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1.
Rev. esp. patol ; 52(2): 76-80, abr.-jun. 2019. ilus, tab
Artigo em Espanhol | IBECS | ID: ibc-182692

RESUMO

Introducción: La tuberculosis constituye un problema importante de salud a nivel mundial y más aún, la detección temprana y el tratamiento adecuado de la misma en países subdesarrollados. Los estudios post mortem (EPM) han permitido el diagnóstico de tuberculosis, aún en casos sin diagnóstico clínico de la enfermedad. Objetivo: Conocer el número de casos con diagnóstico de tuberculosis en EPM, durante un período de 10 años, en el Hospital General San Juan de Dios (HGSJDD) de Guatemala. Material y métodos: Se revisaron los informes finales de EPM del HGSJDD de Guatemala, de abril del 2006 a marzo del 2016. Se identificaron los casos con diagnóstico de tuberculosis y se revisaron cortes histológicos y tinciones especiales de los mismos. Resultados: En los 10 años revisados, se realizaron 859 EPM, en 21 casos se diagnosticó tuberculosis, 18 en adultos y 3 en niños. La mayoría correspondió a tuberculosis pulmonar (80,95%). En ninguno de los casos se había realizado el diagnóstico clínico de tuberculosis y solo en 5 se tuvo sospecha clínica de la enfermedad, pero ninguno fue investigado. Ningún paciente tenía documentado VIH/sida. Conclusión: El EPM sigue siendo de importancia en el estudio de las enfermedades. En el presente estudio se encontró el diagnóstico de 21 casos de tuberculosis, que no se habían diagnosticado en las evaluaciones clínicas


Introduction: Tuberculosis is a very important health problem worldwide. Early detection and adequate treatment of this disease is also a problem in low income countries. Post mortem examination has enabled tuberculosis to be diagnosed, even in cases without a clinical diagnosis of the disease. Objective: To determine the number of tuberculosis cases diagnosed on autopsy during a period of 10 years, at the San Juan de Dios General Hospital, Guatemala (SJDGH). Material and methods: The final autopsy reports at the between April 2006 and March 2016 were reviewed. H&E and special stains in cases with a diagnosis of tuberculosis were revised for confirmation. Results: During the 10 years reviewed, 859 autopsies had been carried out, 21 of which had the diagnosis of tuberculosis; 18 were adults and 3 were children and the majority (80.95%) were cases of pulmonary tuberculosis. However, in only 5 cases had there been a clinical suspicion, but without further investigation and none had a confirmed clinical diagnosis of tuberculosis. No patients had documented HIV/AIDS. Conclusion: Autopsy continues to be important in the study of disease. In this retrospective study, 21 cases of tuberculosis in 21 cases were found in patients with no clinical diagnosis of the disease


Assuntos
Humanos , Tuberculose/epidemiologia , Tuberculose Pulmonar/epidemiologia , Autopsia/estatística & dados numéricos , Guatemala/epidemiologia , Estudos Retrospectivos , Mortalidade Hospitalar/tendências
3.
Rev Esp Patol ; 52(2): 76-80, 2019.
Artigo em Espanhol | MEDLINE | ID: mdl-30902381

RESUMO

INTRODUCTION: Tuberculosis is a very important health problem worldwide. Early detection and adequate treatment of this disease is also a problem in low income countries. Post mortem examination has enabled tuberculosis to be diagnosed, even in cases without a clinical diagnosis of the disease. OBJECTIVE: To determine the number of tuberculosis cases diagnosed on autopsy during a period of 10 years, at the San Juan de Dios General Hospital, Guatemala (SJDGH). MATERIAL AND METHODS: The final autopsy reports at the between April 2006 and March 2016 were reviewed. H&E and special stains in cases with a diagnosis of tuberculosis were revised for confirmation. RESULTS: During the 10 years reviewed, 859 autopsies had been carried out, 21 of which had the diagnosis of tuberculosis; 18 were adults and 3 were children and the majority (80.95%) were cases of pulmonary tuberculosis. However, in only 5 cases had there been a clinical suspicion, but without further investigation and none had a confirmed clinical diagnosis of tuberculosis. No patients had documented HIV/AIDS. CONCLUSION: Autopsy continues to be important in the study of disease. In this retrospective study, 21 cases of tuberculosis in 21 cases were found in patients with no clinical diagnosis of the disease.

4.
Rev. esp. patol ; 51(4): 244-247, oct.-dic. 2018. ilus
Artigo em Espanhol | IBECS | ID: ibc-179170

RESUMO

Los melanomas de vejiga urinaria son poco frecuentes. Presentamos el caso de una paciente femenina de 58 años, quien consultó por disuria y hematuria de 4 meses de evolución. Se le realizó cistoscopia y biopsia, la cual fue interpretada como melanoma invasivo. Posteriormente se realizó cistectomía parcial, en la cual se diagnosticó melanoma, confirmado por positividad de las células neoplásicas para Melan-A y HMB-45 en estudio de inmunohistoquímica. Se demostró invasión neoplásica de todo el espesor de la capa muscular y de bordes quirúrgicos. Cuatro meses después se recibió vejiga urinaria de 13×7×5cm, en la cual se encontró, además del melanoma, melanosis y nevo melanocítico en vejiga urinaria. El nevo melanocítico se demostró mediante positividad a anticuerpos melanocíticos, de células no atípicas en capa basal de urotelio vecino y distante al tumor. La paciente sobrevivió 9 meses


Primary melanoma of the urinary bladder is rare. We report a case of a 58-year-old woman, who presented with a 4 month history of dysuria and hematuria. A biopsy indicated a diagnosis of invasive melanoma and a partial cystectomy was performed. The neoplasm had invaded the entire thickness of the bladder wall and the neoplastic cells were positive for Melan A and HMB-45. Four months later a urinary bladder measuring 13×7×5cm was sent for histopathology. Melanoma, melanosis and a melanocytic nevus were seen; the latter was confirmed by the positivity to melanocytic markers of non-atypical cells in both the urothelial basal layer and areas distant from the tumour. The patient died nine months later


Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Melanoma/patologia , Neoplasias da Bexiga Urinária/patologia , Cistoscopia/métodos , Biópsia/métodos , Disuria/etiologia , Hematúria/etiologia , Invasividade Neoplásica/patologia
5.
Rev Esp Patol ; 51(4): 244-247, 2018 Oct - Dec.
Artigo em Espanhol | MEDLINE | ID: mdl-30269776

RESUMO

Primary melanoma of the urinary bladder is rare. We report a case of a 58-year-old woman, who presented with a 4 month history of dysuria and hematuria. A biopsy indicated a diagnosis of invasive melanoma and a partial cystectomy was performed. The neoplasm had invaded the entire thickness of the bladder wall and the neoplastic cells were positive for Melan A and HMB-45. Four months later a urinary bladder measuring 13×7×5cm was sent for histopathology. Melanoma, melanosis and a melanocytic nevus were seen; the latter was confirmed by the positivity to melanocytic markers of non-atypical cells in both the urothelial basal layer and areas distant from the tumour. The patient died nine months later.

6.
BMC Cancer ; 18(1): 562, 2018 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-29764400

RESUMO

BACKGROUND: A low cost and accurate method for detecting high-risk (HR) human papillomavirus (HPV) is important to permit HPV testing for cervical cancer prevention. We used a commercially available HPV method (H13, Hybribio) which was documented to function accurately in a reduced volume of cervical specimen to determine the most prevalent HPV types and the distribution of HPV infections in over 1795 cancer-free women in Guatemala undergoing primary screening for cervical cancer by cytology. METHODS: HR-HPV detection was attempted in cervical samples from 1795 cancer-free women receiving Pap smears using the Hybribio™ real-time PCR assay of 13 HR types. The test includes a globin gene internal control. HPV positive samples were sequenced to determine viral type. Age-specific prevalence of HPV was also assessed in the study population. RESULTS: A total of 13% (226/1717) of women tested HPV+, with 78 samples (4.3%) failing to amplify the internal control. The highest prevalence was found in younger women (< 30 years, 22%) and older ones (≥60 years, 15%). The six most common HR-HPV types among the 148 HPV+ typed were HPV16 (22%), HPV18 (11%), HPV39 (11%), HPV58 (10%), HPV52 (8%), and HPV45 (8%). CONCLUSIONS: In this sample of cancer free women in Guatemala, HPV16 was the most prevalent HR type in Guatemala and the age-specific prevalence curve peaked in younger ages. Women in the 30-59-year age groups had a prevalence of HR-HPV of 8%, however, larger studies to better describe the epidemiology of HPV in Guatemala are needed.

7.
Rev. Col. Méd. Cir. Guatem ; 156(1): 11-14, 2017 jul. tab
Artigo em Espanhol | LILACS | ID: biblio-908634

RESUMO

Las enfermedades infecciosas crónicas constituyen un problema de salud pública mundial al ser importante causa de mortalidad. En Guatemala no existen estudios postmortem recientes que aborden dicho tema, por lo que se desconoce su prevalencia en autopsias clínicas del país. El presente estudio se delimita las siguientes enfermedades: tuberculosis, candidiasis, neurocisticercosis, aspergilosis, coccidioidomicosis e histoplasmosis. Objetivo: determinar la prevalencia de las enfermedades infecciosas crónicas en autopsias clínicas. Material y Métodos: investigación descriptiva retrospectiva, basada en los datos de 909 boletas de protocolos completos de autopsias clínicas realizadas del año 2006 al 2015 en el Departamento de patología en el Hospital General San Juan de Dios de Guatemala


Assuntos
Humanos , Masculino , Feminino , Pré-Escolar , Criança , Tuberculose/mortalidade , Candidíase/epidemiologia , Doenças Transmissíveis/epidemiologia , Estudos Retrospectivos , Neurocisticercose/epidemiologia , Autopsia/estatística & dados numéricos
8.
Rev. Col. Méd. Cir. Guatem ; 156(1): 30-34, 2017 jul. Tab
Artigo em Espanhol | LILACS | ID: biblio-981378

RESUMO

Antecedentes: La evaluación de la excelencia académica de las universidades toma en cuenta varios indicadores, uno de los más determinantes es la investigación científica, que a su vez es usualmente medida por el número y el impacto de las publicaciones en revistas indexadas. Las universidades necesitan saber su posición en relación al resto de universidades del mundo para desarrollar planes de mejoramiento. Objetivo: estimar cuánto del crédito por investigación que la Universidad de San Carlos de Guatemala (USAC) merece, pudiera estar siendo detectado y evaluado por las entidades dedicadas a estratificar las universidades según su rendimiento académico. Material y método: estudio exploratorio de datos obtenidos de PUBMED sobre artículos científicos atribuibles a la USAC, publicados antes del 2017. Los datos bibliométricos analizados incluyeron la cantidad de artículos y el número de citas por articulo...(AU)


Assuntos
Publicações Periódicas como Assunto , Universidades , Bibliometria , Comunicação Acadêmica
9.
Rev. Col. Méd. Cir. Guatem ; Año 67,155(1): 42-45, jul. 2016.
Artigo em Espanhol | LILACS | ID: biblio-835552

RESUMO

Antecedentes: Los tumores del estroma gastrointestinal (TEG) son los tumores mesenquimales más comunes del tracto gastrointestinal (TGI), se considera que surgen de las células de Cajal, ocurren principalmente en adultos mayores (60-65 años) y se localizan en estómago (50%-70%), intestino delgado (25%-35%), colon-recto (5%-10%) y esófago (<5%). La mayoría se presenta de manera esporádica y hasta el 70% son clínicamente sintomáticos. El diagnóstico definitivo se realiza en el estudio anatomopatológico. El pronóstico de estos tumores se determina por el tamaño, recuento mitótico y localización del tumor, clasificandose: riesgo muy bajo, riesgo bajo, riesgo intermedio y riesgo alto. La cirugía es la opción terapéutica principal...


Background: Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract (GI), areconsidered to arise from the Cajal cells. Theyoccur mainly in older adults, 60-65 years. Theypresent in the stomach (50%-70%), small intestine (25%-35%), colon and rectum (5%-10%)and esophagus (<5%). Most GISTs are sporadicand are clinically symptomatic. The definitivediagnosis is made through anatomic pathology study. To determine the prognosis of this type of tumors we use the size, mitotic count and location of the tumor, classified them in: very low risk, low risk, intermediate risk and high risk. Surgery is the main treatment...


Assuntos
Humanos , Tumores do Estroma Gastrointestinal/cirurgia , Tumores do Estroma Gastrointestinal/classificação , Tumores do Estroma Gastrointestinal/diagnóstico
11.
Rev. esp. patol ; 47(3): 137-141, jul.-sept. 2014.
Artigo em Espanhol | IBECS | ID: ibc-124883

RESUMO

La neurocisticercosis es causa de epilepsia tardía en muchos países, principalmente en los países en vías de desarrollo. Se adquiere al ingerir huevos de Taenia solium en alimentos y agua contaminados. La Taenia solium se adquiere ingiriendo el cisticerco, cuando consumimos carne de cerdo mal cocida. Presentamos los hallazgos de 30 pacientes operados en el Hospital General San Juan de Dios de la ciudad de Guatemala, de junio 2007 a junio 2012, de los cuales 17 son del sexo femenino y 13 del sexo masculino; el rango de edad fue de 11 a 65 años y la década de mayor presentación fue de 21 a 30 años (12 pacientes). Se revisaron los expedientes de 18 pacientes, encontrando que las lesiones fueron 7 en parénquima, 7 intraventriculares y 4 subaracnoideas. Los síntomas más referidos fueron náuseas, cefalea y vómitos. El diagnóstico por imagen se hizo en 11 casos por tomografía axial computarizada y en 7 por resonancia magnética. En 3 hubo eosinofilia. Se realizó la clasificación histológica del estadio del cisticerco, encontrando 12 en el estadio vesicular, 5 en el estadio vesicular coloidal, 12 en el estadio granular nodular y uno en el estadio calcificado (AU)


Neurocysticercosis causes late epilepsy in many countries, but mainly in developing countries. It is acquired by ingesting Taenia solium eggs in contaminated food and water. Taenia solium is acquired by the intake of the cysticercus in undercooked pork. We present 30 patients from the General Hospital San Juan de Dios in Guatemala City, who underwent surgery between June 2007 and June 2012. 17 were female and 13 male, the age range was 11-65 years with a majority of patients (12) aged between 21-30 years. We reviewed the records of 18 patients, finding 7 parenchymal lesions, 7 intraventricular lesions, and 4 subarachnoideal lesions. The most frequent symptoms were nausea, vomiting and headaches. Diagnosis by imaging was carried out in 11 cases by CT scan and 7 by MRI. Three patients had eosinophilia. Histological classification was performed to stage the cysticerci: 12 were in the vesicular stage, 5 in the colloidal vesicular stage, 12 in the granular nodular stage and 1 in the calcified stage (AU)


Assuntos
Humanos , Masculino , Feminino , Criança , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Neurocisticercose/epidemiologia , Neurocisticercose/prevenção & controle , Taenia solium/isolamento & purificação , Técnicas Histológicas/métodos , Técnicas Histológicas , Neurocisticercose/diagnóstico , Neurocisticercose/patologia , Guatemala/epidemiologia , Eosinofilia/complicações , Eosinofilia , Neurocisticercose/cirurgia , Imagem por Ressonância Magnética
12.
Rev. Col. Méd. Cir. Guatem ; 7(1): 5-15, jul. 2014.
Artigo em Espanhol | LILACS | ID: biblio-835539

RESUMO

Objetivo: Determinar la prevalencia de los organos afectados por cáncer diagnosticados en el Departamento de Patología Dr. Carlos Martínez Durán del Hospital General San Juan de Dios, Laboratorio de Patología Dr. Víctor Argueta, Laboratorio de Patología Dr. Roberto Orozco y Laboratorio de Patología y Citología Dr. Miguel Garcés y Dra. Helen Morales, ubicados en la ciudad de Guatemala, años 2,006-2,010. Metodología: La investigación está regida por un estudio cuantitativo, descriptivo, no experimental, retrospectivo, realizado en tres laboratorios privados de patología...


Assuntos
Humanos , Laboratórios Hospitalares/classificação , Laboratórios Hospitalares/estatística & dados numéricos , Neoplasias/patologia
13.
Rev. Col. Méd. Cir. Guatem ; vol. 151: 27-31, jul. 2014. ilus
Artigo em Espanhol | LILACS | ID: biblio-835567

RESUMO

La amebiasis intestinal es una enfermedad frecuente en países en desarrollo, que es común en regiones tropicales y subtropicales, así como en regiones con servicios sanitarios deficientes. Presentamos el caso de un paciente de 74 años de edad, sexo masculino, originario y residente de la ciudad de Guatemala, quién cursó una diarrea y dolor abdominal. Fue intervenido quirúrgicamente por abdomen agudo, con resección intestinal extensa por perforaciones. En el estudio de anatomía patológica se realizó el diagnóstico de colitis amebiana con perforaciones y peritonitis.


Intestinal amoebiasis is a disease common indeveloping countries, which is common in tropicaland subtropical regions, as well as in regions withpoor sanitation. We report the case of a 74-year-oldmale, resident of Guatemala City, who presented withdiarrhea and abdominal pain. He had a laparatomy foracute abdomen, undergoing wide intestinal resectiondue to perforations. The pathology diag-nosis wasamoebic colitis with perforations and peritonitis.


Assuntos
Humanos , Disenteria Amebiana/complicações , Disenteria Amebiana/diagnóstico , Entamoeba histolytica/classificação , Entamoeba histolytica/parasitologia , Perfuração Intestinal/complicações
14.
Mycoses ; 53(3): 259-61, 2010 May.
Artigo em Inglês | MEDLINE | ID: mdl-19389070

RESUMO

Cutaneous infections by Zygomycetes may have underestimated clinical consequences. Apophysomyces elegans is a Zygomycete that rarely causes disease in humans. However, it has been reported with increasing frequency in warm climate zones as a result of infection in healthy patients after injury to the cutaneous barrier. The following case report describes a 30-year-old woman with deep tissue involvement of A. elegans associated with a spider bite and a fatal outcome.


Assuntos
Dermatomicoses/diagnóstico , Mucorales/isolamento & purificação , Mucormicose/diagnóstico , Picaduras de Aranhas/complicações , Adulto , Biópsia , Dermatomicoses/microbiologia , Feminino , Histocitoquímica , Humanos , Microscopia , Mucormicose/microbiologia
15.
BMJ Case Rep ; 20092009.
Artigo em Inglês | MEDLINE | ID: mdl-21686862

RESUMO

We present a case of mucinous cystadenocarcinoma of the renal pelvis associated with a collecting duct carcinoma in a 58-year-old woman with diabetes. Even though several theories about the aetiology of mucinous cystadenocarcinoma of the renal pelvis have been proposed, its origin remains unknown. The present case shows a distinct morphology and immunohistochemical profile that may suggest a clue to its histogenesis.

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