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J Biomech ; 48(9): 1625-30, 2015 Jun 25.
Artigo em Inglês | MEDLINE | ID: mdl-25798760

RESUMO

Topically applied microbicide gels can provide a self-administered and effective strategy to prevent sexually transmitted infections (STIs). We have investigated the interplay between vaginal tissue elasticity and the yield-stress of non-Newtonian fluids during microbicide deployment. We have developed a mathematical model of tissue deformation driven spreading of microbicidal gels based on thin film lubrication approximation and demonstrated the effect of tissue elasticity and fluid yield-stress on the spreading dynamics. Our results show that both elasticity of tissue and yield-stress rheology of gel are strong determinants of the coating behavior. An optimization framework has been demonstrated which leverages the flow dynamics of yield-stress fluid during deployment to maximize retention while reaching target coating length for a given tissue elasticity.


Assuntos
Anti-Infecciosos Locais/química , Vagina/fisiologia , Administração Intravaginal , Fenômenos Biomecânicos , Líquidos Corporais/química , Sistemas de Liberação de Medicamentos , Elasticidade , Feminino , Géis , Humanos , Hidrodinâmica , Modelos Biológicos , Reologia , Resistência ao Cisalhamento
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