencies of elevated NT-pro-BNP and troponin T levels were similar in JIA and controls (p=0.297 and p=0.756) and levels remained within normal range throughout the study, except for one patient with mild troponin T elevation. During TNF blockage therapy, none of the 21 participants had heart failure, ejection fraction or other parameters alterations in conventional and tissue Doppler. Only one had mild pulmonary hypertension. Further analysis revealed that JIA patients with elevated levels of NT-pro-BNP at BL had significantly more active joints (p=0.025) and higher ESR (p=0.034). CONCLUSIONS: Long-term TNF blockage safety was demonstrated in JIA patients in spite of the observed subclinical diastolic involvement. Elevated cardiac biomarker in these patients was associated with inflammatory parameters reinforcing the need for a careful interpretation of this finding in patients with active disease.


Assuntos
Anti-Inflamatórios/uso terapêutico , Artrite Juvenil/tratamento farmacológico , Cardiopatias/etiologia , Fator de Necrose Tumoral alfa/antagonistas & inibidores , Adolescente , Anti-Inflamatórios/efeitos adversos , Artrite Juvenil/complicações , Artrite Juvenil/diagnóstico , Artrite Juvenil/imunologia , Biomarcadores/sangue , Estudos de Casos e Controles , Criança , Pré-Escolar , Ecocardiografia Doppler , Feminino , Cardiopatias/sangue , Cardiopatias/diagnóstico , Cardiopatias/fisiopatologia , Humanos , Masculino , Peptídeo Natriurético Encefálico/sangue , Fragmentos de Peptídeos/sangue , Estudos Prospectivos , Fatores de Risco , Fatores de Tempo , Resultado do Tratamento , Troponina T/sangue , Fator de Necrose Tumoral alfa/metabolismo , Função Ventricular Esquerda/efeitos dos fármacos
7.
BMC Med Educ ; 14: 25, 2014 Feb 05.
Artigo em Inglês | MEDLINE | ID: mdl-24502581

RESUMO

BACKGROUND: Focused echocardiographic examinations performed by intensivists and emergency room physicians can be a valuable tool for diagnosing and managing the hemodynamic status of critically ill children. The aim of this study was to evaluate the learning curve achieved using a theoretical and practical training program designed to enable pediatric intensivists and emergency physicians to conduct targeted echocardiograms. METHODS: Theoretical and practical training sessions were conducted with 16 pediatric intensivist/emergency room physicians. The program included qualitative analyses of the left ventricular (LV) and right ventricular (RV) functions, evaluation of pericardial effusion/cardiac tamponade and valvular regurgitation and measurements of the distensibility index of the inferior vena cava (dIVC), ejection fraction (EF) and cardiac index (CI). The practical training sessions were conducted in the intensive care unit; each student performed 24 echocardiograms. The students in training were evaluated in a practical manner, and the results were compared with the corresponding examinations performed by experienced echocardiographers. The evaluations occurred after 8, 16 and 24 practical examinations. RESULTS: The concordance rates between the students and echocardiographers in the subjective analysis of the LV function were 81.3% at the first evaluation, 96.9% at the second evaluation and 100% at the third evaluation (p < 0.001). For the dIVC, we observed a concordance of 46.7% at the first evaluation, 90.3% at the second evaluation and 87.5% at the third evaluation (p = 0.004). The means of the differences between the students' and echocardiographers' measurements of the EF and CI were 7% and 0.56 L/min/m2, respectively, after the third stage of training. CONCLUSIONS: The proposed training was demonstrated to be sufficient for enabling pediatric physicians to analyze subjective LV function and to measure dIVC, EF and CI. This training course should facilitate the design of other echocardiography training courses that could be implemented in medical residency programs to improve these physicians' technical skills and the care of critically ill patients.


Assuntos
Ecocardiografia , Medicina de Emergência/educação , Pediatria/educação , Adolescente , Criança , Pré-Escolar , Feminino , Ventrículos do Coração/diagnóstico por imagem , Humanos , Lactente , Internato e Residência/métodos , Masculino , Função Ventricular Esquerda
8.
Hepatology ; 59(3): 1043-51, 2014 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-23907731

RESUMO

UNLABELLED: Heart failure (HF) is, after cirrhosis, the second-most common cause of ascites. Serum B-type natriuretic peptide (BNP) plays an important role in the diagnosis of HF. Therefore, we hypothesized that BNP would be useful in the differential diagnosis of ascites. Consecutive patients with new onset ascites were prospectively enrolled in this cross-sectional study. All patients had measurements of serum-ascites albumin gradient (SAAG), total protein concentration in ascitic fluid, serum, and ascites BNP. We enrolled 218 consecutive patients with ascites resulting from HF (n = 44), cirrhosis (n = 162), peritoneal disease (n = 10), and constrictive pericarditis (n = 2). Compared to SAAG and/or total protein concentration in ascites, the test that best discriminated HF-related ascites from other causes of ascites was serum BNP. A cutoff of >364 pg/mL (sensitivity 98%, specificity 99%, and diagnostic accuracy 99%) had the highest positive likelihood ratio (168.1); that is, it was the best to rule in HF-related ascites. Conversely, a cutoff ≤ 182 pg/mL had the lowest negative likelihood ratio (0.0) and was the best to rule out HF-related ascites. These findings were confirmed in a 60-patient validation cohort. CONCLUSIONS: Serum BNP is more accurate than ascites analyses in the diagnosis of HF-related ascites. The workup of patients with new onset ascites could be streamlined by obtaining serum BNP as an initial test and could forego the need for diagnostic paracentesis, particularly in cases where the cause of ascites is uncertain and/or could be the result of HF.


Assuntos
Ascite , Insuficiência Cardíaca , Peptídeo Natriurético Encefálico/sangue , Adulto , Idoso , Ascite/diagnóstico , Ascite/etiologia , Ascite/metabolismo , Estudos Transversais , Diagnóstico Diferencial , Feminino , Insuficiência Cardíaca/complicações , Insuficiência Cardíaca/diagnóstico , Insuficiência Cardíaca/metabolismo , Humanos , Cirrose Hepática/complicações , Cirrose Hepática/diagnóstico , Cirrose Hepática/metabolismo , Masculino , Pessoa de Meia-Idade , Doenças Peritoneais/complicações , Doenças Peritoneais/diagnóstico , Doenças Peritoneais/metabolismo , Reprodutibilidade dos Testes , Sensibilidade e Especificidade
9.
Cardiol Young ; 24(2): 229-35, 2014 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-23458163

RESUMO

Mucopolysaccharidosis type VI (Marateaux-Lamy syndrome) is an autosomal recessive disorder caused by deficient activity of the enzyme N-acetylgalactosamine-4-sulphatase (arylsulphatase B). Cytoplasmic vacuoles full of dermatan sulphate are observed in endothelial cells, myocyte, and fibroblasts, compromising the function of cardiovascular structures and contributing significantly towards morbidity and mortality. The primary objective of this study was to assess the advantages of early replacement therapy with recombinant human arylsulphatase B through the echocardiographic follow-up of sisters who started treatment at quite different ages: one at 9 years and the other at 1 year and 7 months. The older sibling showed striking mitral and aortic valve compromise when she was only 2 years old and finally needed cardiac surgery at the age of 8, even before starting enzyme replacement. Differently, the younger one has developed only mild mitral and aortic lesions throughout the follow-up period of 3 years. The two siblings had left ventricle cardiomyopathy, but partial reverse remodelling was induced by enzyme replacement therapy in both cases. The younger sibling has never received any cardiovascular drugs, whereas the older one has been using ß-blockers and diuretics in addition to enzyme therapy to cope with heart failure. Comparing the outcomes of these two sisters with a very aggressive phenotype of mucopolysaccharidosis type VI, the conclusion was that early onset of therapy may slow down the disease progression and prevent severe cardiac lesions to be established. Moreover, patients' compliance is essential for the success of treatment, as sequential echocardiographic evaluation demonstrated worsening of some cardiac lesions whenever infusions were missed.


Assuntos
Insuficiência da Valva Aórtica/tratamento farmacológico , Cardiomiopatias/tratamento farmacológico , Intervenção Médica Precoce , Terapia de Reposição de Enzimas , Insuficiência da Valva Mitral/tratamento farmacológico , Mucopolissacaridose VI/tratamento farmacológico , N-Acetilgalactosamina-4-Sulfatase/uso terapêutico , Proteínas Recombinantes/uso terapêutico , Irmãos , Insuficiência da Valva Aórtica/diagnóstico por imagem , Insuficiência da Valva Aórtica/etiologia , Cardiomiopatias/diagnóstico por imagem , Cardiomiopatias/etiologia , Estudos de Casos e Controles , Criança , Ecocardiografia , Feminino , Seguimentos , Humanos , Lactente , Insuficiência da Valva Mitral/diagnóstico por imagem , Insuficiência da Valva Mitral/etiologia , Mucopolissacaridose VI/complicações , Mucopolissacaridose VI/diagnóstico por imagem , Remodelação Ventricular
10.
J Am Soc Echocardiogr ; 26(11): 1337-43, 2013 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-23993693

RESUMO

BACKGROUND: Transesophageal echocardiography (TEE) plays an important role in evaluating cardioembolic sources of emboli. The identification of a patent foramen ovale (PFO) is reportedly improved with TEE compared with transthoracic echocardiography (TTE), but the Valsalva maneuver during TEE may be difficult or suboptimal. The aim of this study was to assess the efficacy of the Valsalva maneuver for PFO diagnosis using TEE compared with TTE by evaluating patients with ischemic stroke referred for echocardiography. METHODS: Only patients able to perform the Valsalva maneuver during TTE were included; efficacy was defined by a 20 cm/sec decrease in transmitral E velocity. A PFO was judged present when microbubbles of agitated intravenous saline were seen in the left chambers within three cycles after right atrial opacification. RESULTS: Of 108 patients (mean age, 55 ± 15 years; 61 men), 48 (44%) were judged to have PFOs by TEE and/or TTE. In 36 patients (33% of the total, 75% of those with PFOs), microbubbles were observed both by TEE and TTE, in seven patients only during TTE, and in five patients only during TEE. In patients able to satisfactorily perform the Valsalva maneuver during TEE, 22 PFOs were found, and two shunts (9%) were missed, whereas in patients unable to perform this maneuver, 26 PFOs were observed, with five shunts missed (19%) (P < .05). When a PFO was missed by TTE, either the echocardiographic window was suboptimal or the shunt was small. CONCLUSIONS: An adequate Valsalva maneuver is crucial for diagnosis of PFO; most patients with stroke may be screened using TTE with contrast and the Valsalva maneuver, with TEE indicated in case of suboptimal transthoracic images.


Assuntos
Ecocardiografia Transesofagiana/estatística & dados numéricos , Forame Oval Patente/diagnóstico por imagem , Forame Oval Patente/epidemiologia , Acidente Vascular Cerebral/diagnóstico , Acidente Vascular Cerebral/epidemiologia , Manobra de Valsalva , Brasil/epidemiologia , Causalidade , Comorbidade , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Reprodutibilidade dos Testes , Medição de Risco , Sensibilidade e Especificidade
11.
Ann Hepatol ; 12(1): 85-91, 2013 Jan-Feb.
Artigo em Inglês | MEDLINE | ID: mdl-23293198

RESUMO

BACKGROUND: The impact of end-stage liver disease (ESLD) in cardiac remodeling of patients with cirrhosis is unknown. Our aim was to correlate the severity of ESLD with morphologic and functional heart changes. MATERIAL AND METHODS: 184 patients underwent a protocol providing data on the severity of ESLD and undergoing echocardiography to assess the diameters of the left atrium and right ventricle; the systolic and diastolic diameters of the left ventricle, interventricular septum, and posterior wall of the left ventricle; systolic pulmonary artery pressure; ejection fraction; and diastolic function. Severity of ESLD was assessed by the Model for End-Stage Liver Disease (MELD) score. RESULTS: Left-atrial diameter (r = 0.323; IC 95% 0.190-0.455; p < 0.001), left-ventricular diastolic diameter (r = 0.177; IC 95% 0.033-0.320; p = 0.01) and systolic pulmonary artery pressure (r = 0.185; IC 95% 0.036-0.335; p = 0.02) significantly correlated with MELD score. Patients with MELD ≥ 16 had significantly higher left-atrial diameter and systolic pulmonary artery pressure, compared with patients with MELD scores < 16 points. CONCLUSIONS: Changes in cardiac structure and function correlate with the severity of ESLD.


Assuntos
Cardiomiopatia Dilatada/diagnóstico por imagem , Doença Hepática Terminal/complicações , Hipertensão Pulmonar/diagnóstico por imagem , Cirrose Hepática/complicações , Adulto , Idoso , Cardiomiopatias/diagnóstico por imagem , Cardiomiopatias/etiologia , Cardiomiopatias/fisiopatologia , Cardiomiopatia Dilatada/etiologia , Cardiomiopatia Dilatada/fisiopatologia , Estudos de Coortes , Ecocardiografia , Eletrocardiografia , Doença Hepática Terminal/patologia , Hipertensão Pulmonar Primária Familiar , Feminino , Humanos , Hipertensão Pulmonar/etiologia , Hipertensão Pulmonar/fisiopatologia , Fígado/patologia , Cirrose Hepática/patologia , Masculino , Pessoa de Meia-Idade , Índice de Gravidade de Doença , Remodelação Ventricular
12.
J Thorac Cardiovasc Surg ; 145(5): 1345-1351.e4, 2013 May.
Artigo em Inglês | MEDLINE | ID: mdl-22925567

RESUMO

BACKGROUND: Ventricle retraining with abrupt systolic overload can cause myocardial edema and necrosis, followed by late ventricular failure. Intermittent systolic overload could minimize the inadequacy of conventional pulmonary artery banding. The present study compared ventricle function under dobutamine stress in 2 protocols of systolic overload in young goats. METHODS: Nineteen young goats were divided into 3 groups: sham (n = 7; no systolic pressure overload), continuous (n = 6; systolic overload maintained for 96 hours), and intermittent (n = 6; 4 periods of 12-hour systolic overload, paired with a 12-hour resting period). Echocardiographic and hemodynamic evaluations were performed daily. The myocardial performance index and ejection fraction were evaluated at rest and during dobutamine stress. The goats were then killed for morphologic evaluation. RESULTS: The intermittent group underwent less systolic overload than the continuous group (P < .05). Nevertheless, both groups had increased right ventricular and septal masses compared with the sham group (P < .0002). Echocardiography revealed a major increase in right ventricular wall thickness in the intermittent group (+64.8% ± 23.37%) compared with the continuous group (+43.9% ± 19.26%; P = .015). Only the continuous group remained with significant right ventricular dilation throughout the protocol (P < .001). The intermittent group had a significantly better myocardial performance index at the end of the protocol, under resting and dobutamine infusion, compared with the continuous group (P < .012). CONCLUSIONS: Both systolic overload protocols have induced rapid right ventricular hypertrophy. However, only the intermittent group had better preservation of right ventricular function at the end of the protocol, both at rest and during dobutamine infusion.


Assuntos
Ecocardiografia sob Estresse , Hipertrofia Ventricular Direita/diagnóstico por imagem , Artéria Pulmonar/cirurgia , Animais , Constrição , Modelos Animais de Doenças , Edema Cardíaco/diagnóstico por imagem , Edema Cardíaco/etiologia , Cabras , Hemodinâmica , Hipertrofia Ventricular Direita/etiologia , Hipertrofia Ventricular Direita/fisiopatologia , Contração Miocárdica , Artéria Pulmonar/fisiopatologia , Fatores de Tempo , Função Ventricular Direita , Pressão Ventricular
14.
J Echocardiogr ; 10(2): 67-8, 2012 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-27278047

RESUMO

Endogenous endophthalmitis is a rare complication of endocarditis, rendering poor visual prognosis. We report a case of a 66-year-old female with renal failure who presented with fever, ocular pain, and purulent eye discharge. After a diagnosis of endogenous endophthalmitis, she was treated with antibiotics and enucleation of the eye. Due to persistent fever and positive blood cultures, a transesophageal echocardiography was undertaken, disclosing a large mural vegetation in the right atrium, catheter-associated vegetations, and a patent foramen ovale. Endocarditis is an uncommon source of endogenous endophthalmitis, and has rarely been associated to right-sided endocarditis and paradoxical septic embolization.

17.
Rev. bras. ecocardiogr ; 21(4): 30-38, out.-nov. 2008. tab
Artigo em Português | LILACS | ID: lil-497520

RESUMO

Fundamento e Objetivo: No estudo da função diastólica do ventrículo esquerdo (FDVE) com o ecocardiograma, analisa-se o fluxo mitral (FM) e o fluxo em veia pulmonar com o Doppler tecidual e a velocidade de programação do FM com o Doppler colorido modo-M (VPF). A análise conjunta dessas 5 modalidades ecocardiográficas proporciona a melhor análise da FDVE. Entretanto, nem sempre é possível utilizar todos esses métodos no mesmo paciente. O objetivo deste estudo foi verificar qual a forma de avaliação que apresenta a maior equivalência diagnóstica, com o resultado obtido pela análise em conjunto dos 5 métodos ecocardiográficos de avaliação da FDVE. Método: Estudo seccional em que foi avaliada a FDVE, nos pacientes encaminhados para a realização de ecocardiograma de rotina. Em todos eles, foram utilizadas as 5 formas de avaliação da FDVE. Resultados: Foram estudados 85 pacientes, com média etária 57 + - 14,7 anos de idade, 39 homens. Os pacientes foram distribuídos em 4 grupos, de acordo com a análise conjunta das 5 formas de avaliação da FDVE: G1 - padrão normal de FDVE (n=39); G2 - padrão de alteração do relaxamento do VE (n=22); G3 - padrão pseudonormal (n=11) e G4 - padrão restritivo (n=13). As taxas de concordância de cada método...


Assuntos
Humanos , Feminino , Adulto , Pessoa de Meia-Idade , Idoso de 80 Anos ou mais , Insuficiência Cardíaca/diagnóstico , Ecocardiografia/métodos , Ecocardiografia
19.
J Thorac Cardiovasc Surg ; 133(6): 1510-6, 2007 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-17532949

RESUMO

OBJECTIVES: Rapid ventricular conditioning induced by pulmonary artery banding has been recommended for patients with transposition of the great arteries who have lost the chance for the arterial switch operation or whose systemic (right) ventricle failed after the atrial switch. The present study was designed to experimentally evaluate 2 types of pulmonary artery banding (continuous and intermittent) and verify histologically the changes (hypertrophy or hyperplasia or both) of cardiomyocytes and vascular and interstitial cells from the stimulated ventricle beyond the neonatal period. METHODS: Twenty-one goats, 30 to 60 days old, were divided into 3 groups, each comprising 7 animals, as follows: control group (no surgical procedure); continuously stimulated group (systolic overload maintained for 96 hours); and intermittently stimulated group (4 periods of 12-hour systolic overload, alternated with a resting period of 12 hours). The animals were then killed for histologic and immunohistochemical analysis of the hearts. Murine monoclonal antibody Ki-67 was used as a proliferation cell marker. Myocardial collagen area fraction was determined by Sirius red staining. RESULTS: For both stimulated groups, a significant increase occurred in right ventricular cardiomyocytes and respective nuclei diameters compared with the controls (P < .05). The number of Ki-67-positive cardiomyocytes and interstitial/vessel cells from the right ventricle was augmented in both trained groups in relation to the left ventricle (P < .05). There was no significant difference in the right ventricular collagen area fraction from both trained groups compared with controls. CONCLUSIONS: Irrespective of the shorter training time (periods of overload intercalated with resting), the intermittent stimulation regimen was able to produce a similar training of the subpulmonary ventricle compared with the continuous stimulation regarding mass acquisition, cell hypertrophy, and hyperplasia.


Assuntos
Adaptação Fisiológica , Procedimentos Cirúrgicos Cardíacos/métodos , Miócitos Cardíacos/fisiologia , Artéria Pulmonar/cirurgia , Transposição dos Grandes Vasos/cirurgia , Análise de Variância , Animais , Proliferação de Células , Modelos Animais de Doenças , Ecocardiografia , Cabras , Ventrículos do Coração/diagnóstico por imagem , Ventrículos do Coração/patologia , Hiperplasia , Hipertrofia , Imuno-Histoquímica , Transposição dos Grandes Vasos/diagnóstico por imagem , Transposição dos Grandes Vasos/patologia , Transposição dos Grandes Vasos/fisiopatologia
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