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1.
Parasitol Res ; 118(12): 3535-3542, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31701296

RESUMO

Neospora caninum causes neosporosis, a leading cause of bovine abortion worldwide. Uruguay is a developing economy in South America that produces milk to feed seven times its population annually. Naturally, dairy production is paramount to the country's economy, and bovine reproductive failure impacts it profoundly. Recent studies demonstrated that the vast majority of infectious abortions in dairy cows are caused by N. caninum. To delve into the local situation and contextualize it within the international standing, we set out to characterize the Uruguayan N. caninum strains. For this, we isolated four distinct strains and determined by microsatellite typing that these represent three unique genetic lineages, distinct from those reported previously in the region or elsewhere. An unbiased analysis of the current worldwide genetic diversity of N. caninum strains known, whereby six typing clusters can be resolved, revealed that three of the four Uruguayan strains group closely with regional strains from Argentina and Brazil. The remaining strain groups in an unrelated genetic cluster, suggesting multiple origins of the local strains. Microsatellite typing of N. caninum DNA from fetuses opportunistically collected from local dairy farms correlated more often with one of the isolates. Overall, our results contribute to further understanding of genetic diversity among strains of N. caninum both regionally and worldwide.


Assuntos
Aborto Animal/parasitologia , Doenças dos Bovinos/parasitologia , Coccidiose/veterinária , Neospora/genética , Neospora/isolamento & purificação , Animais , Argentina , Brasil , Bovinos , Doenças dos Bovinos/epidemiologia , Coccidiose/parasitologia , Feminino , Repetições de Microssatélites , Neospora/classificação , Neospora/imunologia , Filogenia , Gravidez , Uruguai
2.
Rev. argent. salud publica ; 10(40): 44-47, 30 de septiembre 2019.
Artigo em Espanhol | LILACS, BINACIS, ARGMSAL | ID: biblio-1024943

RESUMO

El monitoreo de indicadores epidemiológicos es un elemento clave en el fortalecimiento de la respuesta al VIH. OBJETIVO: Se presenta un análisis epidemiológico de las tendencias en indicadores seleccionados en base a las notificaciones de infección reportadas a la Coordinación Salud Sexual, Sida e Infecciones de Transmisión Sexual, dependiente del Ministerio de Salud de la Ciudad Autónoma de Buenos Aires entre 2003 y 2017. MÉTODOS: En dicho análisis se incluyen datos sobre la distribución por sexo e índice de masculinidad, el acceso al diagnóstico de VIH, la distribución por edad al momento del diagnóstico, la cobertura de salud, las vías de transmisión, la tasa de mortalidad por sida, la vigilancia de la transmisión perinatal del VIH y la situación de niños, niñas y adolescentes con VIH. RESULTADOS: Los datos presentados reflejan un perfil metropolitano en el que predomina la transmisión sexual tanto en mujeres como en varones y ponen en evidencia algunas situaciones que precisan un abordaje específico y avalan la importancia de implementar estrategias de prevención diferenciadas de acuerdo a las necesidades de cada grupo poblacional. DISCUSIÓN: La forma en la que se presenta la información muestra una clara intencionalidad de fomentar la interacción entre la epidemiología y la toma de decisiones en salud, a sabiendas de que esa información constituye una herramienta fundamental para la definición y puesta en práctica de políticas públicas. Palabras clave: Epidemiología; VIH; Ciudad de Buenos Aires


Assuntos
Epidemiologia , HIV
3.
Case Rep Pathol ; 2019: 2905078, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31281701

RESUMO

Subarachnoid hemorrhage is a medical emergency. Berry aneurysm rupture is the second most common cause following trauma. Diagnosis is often challenging. Neurogenic heart syndrome often complicates subarachnoid hemorrhage. A concomitant pheochromocytoma can be deadly causing sudden cardiac arrhythmia. Here, we describe a case of subarachnoid hemorrhage with concomitant incidental pheochromocytoma in a relatively young female who died suddenly, diagnosed during autopsy. A 57-year-old Hispanic woman with past medical history of asthma, prediabetes, and uncontrolled hypertension collapsed unexpectedly. She initially had ventricular tachycardia, followed by pulseless electrical activity and finally asystole without response to resuscitation. In the emergency department she was on epinephrine, calcium, naloxone, and tPA with suspected thrombotic stroke. Despite measures, she was pronounced dead. Autopsy revealed subarachnoid hemorrhage due to a ruptured berry aneurysm. Additionally, pheochromocytoma was detected in the right adrenal gland. Subarachnoid hemorrhage has a grave prognosis by itself. This case describes the uncommon detection of pheochromocytoma in the setting of subarachnoid hemorrhage.

4.
Rev. argent. salud publica ; 10(38): 38-42, Abril 2019.
Artigo em Espanhol | LILACS, BINACIS, ARGMSAL | ID: biblio-996494

RESUMO

INTRODUCCIÓN: El diagnóstico oportuno de la infección por VIH es una estrategia clave en el control de la epidemia. El uso de las pruebas rápidas facilita el acceso al diagnóstico en el primer nivel de atención y en espacios por fuera del sistema de salud. MÉTODOS: Se describió el proceso de implementación del test rápido para VIH en la Ciudad Autónoma de Buenos Aires (CABA), analizando indicadores epidemiológicos para evaluar el impacto sanitario. RESULTADOS: Desde el inicio de esta estrategia en 2012 y hasta 2018, el test rápido se implementó en 36 centros de la ciudad, tanto en el sistema de salud como en organizaciones de la sociedad civil. En 2014 se inició una campaña de promoción con testeos mensuales en el espacio público de distintos barrios. El número de personas sometidas a la prueba se duplicó en los centros de testeo y aumentó progresivamente en los laboratorios de los hospitales públicos, con un descenso en la proporción de diagnósticos en estadios sintomáticos. CONCLUSIONES: La implementación de la prueba rápida para el diagnóstico de VIH en CABA muestra un modelo exitoso de oferta de prestación en los puntos de atención, que facilita el acceso al tamizaje y que puede extenderse para el diagnóstico y tratamiento de otras infecciones de transmisión sexual.


Assuntos
Humanos , Saúde Pública , HIV , Diagnóstico , Implementação de Plano de Saúde
5.
An Acad Bras Cienc ; 90(3): 3155-3164, 2018 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-30304242

RESUMO

Rodents used in biomedical research are maintained behind barriers to exclude microbial contaminants. Several check points have to be monitored to eliminate the potential of introducing adventitious agents into the facility. Microbiological monitoring of a mouse facility environment enables to evaluate the efficiency of sanitization and cleaning procedures, air quality, and technician good practices. At our SPF mouse facility, we implemented an environmental microbiological monitoring program based in sedimentation and swabbing, inexpensive and easy to use methods. The aim of this work was to evaluate the results and the efficiency of the monitoring program after seven years. The median for bacteria and fungi counts in the SPF sampled areas was ≤2 CFU/2 h for settle plates and <1 CFU per swabbing plate, satisfying the requirements for grade C of the EU-GMP, with some modifications. The environmental monitoring program was useful to detect early warning of problems and enabled us to define a safe range of microbiological counts. In addition, SPF status defined for our mice was maintained throughout this study, confirmed by our HM program. This work could encourage directors and technicians of other mouse facilities in Latin America and rest of the world to implement this kind of program.


Assuntos
Animais de Laboratório/microbiologia , Microbiologia Ambiental/normas , Monitoramento Ambiental/normas , Animais , Animais de Laboratório/parasitologia , Animais de Laboratório/virologia , Carga Bacteriana , Ambiente Controlado , Arquitetura de Instituições de Saúde , Feminino , Camundongos , Vírus Miúdo do Camundongo , Avaliação de Programas e Projetos de Saúde/métodos , Avaliação de Programas e Projetos de Saúde/normas
6.
Univ. med ; 59(1)20180000. tab
Artigo em Espanhol | LILACS, COLNAL | ID: biblio-994837

RESUMO

Introducción: Conceptos como limitación del esfuerzo terapéutico (LET) son de vital importancia para la práctica diaria. Objetivo: Identificar conocimientos, prácticas, actitudes y opiniones sobre LET en un servicio de pediatría. Método: Estudio observacional descriptivo de corte transversal. Encuesta estructurada. Resultados: Se evaluaron 121 encuestas (80% de la población). El 96% de las personas conocen el término LET, el 91,5% ha estado en contacto con al menos un caso, pero solo el 25% considera haber recibido capacitación en el tema durante su formación; en el 86 % de los casos la decisión de LET se tomó en junta multidisciplinaria o en conjunto con la familia. Conclusiones: Las personas encuestadas están familiarizadas con el término LET; son muy pocas las que recibieron capacitación durante su entrenamiento. Es necesario el desarrollo de herramientas educativas y apoyo respecto a cuidados paliativos pediátricos para el personal de salud a cargo de pacientes pediátricos.


Introduction: Concepts like End of Life Care (ELC) are vital for daily practice. Objective: To identify the knowledge, practices, attitudes and opinions about ELC in a Pediatric Service. Method: Descriptive observational cross-sectional study. Structured survey. Results: 121 surveys (80% of the population) were evaluated. 96% of the people know the term ELC, 91.5% have been in contact with at least one case, but only 25% consider having received training in the subject during their training, in 86% of cases the decisión to ELC was taken in a multidisciplinary meeting or in conjunction with the family. Conclusions: Respondents are familiar with the term ELC, very few are trained during their training. We consider it necessary to develop educational tools and support with regard to pediatric palliative care for health personnel in charge of pediatric patients.


Assuntos
Unidades de Terapia Intensiva Neonatal/ética , Ética Médica
7.
Rev. cientif. cienc. med ; 21(1): 107-112, 2018. ilus
Artigo em Espanhol | LILACS | ID: biblio-959745

RESUMO

El abdomen hostil es una severa complicación, resultado de múltiples intervenciones quirúrgicas de emergencia realizadas para controlar procesos sépticos abdominales, fugas anastomóticas, complicaciones postoperatorias, y evitar un síndrome compartimental. Estas secuencias quirúrgicas llevan a la creación de ostomías, retracción aponeurótica y formación de adherencias fibrosas intraperitoneales; creando un abdomen de difícil abordaje al momento de la reconstrucción y cierre abdominal, una vez superada la fase aguda. Se presenta el caso clínico de un paciente masculino de 24 años con antecedente de nueve cirugías a raíz de una apendicitis complicada, que lo hace portador de ileostomía, hernia insicional gigante y un abdomen congelado. Acude para la restitución de tránsito intestinal y reparación del defecto herniario, representando un reto quirúrgico de manejo multidisciplinario y un impacto psicológico como económico para el paciente donde las decisiones se basan en los hallazgos intraoperatorios.


The hostile abdomen is a severe complication, resulting of multiple emergency surgical interventions, performed to control septic abdominal processes, anastomotic leakage, and postoperative complications and avoid a compartment syndrome. This sequence of surgeries lead to the creation of ostomies, aponeurotic retraction and the formation of intraperitoneal fibrous adhesions; creating a difficult abdomen to approach at the moment of reconstruction and abdominal closure once the acute phase is over.The clinical case of a 24 year-old male patient is presented, with a history of nine surgeries due to a complicated appendicitis, carrying an ileostomy, giant insicional hernia and a frozen abdomen. He came for the restitution of intestinal transit and repair the hernia defect; representing surgical challenge of a multidisciplinary management with high psychological as economic impact for the patient, where decisions are based on intraoperative findings.


Assuntos
Humanos , Masculino , Adulto , Sepse , Apendicite/diagnóstico , Laparoscopia
8.
Environ Pollut ; 231(Pt 1): 415-425, 2017 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-28826075

RESUMO

The harmful effects of oil on various species of flora and fauna have been studied extensively; however, few studies have studied the effects of oil exposure on human health. The objective of this research was to collect information on the acute health effects and serious psychological symptoms of the possible consequences of such exposure to crude oil. Some studies focused on the composition of different chemicals used in the extraction process, and wastes generated proved to be highly harmful to human health. Thus, studies have shown that individuals who live near oil fields or wells - or who take part in activities of cleaning oil spills - have presented health conditions, such as irritation to the skin, eyes, mucous membranes, kidney damage, liver, reproductive, among others. In Ecuador, this reality is not different from other countries, and some studies have shown increased diseases related with oil crude and oil spills, like skin irritation, throat, liver, lung, infertility, and abortions, and it has been linked to childhood leukemia. Other studies suggest a direct relationship between DNA damage because of oil resulting in a genetic instability of the main enzymes of cellular metabolism as well as a relationship with some cancers, such as leukemia.


Assuntos
Indústrias Extrativas e de Processamento , Poluição por Petróleo , Petróleo/toxicidade , Equador , Humanos , Neoplasias
9.
Infect Dis Obstet Gynecol ; 2017: 8572065, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28717342

RESUMO

Human papillomavirus (HPV) is the primary infectious agent for the development of cervical cancer, although the presence of the virus alone is insufficient for viral development and proliferation; this can be attributed to the increase in potential oncogenic risk, along with other risk factors. In the present investigation, the prevalence of high-risk HPV was determined from samples of premalignant or malignant cervical cytology in women from the southern region of Ecuador. The kit we used was able to detect genotypes 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, and 59. In addition, 64.5% of the analyzed samples were positive for HPV, with genotypes 16 and 18 being the most prevalent (16 was detected in 148 samples and 18 in 108). Genotypes 58 and 51 were the third most frequent simple and multiple infections, respectively. The data are very similar to those obtained worldwide, suggesting that the strategy of sex education, and the use of vaccines as primary prevention agents, could significantly decrease the incidence and mortality rate of cervical cancer in the southern region of Ecuador.


Assuntos
Papillomaviridae/isolamento & purificação , Infecções por Papillomavirus/epidemiologia , Neoplasias do Colo do Útero/epidemiologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Estudos Transversais , Equador/epidemiologia , Feminino , Genótipo , Humanos , Pessoa de Meia-Idade , Teste de Papanicolaou , Papillomaviridae/genética , Infecções por Papillomavirus/virologia , Gravidez , Prevalência , Fatores de Risco , Neoplasias do Colo do Útero/virologia , Esfregaço Vaginal , Adulto Jovem
10.
Rev. Rol enferm ; 40(1): 48-54, ene. 2017. tab, ilus
Artigo em Espanhol | IBECS | ID: ibc-159321

RESUMO

En pacientes con neoplasias, la administración de tratamientos debe realizarse por profesionales de enfermería con experiencia y conocimientos de la patología que se ha de tratar, de los fármacos, de las técnicas y de los dispositivos que se han de utilizar para su administración. La implantación de un dispositivo de acceso venoso con reservorio subcutáneo ofrece la posibilidad de múltiples, frecuentes inyecciones y extracción de sangre. Son estéticamente mejor aceptados que los catéteres externos, tiene menor riesgo de salida accidental e infección, precisan menos cuidados y permiten el tratamiento ambulatorio. Otras ventajas son que causan menos limitaciones de actividad diaria e higiene, lo que se relaciona con un aumento de la calidad de vida. Los resultados de éxito en la colocación y la disminución de las complicaciones mejoraron sensiblemente cuando para su implantación se utiliza fluoroscopia y ultrasonido (entre el 99 % y el 100 %), siendo las complicaciones de la colocación (hemorragia, neumotórax) del 0 %. La tasa de infecciones -trombosis venosa profunda (TVP)- no es llamativa, y permanece dentro de los parámetros normales en relación con los sistemas pectorales. Estos dispositivos son especialmente útiles en pacientes con anormalidades de pared del tórax (carcinoma dérmico de la pared del tórax y corazas tumorales). También cuando existen heridas abiertas de la zona torácica, traqueotomía o fibrosis producida por la radioterapia. Y ante la existencia de cicatrices de los colgajos después de una cirugía en cáncer de cuello (o cuando se prevea que el paciente va a recibir este tratamiento quirúrgico), cifosis severa, pacientes obesos y pacientes con insuficiencia respiratoria (AU)


Administering treatments in patients with malignancies must be performed by nursing professionals with experience and knowledge of the pathology being treated, drugs, techniques and devices used for administration. The implantation of a venous access device with subcutaneous reservoir offers the possibility of multiple and long-term frequent injections and also blood extraction from a less invasive way. They are aesthetically more acceptable than external catheters, they have a lower risk of accidental release and infection, they require less care and they allow extra-hospital treatment. Another advantage to consider is that they cause less limitations in daily life, which is associated with an increased quality of life. Placement of devices with camera of brachial location, was done by the first time by venotomy technique with many doubts; however, the results of placement success and the decreased complications, improved significantly when the placement began performing by vascular radiology services using fluoroscopy and ultrasound. Particularly striking is the success rate (between 99 % and 100 %) with a 0 % rate of placement complications (hemorrhage, pneumothorax). The infection rate is not flashy, remaining within normal parameters in relation to the pectoral systems. The rates of deep vein thrombosis (DVT) are assumable and they are consistent with other related studies. These devices are particularly useful in patients with abnormalities of chest wall such as dermal carcinoma and tumor shell in patients with breast cancer (tumour the bottom shell). And also when there are open wounds in the chest area, such as tracheotomy or fibrosis caused by radiation therapy, or in the presence of scars of flaps after surgery in head and neck cancer (or when it is expected that the patient will receive this surgery), severe kyphosis, obese patients and patients with respiratory failure (AU)


Assuntos
Humanos , Masculino , Feminino , Artéria Braquial/cirurgia , Cateterismo Venoso Central/instrumentação , Cateterismo Venoso Central/métodos , Cateterismo Venoso Central/enfermagem , Fluoroscopia , Tela Subcutânea/fisiologia , Extravasamento de Materiais Terapêuticos e Diagnósticos/enfermagem , Cateterismo/efeitos adversos , Enfermagem Perioperatória/métodos , Enfermagem Perioperatória/organização & administração
11.
Rev Enferm ; 40(1): 48-54, 2017 Jan.
Artigo em Espanhol | MEDLINE | ID: mdl-30260163

RESUMO

Administering treatments in patients with malignancies must be performed by nursing professionals with experience and knowledge of the pathology being treated, drugs, techniques and devices used for administration. The implantation of a venous access device with subcutaneous reservoir offers the possibility of multiple and long-term frequent injections and also blood extraction from a less invasive way. They are aesthetically more acceptable than external catheters, they have a lower risk of accidental release and infection, they require less care and they allow extra-hospital treatment. Another advantage to consider is that they cause less limitations in daily life, which is associated with an increased quality of life. Placement of devices with camera of brachial location, was done by the first time by venotomy technique with many doubts; however, the results of placement success and the decreased complications, improved significantly when the placement began performing by vascular radiology services using fluoroscopy and ultrasound. Particularly striking is the success rate (between 99% and 100%) with a 0% rate of placement complications (hemorrhage, pneumothorax). The infection rate is not flashy, remaining within normal parameters in relation to the pectoral systems. The rates of deep vein thrombosis (DVT) are assumable and they are consistent with other related studies. These devices are particularly useful in patients with abnormalities of chest wall such as dermal carcinoma and tumor shell in patients with breast cancer (tumour the bottom shell). And also when there are open wounds in the chest area, such as tracheotomy or fibrosis caused by radiation therapy, or in the presence of scars of flaps after surgery in head and neck cancer (or when it is expected that the patient will receive this surgery), severe kyphosis, obese patients and patients with respiratory failure.


Assuntos
Cateterismo Venoso Central/métodos , Cateteres de Demora , Artéria Braquial , Cateterismo Venoso Central/instrumentação , Cateteres Venosos Centrais , Humanos
12.
Rev. Asoc. Esp. Espec. Med. Trab ; 19(3): 15-20, dic. 2010. tab
Artigo em Espanhol | IBECS | ID: ibc-89301

RESUMO

En los pacientes con traumatismos menores de la extremidad inferior no se recomienda instaurar tromboprofilaxis de forma sistemática. Se revisaron las características clínicas y la presencia de trombofilia en estos casos. Método: Estudio retrospectivo de casos de enfermedad tromboembólica venosa tras traumatismos menores de la extremidad inferior. Resultados: Entre marzo de 2001 y marzo de 2006, se diagnosticaron 21 casos de enfermedad tromboembólica venosa tras traumatismos menores de la extremidad inferior. Veinte pacientes presentaron trombosis venosa profunda (TVP); hubo dos casos de tromboembolismo pulmonar. En 10 (71%) de los 14 pacientes que participaron en el estudio de trombofilia se encontraron alteraciones. Conclusiones: Los traumatismos menores de la extremidad inferior constituyen un factor de riesgo para el desarrollo de enfermedad tromboembólica venosa. En este tipo de traumatismos debe considerarse la posibilidad de instaurar tromboprofilaxis. El diagnóstico de trombofilia debe de tenerse en cuenta cuando se desarrolla enfermedad tromboembólica venosa tras traumatismos menores de la extremidad inferior (AU)


Background: In patients with minor trauma of the lower limbs, no systematic thrombopeophylaxis is recommended. We have reviewed the clinical features and the presence of thrombophilia in such cases. Method: Retrospective study of cases of venous thromboembolic disease after minor trauma of the lower limbs. Results: Twenty-one cases of venous thromboembolic disease following minor trauma to the lower limbs were diagnosed between March 2001 and March 2006. Twenty patients had deep venous thrombosis, with two cases of pulmonary embolism. Some abnormality was detected in 10 (71%) of the 14 patients participating in the thrombophilia study. Conclusions: Minor trauma to the lower limbs represents a risk factor for the development of venous thromboembolic disease. The possibility to initiate thromboprophylaxis should therefore be considered in this setting. Thrombophilia should be considered and ruled out when venous thromboembolic disease develops following minor trauma to the lower limbs (AU)


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Trombose Venosa/etiologia , Traumatismos da Perna/complicações , Trombose Venosa/prevenção & controle , Extremidade Inferior/lesões , Trombofilia/tratamento farmacológico , Anticoagulantes/uso terapêutico
13.
Gac. méd. boliv ; 33(1): 28-33, 2010. ilus
Artigo em Espanhol | LILACS-Express | ID: lil-737803

RESUMO

La apendicitis aguda es una patología muy frecuente en los servicios de emergencias en los hospitales de todo el mundo, para esta patología el abordaje del apéndice se realiza por incisiones medianas, transversales, paramedianas, laparoscopica ¹ y el abordaje transumbilical.² Este trabajo está basado en los conceptos actuales de cirugía mínimamente invasiva de la pared abdominal, consiste en extirpar el apéndice a través de la región umbilical con una incisión a través del ombligo que no excede los 5cm de longitud. Este abordaje cumple los postulados de Maingot, brinda una solución segura al problema consiguiendo una cicatriz estética aceptable. El estudio fue realizado en el Hospital Obrero N°2 de la Caja Nacional de Salud donde se operaron a 57 pacientes entre Junio de 2006 a enero de 2010 con la técnica transumbilical. La morbilidad fue de 13% no existiendo mortalidad, se realizó seguimiento a tres años y medio sin encontrarse incidencia de hernias incisionales ni datos de oclusión intestinal. Se recomienda realizar el abordaje quirúrgico transumbilical para la apendicectomía en apendicitis aguda no complicada ya que es segura, fácil de realizar y brinda resultados estéticos superiores a otras vías de abordaje.


Acute appendicitis it's a frequent disease in every emergency room around world hospitals; for this disease the boarding of appendix is through median, transversal, para median laparoscopic incisión and transumbilical boarding. This Word it's based in actual facts of minimal invading surgery of the abdominal wall; that involves remove the appendix through the umbilical región with an incisión through the umbilicus that does not exceed 5cm in length. This boarding fulfils Maingot postulates aside offering a safe solution also obtains an acceptable aesthetics scar. The study was conducted at the Hospital Obrero N°2 de la Caja Nacional de Salud where 57 patients were submitted to surgery between June 2006 to January 2010 with transumbilical technique. Morbidity was 13% without mortality; a seeking of two and a half years was made without finding incisión hernias or intestinal occlusion. We recommend realizing transumbilical surgical for appendectomy in acute non complicated appendicitis that because it's safe, it's easy to perform and provides superior cosmetic results than the other boarding of approach.

14.
Vaccine ; 27(34): 4560-4, 2009 Jul 23.
Artigo em Inglês | MEDLINE | ID: mdl-19508910

RESUMO

The objective of this study was to evaluate the validity of information reported by the elderly on 23-valent pneumococcal polysaccharide vaccine (23vPPV) vaccination status. A cross-sectional, observational study was carried out in patients aged >or=65 years admitted to five Spanish hospitals. Data on 23vPPV vaccination history were obtained through interview of the patient or close relative and review of written medical information. The validity of the patient self-report was compared to the written medical information by calculation of the sensitivity, specificity, concordance, positive predictive value (PPV) and negative predictive value (NPV). A total of 2484 patients were initially included of whom 1814 patients (73%) responded about their vaccination status. The global sensitivity of the patient self-report was 0.74 and the specificity 0.95. The PPV was 0.92, the NPV 0.84 and the concordance 87. Vaccination cards and centralized vaccination registries in primary health care centres and hospitals should be potentiated in order to ensure that neither more nor less vaccinations are administered than are necessary.


Assuntos
Coleta de Dados/métodos , Infecções Pneumocócicas/prevenção & controle , Vacinas Pneumocócicas/imunologia , Vacinação/estatística & dados numéricos , Idoso , Idoso de 80 Anos ou mais , Estudos Transversais , Humanos , Registros Médicos , Valor Preditivo dos Testes , Sensibilidade e Especificidade , Espanha
15.
J Agric Food Chem ; 56(5): 1574-81, 2008 Mar 12.
Artigo em Inglês | MEDLINE | ID: mdl-18278866

RESUMO

A hydroalcoholic extract of lime ( Citrus aurantifolia) leaves has been developed in Cuba to be used as a nutritional supplement and phytomedicine in the form of tincture (TLL). A HPLC-PDA-ESI/MS/MS method has been used for the comprehensive analysis of C-glycosyl flavones in TLL. Six C-glycosyl flavones were characterized and, to confirm the proposed structures and to elucidate the nature of the sugar units, a preparative procedure was applied, and isolated compounds were characterized by NMR. Apigenin-6,8-di-C-beta-D-glucopyranoside (vicenin II) (1), diosmetin-6,8-di- C-beta- d-glucopyranoside (2), apigenin-8-C-beta-D-glucopyranoside (vitexin) (3), apigenin-8-C-[alpha-L-arabinopyranosyl-(1-->6)]-O-beta-D-glucopyranoside (4), apigenin-6-C-[alpha-l-arabinopyranosyl-(1-->6)]-O-beta-D-glucopyranoside (5). and apigenin-6-C-beta-D-glucopyranoside (isovitexin) (6) were identified in TLL and quantified by HPLC-PDA. Compounds 4 and 5 were two new arabinosyl derivatives of vitexin and isovitexin. Inhibitor effect of TLL on platelet aggregation induced by physiological agonists of platelets was evaluated in human plasma. TLL inhibited significantly ADP and epinephrine-induced platelet aggregation in a concentration-dependent manner (IC 50=0.40 and 0.32 mg/mL, respectively).


Assuntos
Citrus aurantiifolia/química , Monossacarídeos/análise , Monossacarídeos/farmacologia , Agregação Plaquetária/efeitos dos fármacos , Cromatografia Líquida de Alta Pressão/métodos , Suplementos Nutricionais , Flavonas/química , Flavonas/isolamento & purificação , Glicosídeos , Espectroscopia de Ressonância Magnética/métodos , Monossacarídeos/química , Monossacarídeos/isolamento & purificação , Extratos Vegetais/química , Extratos Vegetais/isolamento & purificação , Folhas de Planta/química
16.
Gac. méd. boliv ; 30(1): 63-65, 2007. ilus
Artigo em Espanhol | LILACS-Express | ID: lil-737756

RESUMO

Los quistes mesentéricos son tumores abdominales de asiento en el intestino delgado se originan de los leiomiomas yeyunales que en su evolución desarrollan un quiste mesenterio gigante, o puede ser un tumor primario originado en las hojas mesentéricas constituyen una patología poco frecuente en el adulto, la causa es un defecto en el desarrollo de los linfáticos mesentéricos, existiendo espacios cerrados en los que se acumula contenido linfático. Los quistes mesentéricos son tumores abdominales benignos poco frecuentes de etiología aún no determinada ocurren en cualquier edad, son causa de abdomen agudo, obstrucción intestinal y el 3% se puede malignizarse. Presentamos el caso de un paciente de sexo masculino de 72 años con abdomen agudo secundario a quiste mesenterio.


The Mesenteric cysts are abdominal tumors that develop in thin intestine, they origin from yayunal leiomiomas that in their evolution develop a giant mesenteric cyst, or it can be a primary tumor originated in the mesenteric leafs. They constitute a not very frequent pathology in adults the cause is a defect in the development of mesenteric lymphatics, existing closed spaces in which accumulates lymphatic content. The mesenteric cysts are not very frequent benign abdominal of uncertain etiologv, they appear at any age. they are cause of abdomen pain, intestinal obstruction and 3 % of them can become malignant. We present the case of a masculine sex patient of 72 years old with secondary abdomen pain to cyst mesenteric.

17.
Ciênc. cult. (Säo Paulo) ; 48(1/2): 103-8, Jan.-Apr. 1996. ilus, tab
Artigo em Inglês | LILACS | ID: lil-191249

RESUMO

The toxicity of a polyhydroxy derivative of p-benzoquinone, tetrahydroxy-l,4-benzoquinone (THQ), was investigated in Chinese hamster ribroblasts (V79-M8 line). The fast oxidative degradation of THQ, yielding reactive oxygen species, allowed its use as a suitable tool to study the mechanisms of cell injury under oxidative stress. Toxicity of THQ to V79 cells was evaluated by measuring its inhibitory effects on cell growth and upon DNA synthesis rate. Complete prevention of both effects by catalase implicated hydrogen peroxide as the central key in the mechanism of THQ cytotoxicity. The roles of the primary oxidative product of THQ, rhodizonic acid (RDZ), as well as that of calcium, were investigated. The dependence of THQ on hydrogen peroxide for cytotoxicity, together with the possibility of iron chelation by RDZ, led us to propose an intracellular Fenton-type reaction as the mediator of THQ toxicity toward V79 cells. The understanding of THQ toxicity mechanisms can help to gain insights into the way structurally related physiological compounds, such as catechol derivatives, produce their toxic effects on target cells.


Assuntos
Animais , Cricetinae , Benzoquinonas/toxicidade , Espécies Reativas de Oxigênio , Estresse Oxidativo , Divisão Celular , DNA/biossíntese , Fibroblastos/citologia , Fibroblastos/efeitos dos fármacos , Radicais Livres , Peróxido de Hidrogênio , Inibidores da Síntese de Ácido Nucleico
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